Detailed information for compound 81796

Basic information

Technical information
  • TDR Targets ID: 81796
  • Name: (4S)-4-[[(2S)-2-acetamido-3-(4-phosphonooxyph enyl)propanoyl]amino]-5-(diheptylamino)-5-oxo pentanoic acid
  • MW: 627.706 | Formula: C30H50N3O9P
  • H donors: 5 H acceptors: 8 LogP: 4.38 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCN(C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)OP(=O)(O)O)NC(=O)C)CCC(=O)O)CCCCCCC
  • InChi: 1S/C30H50N3O9P/c1-4-6-8-10-12-20-33(21-13-11-9-7-5-2)30(38)26(18-19-28(35)36)32-29(37)27(31-23(3)34)22-24-14-16-25(17-15-24)42-43(39,40)41/h14-17,26-27H,4-13,18-22H2,1-3H3,(H,31,34)(H,32,37)(H,35,36)(H2,39,40,41)/t26-,27-/m0/s1
  • InChiKey: NNMUPQCRQGLIJF-SVBPBHIXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S)-4-[[(2S)-2-acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-5-(diheptylamino)-5-oxo-pentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-1-oxo-3-(4-phosphonooxyphenyl)propyl]amino]-5-(diheptylamino)-5-oxopentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-5-(diheptylamino)-5-keto-valeric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cyclin 0.0018 0.0094 0.0506
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0416 0.0904
Schistosoma mansoni tyrosine kinase 0.0038 0.0416 0.1903
Schistosoma mansoni caspase-3 (C14 family) 0.0137 0.1971 0.902
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0364 0.0364
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0033 0.0336 0.0336
Leishmania major hypothetical protein, conserved 0.0015 0.0051 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0273 0.1251
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.1513 0.3288
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0554 0.064
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0069 0.0455
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0164 0.034
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0098 0.1358 0.8977
Plasmodium vivax methionine aminopeptidase 2, putative 0.0046 0.0538 0.8353
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0066 0.0433
Leishmania major hypothetical protein, conserved 0.0025 0.0214 0.1415
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0554 0.1205
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0416 0.0904
Trypanosoma cruzi metacaspase, putative 0.0052 0.0631 0.4172
Mycobacterium tuberculosis Conserved protein 0.0035 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Plasmodium falciparum HP12 protein homolog, putative 0.0016 0.0069 0.006
Loa Loa (eye worm) TK protein kinase 0.0034 0.0357 0.0413
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0554 0.1205
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0079 0.106 0.2304
Brugia malayi bZIP transcription factor family protein 0.0082 0.1101 0.1273
Loa Loa (eye worm) hypothetical protein 0.0304 0.4599 0.5313
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0554 0.064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0273 0.1251
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0167 0.0367
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1575 0.3426
Loa Loa (eye worm) hypothetical protein 0.0097 0.1345 0.1554
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0066 0.0144
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0087 0.01
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0416 0.0904
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0907 0.4151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Trypanosoma brucei metacaspase 0.0052 0.0631 0.4172
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0554 0.2535
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.213 0.213
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0631 1
Schistosoma mansoni hypothetical protein 0.0015 0.0051 0.0232
Brugia malayi Troponin I 0.0121 0.1726 0.1994
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.1513 0.3133
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0577 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0024 0.0162
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0049 0.0588 0.9239
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.1358 0.2946
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0416 0.0904
Loa Loa (eye worm) hypothetical protein 0.0304 0.4599 0.5313
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.1513 0.1748
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0164 0.019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0554 0.064
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0209 0.2543
Mycobacterium tuberculosis Conserved protein 0.0035 0.0364 0.0364
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0364 0.0364
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0554 0.064
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0091 0.0197
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0167 0.0765
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0554 0.064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Echinococcus granulosus zinc finger protein 0.0019 0.0116 0.0252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.222 0.2565
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0364 0.0364
Schistosoma mansoni hypothetical protein 0.0034 0.0354 0.1618
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.4552 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0538 0.1182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0554 0.1205
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0019 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.066 0.1451
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Loa Loa (eye worm) hypothetical protein 0.0079 0.106 0.1224
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0588 0.3888
Echinococcus multilocularis GPCR, family 2 0.0048 0.0577 0.1255
Brugia malayi Uncoordinated protein 44 0.0014 0.0037 0.0042
Entamoeba histolytica hypothetical protein 0.0098 0.1358 0.2946
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0809 0.0935
Toxoplasma gondii ABC1 family protein 0.0035 0.0364 0.3889
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0206 0.0238
Trypanosoma brucei mitotic cyclin 6 0.0018 0.0094 0.0622
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0907 0.1048
