Detailed information for compound 817360

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.438 | Formula: C22H25NO4
  • H donors: 0 H acceptors: 1 LogP: 3.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc2c1OCCN(C2)C(=O)C1CCC1)c1cccc(c1)OC
  • InChi: 1S/C22H25NO4/c1-25-19-8-4-7-16(12-19)17-11-18-14-23(22(24)15-5-3-6-15)9-10-27-21(18)20(13-17)26-2/h4,7-8,11-13,15H,3,5-6,9-10,14H2,1-2H3
  • InChiKey: QWBJMXPGBFOFIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0572 0.3075 0.5901
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Echinococcus multilocularis neuroendocrine convertase 2 0.1399 0.7864 1
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Echinococcus multilocularis serotonin receptor 0.0087 0.027 0.0343
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0087 0.027 0.027
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0127 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni retinoblastoma binding protein 0.007 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis serotonin receptor 0.0087 0.027 0.0343
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni neuropeptide receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis neuropeptide receptor 0.0087 0.027 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Loa Loa (eye worm) hypothetical protein 0.0061 0.0121 0.0121
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.009 0.0288 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0087 0.027 0.027
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0087 0.027 0.0343
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.027 0.0343
Echinococcus granulosus peptide allatostatin:somatostatin 0.0087 0.027 0.027
Toxoplasma gondii subtilisin SUB12 0.009 0.0288 0.5729
Echinococcus granulosus orexin receptor type 2 0.0087 0.027 0.027
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.009 0.0288 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0087 0.027 0.0343
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni opsin-like receptor 0.0087 0.027 0.027
Brugia malayi Subtilase family protein 0.009 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.009 0.0288 0.5167
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0572 0.3075 0.3075
Onchocerca volvulus 0.0087 0.027 0.1589
Loa Loa (eye worm) hypothetical protein 0.009 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0356 0.1825 0.1825
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Echinococcus multilocularis somatostatin receptor 0.0087 0.027 0.0343
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.027 0.027
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.1698 0.1698
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.027 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Loa Loa (eye worm) endoprotease bli-4 0.1769 1 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0135 0.0547 0.0547
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Onchocerca volvulus 0.0087 0.027 0.1589
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.009 0.0288 1
Schistosoma mansoni histamine h1 receptor 0.0087 0.027 0.027
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.009 0.0288 0.0366
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0572 0.3075 0.5901
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Echinococcus multilocularis caspase 2 0.0061 0.0121 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Echinococcus granulosus alpha 1A adrenergic receptor 0.0087 0.027 0.027
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Brugia malayi neuropeptide F receptor 0.0087 0.027 0.027
Echinococcus granulosus g-protein coupled receptor 0.0087 0.027 0.027
Schistosoma mansoni biogenic amine receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.009 0.0288 0.0288
Onchocerca volvulus 0.0087 0.027 0.1589
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0087 0.027 0.0343
Echinococcus multilocularis G-protein coupled receptor, putative 0.0087 0.027 0.0343
Onchocerca volvulus 0.0087 0.027 0.1589
Onchocerca volvulus 0.0087 0.027 0.1589
Loa Loa (eye worm) TYRA-2 protein 0.0087 0.027 0.027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.027 0.027
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0087 0.027 0.0343
Trichomonas vaginalis WD repeat domain, putative 0.0134 0.0541 0.1038
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0087 0.027 0.027
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.009 0.0288 0.6256
Trichomonas vaginalis retinoblastoma binding protein, putative 0.007 0.0172 0.0331
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0087 0.027 0.027
Brugia malayi Cell death protein 3 precursor 0.0061 0.0121 0.0121
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.0305 0.5565
Toxoplasma gondii prolyl endopeptidase 0.0127 0.0502 1
Schistosoma mansoni furin-1 (S08 family) 0.0918 0.5077 0.5077
Brugia malayi celfurPC protein 0.136 0.7638 0.7638
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.0502 0.0502
