Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0062 | 0.3022 | 0.3022 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0303 | 0.0303 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0157 | 0.0157 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0105 | 0.5362 | 0.5362 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0303 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0303 | 0.0346 |
Echinococcus granulosus | intermediate filament protein | 0.0062 | 0.3022 | 0.3022 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.1461 | 0.1665 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0157 | 0.0179 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0303 | 0.0346 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.003 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0105 | 0.5362 | 0.611 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0303 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.8775 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0157 | 0.0157 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.003 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.296 | 0.3373 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0303 | 0.0303 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | smad | 0.0009 | 0.0157 | 0.0157 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0105 | 0.5362 | 0.5362 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.6945 | 0.7914 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0157 | 0.0179 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0157 | 0.0157 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0105 | 0.5362 | 0.5362 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.6945 | 0.7914 |
Echinococcus granulosus | lamin dm0 | 0.0062 | 0.3022 | 0.3022 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0303 | 0.0346 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0303 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3022 | 0.3443 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0062 | 0.3022 | 0.3443 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0157 | 0.0157 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0033 | 0.1461 | 0.1665 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0105 | 0.5362 | 0.611 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0157 | 0.0179 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0303 | 0.0346 |
Loa Loa (eye worm) | intermediate filament protein | 0.0062 | 0.3022 | 0.3443 |
Schistosoma mansoni | lamin | 0.0062 | 0.3022 | 0.3022 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0303 | 0.0303 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0303 | 0.0303 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0105 | 0.5362 | 0.5362 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0303 | 0.0303 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0157 | 0.0157 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0157 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.8775 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.8775 | 0.8775 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.8775 | 0.8775 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.8775 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0303 | 0.0303 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0303 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.6945 | 0.7914 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0303 | 0.0303 |
Echinococcus multilocularis | lamin | 0.0062 | 0.3022 | 0.3022 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0062 | 0.3022 | 0.3443 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0303 | 0.0346 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0157 | 0.0157 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0105 | 0.5362 | 0.5362 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0157 | 0.0157 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0157 | 0.0157 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | musashi | 0.0062 | 0.3022 | 0.3022 |
Onchocerca volvulus | 0.0062 | 0.3022 | 1 | |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0157 | 0.0157 |
Schistosoma mansoni | intermediate filament proteins | 0.0062 | 0.3022 | 0.3022 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0303 | 0.0303 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0157 | 0.0179 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1221 | 0.1391 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | smad | 0.0009 | 0.0157 | 0.0157 |
Schistosoma mansoni | lamin | 0.0062 | 0.3022 | 0.3022 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1282 | 0.1461 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1221 | 0.1391 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0303 | 0.0303 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0303 | 0.0303 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0105 | 0.5362 | 0.5362 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0303 | 0.0303 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0105 | 0.5362 | 0.5362 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0157 | 0.0179 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0303 | 0.0303 |
Echinococcus multilocularis | geminin | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0157 | 0.0179 |
Onchocerca volvulus | 0.0062 | 0.3022 | 1 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0303 | 0.0346 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | Smad1 | 0.0009 | 0.0157 | 0.0179 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0303 | 0.0346 |
Brugia malayi | intermediate filament protein | 0.0062 | 0.3022 | 0.3443 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0157 | 0.0157 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.8775 | 0.8775 |
Echinococcus granulosus | smad | 0.0009 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0303 | 0.0346 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0303 | 0.0303 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0157 | 0.0157 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0303 | 0.0346 |
Echinococcus multilocularis | lamin dm0 | 0.0062 | 0.3022 | 0.3022 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0303 | 0.0303 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0303 | 0.0346 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0303 | 0.0303 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0303 | 0.0303 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.