Detailed information for compound 81482

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.528 | Formula: C20H19N5S2
  • H donors: 1 H acceptors: 1 LogP: 3.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS/C(=N\c1cccc(c1)C1N=C2N(C1)CCS2)/Nc1cccc(c1)C#N
  • InChi: 1S/C20H19N5S2/c1-26-19(22-16-6-2-4-14(10-16)12-21)23-17-7-3-5-15(11-17)18-13-25-8-9-27-20(25)24-18/h2-7,10-11,18H,8-9,13H2,1H3,(H,22,23)
  • InChiKey: CYUNINXPZSNQRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0243 0.1395 0.314
Schistosoma mansoni suppressor of variegation 4-20-related 0.014 0.0738 0.1645
Trypanosoma cruzi arginine N-methyltransferase, type II, putative 0.0044 0.0132 0.0374
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0044 0.0065
Echinococcus granulosus PWWP domain containing protein 2A 0.0038 0.0096 0.0183
Toxoplasma gondii bicoid-interacting protein BIN3 0.0048 0.016 0.1478
Loa Loa (eye worm) hypothetical protein 0.0035 0.0075 0.006
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0048 0.016 0.0465
Brugia malayi jmjC domain containing protein 0.0038 0.0095 0.0095
Echinococcus granulosus protein arginine N methyltransferase 8 0.0032 0.0054 0.0088
Leishmania major arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640 0.0044 0.0132 0.0374
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0054 0.0044
Schistosoma mansoni phd finger protein 0.0038 0.0096 0.0183
Brugia malayi Pre-SET motif family protein 0.1303 0.8124 0.8124
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0398 0.2379 0.2379
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0138 0.0731 0.2304
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0248 0.0233
Schistosoma mansoni cpg binding protein 0.0103 0.0505 0.1114
Schistosoma mansoni hypothetical protein 0.0038 0.0096 0.0183
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0216 0.1221 0.1207
Schistosoma mansoni jumonji domain containing protein 0.0078 0.035 0.0763
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0161 0.0876 1
Loa Loa (eye worm) hypothetical protein 0.1599 1 1
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0216 0.1221 0.2743
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0044 0.0029
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0051 0.0173 0.0508
Schistosoma mansoni cpg binding protein 0.0101 0.0494 0.1089
Echinococcus multilocularis disco interacting protein 2 0.0082 0.0372 0.0811
Brugia malayi Bromodomain containing protein 0.0028 0.0032 0.0032
Onchocerca volvulus 0.0038 0.0096 0.0091
Plasmodium vivax spermidine synthase, putative 0.0515 0.3124 1
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0161 0.0876 0.2768
Schistosoma mansoni hypothetical protein 0.0175 0.0965 0.216
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0479 0.1056
Trypanosoma cruzi arginine N-methyltransferase, putative 0.008 0.0361 0.1113
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.014 0.0738 0.1645
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0161 0.0876 0.8801
Leishmania major arginine N-methyltransferase-like protein 0.0032 0.0054 0.0125
Treponema pallidum pfs protein (pfs) 0.0026 0.0015 0.5
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0048 0.016 0.0465
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0029
Loa Loa (eye worm) hypothetical protein 0.008 0.0361 0.0346
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0081
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0044 0.0065
Echinococcus granulosus protein arginine N methyltransferase 7 0.0048 0.016 0.0329
Brugia malayi Skb1 methyltransferase family protein 0.0069 0.0288 0.0288
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0205 0.1157 0.2597
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0032 0.0054 0.0396
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0044 0.0132 0.0131
Echinococcus granulosus methylthioadenosine phosphorylase 0.0138 0.0731 0.163
Schistosoma mansoni hypothetical protein 0.0038 0.0096 0.0183
Schistosoma mansoni methylthioadenosine phosphorylase 0.0138 0.0731 0.163
Echinococcus granulosus geminin 0.0175 0.0965 0.216
Schistosoma mansoni protein arginine n-methyltransferase 0.0169 0.0926 0.2071
Loa Loa (eye worm) PWWP domain-containing protein 0.0038 0.0096 0.0081
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3124 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0132 0.0688 0.6875
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0073 0.0316 0.0685
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0216 0.1221 0.3878
Echinococcus granulosus protein arginine N methyltransferase 5 0.0069 0.0288 0.0621
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0048 0.016 0.0465
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0048 0.016 0.0465
Brugia malayi Protein arginine N-methyltransferase 0.0048 0.016 0.016
Echinococcus multilocularis geminin 0.0175 0.0965 0.216
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0113 0.0569 0.2435
Trypanosoma brucei histone-lysine n-methyltransferase 0.0051 0.0173 0.0508
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0026 0.0015 0.0015
Leishmania major modification methylase-like protein 0.0161 0.0876 0.2768
