Detailed information for compound 816504

Basic information

Technical information
  • TDR Targets ID: 816504
  • Name: 4-fluoro-N-[5-(3-methylphenyl)-1H-pyrazol-3-y l]benzamide
  • MW: 295.311 | Formula: C17H14FN3O
  • H donors: 2 H acceptors: 2 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)Nc1[nH]nc(c1)c1cccc(c1)C
  • InChi: 1S/C17H14FN3O/c1-11-3-2-4-13(9-11)15-10-16(21-20-15)19-17(22)12-5-7-14(18)8-6-12/h2-10H,1H3,(H2,19,20,21,22)
  • InChiKey: QLPDOBMQOXKXHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00378247
  • Oprea1_238155
  • BIM-0008874.P001
  • 4-Fluoro-N-(5-m-tolyl-2H-pyrazol-3-yl)-benzamide
  • BAS 02231173
  • CBMicro_008751
  • Oprea1_348458

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0179 0.0613
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0179 0.4732
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0179 0.4732
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0037 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0179 0.4732
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0064 0.0179 0.0613
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.6225
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0179 0.4732
Loa Loa (eye worm) hypothetical protein 0.0064 0.0179 0.0602
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0222 0.0992 0.136
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0179 0.4732
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0059 0.1077
Brugia malayi glutathione reductase 0.0097 0.0351 0.149
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.142 0.7139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0059 0.0161
Schistosoma mansoni hypothetical protein 0.0034 0.0027 0.0012
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0351 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.6225
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.6225
Loa Loa (eye worm) glutathione reductase 0.0097 0.0351 0.1286
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1114 0.4314
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Leishmania major trypanothione reductase 0.0097 0.0351 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0037 0.0051
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0351 0.0459
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0247 0.1119 0.1539
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0179 0.4732
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0064 0.0179 0.0613
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0558 0.2712 0.2694
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0197 0.0674
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0324
Brugia malayi TAR-binding protein 0.0064 0.0179 0.0704
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0064 0.0179 0.4732
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Plasmodium falciparum glutathione reductase 0.0097 0.0351 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0558 0.2712 0.2798
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0461 0.2218 0.8699
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0001 0.004
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0197 0.5288
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0109 0.0386
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0064 0.0179 0.4732
Loa Loa (eye worm) hypothetical protein 0.0525 0.2546 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0179 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0064 0.0179 0.0705
Brugia malayi RNA binding protein 0.0064 0.0179 0.0704
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0059 0.3315
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0059 0.1077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0461 0.2218 0.8699
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0064 0.0179 0.0613
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0179 0.0613
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Brugia malayi MH2 domain containing protein 0.0246 0.1114 0.4968
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0461 0.2218 1
Trypanosoma brucei unspecified product 0.0041 0.0059 0.1077
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1978 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Leishmania major DNA polymerase eta, putative 0.0039 0.0053 0.0888
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0059 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0064 0.0179 0.0705
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0059 0.0128
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0064 0.0179 0.0613
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0179 0.4732
Mycobacterium tuberculosis Probable reductase 0.0222 0.0992 0.136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Leishmania major hypothetical protein, conserved 0.0064 0.0179 0.4732
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0247 0.1119 0.0207
Schistosoma mansoni hypothetical protein 0.0036 0.0037 0.0051
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0024 0.0092
Echinococcus granulosus dna polymerase kappa 0.0041 0.0059 0.014
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Loa Loa (eye worm) PDE1B protein 0.0064 0.0179 0.0602
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0037 0.0051
Mycobacterium tuberculosis Probable oxidoreductase 0.0247 0.1119 0.1539
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0179 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0179 0.0613
Giardia lamblia Hypothetical protein 0.0064 0.0179 0.0699
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis MYB, putative 0.0029 0.0001 0.004
Giardia lamblia hypothetical protein 0.0064 0.0179 0.0699
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0179 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0222 0.0992 0.136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0222 0.0992 0.136
Giardia lamblia DINP protein human, muc B family 0.0041 0.0059 0.023
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0059 0.0049
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0064 0.0179 0.0602
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0179 0.4732
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0064 0.0179 0.4732
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1978 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0179 0.0601
Leishmania major hypothetical protein, conserved 0.0064 0.0179 0.4732
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Leishmania major cAMP-specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0064 0.0179 0.0705
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0179 0.0613
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0558 0.2712 0.2694
