Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0145 | 0.1321 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0274 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0145 | 0.1321 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0145 | 0.1321 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0089 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.1672 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0671 | 0.7228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0274 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0028 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0089 | 0.0535 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Trypanosoma brucei | oxidoreductase-like protein | 0.0028 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0176 | 0.1672 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0274 | 0.0274 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0274 | 0.0274 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0406 | 0.4254 | 0.5885 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0145 | 0.1321 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0406 | 0.4254 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0406 | 0.4254 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0406 | 0.4254 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0028 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0406 | 0.4254 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0406 | 0.4254 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0671 | 0.7228 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.1672 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0406 | 0.4254 | 0.5885 |
Echinococcus multilocularis | geminin | 0.0176 | 0.1672 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0089 | 0.3266 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0406 | 0.4254 | 0.5885 |
Trypanosoma brucei | pteridine reductase 1 | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0671 | 0.7228 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0406 | 0.4254 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0028 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.