Loa Loa (eye worm) hypothetical protein 0.0115 0.058 0.0566
Giardia lamblia PHD finger protein 15 0.003 0.0044 1
Echinococcus granulosus probable protein arginine n-methyltransferase 0.0318 0.1869 0.4218
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0096 0.0259
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0044 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0327 0.071
Toxoplasma gondii hypothetical protein 0.0051 0.0173 0.1616
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0138 0.0731 0.0717
Brugia malayi hypothetical protein 0.0166 0.0904 0.0904
Brugia malayi hypothetical protein 0.0038 0.0096 0.0096
Brugia malayi Pre-SET motif family protein 0.0167 0.091 0.091
Echinococcus multilocularis PWWP domain containing protein 2A 0.0038 0.0096 0.0183
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0169 0.0926 0.2071
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0044 0.0293
Echinococcus granulosus methyl CpG binding domain protein 2 0.0027 0.0022 0.0014
Brugia malayi Bromodomain containing protein 0.003 0.0044 0.0044
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0048 0.016 0.0329
Brugia malayi MTAP 0.0138 0.0731 0.0731
Loa Loa (eye worm) Skb1 methyltransferase 0.0069 0.0288 0.0273
Echinococcus multilocularis histone h3 methyltransferase 0.0398 0.2379 0.5379
Loa Loa (eye worm) hypothetical protein 0.0166 0.0904 0.089
Leishmania major arginine N-methyltransferase, type I 0.0048 0.016 0.0465
Onchocerca volvulus 0.1423 0.8882 1
Brugia malayi SET domain containing protein 0.0205 0.1157 0.1157
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.005 0.0172 0.0357
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0048 0.016 0.0163
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0048 0.016 0.0465
Onchocerca volvulus Alhambra homolog 0.003 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0166 0.0904 0.089
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0329
Echinococcus granulosus PWWP domain containing protein 2A 0.0038 0.0096 0.0183
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0051 0.0173 0.0508
Schistosoma mansoni shk1 kinase-binding protein 0.0069 0.0288 0.0621
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0054 0.0088
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0169 0.0926 0.9308
Schistosoma mansoni methylthioadenosine phosphorylase 0.0138 0.0731 0.163
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0084 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0193 0.1079 0.242
Schistosoma mansoni hypothetical protein 0.003 0.0044 0.0065
Leishmania major hypothetical protein, conserved 0.0051 0.0173 0.0508
Toxoplasma gondii hypothetical protein 0.0038 0.0096 0.0823
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3124 1
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0048 0.016 0.1679
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0119 0.0236
Schistosoma mansoni cpg binding protein 0.0103 0.0505 0.1114
Onchocerca volvulus 0.0038 0.0096 0.0091
Plasmodium vivax hypothetical protein, conserved 0.003 0.0044 0.0092
Plasmodium falciparum spermidine synthase 0.0515 0.3124 1
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0205 0.1157 0.2597
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0216 0.1221 0.3878
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0193 0.1079 0.242
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0032 0.0039
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.005 0.0172 0.0357
Loa Loa (eye worm) CXXC zinc finger family protein 0.0101 0.0494 0.0479
Loa Loa (eye worm) hypothetical protein 0.0398 0.2379 0.2367
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0051 0.0173 0.0508
Brugia malayi uridine phosphorylase family protein 0.0026 0.0015 0.0015
Loa Loa (eye worm) spermidine synthase 0.0515 0.3124 0.3113
Echinococcus granulosus disco interacting protein 2 0.0082 0.0372 0.0811
Loa Loa (eye worm) Carm1-pending protein 0.0169 0.0926 0.0912
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0193 0.1079 0.242
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.441 1
Onchocerca volvulus 0.0166 0.0904 0.1002
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0026 0.0015 0.5
Echinococcus granulosus spermidine synthase 0.0515 0.3124 0.7074
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0138 0.0731 0.163
Loa Loa (eye worm) hypothetical protein 0.0071 0.0304 0.0289
Mycobacterium leprae probable uridine phosphorylase 0.0026 0.0015 0.5
Trypanosoma brucei spermidine synthase 0.0515 0.3124 1
Brugia malayi hypothetical protein 0.008 0.0361 0.0361
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0161 0.0876 0.2768
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0105 0.0519 0.162
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0161 0.0876 0.1958
Echinococcus granulosus SET and MYND domain containing protein 3 0.0073 0.0316 0.0685
Onchocerca volvulus 0.0082 0.0372 0.0402
Echinococcus multilocularis protein arginine N methyltransferase 5 0.0069 0.0288 0.0621
Chlamydia trachomatis AMP nucleosidase 0.0026 0.0015 0.5
Echinococcus granulosus peregrin 0.0068 0.0287 0.0618