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0496 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0554 0.064
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0416
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0024 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0631 0.1387
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0091 0.0197
Loa Loa (eye worm) glutathione reductase 0.0046 0.0535 0.0618
Loa Loa (eye worm) hypothetical protein 0.0035 0.0364 0.042
Trypanosoma cruzi ISWI complex protein 0.0015 0.0051 0.0334
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0164 0.019
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0019 0.0041
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0631 0.6752
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0137 0.1971 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1513 0.6926
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0416 0.0904
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0164 0.019
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.2093 0.9581
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0077 0.0168
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0037 0.0079
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1456 0.1456
Trypanosoma brucei ISWI complex protein 0.0015 0.0051 0.0334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Giardia lamblia Hypothetical protein 0.0018 0.0094 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Echinococcus granulosus cyclin B 0.0018 0.0094 0.0205
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.0094 0.0109
Loa Loa (eye worm) hypothetical protein 0.0079 0.1066 0.1232
Brugia malayi nuclear hormone receptor 0.0022 0.0164 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0554 0.064
Onchocerca volvulus 0.0029 0.0273 0.0566
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0577 0.1255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0538 0.1182
Echinococcus multilocularis caspase 8 0.0052 0.0631 0.1373
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0554 0.1147
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0554 0.064
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0066 0.0142
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0164 0.0357
Brugia malayi PHD-finger family protein 0.0013 0.0021 0.0025
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0164 0.0752
Echinococcus granulosus peregrin 0.0036 0.039 0.0848
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0098 0.1358 0.1569
Entamoeba histolytica protein kinase, putative 0.0098 0.1358 0.2946
Onchocerca volvulus 0.0022 0.0164 0.034
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.0094 0.0205
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0564 0.1226
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.1513 0.1748
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0554 0.2535
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0554 0.2535
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0167 0.0765
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0564 0.1226
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0206 0.0448
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0577 0.1255
Brugia malayi Pre-SET motif family protein 0.0029 0.0273 0.0316
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0164 0.0357
Echinococcus multilocularis cyclin b3 0.0018 0.0094 0.0205
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0242
Echinococcus granulosus Smad4 0.0017 0.0091 0.0197
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0164 0.019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0554 0.2535
Echinococcus granulosus caspase 0.0137 0.1971 0.4286
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0554 0.1205
Echinococcus granulosus cyclin B3 1 0.0018 0.0094 0.0205
Trichomonas vaginalis cyclins, putative 0.0018 0.0094 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0631 0.1387
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0534 0.1162
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Brugia malayi hypothetical protein 0.0025 0.0206 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0554 0.064
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0357 0.0777
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0164 0.0357
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0151 0.2185 0.4523
Brugia malayi hypothetical protein 0.0072 0.0949 0.1096
Schistosoma mansoni jun-related protein 0.0066 0.0861 0.394
Brugia malayi hypothetical protein 0.0319 0.483 0.5581
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Echinococcus granulosus caspase 2 0.01 0.139 0.3023
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0161 0.0351
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0354 0.3781
Echinococcus granulosus cyclins 0.0018 0.0094 0.0205
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0049 0.0588 0.9239
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0137 0.1971 0.4286
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0049 0.0588 0.1279
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0364 0.2403
Loa Loa (eye worm) troponin 0.0072 0.0949 0.1096
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0554 0.2535
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.336 0.3883
Schistosoma mansoni zinc finger protein 0.0015 0.0051 0.0232
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0037 0.0079
Schistosoma mansoni acetylcholinesterase 0.0022 0.0167 0.0765
Brugia malayi TAR-binding protein 0.0069 0.0907 0.1048
Schistosoma mansoni netrin receptor unc5 0.0014 0.0037 0.0167
Brugia malayi hypothetical protein 0.0016 0.007 0.0081
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0161 0.0739
Echinococcus granulosus tar DNA binding protein 0.0069 0.0907 0.1972
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0209 0.1384
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0554 0.1147
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1513 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0416 0.0904
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.4552 1
Schistosoma mansoni tsg101-related 0.0066 0.0852 0.3899
Echinococcus multilocularis zinc finger protein 0.0019 0.0116 0.0252
Entamoeba histolytica hypothetical protein 0.0145 0.2093 0.457
