Detailed information for compound 817976

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.514 | Formula: C19H27N5O3S
  • H donors: 2 H acceptors: 4 LogP: 1.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)C(=O)c1sc2c(c1C)c(NCC1CCCO1)ncn2
  • InChi: 1S/C19H27N5O3S/c1-13-15-17(20-11-14-3-2-10-27-14)21-12-22-18(15)28-16(13)19(26)24-6-4-23(5-7-24)8-9-25/h12,14,25H,2-11H2,1H3,(H,20,21,22)
  • InChiKey: PURBWYHXDAQSOQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0209 0.4684
Mycobacterium ulcerans carboxylesterase, LipT 0.0128 0.0725 0.0788
Brugia malayi Transient-receptor-potential like protein 0.0034 0.0139 0.0298
Echinococcus multilocularis transient receptor potential ion channel A 0.0089 0.0484 0.0484
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0325 0.0698
Brugia malayi MH2 domain containing protein 0.0133 0.0758 0.1624
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0161 0.0161
Brugia malayi Bromodomain containing protein 0.0041 0.0181 0.0388
Giardia lamblia PHD finger protein 15 0.0031 0.012 0.2713
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0014 0.003
Echinococcus granulosus chromobox protein 1 0.0075 0.0393 0.0842
Loa Loa (eye worm) hypothetical protein 0.005 0.0239 0.0512
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0087 0.2444
Echinococcus multilocularis acetylcholinesterase 0.0757 0.4663 0.4663
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0014 0.0014
Schistosoma mansoni BC026374 protein (S09 family) 0.0128 0.0725 0.1553
Schistosoma mansoni zinc finger protein 0.0021 0.0056 0.0118
Schistosoma mansoni hypothetical protein 0.0532 0.3259 0.6989
Echinococcus multilocularis BC026374 protein (S09 family) 0.0128 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0154 0.0892 0.1911
Brugia malayi Importin beta-1 subunit 0.0062 0.0312 0.0667
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0128 0.0725 0.4774
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0039 0.0083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0239 0.0239
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0093 0.2669
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0209 0.4848
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0177 0.3905
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.0256
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0393 0.0841
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.004 0.0177 0.0378
Echinococcus granulosus lysine specific histone demethylase 1A 0.0081 0.0431 0.0925
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0128 0.0725 0.1076
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0014 0.0029
Loa Loa (eye worm) carboxylesterase 0.0757 0.4663 1
Brugia malayi follicle stimulating hormone receptor 0.0223 0.1323 0.2836
Loa Loa (eye worm) carboxylesterase 0.0128 0.0725 0.1553
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0177 0.3905
Schistosoma mansoni bromodomain containing protein 0.0068 0.035 0.0748
Loa Loa (eye worm) hypothetical protein 0.0106 0.0585 0.1254
Echinococcus multilocularis peregrin 0.0034 0.0136 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0431 1
Schistosoma mansoni ran 0.0046 0.0209 0.0448
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0014 0.0309
Brugia malayi CHD4 protein 0.0014 0.0013 0.0028
Onchocerca volvulus 0.0128 0.0725 0.4774
Echinococcus granulosus short transient receptor potential channel 6 0.0061 0.0307 0.0659
Echinococcus granulosus transient receptor potential ion channel A 0.0089 0.0484 0.1038
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0557
Entamoeba histolytica hypothetical protein 0.0039 0.0166 0.695
Schistosoma mansoni amine oxidase 0.0081 0.0431 0.0924
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0177 0.7352
Onchocerca volvulus 0.0033 0.013 0.0852
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0833 0.1786
Toxoplasma gondii histone lysine-specific demethylase 0.0081 0.0431 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0566 0.1214
Schistosoma mansoni hypothetical protein 0.0049 0.023 0.0492
Plasmodium vivax hypothetical protein, conserved 0.0031 0.012 0.2773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0833 0.0833
Echinococcus multilocularis 0.0081 0.0431 0.0431
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0177 0.5
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0209 0.0448
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0063 0.0133
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0081 0.0431 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0177 0.5
Brugia malayi Carboxylesterase family protein 0.0757 0.4663 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0332 0.0224
Echinococcus multilocularis zinc finger protein 0.0021 0.0056 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0174 0.0372
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0277
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0177 0.4094
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.0399
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0585 0.1254
Loa Loa (eye worm) acetylcholinesterase 1 0.0757 0.4663 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0211 0.0451
Echinococcus granulosus chromobox protein 2 0.0012 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0223 0.1324 0.2838
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0199
Onchocerca volvulus 0.0128 0.0725 0.4774
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0431 1
Leishmania major hypothetical protein, conserved 0.0016 0.0027 0.0309
Onchocerca volvulus 0.0128 0.0725 0.4774
Echinococcus granulosus importin subunit beta 1 0.0062 0.0312 0.0669
Entamoeba histolytica hypothetical protein 0.0039 0.0166 0.695
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0174 0.0372
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.012 0.012
Echinococcus granulosus peregrin 0.0034 0.0136 0.0291
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0087 0.0185
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.0725 0.1553
Loa Loa (eye worm) hypothetical protein 0.0062 0.0312 0.0667