Echinococcus granulosus methyltransferase protein 5 0.0048 0.016 0.0329
Echinococcus multilocularis hepatoma derived growth factor protein 0.0038 0.0096 0.0183
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0048 0.016 0.0163
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0032 0.0054 0.0125
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0161 0.0876 0.2768
Loa Loa (eye worm) SET domain-containing protein 0.014 0.0738 0.0724
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0138 0.0731 0.2304
Onchocerca volvulus 0.0101 0.0494 0.054
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0105 0.0519 0.162
Echinococcus multilocularis protein arginine methyltransferase 0.0032 0.0054 0.0088
Leishmania major methylthioadenosine phosphorylase, putative 0.0138 0.0731 0.2304
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0384 0.2288 1
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3124 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0095 0.0181
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0027 0.0022 0.0014
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0048 0.016 0.1478
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0032 0.0054 0.0125
Loa Loa (eye worm) hypothetical protein 0.0111 0.056 0.0546
Echinococcus granulosus hepatoma derived growth factor protein 0.0038 0.0096 0.0183
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0054 0.0088
Loa Loa (eye worm) hypothetical protein 0.0193 0.1079 0.1065
Schistosoma mansoni hepatoma derived growth factor 0.0038 0.0096 0.0183
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0044 0.0132 0.0131
Echinococcus multilocularis PWWP domain containing protein 2A 0.0038 0.0096 0.0183
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0161 0.0876 0.1958
Brugia malayi hypothetical protein 0.0166 0.0904 0.0904
Echinococcus granulosus protein arginine methyltransferase 0.0032 0.0054 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0132 0.0688 0.153
Echinococcus multilocularis cpg binding protein 0.0103 0.0505 0.1114
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0169 0.0926 0.2071
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0138 0.0731 0.2304
Schistosoma mansoni hypothetical protein 0.0175 0.0965 0.216
Entamoeba histolytica hypothetical protein 0.0038 0.0096 0.0935
Trypanosoma cruzi arginine N-methyltransferase, putative 0.008 0.0361 0.1113
Echinococcus multilocularis peregrin 0.0068 0.0287 0.0618
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0119 0.0236
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0216 0.1221 0.3878
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0032 0.0039
Echinococcus granulosus cpg binding protein 0.0103 0.0505 0.1114
Mycobacterium ulcerans spermidine synthase 0.0384 0.2288 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0904 0.089
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0216 0.1221 0.3878
Leishmania major hypothetical protein, conserved 0.0051 0.0173 0.0508
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.441 1
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0035 0.0075 0.0135
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0095 0.0181
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0166
Toxoplasma gondii DNA methyltransferase 2, putative 0.0161 0.0876 0.8801
Brugia malayi Disco-interacting protein 2 homolog 0.0082 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0006
Plasmodium falciparum protein arginine N-methyltransferase 5, putative 0.0069 0.0288 0.0877
Leishmania major S-adenosylmethionine decarboxylase 0.0216 0.1221 0.3878
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0085 0.0393 0.1215
Schistosoma mansoni hepatoma derived growth factor 0.0038 0.0096 0.0183
Plasmodium vivax protein arginine N-methyltransferase 5, putative 0.0069 0.0288 0.0877
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0048 0.016 0.0163
Brugia malayi SET domain containing protein 0.0124 0.0637 0.0637
Leishmania major spermidine synthase 0.0515 0.3124 1
Echinococcus granulosus microtubule associated protein 2 0.0718 0.441 1
Brugia malayi hypothetical protein 0.0038 0.0096 0.0096
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0054 0.0044
Schistosoma mansoni SET domain protein 0.0052 0.0183 0.0382
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0048 0.016 0.0465
Loa Loa (eye worm) hypothetical protein 0.0082 0.0372 0.0357
Schistosoma mansoni methyl-cpg binding protein mbd 0.0027 0.0022 0.0014
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0038 0.0096 0.0259
Schistosoma mansoni enhancer of zeste ezh 0.0205 0.1157 0.2597
Brugia malayi PWWP domain containing protein 0.0038 0.0096 0.0096
Brugia malayi CXXC zinc finger family protein 0.0101 0.0494 0.0494
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0026 0.0015 0.5
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0051 0.0173 0.0508
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0038 0.0096 0.0259
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.008 0.0361 0.402
Loa Loa (eye worm) SET domain-containing protein 0.0205 0.1157 0.1143
Schistosoma mansoni hypothetical protein 0.0038 0.0096 0.0183
