Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.1291 | 0.5536 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.0566 | 0.0566 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0213 | 0.0499 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.5657 | 0.5657 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.1291 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.1291 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.1291 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0125 | 0.0129 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0046 | 0.216 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0125 | 0.0129 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0213 | 0.0213 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.5657 | 0.5657 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.5657 | 0.5839 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.5657 | 0.5657 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0152 | 0.9689 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.5657 | 0.5657 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0034 | 0.1291 | 0.1291 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0125 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1283 | 0.1283 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3821 | 0.3821 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.1888 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0213 | 0.0213 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0213 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0125 | 0.0125 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0125 | 0.0125 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.1291 | 0.1332 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2388 | 0.2388 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3821 | 0.3821 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0786 | 0.0786 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0213 | 0.0433 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0156 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0034 | 0.1291 | 0.1291 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0.1888 | 1 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3821 | 0.3821 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0046 | 0.216 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.1291 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3821 | 0.3821 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3821 | 0.3821 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.1291 | 0.5729 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3821 | 0.3821 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.1291 | 0.5536 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.5657 | 0.5657 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2388 | 0.2388 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0213 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0156 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Mycobacterium ulcerans | pyruvate kinase | 0.0034 | 0.1291 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.216 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.1291 | 0.5729 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0213 | 0.0213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3821 | 0.3821 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.5657 | 0.5657 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0566 | 0.0566 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3821 | 0.3821 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3821 | 0.3821 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.1888 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0156 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0034 | 0.1291 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1283 | 0.1283 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.5657 | 0.5839 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0213 | 0.0219 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.1291 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.1291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1283 | 0.1283 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3821 | 0.3821 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0024 | 0.0566 | 0.2108 |
Leishmania major | pyruvate kinase | 0.0034 | 0.1291 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0125 | 0.0129 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.1291 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0046 | 0.216 | 0.223 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.5657 | 0.5657 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0046 | 0.216 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3821 | 0.3944 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.1291 | 0.1332 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0213 | 0.0213 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.1291 | 0.6612 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2388 | 0.2388 |
Leishmania major | pyruvate kinase | 0.0034 | 0.1291 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.1291 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2388 | 0.2388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3821 | 0.3821 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0046 | 0.216 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.1291 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0213 | 0.0499 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.1291 | 0.1291 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0125 | 0.0125 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.1291 | 0.6612 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3821 | 0.3821 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0213 | 0.0433 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.