Echinococcus multilocularis g protein coupled receptor 0.0087 0.027 0.0343
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0087 0.027 0.0343
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.027 0.027
Echinococcus multilocularis g protein coupled receptor 0.0087 0.027 0.0343
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Echinococcus multilocularis prolyl endopeptidase 0.0127 0.0502 0.0638
Plasmodium vivax subtilisin-like protease 2, putative 0.009 0.0288 1
Brugia malayi G protein-coupled receptor 0.0087 0.027 0.027
Echinococcus multilocularis Furin 1 0.0572 0.3075 0.391
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0288 0.0552
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0164 0.0713 0.0713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0209 0.0209
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.027 0.0343
Echinococcus multilocularis set1:ash2 histone methyltransferase complex 0.0041 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0135 0.0547 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Onchocerca volvulus Deterin homolog 0.0135 0.0547 0.3224
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.027 0.027
Echinococcus multilocularis neuropeptide s receptor 0.0087 0.027 0.0343
Treponema pallidum cell division protein (ftsJ) 0.0041 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0288 0.0552
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0087 0.027 0.0343
Brugia malayi Melatonin receptor type 1A 0.0087 0.027 0.027
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0058 0.1164
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Brugia malayi Dopamine receptor 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0239 0.115 0.115
Schistosoma mansoni hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni site-1 peptidase (S08 family) 0.009 0.0288 0.0288
Toxoplasma gondii subtilisin SUB11 0.009 0.0288 0.5729
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.009 0.0288 0.5167
Leishmania major subtilisin-like serine peptidase 0.009 0.0288 0.5167
Onchocerca volvulus 0.0087 0.027 0.1589
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0408 0.2128 0.4083
Onchocerca volvulus 0.0061 0.0121 0.0711
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0941 0.521 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi Dopamine receptor protein 2 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Schistosoma mansoni tyrosine kinase 0.0314 0.1584 0.1584
Echinococcus multilocularis epidermal growth factor receptor 0.0314 0.1584 0.2014
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0288 0.0552
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Loa Loa (eye worm) hypothetical protein 0.0901 0.498 0.498
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.009 0.0288 0.6256
Brugia malayi G-protein coupled receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis neuropeptide FF receptor 2 0.0087 0.027 0.0343
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0941 0.521 0.6625
Echinococcus multilocularis neuropeptide receptor 0.0087 0.027 0.0343
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0087 0.027 0.027
Echinococcus multilocularis neuropeptide receptor A26 0.0087 0.027 0.0343
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0127 0.0502 0.0502
Echinococcus multilocularis dro:myosuppressin receptor 0.0087 0.027 0.0343
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.027 0.027
Echinococcus granulosus neuroendocrine convertase 2 0.1399 0.7864 0.7864
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0087 0.027 0.027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0087 0.027 0.027
Echinococcus granulosus rho-associated protein kinase 1 0.0334 0.1698 0.1698
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1769 1 1
Onchocerca volvulus 0.0135 0.0547 0.3224
Schistosoma mansoni adenoreceptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Loa Loa (eye worm) hypothetical protein 0.0135 0.0547 0.0547
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0164 0.0713 0.1368
Schistosoma mansoni trithorax protein ash2 0.0041 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0087 0.027 0.027
Echinococcus granulosus g protein coupled receptor 0.0087 0.027 0.027
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0058 0.1164
Loa Loa (eye worm) hypothetical protein 0.0061 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.0425 1
Brugia malayi larval opioid receptor 0.0087 0.027 0.027
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0001 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0087 0.027 0.027
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.027 0.027
Giardia lamblia High cysteine membrane protein Group 2 0.0443 0.2327 0.9113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Brugia malayi Protein kinase domain containing protein 0.1037 0.5767 0.5767
Schistosoma mansoni biogenic amine receptor 0.0087 0.027 0.027
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0087 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Schistosoma mansoni amine GPCR 0.0087 0.027 0.027