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0014 0.0309
Brugia malayi chromobox protein homolog 3 0.0042 0.0187 0.0399
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0892 0.1911
Echinococcus granulosus carboxylesterase 5A 0.0757 0.4663 1
Echinococcus granulosus neuroligin 0.0128 0.0725 0.1554
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0758 0.1624
Echinococcus granulosus transient receptor potential gamma protein 0.0093 0.0503 0.1079
Trypanosoma brucei ISWI complex protein 0.0016 0.0027 0.0433
Schistosoma mansoni gliotactin 0.0128 0.0725 0.1553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0892 0.1911
Trypanosoma cruzi ISWI complex protein 0.0016 0.0027 0.0309
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.012 0.2773
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0093 0.2156
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0166 0.0355
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0174 0.0372
Leishmania major importin beta-1 subunit, putative 0.005 0.0238 0.538
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0125 0.2882
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0087 0.0186
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0008 0.0016
Onchocerca volvulus 0.0081 0.0431 0.2839
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Echinococcus multilocularis short transient receptor potential channel 6 0.0061 0.0307 0.0307
Echinococcus granulosus snurportin 1 0.0661 0.4065 0.8718
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.0725 0.1553
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0039 0.0039
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0128 0.0725 0.0725
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0166 0.0166
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0014 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0431 1
Brugia malayi Carboxylesterase family protein 0.0128 0.0725 0.1553
Plasmodium vivax importin-beta 2, putative 0.0062 0.0312 0.7227
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0892 0.1911
Plasmodium vivax SET domain protein, putative 0.0032 0.0125 0.2882
Loa Loa (eye worm) carboxylesterase 0.0128 0.0725 0.1553
Plasmodium falciparum phd finger protein, putative 0.0031 0.012 0.2773
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0001 0.0001
Onchocerca volvulus 0.0044 0.0201 0.1324
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0093 0.2156
Schistosoma mansoni transient receptor potential channel 0.0061 0.0307 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0125 0.0266
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.0029
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0014 0.0029
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0177 0.4094
Loa Loa (eye worm) hypothetical protein 0.0044 0.0198 0.0423
Brugia malayi PHD-finger family protein 0.0031 0.012 0.0256
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0187 0.1226
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0076 0.0161
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0056
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0209 0.6562
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0431 1
Brugia malayi SWIRM domain containing protein 0.0081 0.0431 0.0924
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0014 0.0014
Echinococcus multilocularis acetylcholinesterase 0.0757 0.4663 0.4663
Mycobacterium tuberculosis Carboxylesterase LipT 0.0128 0.0725 0.1076
Schistosoma mansoni hypothetical protein 0.0022 0.0063 0.0133
Brugia malayi isocitrate dehydrogenase 0.0014 0.0014 0.0029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0209 0.0449
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0238 0.538
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0332 0.0224
Schistosoma mansoni neuroligin 3 (S09 family) 0.0128 0.0725 0.1553
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0833 0.1786
Echinococcus granulosus TRP transient receptor potential channel 0.0034 0.0139 0.0299
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0034 0.0139 0.0139
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0661 0.4065 0.8718
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0087 0.0568
Echinococcus granulosus zinc finger protein 0.0021 0.0056 0.0119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.023 0.023
Brugia malayi hypothetical protein 0.0027 0.0093 0.0199
Mycobacterium ulcerans oxidoreductase 0.0081 0.0431 0.0366
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.023 0.0493
Echinococcus multilocularis chromobox protein 1 0.0075 0.0393 0.0393
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.012 0.0257
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0177 0.5471
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0166 0.0166
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.115 0.7129 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.012 0.2773
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0177 0.7413
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0081 0.0431 1
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0197 0.0422
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0128 0.0725 0.1076
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0087 0.0185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0117 0.0251
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0207 0.1358
Mycobacterium ulcerans dehydrogenase 0.0081 0.0431 0.0366
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0087 0.0185
Schistosoma mansoni hypothetical protein 0.0031 0.012 0.0256
Brugia malayi Carboxylesterase family protein 0.0128 0.0725 0.1553
Schistosoma mansoni chromobox protein 0.0075 0.0393 0.0841
Entamoeba histolytica hypothetical protein 0.0039 0.0166 0.695
Onchocerca volvulus 0.0128 0.0725 0.4774
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0238 0.1568
Schistosoma mansoni ap endonuclease 0.004 0.0177 0.0378
Echinococcus granulosus short transient receptor potential channel 6 0.0061 0.0307 0.0659
