TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.492 | Formula: C24H29NO3
H donors: 1 H acceptors: 2 LogP: 5.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1C)C(=O)NC1(CCCCC1)C(=O)c1cc(C)cc(c1)C
InChi: 1S/C24H29NO3/c1-16-13-17(2)15-19(14-16)22(26)24(11-6-5-7-12-24)25-23(27)20-9-8-10-21(28-4)18(20)3/h8-10,13-15H,5-7,11-12H2,1-4H3,(H,25,27)
InChiKey: SUAHMLFOJLHFHS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bombyx mori	Ecdysone receptor	Starlite/ChEMBL	References
Choristoneura fumiferana	Ecdysone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	ecdysteroid receptor	Get druggable targets OG5_134445	All targets in OG5_134445
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_134445	All targets in OG5_134445
Onchocerca volvulus	Bile acid receptor homolog	Get druggable targets OG5_134445	All targets in OG5_134445

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	Probable nuclear hormone receptor HR3, putative	Ecdysone receptor	513 aa	416 aa	25.7 %
Drosophila melanogaster	Hepatocyte nuclear factor 4	Ecdysone receptor	513 aa	435 aa	27.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0698	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0698	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0022	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Trichomonas vaginalis	pten, drome, putative	0.0017	0.0022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0023	0.0173	0.0204
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Echinococcus granulosus	ecdysone induced protein 78C	0.0044	0.0698	0.0828
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Onchocerca volvulus	Bile acid receptor homolog	0.0415	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.011	0.0129
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0044	0.0698	0.0828
Brugia malayi	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Schistosoma mansoni	nuclear hormone receptor	0.0044	0.0698	0.0828
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0022	0.0024
Onchocerca volvulus		0.0021	0.011	0.0089
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0173	0.0204
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0044	0.0698	0.0828
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0044	0.0698	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	photoreceptor-specific nuclear receptor	0.0044	0.0698	0.0698
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0023	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0022	0.0024
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0044	0.0698	0.0828
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0044	0.0698	0.0828
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0021	0.011	0.011
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0021	0.011	0.0089
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.011	0.0129
Brugia malayi	Steroid receptor seven-up type 2	0.0044	0.0698	0.0698
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0044	0.0698	0.0698
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0044	0.0698	0.0677
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.011	0.0129
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.011	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0022	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0351	0.8409	0.8409
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0021	0.011	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0044	0.0698	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Brugia malayi	intermediate filament protein	0.0031	0.0359	0.0359
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0698	0.0828
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0239	0.5579	0.6634
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.011	0.0129
Brugia malayi	nuclear receptor NHR-88	0.0044	0.0698	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Echinococcus granulosus	FTZ F1 alpha	0.0044	0.0698	0.0828
Brugia malayi	nuclear hormone receptor	0.0021	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0351	0.8409	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0698	0.0698
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	nuclear receptor NHR-88	0.0021	0.011	0.011
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0017	0.0022	0.0024
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0017	0.0022	0.0024
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0044	0.0698	0.0828
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0017	0.0022	0.0022
Echinococcus multilocularis	lamin dm0	0.0031	0.0359	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0173
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0359	0.0359
Loa Loa (eye worm)	DR-78	0.0021	0.011	0.011
Brugia malayi	nuclear receptor RXR	0.0021	0.011	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0698	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0044	0.0698	0.0698
Brugia malayi	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Schistosoma mansoni	nuclear receptor	0.0021	0.011	0.0129
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0044	0.0698	0.0828
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0017	0.0022	0.0022
Echinococcus multilocularis	lamin	0.0031	0.0359	0.0426
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0044	0.0698	0.0698
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0017	0.0022	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0359	0.0359
Brugia malayi	hypothetical protein	0.0023	0.0173	0.0173
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0021	0.011	0.0129
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0044	0.0698	0.0828
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0044	0.0698	0.0698
Echinococcus multilocularis	musashi	0.0031	0.0359	0.0426
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0017	0.0022	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Schistosoma mansoni	lamin	0.0031	0.0359	0.0426
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0017	0.0022	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus granulosus	lamin dm0	0.0031	0.0359	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0351	0.8409	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor	0.0021	0.011	0.011
Schistosoma mansoni	RAR-like nuclear receptor	0.0044	0.0698	0.0828
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0698	0.0828
Schistosoma mansoni	nuclear receptor nhr-48	0.0021	0.011	0.0129
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0017	0.0022	0.0022
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0044	0.0698	0.0828
Brugia malayi	hypothetical protein	0.0021	0.011	0.011
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0044	0.0698	0.0828
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0021	0.011	0.011
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0017	0.0022	0.5
Echinococcus granulosus	lamin	0.0031	0.0359	0.0426
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0044	0.0698	0.0698
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0239	0.5579	0.6634
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Onchocerca volvulus	Protein ultraspiracle homolog	0.0044	0.0698	0.0677
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0044	0.0698	0.0828
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0351	0.8409	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0044	0.0698	0.0698
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.011	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Echinococcus multilocularis	nuclear receptor nhr 48	0.0021	0.011	0.0129
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0022	0.0024
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0021	0.011	0.0129
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0044	0.0698	0.0828
Brugia malayi	hypothetical protein	0.0023	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0021	0.011	0.011
Onchocerca volvulus		0.0031	0.0359	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.011	0.0129
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0017	0.0022	0.0024
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.011	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0698	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0017	0.0022	0.0022
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0023	0.0173	0.0204
Echinococcus granulosus	thyroid hormone receptor alpha	0.0021	0.011	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0698	0.0698
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0022	0.0024
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0044	0.0698	0.0828
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0017	0.0022	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus granulosus	nuclear receptor nhr 48	0.0021	0.011	0.0129
Giardia lamblia	Protein tyrosine phosphatase	0.0017	0.0022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0173
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0022	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0044	0.0698	0.0828
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0359	0.0426
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0022	0.0024
Brugia malayi	ecdysone receptor	0.0021	0.011	0.011
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0021	0.011	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0022	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0044	0.0698	0.0698
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Brugia malayi	Protein-tyrosine phosphatase 1	0.0017	0.0022	0.0022
Brugia malayi	nuclear hormone receptor family member odr-7	0.0021	0.011	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0351	0.8409	0.8409
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0044	0.0698	0.0698
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0084	0.1698	0.2018
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Schistosoma mansoni	retinoic acid receptor RXR	0.0044	0.0698	0.0828
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0021	0.011	0.0129
Brugia malayi	nuclear receptor NHR-67	0.0021	0.011	0.011
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.011	0.011
Schistosoma mansoni	pcd6 interacting protein-related	0.0017	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Brugia malayi	steroid hormone receptor	0.0044	0.0698	0.0698
Brugia malayi	tailless protein	0.0021	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0044	0.0698	0.0698
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0044	0.0698	0.0698
Brugia malayi	orphan nuclear receptor NR2E1	0.0021	0.011	0.011
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0173
Loa Loa (eye worm)	steroid hormone receptor	0.0044	0.0698	0.0698
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0023	0.0173	0.0204
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0022	0.0024
Echinococcus multilocularis		0.0017	0.0022	0.0024
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0698	0.0698
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0022	0.0024
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0698	0.0698
Echinococcus granulosus	intermediate filament protein	0.0031	0.0359	0.0426
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0017	0.0022	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	ecdysone induced protein 78C	0.0044	0.0698	0.0828
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0017	0.0022	0.0024
Brugia malayi	nuclear receptor RXR	0.0023	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0359	0.0359
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0017	0.0022	0.0022
Leishmania major	tyrosine specific protein phosphatase, putative	0.0017	0.0022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0173
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0044	0.0698	0.0828
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0017	0.0022	0.0022
Brugia malayi	conserved hypotetical protein	0.0021	0.011	0.011
Onchocerca volvulus		0.0044	0.0698	0.0677
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0044	0.0698	0.0698
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0022	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0044	0.0698	0.0828
Loa Loa (eye worm)	hypothetical protein	0.003	0.0345	0.0345
Brugia malayi	nuclear hormone receptor	0.0044	0.0698	0.0698
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0239	0.5579	1
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0698	0.0828
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus multilocularis	hypothetical protein	0.0017	0.0022	0.0024
Schistosoma mansoni	zinc finger protein	0.0021	0.011	0.0129
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0021	0.011	0.011
Onchocerca volvulus		0.0031	0.0359	0.0338
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0239	0.5579	0.6634
Onchocerca volvulus		0.0021	0.011	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0017	0.0022	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0022	0.0024
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Schistosoma mansoni	nuclear receptor	0.0021	0.011	0.0129
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0017	0.0022	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0022	0.0024
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0084	0.1698	0.2018
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0021	0.011	0.011
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0173	0.0173
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0044	0.0698	0.0828
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0021	0.011	0.0129
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0017	0.0022	0.0024
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0017	0.0022	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0698	0.0698
Brugia malayi	Nuclear hormone receptor-like 1	0.0044	0.0698	0.0698
Schistosoma mansoni	lamin	0.0031	0.0359	0.0426
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0022	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0044	0.0698	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0415	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0021	0.011	0.011
Echinococcus multilocularis	FTZ F1 alpha	0.0044	0.0698	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0698	0.0698
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0044	0.0698	0.0698
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0022	0.0024
Schistosoma mansoni	coup transcription factor	0.0044	0.0698	0.0828
Brugia malayi	hypothetical protein	0.0017	0.0022	0.0022