Plasmodium vivax metacaspase 1, putative 0.0052 0.0631 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0238
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0273 0.2923
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.0554 0.1205
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0167 0.0363
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.1101 0.2395
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3001 0.3468
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0538 0.1182
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0151 0.2185 0.4751
Echinococcus granulosus dual specificity 0.0098 0.1358 0.2954
Trypanosoma brucei metacaspase 5, putative 0.0052 0.0631 0.4172
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0364 0.0029
Brugia malayi Smad1 0.0017 0.0091 0.0105
Trypanosoma cruzi metacaspase, putative 0.0052 0.0631 0.4172
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0054
Brugia malayi SRC-1 0.0038 0.0416 0.048
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.1513 0.329
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0354 0.1618
Brugia malayi Carboxylesterase family protein 0.0022 0.0167 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0554 0.064
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0416 0.0904
Entamoeba histolytica cyclin family protein 0.0018 0.0094 0.0154
Echinococcus granulosus tyrosine kinase 0.0034 0.0357 0.0777
Brugia malayi Carboxylesterase family protein 0.0022 0.0167 0.0193
Loa Loa (eye worm) hypothetical protein 0.0097 0.1345 0.1554
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0935 0.2033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0935 0.0935
Mycobacterium ulcerans lipase LipD 0.0035 0.0364 0.0364
Echinococcus granulosus cyclins 0.0018 0.0094 0.0205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0364 0.042
Echinococcus multilocularis Ankyrin 0.0014 0.0038 0.0083
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0588 0.3888
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0046 0.0538 0.3556
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0164 0.0752
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0072 0.0949 0.1965
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0364 0.0799
Brugia malayi conserved hypotetical protein 0.0022 0.0164 0.019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.2093 0.4552
Echinococcus multilocularis cyclin B3 1 0.0018 0.0094 0.0205
Trichomonas vaginalis esterase, putative 0.0035 0.0364 0.0799
Echinococcus granulosus cyclins 0.0018 0.0094 0.0205
Schistosoma mansoni hypothetical protein 0.0048 0.0577 0.2641
Trichomonas vaginalis set domain proteins, putative 0.023 0.3441 0.756
Trichomonas vaginalis cyclins, putative 0.0018 0.0094 0.0207
Plasmodium falciparum methionine aminopeptidase 2 0.0046 0.0538 0.8353
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0033 0.0336 1
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0164 0.0357
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0167 0.0167
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0164 0.019
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0354 0.509
Trypanosoma brucei trypanothione reductase 0.0046 0.0535 0.3536
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0033 0.0336 0.1537
Loa Loa (eye worm) hypothetical protein 0.0562 0.8655 1
Trichomonas vaginalis cyclin D, putative 0.0018 0.0094 0.0207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Brugia malayi protein-tyrosine kinase 0.0034 0.0357 0.0413
Leishmania major methionine aminopeptidase 2, putative 0.0046 0.0538 0.3556
Plasmodium falciparum metacaspase-like protein 0.0052 0.0631 1
Trypanosoma cruzi cyclin 6, putative 0.0018 0.0094 0.0622
Trichomonas vaginalis cyclin D, putative 0.0018 0.0094 0.0207
Echinococcus multilocularis muscleblind protein 1 0.0304 0.4599 1
Echinococcus multilocularis cyclin B 0.0018 0.0094 0.0205
Trichomonas vaginalis hypothetical protein 0.0038 0.0422 0.0927
Schistosoma mansoni caspase-7 (C14 family) 0.0137 0.1971 0.902
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0132 0.0153
Brugia malayi steroid hormone receptor 0.0047 0.0554 0.064
Schistosoma mansoni hypothetical protein 0.0048 0.0577 0.2641
Loa Loa (eye worm) troponin T 0.0072 0.0949 0.1096
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.034 0.074
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0033 0.0336 0.073
Trichomonas vaginalis cyclins, putative 0.0018 0.0094 0.0207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0554 0.1205
Onchocerca volvulus 0.0047 0.0554 0.1147
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0167 0.0167
Entamoeba histolytica cyclin, putative 0.0018 0.0094 0.0154
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.2093 0.4552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.002 0.0132 0.0605
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0164 0.019
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0091 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0907 0.4151
Loa Loa (eye worm) carboxylesterase 0.0022 0.0167 0.0193
Trypanosoma brucei metacaspase MCA2 0.0052 0.0631 0.4172
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0038 0.0176
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0538 0.1182
Echinococcus granulosus caspase 3 0.0085 0.1156 0.2514
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0033 0.0336 0.3593
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0273 0.0594
Loa Loa (eye worm) hypothetical protein 0.0072 0.0949 0.1096
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0046 0.0538 0.2463
Brugia malayi PHD-finger family protein 0.0024 0.0198 0.0228
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0534 0.1162
Plasmodium vivax SET domain protein, putative 0.0029 0.0273 0.3672
Brugia malayi beta-lactamase family protein 0.0035 0.0364 0.042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.4552 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0364 0.042
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0357 0.0777
Entamoeba histolytica hypothetical protein 0.0145 0.2093 0.457
Mycobacterium leprae Probable lipase LipE 0.0035 0.0364 0.0029
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0206 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0554 0.064
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Onchocerca volvulus 0.0035 0.0364 0.0753
