Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0417 | 0.3894 | 1 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0028 | 0.0098 | 0.5149 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0417 | 0.3894 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0028 | 0.0098 | 0.5149 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0417 | 0.3894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0172 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0028 | 0.0098 | 0.5683 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0028 | 0.0098 | 0.0251 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0028 | 0.0098 | 0.5683 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Trichomonas vaginalis | hypothetical protein | 0.0417 | 0.3894 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.019 | 0.019 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0028 | 0.0098 | 0.5683 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0172 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0172 | 0.0442 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0172 | 0.906 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.019 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.019 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0028 | 0.0098 | 0.0098 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.0172 | 0.0172 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0028 | 0.0098 | 0.0251 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.5683 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0172 | 0.0442 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 0.0172 | 0.906 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0028 | 0.0098 | 0.0098 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0172 | 0.906 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0417 | 0.3894 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.5683 |
Mycobacterium ulcerans | oxidoreductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Loa Loa (eye worm) | oxidoreductase | 0.0028 | 0.0098 | 0.5683 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0417 | 0.3894 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 0.0172 | 0.906 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0028 | 0.0098 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0098 | 0.5683 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0.0172 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0028 | 0.0098 | 0.0251 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0172 | 0.0442 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0028 | 0.0098 | 0.5683 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0172 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0028 | 0.0098 | 0.5683 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0028 | 0.0098 | 0.5683 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0172 | 0.906 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0417 | 0.3894 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0028 | 0.0098 | 0.5683 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0028 | 0.0098 | 0.5683 |
Leishmania major | pteridine reductase 1 | 0.0028 | 0.0098 | 0.5683 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0417 | 0.3894 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.019 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0028 | 0.0098 | 0.5149 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.019 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.019 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Onchocerca volvulus | 0.0028 | 0.0098 | 0.5 | |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 0.0172 | 0.906 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0028 | 0.0098 | 0.5149 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.019 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0.0172 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Onchocerca volvulus | 0.0028 | 0.0098 | 0.5 | |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0028 | 0.0098 | 0.0251 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 0.0172 | 0.906 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.019 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0028 | 0.0098 | 0.0251 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0028 | 0.0098 | 0.0251 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0172 | 0.906 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.5683 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0417 | 0.3894 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0028 | 0.0098 | 0.0251 |
Schistosoma mansoni | dihydropteridine reductase | 0.0028 | 0.0098 | 0.5149 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 0.0172 | 0.906 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.019 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0028 | 0.0098 | 0.5683 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0172 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0028 | 0.0098 | 0.0251 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0028 | 0.0098 | 0.0251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.