Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0494 | 1 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0193 | 0.3401 | 0.9136 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0494 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0114 | 0.1692 | 0.0993 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0207 | 0.3723 | 1 |
Echinococcus granulosus | presenilin | 0.0207 | 0.3723 | 0.3723 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0293 | 0.5592 | 0.5221 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0207 | 0.3723 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0207 | 0.3723 | 1 |
Echinococcus granulosus | Nicastrin | 0.0101 | 0.1398 | 0.1398 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0207 | 0.3723 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0293 | 0.5596 | 0.5596 |
Brugia malayi | Animal haem peroxidase family protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0293 | 0.5592 | 0.5221 |
Brugia malayi | Animal haem peroxidase family protein | 0.0293 | 0.5592 | 0.5221 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0115 | 0.1708 | 0.1708 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0193 | 0.3401 | 0.9136 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Brugia malayi | hypothetical protein | 0.0101 | 0.1398 | 0.0674 |
Brugia malayi | Peroxidasin | 0.0293 | 0.5596 | 0.5225 |
Echinococcus multilocularis | Nicastrin | 0.0101 | 0.1398 | 0.1398 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0494 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0293 | 0.5592 | 0.5221 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0195 | 0.3444 | 0.2892 |
Brugia malayi | Presenilin family protein | 0.0207 | 0.3723 | 0.3194 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0207 | 0.3723 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0114 | 0.1692 | 0.0993 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5596 | 0.5225 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0293 | 0.5592 | 0.5221 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0195 | 0.3444 | 0.3444 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0207 | 0.3723 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Brugia malayi | Animal haem peroxidase family protein | 0.0293 | 0.5592 | 0.5221 |
Schistosoma mansoni | peroxidasin | 0.0293 | 0.5596 | 0.488 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0059 | 0.0469 | 0.1259 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0207 | 0.3723 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0114 | 0.1692 | 0.1692 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1398 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Echinococcus granulosus | peroxidasin | 0.0293 | 0.5596 | 0.5596 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0195 | 0.3444 | 0.2892 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0193 | 0.3401 | 0.9136 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0207 | 0.3723 | 1 |
Brugia malayi | hypothetical protein | 0.0101 | 0.1398 | 0.0674 |
Echinococcus multilocularis | presenilin | 0.0207 | 0.3723 | 0.3723 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0207 | 0.3723 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0294 | 0.5616 | 1 |
Brugia malayi | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Toxoplasma gondii | hypothetical protein | 0.0073 | 0.0776 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0293 | 0.5592 | 0.5221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5592 | 0.5221 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0195 | 0.3444 | 0.3444 |
Schistosoma mansoni | peroxidasin | 0.0293 | 0.5592 | 0.4876 |
Echinococcus multilocularis | Nicastrin | 0.0101 | 0.1398 | 0.1398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.