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0364 0.1664
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0364 0.0364
Brugia malayi Protein kinase domain containing protein 0.0098 0.1358 0.1569
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0167 0.0765
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Brugia malayi initiation factor 2-associated protein. 0.0046 0.0538 0.0622
Trypanosoma brucei metacaspase MCA3 0.0052 0.0631 0.4172
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0066 0.0433
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0209 0.2543
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0091 0.0105
Loa Loa (eye worm) hypothetical protein 0.0069 0.0899 0.1038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0167 0.0167
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0164 0.0357
Toxoplasma gondii thioredoxin reductase 0.0046 0.0535 0.5723
Mycobacterium tuberculosis Conserved protein 0.0035 0.0364 0.0364
Brugia malayi nuclear receptor RXR 0.0022 0.0164 0.019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0366 0.0797
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0466 0.1014
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0206 0.0943
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.1358 0.8977
Onchocerca volvulus Alhambra homolog 0.0034 0.0354 0.0732
Trichomonas vaginalis cyclin A, putative 0.0018 0.0094 0.0207
Entamoeba histolytica cyclin family protein 0.0018 0.0094 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0206 0.0238
Toxoplasma gondii hypothetical protein 0.0016 0.0069 0.0737
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0577 0.0667
Schistosoma mansoni tsg101-related 0.0054 0.0662 0.3031
Entamoeba histolytica cyclin, putative 0.0018 0.0094 0.0154
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0554 0.064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0935 0.0935
Mycobacterium ulcerans methionine aminopeptidase 0.0033 0.0336 0.0336
Leishmania major hypothetical protein, conserved 0.0016 0.0069 0.0455
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0364 0.0799
Trypanosoma cruzi metacaspase, putative 0.0052 0.0631 0.4172
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0167
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0364 0.042
Trypanosoma cruzi CYC2-like cyclin, putative 0.0018 0.0094 0.0622
Brugia malayi hypothetical protein 0.0022 0.0167 0.0193
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0091 0.0197
Echinococcus granulosus acetylcholinesterase 0.0132 0.1891 0.4112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0554 0.064
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0297 0.0647
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0354 0.0408
Toxoplasma gondii hypothetical protein 0.0013 0.0027 0.029
Brugia malayi RNA binding protein 0.0069 0.0907 0.1048
Mycobacterium ulcerans beta-lactamase 0.0035 0.0364 0.0364
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0357 0.0777
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.0554 0.2535
Brugia malayi MH2 domain containing protein 0.0017 0.0091 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0935 0.4279
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0943 0.2051
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0907 0.1048
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0098 0.1358 0.8977
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0535 0.1163
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0935 0.0935
Trichomonas vaginalis cyclin B, putative 0.0018 0.0094 0.0207
Loa Loa (eye worm) hypothetical protein 0.0132 0.1891 0.2185
Onchocerca volvulus 0.0035 0.0364 0.0753
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0364 0.0799
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0554 0.064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0577 0.0667
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0554 0.1205
Schistosoma mansoni troponin I 0.0121 0.1726 0.7898
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0631 0.1387
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1513 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.3312 0.3312
Echinococcus multilocularis caspase 2 0.01 0.139 0.3023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.222 0.2565
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1456 0.1159
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Brugia malayi tailless protein 0.0022 0.0164 0.019
Schistosoma mansoni caspase-7 (C14 family) 0.01 0.139 0.6363
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0077 0.0168
Onchocerca volvulus 0.0231 0.3443 0.7128
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0554 0.064
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0554 0.064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0575 0.0665
Onchocerca volvulus 0.0048 0.0575 0.1191
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0416 0.0904
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0364 0.0799
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0554 0.1205
Loa Loa (eye worm) Smad1 0.0017 0.0091 0.0105
Brugia malayi jmjC domain containing protein 0.0112 0.1575 0.182
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.1513 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0066 0.0701
Trichomonas vaginalis cyclin B, putative 0.0018 0.0094 0.0207
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0049 0.0588 0.3888
Echinococcus granulosus jun protein 0.0082 0.1101 0.2395
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0164 0.034
Brugia malayi MH2 domain containing protein 0.0256 0.3842 0.444
Schistosoma mansoni tsg101-related 0.0066 0.0852 0.3899
Brugia malayi glutathione reductase 0.0046 0.0535 0.0618
Leishmania major cyclin 0.0018 0.0094 0.0622
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0416 0.0904
Brugia malayi MH1 domain containing protein 0.0017 0.0091 0.0105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Schistosoma mansoni hypothetical protein 0.0063 0.0809 0.3703
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0077 0.0355
Echinococcus multilocularis dual specificity 0.0098 0.1358 0.2954
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0631 0.1387
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0554 0.064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0535 0.1163
