Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0093 | 0.0328 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0213 | 0.0985 | 0.1353 |
Brugia malayi | hypothetical protein | 0.0036 | 0.001 | 0.0093 |
Echinococcus multilocularis | dna polymerase kappa | 0.0038 | 0.0023 | 0.0079 |
Leishmania major | DNA polymerase eta, putative | 0.0063 | 0.0161 | 0.4638 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.1333 | 0.7129 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0523 | 0.2686 | 0.2769 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0523 | 0.2686 | 0.2669 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0523 | 0.2686 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 0.1653 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0038 | 0.0023 | 1 |
Trichomonas vaginalis | MYB, putative | 0.0037 | 0.0019 | 0.1819 |
Plasmodium falciparum | glutathione reductase | 0.0093 | 0.0328 | 0.5 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0037 | 0.0019 | 0.1819 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0161 | 0.1452 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 0.1653 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0086 | 0.0773 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0063 | 0.0161 | 0.4638 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0037 | 0.0018 | 0.5903 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0023 | 0.0199 |
Echinococcus granulosus | dna polymerase kappa | 0.0038 | 0.0023 | 0.0079 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0038 | 0.0023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0086 | 0.0773 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0236 | 0.111 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0086 | 0.0773 |
Mycobacterium tuberculosis | Probable reductase | 0.0213 | 0.0985 | 0.1353 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0236 | 0.111 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0093 | 0.0328 | 0.2952 |
Echinococcus multilocularis | dna polymerase eta | 0.0063 | 0.0161 | 0.0918 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0213 | 0.0985 | 0.1353 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0093 | 0.0328 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0038 | 0.0023 | 0.0141 |
Leishmania major | DNA polymerase kappa, putative | 0.0038 | 0.0023 | 0.0199 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1857 | 1 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0093 | 0.0328 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0213 | 0.0985 | 0.1353 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0038 | 0.0023 | 0.0199 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.001 | 0.0063 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0037 | 0.0018 | 0.5903 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.001 | 0.0063 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.0023 | 0.0079 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0063 | 0.0161 | 0.1452 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0159 | 0.0963 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.1333 | 0.7129 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.0023 | 0.0079 |
Giardia lamblia | DINP protein human, muc B family | 0.0038 | 0.0023 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1857 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0159 | 0.0963 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0159 | 0.0906 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0159 | 0.1435 |
Brugia malayi | glutathione reductase | 0.0093 | 0.0328 | 0.2952 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0159 | 0.1435 |
Echinococcus granulosus | geminin | 0.0335 | 0.1653 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0237 | 0.1115 | 0.0212 |
Plasmodium vivax | glutathione reductase, putative | 0.0093 | 0.0328 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0038 | 0.0023 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0038 | 0.0023 | 0.0141 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0038 | 0.0023 | 0.0211 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0237 | 0.1115 | 0.1537 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0159 | 0.0906 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0037 | 0.0018 | 0.5903 |
Trypanosoma brucei | trypanothione reductase | 0.0093 | 0.0328 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0159 | 0.1435 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0063 | 0.0161 | 0.4529 |
Echinococcus multilocularis | geminin | 0.0335 | 0.1653 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1857 | 1 | 1 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.0037 | 0.0019 | 0.0007 |
Toxoplasma gondii | thioredoxin reductase | 0.0093 | 0.0328 | 0.1163 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0023 | 0.0199 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0159 | 0.1435 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0037 | 0.0018 | 0.5903 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0213 | 0.0985 | 0.1353 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0023 | 0.0199 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0093 | 0.0328 | 0.1931 |
Schistosoma mansoni | DNA polymerase eta | 0.0063 | 0.0161 | 0.0975 |
Brugia malayi | MH2 domain containing protein | 0.0236 | 0.111 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0093 | 0.0328 | 0.1931 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0038 | 0.0023 | 0.0211 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0159 | 0.1435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0159 | 0.0963 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0037 | 0.0018 | 0.5903 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0093 | 0.0328 | 0.0428 |
Loa Loa (eye worm) | glutathione reductase | 0.0093 | 0.0328 | 0.2952 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0159 | 0.1435 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0086 | 0.0773 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0237 | 0.1115 | 0.1537 |
Brugia malayi | Thioredoxin reductase | 0.0093 | 0.0328 | 0.2952 |
Leishmania major | trypanothione reductase | 0.0093 | 0.0328 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0237 | 0.1115 | 0.1537 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0023 | 0.0199 |
Echinococcus granulosus | dna polymerase eta | 0.0063 | 0.0161 | 0.0918 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0159 | 0.0963 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0037 | 0.0019 | 0.1819 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0213 | 0.0985 | 0.1353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0159 | 0.0963 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 30.05 nM ml-1 | Compound was evaluated in vitro for its root inhibition activity using seedlings of L. sativum | ChEMBL. | 1905760 |
MIC (functional) | = 16 nM | Compound was evaluated in vitro for its antibacterial activity against B. subtilis | ChEMBL. | 1905760 |
Relative potency (functional) | = 0.09 | In vitro antibacterial activity measured against B. subtilis,and relative potency expressed with respect to streptonigrin. | ChEMBL. | 1905760 |
Relative potency (functional) | = 0.42 | In vitro root inhibition activity measured using seedlings of L. sativum, and relative potency expressed with respect tostreptonigrin. | ChEMBL. | 1905760 |
Slope (functional) | = 11.31 | Antibacterial activity against B. subtilis and values were expressed as standard error for slope | ChEMBL. | 1905760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.