Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0143 | 0.1205 | 1 |
Onchocerca volvulus | 0.0118 | 0.0876 | 0.668 | |
Echinococcus granulosus | geminin | 0.0169 | 0.154 | 0.0998 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0118 | 0.0876 | 0.5686 |
Echinococcus multilocularis | cathepsin b | 0.0143 | 0.1205 | 0.0333 |
Mycobacterium ulcerans | proteasome PrcA | 0.0813 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0143 | 0.1205 | 0.7823 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0514 | 0.6078 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.154 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0143 | 0.1205 | 0.7823 |
Brugia malayi | Protein kinase domain containing protein | 0.013 | 0.1037 | 0.4901 |
Toxoplasma gondii | kringle domain-containing protein | 0.013 | 0.1037 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 0.154 | 0.0998 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1037 | 0.4901 |
Schistosoma mansoni | hypothetical protein | 0.013 | 0.1037 | 0.6733 |
Echinococcus granulosus | cathepsin b | 0.0143 | 0.1205 | 0.0333 |
Leishmania major | hypothetical protein, conserved | 0.013 | 0.1037 | 0.5 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0813 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0143 | 0.1205 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1205 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0514 | 0.6078 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.013 | 0.1037 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0143 | 0.1205 | 0.7823 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0143 | 0.1205 | 0.7823 |
Onchocerca volvulus | 0.013 | 0.1037 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0143 | 0.1205 | 0.0333 |
Echinococcus multilocularis | cathepsin b | 0.0143 | 0.1205 | 0.0333 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.154 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0118 | 0.0876 | 0.5686 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.013 | 0.1037 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.013 | 0.1037 | 0.4901 |
Brugia malayi | Kringle domain containing protein | 0.013 | 0.1037 | 0.4901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.