Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0782 | 0.0918 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0782 | 0.0782 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1276 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0782 | 0.6125 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1276 | 0.1498 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.852 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0782 | 0.0782 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1276 | 1 |
Onchocerca volvulus | 0.0026 | 0.1276 | 1 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0782 | 0.0782 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1276 | 0.1276 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0084 | 0.0084 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0782 | 0.0782 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.852 | 0.852 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1276 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0782 | 0.0918 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0782 | 0.6125 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0782 | 0.0782 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0782 | 0.0782 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.001 | 0.0084 | 0.0656 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0255 | 0.0299 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0782 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1276 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Schistosoma mansoni | lamin | 0.0026 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1276 | 1 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0782 | 0.6125 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0782 | 0.6125 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0782 | 0.0918 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1276 | 0.1276 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1276 | 0.1276 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.001 | 0.0084 | 0.0084 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.036 | 0.2818 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | nuclear receptor RXR | 0.001 | 0.0084 | 0.0656 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0219 | 0.1713 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.036 | 0.2818 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0782 | 0.0918 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0782 | 0.6125 |
Echinococcus granulosus | lamin | 0.0026 | 0.1276 | 0.1498 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1276 | 0.1498 |
Brugia malayi | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0782 | 0.0918 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.001 | 0.0084 | 0.0084 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0782 | 0.0782 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.001 | 0.0084 | 0.0098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0255 | 0.1996 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0782 | 0.0918 |
Onchocerca volvulus | 0.0026 | 0.1276 | 1 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0782 | 0.6125 |
Onchocerca volvulus | 0.002 | 0.0782 | 0.6125 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0084 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0219 | 0.1713 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0782 | 0.6125 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0782 | 0.0918 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0782 | 0.0782 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0782 | 0.0782 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0782 | 0.0918 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0084 | 0.0656 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0782 | 0.0782 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0782 | 0.0782 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0782 | 0.6125 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0782 | 0.0782 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.852 | 0.852 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.124 | 0.9717 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | lamin | 0.0026 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0084 | 0.0656 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0782 | 0.6125 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0782 | 0.0782 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0782 | 0.6125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.