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 1.11 uM	Dose affording 50% of maximum transactivation for ecdysone receptor from Choristoneura fumiferana (CfEcR) and a luciferase reporter gene in CHO cells	ChEMBL.	12749890
EC50 (functional)	= 1.11 uM	Dose affording 50% of maximum transactivation for ecdysone receptor from Choristoneura fumiferana (CfEcR) and a luciferase reporter gene in CHO cells	ChEMBL.	12749890
EC50 (functional)	= 1.41 uM	Dose affording 50% of maximum transactivation for ecdysone receptor from Bombyx mori (BmEcR) and a beta-galactosidase reporter gene in HEK-293 cell-line	ChEMBL.	12749890
EC50 (functional)	= 1.41 uM	Dose affording 50% of maximum transactivation for ecdysone receptor from Bombyx mori (BmEcR) and a beta-galactosidase reporter gene in HEK-293 cell-line	ChEMBL.	12749890
Ratio (functional)	= 0.96	Ratio of maximum level of gene expression (ecdysone receptor and luciferase gene) of compound to maximum level of gene expression with GSTM-E expressed as RMFI	ChEMBL.	12749890
Ratio (functional)	= 0.99	Ratio of maximum level of gene expression (ecdysone receptor and beta-galactosidase receptor) of compound to maximum level of gene expression with GSTM-E expressed as RMFI	ChEMBL.	12749890
Ratio (functional)	= 0.96	Ratio of maximum level of gene expression (ecdysone receptor and luciferase gene) of compound to maximum level of gene expression with GSTM-E expressed as RMFI	ChEMBL.	12749890
Ratio (functional)	= 0.99	Ratio of maximum level of gene expression (ecdysone receptor and beta-galactosidase receptor) of compound to maximum level of gene expression with GSTM-E expressed as RMFI	ChEMBL.	12749890

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL55869

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 81774