Echinococcus multilocularis sex peptide receptor 0.0087 0.027 0.0343
Echinococcus multilocularis inhibitor of apoptosis protein 0.0135 0.0547 0.0696
Echinococcus granulosus membrane bound transcription factor site 1 0.009 0.0288 0.0288
Toxoplasma gondii subtilisin SUB6 0.009 0.0288 0.5729
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.0502 0.0502
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Echinococcus granulosus prolyl endopeptidase 0.0127 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni gamma-secretase subunit aph-1 0.0239 0.115 0.115
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0087 0.027 0.027
Brugia malayi follicle stimulating hormone receptor 0.0087 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Loa Loa (eye worm) melatonin receptor type 1A 0.0087 0.027 0.027
Echinococcus granulosus furin 0.1769 1 1
Echinococcus multilocularis allatostatin A receptor 0.0087 0.027 0.0343
Echinococcus granulosus G protein coupled receptor 139 0.0087 0.027 0.027
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0087 0.027 0.027
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.027 0.027
Echinococcus multilocularis rho associated protein kinase 0.0334 0.1698 0.2158
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.027 0.027
Echinococcus granulosus g protein coupled receptor 0.0087 0.027 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Brugia malayi prolyl oligopeptidase family protein 0.0127 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0087 0.027 0.027
Echinococcus multilocularis fmrfamide receptor 0.0087 0.027 0.0343
Onchocerca volvulus 0.0087 0.027 0.1589
Schistosoma mansoni hypothetical protein 0.0087 0.027 0.027
Brugia malayi SPRY domain containing protein 0.0041 0.0001 0.0001
Onchocerca volvulus Prolyl endopeptidase homolog 0.0127 0.0502 0.2956
Echinococcus granulosus neuropeptide s receptor 0.0087 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Echinococcus granulosus Mastin 0.0077 0.0209 0.0209
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.027 0.027
Schistosoma mansoni neuropeptide receptor 0.0087 0.027 0.027
Toxoplasma gondii subtilisin SUB5 0.009 0.0288 0.5729
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi putative neuropeptide receptor 0.0087 0.027 0.027
Brugia malayi neuropeptide F receptor 0.0087 0.027 0.027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0087 0.027 0.027
Schistosoma mansoni growth hormone secretagogue receptor 0.0087 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0172 0.0331
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0135 0.0547 0.0696
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0288 0.0552
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Echinococcus granulosus Furin 1 0.0572 0.3075 0.3075
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis apoptotic protease activating factor 1 0.0061 0.0121 0.0153
Onchocerca volvulus Neuropeptide F receptor homolog 0.0087 0.027 0.1589
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0288 0.0552
Plasmodium falciparum subtilisin-like protease 1 0.009 0.0288 1
Loa Loa (eye worm) proprotein convertase 2 0.0572 0.3075 0.3075
Echinococcus multilocularis g protein coupled receptor 0.0087 0.027 0.0343
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0087 0.027 0.027
Brugia malayi Serotonin receptor 0.0087 0.027 0.027
Brugia malayi gamma-secretase subunit aph-1 0.0239 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0572 0.3075 0.5901
Trypanosoma cruzi subtilisin peptidase 0.009 0.0288 0.5167
Echinococcus granulosus gamma secretase subunit aph 1 0.0239 0.115 0.115
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0121 0.0711
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.009 0.0288 0.0288
Schistosoma mansoni neuropeptide receptor 0.0087 0.027 0.027
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Plasmodium vivax subtilisin-like serine protease, putative 0.009 0.0288 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0087 0.027 0.027
Echinococcus granulosus 7TM GPCR rhodopsin 0.0087 0.027 0.027
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.027 0.027
Trichomonas vaginalis hypothetical protein 0.0408 0.2128 0.4083
Schistosoma mansoni amine GPCR 0.0087 0.027 0.027
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.027 0.027
Echinococcus multilocularis orexin receptor type 2 0.0087 0.027 0.0343
Schistosoma mansoni neuropeptide f receptor 76f 0.0087 0.027 0.027
Brugia malayi ORL1-like opioid receptor 0.0087 0.027 0.027
Brugia malayi proprotein convertase 2 0.1399 0.7864 0.7864
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.027 0.0343
Loa Loa (eye worm) hypothetical protein 0.1769 1 1
Echinococcus multilocularis wd40 repeat 0.007 0.0172 0.0219
Echinococcus granulosus g protein coupled receptor 0.0087 0.027 0.027
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.027 0.027
Echinococcus granulosus enteropeptidase 0.0077 0.0209 0.0209