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0332 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0187 0.1226
Schistosoma mansoni hypothetical protein 0.0532 0.3259 0.6989
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0093 0.2156
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0924
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0093 0.1905
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0207 0.1358
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Schistosoma mansoni ran 0.0046 0.0209 0.0448
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0312 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0087 0.0185
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0223 0.1323 0.2836
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0125 0.0125
Onchocerca volvulus 0.0012 0.0001 0.000000055456
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0833 0.1787
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0393 0.2584
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0238 0.1568
Loa Loa (eye worm) hypothetical protein 0.0049 0.023 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.003 0.011 0.0721
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0431 0.0632
Brugia malayi PHD-finger family protein 0.0027 0.0091 0.0195
Onchocerca volvulus 0.0128 0.0725 0.4774
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0082
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0087 0.2
Schistosoma mansoni chromobox protein 0.0075 0.0393 0.0841
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0833 0.1786
Echinococcus granulosus acetylcholinesterase 0.0757 0.4663 1
Brugia malayi Heterochromatin protein 1 0.0075 0.0393 0.0841
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0239 0.0513
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0081 0.0431 0.5
Brugia malayi Latrophilin receptor protein 2 0.0049 0.023 0.0492
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0166 0.0355
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0329 0.0704
Brugia malayi hypothetical protein 0.0128 0.0725 0.1553
Echinococcus granulosus Chromobox protein 3 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0207 0.1358
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0239 0.0512
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0332 0.0482
Echinococcus multilocularis short transient receptor potential channel 6 0.0061 0.0307 0.0307
Brugia malayi Carboxylesterase family protein 0.0128 0.0725 0.1553
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0332 0.0712
Echinococcus granulosus acetylcholinesterase 0.0757 0.4663 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.0256
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0924
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.012 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0833 0.1786
Schistosoma mansoni zinc finger protein 0.0016 0.0027 0.0056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.023 0.023
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0081 0.0431 0.0366
Schistosoma mansoni hypothetical protein 0.0039 0.0166 0.0355
Brugia malayi Pre-SET motif family protein 0.0032 0.0125 0.0266
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0014 0.0309
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0177 0.0379
Entamoeba histolytica hypothetical protein 0.0039 0.0166 0.695
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0076 0.0162
Brugia malayi SET domain containing protein 0.0013 0.0008 0.0016
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0174 0.0373
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0924
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0081 0.0431 0.0924
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0087 0.1745
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0128 0.0725 0.1554
Plasmodium falciparum protoporphyrinogen oxidase 0.0081 0.0431 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0833 0.1786
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.0725 0.1553
Trichomonas vaginalis spcc417.12 protein, putative 0.0128 0.0725 0.4774
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0093 0.1905
Echinococcus multilocularis geminin 0.0532 0.3259 0.3259
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0087 0.0087
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0081 0.0431 0.0431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0924
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0924
Trichomonas vaginalis ran, putative 0.0046 0.0209 0.1377
Leishmania major GTP-binding protein, putative 0.0046 0.0209 0.4684
Brugia malayi jmjC domain containing protein 0.0103 0.0566 0.1213
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0177 0.3905
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0325 0.0325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0616
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0209 0.4848
Trichomonas vaginalis chaperonin, putative 0.0026 0.0087 0.0568
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0209 0.0448
Echinococcus multilocularis para nitrobenzyl esterase 0.0128 0.0725 0.0725
Brugia malayi Carboxylesterase family protein 0.0128 0.0725 0.1553
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0833 0.1787
Brugia malayi hypothetical protein 0.0081 0.0431 0.0924
Plasmodium falciparum importin beta, putative 0.0062 0.0312 0.7227
Schistosoma mansoni acetylcholinesterase 0.0128 0.0725 0.1553
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0081 0.0431 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.1324 0.2838
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0177 0.1162
Trichomonas vaginalis set domain proteins, putative 0.0254 0.1517 1
Toxoplasma gondii exonuclease III APE 0.004 0.0177 0.4094
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0434 0.093
Brugia malayi Bromodomain containing protein 0.0081 0.0428 0.0918
Echinococcus multilocularis snurportin 1 0.0661 0.4065 0.4065
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0332 0.0332
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0013 0.0028