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0554 0.1205
Brugia malayi Carboxylesterase family protein 0.0022 0.0167 0.0193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0364 0.0364
Echinococcus granulosus troponin i 0.0121 0.1726 0.3753
Giardia lamblia PHD finger protein 15 0.0034 0.0354 0.0642
Echinococcus granulosus GPCR family 2 0.0048 0.0577 0.1255
Loa Loa (eye worm) hypothetical protein 0.01 0.139 0.1606
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.034 0.074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0935 0.0935
Entamoeba histolytica hypothetical protein 0.0145 0.2093 0.457
Brugia malayi nuclear receptor NHR-88 0.0022 0.0164 0.019
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0631 0.6752
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0164 0.0752
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0206 0.0943
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.066 0.1451
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0164 0.0752
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1456 0.1456
Trichomonas vaginalis cyclin B, putative 0.0018 0.0094 0.0207
Brugia malayi Troponin family protein 0.0121 0.1726 0.1994
Brugia malayi ecdysone receptor 0.0022 0.0164 0.019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0416 0.0904
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0577 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Trypanosoma cruzi cyclin, putative 0.0018 0.0094 0.0622
Mycobacterium ulcerans hypothetical protein 0.0035 0.0364 0.0364
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0809 0.1759
Onchocerca volvulus 0.0022 0.0167 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0907 0.4151
Schistosoma mansoni hypothetical protein 0.0048 0.0577 0.2641
Giardia lamblia G2/mitotic-specific cyclin B 0.0018 0.0094 0.0064
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Brugia malayi nuclear receptor NHR-88 0.0047 0.0554 0.064
Brugia malayi Bromodomain containing protein 0.0036 0.039 0.045
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Echinococcus granulosus cyclins 0.0018 0.0094 0.0205
Leishmania major trypanothione reductase 0.0046 0.0535 0.3536
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0066 0.03
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0077 0.0355
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0046 0.0538 0.3556
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1891 0.4112
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0037 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0209 0.2543
Echinococcus multilocularis muscleblind protein 0.0304 0.4599 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0214 0.1415
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0416
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0496 0.2269
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0069 0.0455
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0066 0.0066
Brugia malayi hypothetical protein 0.0064 0.0826 0.0954
Chlamydia trachomatis methionine aminopeptidase 0.0033 0.0336 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1456 0.1456
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.0094 0.0205
Schistosoma mansoni zinc finger protein 0.0019 0.0116 0.0531
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.4552 1
Brugia malayi ecdysteroid receptor 0.0047 0.0554 0.064
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0429 0.0933
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.1891 0.2185
Treponema pallidum methionine aminopeptidase (map) 0.0033 0.0336 0.0603
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0094 0.0109
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0535 0.8299
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0214 0.1415
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0554 0.2535
Echinococcus granulosus cyclins 0.0018 0.0094 0.0205
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0091 0.0197
Brugia malayi hypothetical protein 0.0025 0.0209 0.0242
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0037 0.0167
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0066 0.0433
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0554 0.1205
Loa Loa (eye worm) hypothetical protein 0.0022 0.0167 0.0193
Giardia lamblia Methionine aminopeptidase 0.0046 0.0538 0.1053
Echinococcus multilocularis neuroligin 0.0022 0.0167 0.0363
Trichomonas vaginalis cyclins, putative 0.0018 0.0094 0.0207
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0033 0.0336 0.0336
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Trypanosoma cruzi ISWI complex protein 0.0015 0.0051 0.0334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0496 0.1078
Schistosoma mansoni gliotactin 0.0022 0.0167 0.0765
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0161 0.0351
Echinococcus granulosus death domain containing protein 0.0014 0.0037 0.0079
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0037 0.0076
Plasmodium falciparum thioredoxin reductase 0.0046 0.0535 0.8299
Brugia malayi Carboxylesterase family protein 0.0132 0.1891 0.2185
Brugia malayi hypothetical protein 0.0145 0.2093 0.2419
Schistosoma mansoni hypothetical protein 0.0121 0.1726 0.7898
Loa Loa (eye worm) carboxylesterase 0.0022 0.0167 0.0193
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0554 0.1205
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0046 0.0538 0.3556
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Brugia malayi Death domain containing protein 0.0014 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0109
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0416 0.0904
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0416 0.0904
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0535 0.0618
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0167 0.0363
Entamoeba histolytica protein kinase, putative 0.0031 0.0297 0.0603
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0033 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0364 0.042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0534 0.2445
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0364 0.2403
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1638 0.1638
