Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0145 | 0.4085 | 1 |
Echinococcus granulosus | cathepsin b | 0.0145 | 0.4085 | 1 |
Onchocerca volvulus | 0.0217 | 1 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0095 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 0.4085 | 0.4085 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 0.4085 | 0.4085 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0217 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0095 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0145 | 0.4085 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0095 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0145 | 0.4085 | 1 |
Onchocerca volvulus | 0.019 | 0.7814 | 0.7814 | |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0217 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 0.4085 | 0.4085 |
Echinococcus granulosus | cathepsin b | 0.0145 | 0.4085 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4085 | 0.4085 |
Toxoplasma gondii | kringle domain-containing protein | 0.0095 | 0 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0145 | 0.4085 | 0.4085 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0145 | 0.4085 | 0.4085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.