Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase c epsilon type | 0.0085 | 0.729 | 0.729 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0085 | 0.729 | 0.729 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.6745 | 0.6745 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0085 | 0.729 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0078 | 0.6593 | 0.6593 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0913 | 0.0913 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0992 | 0.0992 |
Echinococcus multilocularis | Mastin | 0.0018 | 0.0913 | 0.0913 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0697 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.007 | 0.5794 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Brugia malayi | Trypsin family protein | 0.0018 | 0.0913 | 0.1252 |
Schistosoma mansoni | atypical protein kinase C | 0.0015 | 0.0577 | 0.0577 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0992 | 0.0992 |
Echinococcus granulosus | protein kinase C gamma type | 0.001 | 0.012 | 0.012 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0018 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0992 | 0.0992 |
Echinococcus granulosus | enteropeptidase | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0992 | 0.0992 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0992 | 0.0992 |
Brugia malayi | Trypsin family protein | 0.0018 | 0.0913 | 0.1252 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0992 | 0.0992 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0018 | 0.0913 | 0.0913 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0015 | 0.0577 | 0.0577 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0018 | 0.0913 | 0.1252 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.0992 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0992 | 0.0992 |
Echinococcus multilocularis | enteropeptidase | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Mastin | 0.0018 | 0.0913 | 0.0913 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0018 | 0.0913 | 0.0913 |
Brugia malayi | Trypsin family protein | 0.0018 | 0.0913 | 0.1252 |
Brugia malayi | protein kinase C II. | 0.0085 | 0.729 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0018 | 0.0913 | 0.0913 |
Toxoplasma gondii | AGC kinase | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.007 | 0.5794 | 0.5794 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0992 | 0.0992 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0016 | 0.0697 | 0.0697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0085 | 0.729 | 0.729 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0697 | 0.0697 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.0913 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Onchocerca volvulus | 0.0019 | 0.0992 | 1 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0018 | 0.0913 | 0.1252 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0018 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0992 | 0.136 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0992 | 0.0992 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.0992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0992 | 0.136 |
Onchocerca volvulus | 0.0019 | 0.0992 | 1 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Echinococcus multilocularis | protein kinase c iota type | 0.0015 | 0.0577 | 0.0577 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0018 | 0.0913 | 0.0913 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0992 | 0.136 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0992 | 0.136 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Echinococcus granulosus | RUN | 0.0019 | 0.0992 | 0.0992 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | trypsin family protein | 0.0018 | 0.0913 | 0.1252 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0009 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0992 | 0.136 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0018 | 0.0913 | 0.1252 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0016 | 0.0697 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0992 | 0.0992 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0018 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0913 | 0.1252 |
Echinococcus multilocularis | serine threonine protein kinase | 0.001 | 0.012 | 0.012 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0018 | 0.0913 | 0.0913 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0992 | 0.136 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0992 | 0.0992 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity index (functional) | = 3.9 | Activity index by dog hypotension screen assay at 10 ug/Kg per min for 15 min. | ChEMBL. | 2999403 |
ID50 (functional) | = 0.3 mg kg-1 | Inhibitory dose by PCA test in rat peritoneal mast cells. | ChEMBL. | 2999403 |
Inhibition (functional) | = 39 % | Percent inhibition by dog hypotension screen assay at 10 ug/Kg per min for 15 min. | ChEMBL. | 2999403 |
Potency ratio (functional) | = 9.9 | Potency ratio of the compound to that of sodium cromoglycate (1.0) using PCA test. | ChEMBL. | 2999403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.