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0064 0.0179 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Plasmodium falciparum thioredoxin reductase 0.0097 0.0351 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0525 0.2546 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0064 0.0179 0.4732
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0179 0.0613
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0064 0.0179 0.0613
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0064 0.0179 0.4732
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0525 0.2546 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0247 0.1119 0.1539
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0059 0.014
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Schistosoma mansoni hypothetical protein 0.0349 0.1643 0.6422
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0024 0.0086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0064 0.0179 0.0613
Loa Loa (eye worm) RNA binding protein 0.0064 0.0179 0.0601
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0179 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0053 0.0193
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0064 0.0179 0.0705
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0059 0.014
Loa Loa (eye worm) hypothetical protein 0.0064 0.0179 0.0602
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0179 0.0602
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0059 0.014
Trypanosoma brucei trypanothione reductase 0.0097 0.0351 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Echinococcus granulosus dna polymerase eta 0.0067 0.0197 0.0686
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0064 0.0179 0.0613
Brugia malayi Thioredoxin reductase 0.0097 0.0351 0.149
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0525 0.2546 1
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0024 0.1344
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0059 0.014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0059 0.014
Echinococcus granulosus tar DNA binding protein 0.0064 0.0179 0.0613
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0179 1
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0351 0.1286
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0179 0.4732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0558 0.2712 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0179 0.0601
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0064 0.0179 0.0705
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0109 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Brugia malayi hypothetical protein 0.0036 0.0037 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0059 0.1077
Echinococcus granulosus geminin 0.0349 0.1643 0.6422
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0222 0.0992 0.136
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0525 0.2546 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0064 0.0179 0.0613
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Echinococcus multilocularis geminin 0.0349 0.1643 0.6422
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0064 0.0179 0.0613
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0064 0.0179 0.0613
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0197 0.5288
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1978 1 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0064 0.0179 0.0613
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0525 0.2546 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0351 0.1296
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0064 0.0179 0.4732
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0001 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Plasmodium vivax glutathione reductase, putative 0.0097 0.0351 1
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0179 0.4732
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0059 0.0035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0222 0.0992 0.136
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0059 0.0035
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0351 0.1296
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0109 0.0324
Schistosoma mansoni DNA polymerase eta 0.0067 0.0197 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0179 0.0704
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Leishmania major DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0064 0.0179 0.4732
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0179 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0027 0.0014
Leishmania major DNA polymerase eta, putative 0.0067 0.0197 0.5288
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0059 0.1077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0525 0.2546 1
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0351 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0064 0.0179 0.4732
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0461 0.2218 0.8698
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.142 0.7139 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0179 0.0613
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0059 0.1077
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0064 0.0179 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0179 1
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0197 0.0788
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0179 0.0613
Plasmodium falciparum phosphodiesterase gamma, putative 0.0064 0.0179 0.4732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0525 0.2546 0.9386
Toxoplasma gondii thioredoxin reductase 0.0097 0.0351 0.1292
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0053 0.0888
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 1
Echinococcus multilocularis dna polymerase eta 0.0067 0.0197 0.0686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0059 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0179 0.0657
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0059 0.3315
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0064 0.0179 0.0613
Schistosoma mansoni hypothetical protein 0.0349 0.1643 0.6422
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0064 0.0179 0.4732
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1114 0.4314
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0064 0.0179 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0179 0.0613
Plasmodium falciparum phosphodiesterase delta, putative 0.0064 0.0179 0.4732
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0024 0.0086
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0024 0.1344
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.6225

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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