Leishmania major hypothetical protein, conserved 0.0038 0.0096 0.0259
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0284 0.2752
Brugia malayi Carm1-pending protein 0.0169 0.0926 0.0926
Trichomonas vaginalis set domain proteins, putative 0.1423 0.8882 1
Brugia malayi PHD-finger family protein 0.003 0.0044 0.0044
Onchocerca volvulus 0.0243 0.1395 0.1556
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0054 0.0044
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0095 0.0181
Plasmodium falciparum phd finger protein, putative 0.003 0.0044 0.0092
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0216 0.1221 0.1221
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3124 1
Toxoplasma gondii hypothetical protein 0.018 0.0993 1
Plasmodium vivax SET domain protein, putative 0.0132 0.0688 0.2163
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.008 0.0361 0.1113
Echinococcus granulosus histone lysine methyltransferase setb 0.0193 0.1079 0.242
Entamoeba histolytica Skb1 methyltransferase, putative 0.0069 0.0288 0.317
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0154 0.0833 0.1861
Leishmania major histone-lysine N-methyltransferase, putative 0.0051 0.0173 0.0508
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.1599 1 1
Toxoplasma gondii histone arginine methyltransferase PRMT5 0.0069 0.0288 0.279
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0048 0.016 0.0145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0479 0.1056
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.018 0.0993 0.3146
Onchocerca volvulus 0.0134 0.0703 0.0775
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1303 0.8124 0.8121
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0216 0.1221 0.3878
Echinococcus multilocularis spermidine synthase 0.0515 0.3124 0.7074
Entamoeba histolytica hypothetical protein 0.008 0.0361 0.402
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0054 0.0088
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0046 0.0046
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0216 0.1221 0.2743
Schistosoma mansoni methyl-cpg binding protein mbd 0.0027 0.0022 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0044 0.0293
Treponema pallidum uridine phosphorylase (udp) 0.0026 0.0015 0.5
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0138 0.0731 0.315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0035 0.0044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0132 0.0688 0.153
Brugia malayi jmjC domain containing protein 0.0099 0.0479 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0096 0.0259
Loa Loa (eye worm) hypothetical protein 0.1599 1 1
Echinococcus granulosus histone h3 methyltransferase 0.0398 0.2379 0.5379
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0085 0.0393 0.1215
Brugia malayi Spermidine synthase 0.0515 0.3124 0.3124
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0082 0.0372 0.0811
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0035 0.0075 0.0135
Echinococcus granulosus DNA methyltransferase 2, putative 0.0161 0.0876 0.1958
Schistosoma mansoni hypothetical protein 0.0054 0.0194 0.0407
Trypanosoma brucei transcription elongation factor s-II, putative 0.0038 0.0096 0.0259
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0051 0.0173 0.0508
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0038 0.0096 0.0259
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0032 0.0054 0.0088
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0051 0.0173 0.0508
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0095 0.008
Schistosoma mansoni histone J3 methyltransferase 0.0398 0.2379 0.5379
Brugia malayi SET domain containing protein 0.014 0.0738 0.0738
Trypanosoma brucei arginine N-methyltransferase, type II 0.0044 0.0132 0.0374
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.014 0.0738 0.1645

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 % Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 50 mg/kg of the compound ; ND means no data ChEMBL. 3116256
Activity (functional) = 63 % Anthelmintic activity against adult liver fluke (Fasciola hepatica) in sheep, after peroral administration of 15 mg/kg of the compound was determined ChEMBL. 3116256
Activity (functional) = 100 % Anthelmintic activity against adult liver fluke (Fasciola hepatica) in 3 sheep, after peroral administration of 30 mg/kg of the compound was determined. Value in parentheses indicate number of animals used ChEMBL. 3116256
Activity (functional) = 100 % Anthelmintic activity against adult liver fluke (Fasciola hepatica) in sheep, after peroral administration of 20 mg/kg of the compound was determined ChEMBL. 3116256
Reduction (functional) = 54 % Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 100 mg/kg ChEMBL. 3116256
Reduction (functional) = 54 % Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 100 mg/kg ChEMBL. 3116256
Reduction (functional) = 100 % Nematocidal activity against Nematospiroides dubius induced necropsy in mouse, oral administration 200 mg/kg ChEMBL. 3116256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.