Brugia malayi DnaJ domain containing protein 0.0063 0.0809 0.0935
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0647 1 1
Schistosoma mansoni smad 0.0017 0.0091 0.0416
Entamoeba histolytica methionine aminopeptidase, putative 0.0046 0.0538 0.1135
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0554 0.1205
Loa Loa (eye worm) hypothetical protein 0.0104 0.146 0.1686
Brugia malayi nuclear receptor RXR 0.0025 0.0206 0.0238
Schistosoma mansoni cyclin B3 0.0018 0.0094 0.0431
Loa Loa (eye worm) hypothetical protein 0.0153 0.222 0.2565
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0554 0.1205
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0554 0.064
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0354 0.0769
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0907 0.1048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.222 0.2565
Loa Loa (eye worm) DR-78 0.0022 0.0164 0.019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0631 0.0729
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0066 0.0144
Schistosoma mansoni nuclear receptor 0.0022 0.0164 0.0752
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0354 0.3781
Loa Loa (eye worm) hypothetical protein 0.0035 0.0364 0.042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0066 0.0066
Echinococcus multilocularis caspase 3 0.0085 0.1156 0.2514
Schistosoma mansoni cyclins 0.0018 0.0094 0.0431
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.146 0.1686
Schistosoma mansoni hypothetical protein 0.0066 0.0861 0.394
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0033 0.0336 0.4779
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0209 0.1384
Echinococcus multilocularis caspase 0.0137 0.1971 0.4286
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0164 0.0357
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0037 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.073 0.1587
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0164 0.019
Echinococcus multilocularis Smad4 0.0017 0.0091 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0364 0.2403
Echinococcus granulosus methionyl aminopeptidase 2 0.0046 0.0538 0.117
Trypanosoma brucei Metacaspase-4 0.0052 0.0631 0.4172
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0357 0.0777
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1638 0.1348
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.1891 0.4112
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0033 0.0336 0.1537
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0554 0.2535
Trichomonas vaginalis cyclins, putative 0.0018 0.0094 0.0207
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0554 0.1205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0364 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0554 0.064
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0943 0.2051
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0018 0.0094 0.0622
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Brugia malayi Carboxylesterase family protein 0.0022 0.0167 0.0193
Schistosoma mansoni troponin t invertebrate 0.0151 0.2185 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0238
Loa Loa (eye worm) hypothetical protein 0.0046 0.0534 0.0617
Echinococcus granulosus carboxylesterase 5A 0.0132 0.1891 0.4112
Schistosoma mansoni zinc finger protein 0.0022 0.0164 0.0752
Leishmania major metacaspase, putative 0.0052 0.0631 0.4172
Brugia malayi hypothetical protein 0.0079 0.106 0.1224
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0416 0.0904
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0167 0.0363
Giardia lamblia Kinase, PLK 0.0108 0.1513 0.3227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Plasmodium falciparum phd finger protein, putative 0.0034 0.0354 0.509
Echinococcus granulosus Ankyrin 0.0014 0.0038 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0009 0.004
Brugia malayi Bromodomain containing protein 0.0037 0.0403 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0554 0.1205
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0809 0.1777
Brugia malayi Muscleblind-like protein 0.0304 0.4599 0.5313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0256 0.0558
Schistosoma mansoni jumonji domain containing protein 0.0089 0.1214 0.5556
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0164 0.0357
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0364 0.0364
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0094 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0238
Toxoplasma gondii methionine aminopeptidase 0.0049 0.0588 0.6292
Trichomonas vaginalis cyclin B, putative 0.0018 0.0094 0.0207
Plasmodium falciparum metacaspase 1 0.0052 0.0631 1
Toxoplasma gondii methionine aminopeptidase 0.0033 0.0336 0.3593
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0554 0.1147
Leishmania major hypothetical protein, conserved 0.0025 0.0209 0.1384
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Brugia malayi Protein kinase domain containing protein 0.0015 0.005 0.0058
Schistosoma mansoni coup transcription factor 0.0047 0.0554 0.2535
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0631 0.1387
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0167 0.0363
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0534 0.2445
Loa Loa (eye worm) hypothetical protein 0.0121 0.1726 0.1994
Trypanosoma cruzi metacaspase, putative 0.0052 0.0631 0.4172
Onchocerca volvulus 0.0022 0.0167 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0094 0.0207
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0094 0.0109
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0554 0.064
Loa Loa (eye worm) hypothetical protein 0.004 0.044 0.0508
Brugia malayi MH2 domain containing protein 0.0017 0.0091 0.0105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Loa Loa (eye worm) hypothetical protein 0.0034 0.0354 0.0408
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0354 0.0769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0554 0.1205
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0164 0.0357
Onchocerca volvulus 0.0064 0.0826 0.1709
Loa Loa (eye worm) troponin I 0.0121 0.1726 0.1994
Echinococcus multilocularis jun protein 0.0082 0.1101 0.2395
Loa Loa (eye worm) hypothetical protein 0.0121 0.1726 0.1994