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.009 0.0288 1
Echinococcus multilocularis 0.136 0.7638 0.9712
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0087 0.027 0.027
Toxoplasma gondii subtilisin SUB8 0.009 0.0288 0.5729
Brugia malayi sulfakinin receptor protein 0.0087 0.027 0.027
Toxoplasma gondii subtilisin SUB10 0.009 0.0288 0.5729
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0121 0.0121
Trypanosoma cruzi prolyl endopeptidase 0.0127 0.0502 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.027 0.0343
Echinococcus granulosus hypothetical protein 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0366
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.027 0.0343
Onchocerca volvulus 0.0087 0.027 0.1589
Echinococcus granulosus inhibitor of apoptosis protein 0.0135 0.0547 0.0547
Brugia malayi AKH receptor 0.0087 0.027 0.027
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0087 0.027 0.027
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Toxoplasma gondii subtilisin SUB2 0.009 0.0288 0.5729
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Brugia malayi hypothetical protein 0.0061 0.0121 0.0121
Echinococcus granulosus neuropeptide FF receptor 2 0.0087 0.027 0.027
Loa Loa (eye worm) SPRY domain-containing protein 0.0041 0.0001 0.0001
Echinococcus multilocularis enteropeptidase 0.0077 0.0209 0.0266
Schistosoma mansoni hypothetical protein 0.0408 0.2128 0.2128
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0061 0.0121 0.0121
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0482 0.2553 0.49
Plasmodium falciparum subtilisin-like protease 2 0.009 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Plasmodium vivax subtilisin-like protease 1 0.009 0.0288 1
Onchocerca volvulus 0.0334 0.1698 1
Schistosoma mansoni amine GPCR 0.0087 0.027 0.027
Loa Loa (eye worm) TK/EGFR protein kinase 0.0314 0.1584 0.1584
Echinococcus granulosus caspase 2 0.0061 0.0121 0.0121
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0135 0.0547 0.0547
Toxoplasma gondii subtilisin SUB9 0.009 0.0288 0.5729
Plasmodium falciparum subtilisin-like protease 3 0.009 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0172 0.0172
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Schistosoma mansoni inhibitor of apoptosis protein 0.0135 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0572 0.3075 0.5901
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0572 0.3075 0.5901
Onchocerca volvulus 0.0087 0.027 0.1589
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0087 0.027 0.027
Echinococcus multilocularis fmrfamide receptor 0.0087 0.027 0.0343
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0941 0.521 1
Toxoplasma gondii subtilisin SUB7 0.009 0.0288 0.5729
Echinococcus granulosus protein will die slowly 0.0134 0.0541 0.0541
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.027 0.0343
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus granulosus apoptotic protease activating factor 1 0.0061 0.0121 0.0121
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.007 0.0172 0.0172
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0087 0.027 0.0343
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0134 0.0541 0.0541
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.009 0.0288 0.6256
Echinococcus granulosus neuropeptide receptor 0.0087 0.027 0.027
Echinococcus granulosus neuropeptide receptor A26 0.0087 0.027 0.027
Entamoeba histolytica ribosomal RNA methyltransferase, putative 0.0041 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.009 0.0288 0.5167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Schistosoma mansoni opsin-like receptor 0.0087 0.027 0.027
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.027 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.027 0.0343
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis G protein coupled receptor 139 0.0087 0.027 0.0343
Schistosoma mansoni opsin-like receptor 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Trypanosoma brucei subtilisin peptidase 0.009 0.0288 0.5729
Schistosoma mansoni myosin xvIII 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0087 0.027 0.0343
Toxoplasma gondii subtilisin SUB4 0.009 0.0288 0.5729
Trypanosoma brucei prolyl endopeptidase 0.0127 0.0502 1
Echinococcus multilocularis Mastin 0.0077 0.0209 0.0266
Echinococcus multilocularis membrane bound transcription factor site 1 0.009 0.0288 0.0366
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Trypanosoma brucei oligopeptidase b 0.0051 0.0058 0.1164
Schistosoma mansoni amine GPCR 0.0087 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0087 0.027 0.027
Onchocerca volvulus 0.0333 0.1693 0.9976
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi GnHR receptor homolog 0.0087 0.027 0.027
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.027 0.027
Echinococcus granulosus dro:myosuppressin receptor 0.0087 0.027 0.027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.027 0.027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0087 0.027 0.027
