Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0467 | 0.1759 | 0.0474 |
Echinococcus granulosus | carboxylesterase 5A | 0.2388 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0403 | 0.1488 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0403 | 0.1488 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2388 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0403 | 0.1488 | 1 |
Brugia malayi | hypothetical protein | 0.0403 | 0.1488 | 0.0752 |
Schistosoma mansoni | acetylcholinesterase | 0.0403 | 0.1488 | 0.016 |
Echinococcus granulosus | acetylcholinesterase | 0.2388 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0403 | 0.1488 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0351 | 0.1264 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0403 | 0.1488 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Loa Loa (eye worm) | carboxylesterase | 0.0403 | 0.1488 | 0.0867 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0403 | 0.1488 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Brugia malayi | Carboxylesterase family protein | 0.2388 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2388 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2388 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2388 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0403 | 0.1488 | 0.0752 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0166 | 0.047 | 0.3643 |
Loa Loa (eye worm) | hypothetical protein | 0.2388 | 1 | 1 |
Onchocerca volvulus | 0.0403 | 0.1488 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0351 | 0.1264 | 1 |
Onchocerca volvulus | 0.0403 | 0.1488 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0403 | 0.1488 | 0.0752 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2388 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0403 | 0.1488 | 0.016 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2388 | 1 | 1 |
Onchocerca volvulus | 0.0403 | 0.1488 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0403 | 0.1488 | 0.0752 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0351 | 0.1264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0802 | 0.3198 | 0.2701 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0403 | 0.1488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Schistosoma mansoni | gliotactin | 0.0403 | 0.1488 | 0.016 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0403 | 0.1488 | 0.016 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2388 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0403 | 0.1488 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0242 | 0.0796 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.2388 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0351 | 0.1264 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0403 | 0.1488 | 0.0867 |
Onchocerca volvulus | 0.0403 | 0.1488 | 1 | |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.1018 | 0.4123 | 0.3615 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0403 | 0.1488 | 0.016 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.0905 | 0.378 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.1605 | 0.0993 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1488 | 0.0867 |
Onchocerca volvulus | 0.0403 | 0.1488 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0403 | 0.1488 | 0.0752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.