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0167 0.0167
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0206 0.0238
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0046 0.0538 0.5756
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0357 0.0777
Brugia malayi Carboxylesterase family protein 0.0132 0.1891 0.2185
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0575 0.1251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0554 0.064
Brugia malayi jmjC domain containing protein 0.0043 0.0496 0.0573
Brugia malayi hypothetical protein 0.0022 0.0164 0.019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0164 0.0357
Onchocerca volvulus Cell death protein 3 homolog 0.01 0.139 0.2878
Loa Loa (eye worm) hypothetical protein 0.0047 0.0554 0.064
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0535 0.3536
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0066 0.0433
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0049 0.0588 0.3888
Echinococcus multilocularis peregrin 0.0036 0.039 0.0848
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0033 0.0336 0.4779
Echinococcus granulosus acetylcholinesterase 0.0132 0.1891 0.4112
Echinococcus granulosus oncosphere protein Tso22e 0.0151 0.2185 0.4751
Echinococcus multilocularis methionyl aminopeptidase 2 0.0046 0.0538 0.117
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0066 0.0076
Trypanosoma brucei methionine aminopeptidase, putative 0.0049 0.0588 0.3888
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Onchocerca volvulus 0.0018 0.0094 0.0195
Schistosoma mansoni troponin I 0.0121 0.1726 0.7898
Echinococcus granulosus smad 0.0017 0.0091 0.0197
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0049 0.0588 0.1279
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1638 0.1638
Brugia malayi nuclear hormone receptor 0.0047 0.0554 0.064
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0052 0.0631 0.289
Onchocerca volvulus 0.0022 0.0164 0.034
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0054 0.0662 0.1409
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0069 0.006
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0416 0.0904
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0416 0.0904
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0079 0.106 0.2304
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0209 0.2239
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0554 0.064
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0164 0.0752
Onchocerca volvulus Troponin I homolog 0.0121 0.1726 0.3573
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Loa Loa (eye worm) TK protein kinase 0.0031 0.0297 0.0344
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1891 0.4112
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0907 0.4151
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0209 0.1384
Schistosoma mansoni kinase 0.0055 0.0683 0.3125
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0066 0.0433
Schistosoma mansoni nuclear receptor 0.0022 0.0164 0.0752
Plasmodium falciparum glutathione reductase 0.0046 0.0535 0.8299
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0167 0.0363
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0069 0.0455
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.3842 0.444
Schistosoma mansoni cyclin B 0.0018 0.0094 0.0431
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0554 0.2535
Loa Loa (eye worm) hypothetical protein 0.0035 0.0364 0.042
Loa Loa (eye worm) hypothetical protein 0.0059 0.0737 0.0852
Mycobacterium tuberculosis Probable reductase 0.0104 0.1456 0.1456
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0066 0.0142
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.213 0.1856
Loa Loa (eye worm) methionine aminopeptidase type I 0.0049 0.0588 0.068
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0164 0.0357
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0631 0.1387
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.1358 0.8977
Brugia malayi nuclear receptor NHR-67 0.0022 0.0164 0.019
Onchocerca volvulus 0.0022 0.0167 0.0346
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0364 0.0791
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.1513 0.329
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0364 0.042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0535 0.0535
Brugia malayi beta-lactamase family protein 0.0035 0.0364 0.042
Schistosoma mansoni hypothetical protein 0.0048 0.0575 0.2633
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1638 0.1638
Loa Loa (eye worm) hypothetical protein 0.0041 0.0469 0.0542
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.073 0.1587
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0038 0.0044
Loa Loa (eye worm) SRC-1 0.0038 0.0416 0.048
Loa Loa (eye worm) hypothetical protein 0.0319 0.483 0.5581
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0164 0.0357
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0167 0.0363
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0066 0.0066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0577 0.1255
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0575 0.1251
Brugia malayi Troponin T 0.0072 0.0949 0.1096
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.1101 0.2395
Schistosoma mansoni hypothetical protein 0.0145 0.2093 0.9581
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0167 0.0367
Schistosoma mansoni bromodomain containing protein 0.0062 0.0785 0.3592
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0052 0.0631 0.0729
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0554 0.2535
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1358 0.6217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0577 0.1255
Echinococcus granulosus cyclin b3 0.0018 0.0094 0.0205
Loa Loa (eye worm) RNA binding protein 0.0069 0.0907 0.1048
Brugia malayi MH1 domain containing protein 0.0017 0.0091 0.0105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0554 0.2535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0554 0.064
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0631 0.4172
Schistosoma mansoni Smad4 0.0017 0.0091 0.0416
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0496 0.2269
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0809 0.1759