Brugia malayi Will die slowly protein 0.0134 0.0541 0.0541
Onchocerca volvulus 0.0134 0.0541 0.3187
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0087 0.027 0.0343
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Echinococcus multilocularis protein will die slowly 0.0134 0.0541 0.0688
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0572 0.3075 0.5901
Loa Loa (eye worm) subtilase 0.009 0.0288 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0135 0.0547 0.0547
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.009 0.0288 0.0288
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0087 0.027 0.027
Onchocerca volvulus 0.009 0.0288 0.1694
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.027 0.0343
Brugia malayi G-protein coupled receptor 0.0087 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0135 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0135 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Echinococcus granulosus set1:ash2 histone methyltransferase complex 0.0041 0.0001 0.0001
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1037 0.5767 0.5767
Trichomonas vaginalis conserved hypothetical protein 0.0408 0.2128 0.4083
Brugia malayi Furin-like cysteine rich region family protein 0.0314 0.1584 0.1584
Brugia malayi RE15519p 0.0087 0.027 0.027
Mycobacterium leprae Possible secreted protease 0.009 0.0288 1
Echinococcus granulosus neuropeptide receptor 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Echinococcus granulosus serotonin receptor 0.0087 0.027 0.027
Onchocerca volvulus 0.0074 0.0192 0.1128
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.009 0.0288 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.009 0.0288 0.6256
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Brugia malayi Dopamine receptor protein 1 0.0087 0.027 0.027
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0482 0.2553 0.49
Echinococcus granulosus sex peptide receptor 0.0087 0.027 0.027
Schistosoma mansoni biogenic amine receptor 0.0087 0.027 0.027
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0087 0.027 0.027
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.0305 0.5565
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.027 0.027
Schistosoma mansoni amine GPCR 0.0087 0.027 0.027
Echinococcus granulosus 7tm_1 domain containing protein 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Toxoplasma gondii subtilisin SUB1 0.009 0.0288 0.5729
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.027 0.027
Echinococcus granulosus epidermal growth factor receptor 0.0314 0.1584 0.1584
Echinococcus multilocularis gamma secretase subunit aph 1 0.0239 0.115 0.1463
Trypanosoma brucei Aph-1 protein, putative 0.0093 0.0305 0.6082
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.027 0.027
Echinococcus granulosus wd40 repeat 0.007 0.0172 0.0172
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.009 0.0288 0.5729
Echinococcus granulosus fmrfamide receptor 0.0087 0.027 0.027
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.027 0.027
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.027 0.027
Brugia malayi putative neuropeptide receptor NPR1 0.0087 0.027 0.027
Schistosoma mansoni site-1 peptidase (S08 family) 0.009 0.0288 0.0288
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0087 0.027 0.027
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0941 0.521 0.521
Schistosoma mansoni neuropeptide receptor 0.0087 0.027 0.027
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0087 0.027 0.027
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.027 0.027
Echinococcus multilocularis g-protein coupled receptor 0.0087 0.027 0.0343
Onchocerca volvulus 0.0087 0.027 0.1589
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0001 0.0002
Loa Loa (eye worm) WD40 repeat protein 0.0134 0.0541 0.0541
Echinococcus granulosus glycoprotein Antigen 5 0.0077 0.0209 0.0209
Brugia malayi Serotonin receptor 0.0087 0.027 0.027
Brugia malayi neuroendocrine convertase 1 precursor 0.1682 0.9498 0.9498
Echinococcus granulosus allatostatin A receptor 0.0087 0.027 0.027
Onchocerca volvulus 0.0087 0.027 0.1589
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.009 0.0288 0.0288
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0087 0.027 0.1589
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.027
Brugia malayi G protein-coupled receptor F59B2.13 0.0087 0.027 0.027
Brugia malayi hypothetical protein 0.0087 0.027 0.027
Giardia lamblia Furin precursor putative serine protease 0.0482 0.2553 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.027 0.027
Echinococcus multilocularis glycoprotein Antigen 5 0.0077 0.0209 0.0266
Plasmodium falciparum SPRY domain, putative 0.0041 0.0001 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.027 0.0343
Echinococcus granulosus somatostatin receptor 0.0087 0.027 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0288 0.0552

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.