Schistosoma mansoni hypothetical protein 0.0104 0.146 0.6681
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0647 1 1
Brugia malayi hypothetical protein 0.0025 0.0206 0.0238
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0631 0.4172
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.0554 0.1205
Onchocerca volvulus 0.0022 0.0167 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0554 0.064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0404 0.0466
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0364 0.0364
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0066 0.0433
Brugia malayi follicle stimulating hormone receptor 0.0225 0.336 0.3883
Brugia malayi hypothetical protein 0.0022 0.0164 0.019
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0066 0.0433
Trypanosoma brucei polo-like protein kinase 0.0108 0.1513 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1456 0.1456
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0554 0.2535
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0631 0.1387
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0164 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0364 0.0799
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0167 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.1891 0.8655
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0046 0.0538 0.1114
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0046 0.0538 0.3556
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0167 0.0765
Entamoeba histolytica protein kinase, putative 0.0098 0.1358 0.2946
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0049 0.0588 0.3888
Brugia malayi Thioredoxin reductase 0.0046 0.0535 0.0618
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.3842 0.444
Leishmania major hypothetical protein, conserved 0.0035 0.0364 0.2403
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0364 0.0791
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0925 0.1069
Brugia malayi Methionine aminopeptidase protein type I 0.0049 0.0588 0.068
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0631 0.6752
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0935 0.6179
Brugia malayi Pre-SET motif family protein 0.0202 0.3001 0.3468
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0364 0.0364
Echinococcus multilocularis smad 0.0017 0.0091 0.0197
Echinococcus granulosus neuroligin 0.0022 0.0167 0.0363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1456 0.1456
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0238
Loa Loa (eye worm) initiation factor 2-associated protein 0.0046 0.0538 0.0622
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0297 0.0647
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0935 0.2033
Brugia malayi hypothetical protein 0.0048 0.0575 0.0665
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0935 0.4279
Brugia malayi small heat shock protein 0.0562 0.8655 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0364 0.5269
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0554 0.1205
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0935 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0366 0.0797
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0364 0.1664
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0066 0.0433
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1575 0.3426
Plasmodium vivax glutathione reductase, putative 0.0046 0.0535 0.8299
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0164 0.019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.019
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0416 0.0904
Echinococcus granulosus caspase 8 0.0052 0.0631 0.1373
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0238
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0024 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0042
Schistosoma mansoni troponin I 0.0121 0.1726 0.7898
Schistosoma mansoni hypothetical protein 0.0048 0.0577 0.2641
Loa Loa (eye worm) carboxylesterase 0.0132 0.1891 0.2185
Schistosoma mansoni troponin I 0.0121 0.1726 0.7898
Brugia malayi Cell death protein 3 precursor 0.01 0.139 0.1606
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0054
Trypanosoma cruzi cyclin, putative 0.0018 0.0094 0.0622
Schistosoma mansoni tyrosine kinase 0.0038 0.0416 0.1903
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0164 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1513 0.3324
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0091 0.0416
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0094 0.0207
Onchocerca volvulus 0.0022 0.0167 0.0346
Brugia malayi beta-lactamase 0.0035 0.0364 0.042
Brugia malayi Troponin T 0.0072 0.0949 0.1096
Echinococcus granulosus muscleblind protein 0.0304 0.4599 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0066 0.0433
Onchocerca volvulus 0.0035 0.0364 0.0753
Echinococcus multilocularis cyclins 0.0018 0.0094 0.0205
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0037 0.0042
Echinococcus multilocularis troponin i 0.0121 0.1726 0.3753
Brugia malayi Troponin T 0.0072 0.0949 0.1096
Giardia lamblia Cyclin A 0.0018 0.0094 0.0064
Loa Loa (eye worm) beta-lactamase 0.0035 0.0364 0.042
Brugia malayi Bromodomain containing protein 0.0073 0.0964 0.1114
Brugia malayi PHD-finger family protein 0.0034 0.0354 0.0408
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Entamoeba histolytica hypothetical protein 0.0145 0.2093 0.457
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0066 0.0433
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0416
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0907 0.1972
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0066 0.0701
Onchocerca volvulus 0.0319 0.483 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1891 0.2185
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0907 0.4151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4552 1
Trichomonas vaginalis cyclin B, putative 0.0018 0.0094 0.0207

Activities

Activity type Activity value Assay description Source Reference
Ratio (binding) = 327 Binding affinity against c-Src tyrosine kinase SH2 domain expressed as ratio of IC50 of test compound over IC50 of AcYEEIE ChEMBL. 9599239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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