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0393 0.2584
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0177 0.0378
Echinococcus granulosus lysine specific histone demethylase 1A 0.0081 0.0431 0.0925
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0239 0.0512
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0081 0.0431 1
Trichomonas vaginalis importin beta-1, putative 0.005 0.0238 0.1568
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0332 0.7703
Schistosoma mansoni amine oxidase 0.0081 0.0431 0.0924
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0661 0.4065 0.8718
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.023 0.0492
Echinococcus multilocularis neuroligin 0.0128 0.0725 0.0725
Entamoeba histolytica hypothetical protein 0.005 0.0238 1
Brugia malayi PHD-finger family protein 0.0012 0.0001 0.0001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0209 1
Brugia malayi jmjC domain containing protein 0.004 0.0174 0.0372
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0209 0.4684
Loa Loa (eye worm) hypothetical protein 0.0757 0.4663 1
Leishmania major hypothetical protein, conserved 0.0027 0.0093 0.1905
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0187 0.1226
Echinococcus multilocularis Chromo domain 0.0012 0.0001 0.0001
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0087 0.0185
Echinococcus granulosus Chromo domain 0.0012 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.003 0.011 0.0721
Echinococcus multilocularis chromobox protein 1 0.0075 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0298
Echinococcus granulosus para nitrobenzyl esterase 0.0128 0.0725 0.1554
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0332 0.0712
Echinococcus multilocularis protoporphyrinogen oxidase 0.0081 0.0431 0.0431
Trypanosoma cruzi ISWI complex protein 0.0016 0.0027 0.0309
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0081 0.0431 1
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0389
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0177 0.1162
Schistosoma mansoni transient receptor potential channel 0.0061 0.0307 0.0658
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0093 0.2156
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0332 0.763
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0177 0.0378
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.023 0.0493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0034 0.0136 0.029
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0332 0.0713
Brugia malayi RNA, U transporter 1 0.0176 0.1027 0.2201
Schistosoma mansoni transient receptor potential channel 0.0093 0.0503 0.1078
Schistosoma mansoni hypothetical protein 0.0049 0.023 0.0492
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0924
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0312 0.7227
Brugia malayi Carboxylesterase family protein 0.0757 0.4663 1
Schistosoma mansoni importin beta-1 0.0062 0.0312 0.0667
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0166 0.0356
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0758 0.1624
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.012 0.0256
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0201 0.0431
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0087 0.2
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0197 0.0197
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0087 0.1745
Brugia malayi amine oxidase, flavin-containing family protein 0.0081 0.0431 0.0924
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0087 0.3621
Echinococcus granulosus BC026374 protein S09 family 0.0128 0.0725 0.1554
Schistosoma mansoni hypothetical protein 0.0106 0.0585 0.1254
Echinococcus multilocularis carboxylesterase 5A 0.0757 0.4663 0.4663
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0757 0.4663 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0177 0.0247
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0087 0.2
Leishmania major UDP-galactopyranose mutase 0.0081 0.0431 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0087 0.0185
Loa Loa (eye worm) hypothetical protein 0.0128 0.0725 0.1553
Onchocerca volvulus Alhambra homolog 0.0031 0.012 0.0787
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0014 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0312 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0093 0.0503 0.0503
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1069 0.6622 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0431 0.0632
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1078
Echinococcus multilocularis GPCR, family 2 0.0049 0.023 0.023
Chlamydia trachomatis protoporphyrinogen oxidase 0.0081 0.0431 0.5
Echinococcus multilocularis chromobox protein 2 0.0012 0.0001 0.0001
Brugia malayi hypothetical protein 0.0039 0.0166 0.0355
Echinococcus granulosus geminin 0.0532 0.3259 0.6989
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0312 0.0312
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.115 0.7129 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0566 0.0566
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0081 0.0431 0.0924
Brugia malayi hypothetical protein 0.0017 0.0033 0.007
Schistosoma mansoni transient receptor potential channel 4 0.0093 0.0503 0.1078
Mycobacterium ulcerans monoamine oxidase 0.0081 0.0431 0.0366
Echinococcus granulosus GPCR family 2 0.0049 0.023 0.0493
Loa Loa (eye worm) hypothetical protein 0.0076 0.04 0.0856
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0209 0.4848
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0209 0.0209
Entamoeba histolytica Ran family GTPase 0.0046 0.0209 0.8779
Schistosoma mansoni hypothetical protein 0.0049 0.023 0.0492
Schistosoma mansoni hypothetical protein 0.0049 0.023 0.0492
Echinococcus granulosus chromobox protein 1 0.0075 0.0393 0.0842
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0013 0.0028
Onchocerca volvulus 0.0254 0.1517 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.023 0.0492
Loa Loa (eye worm) hypothetical protein 0.0757 0.4663 1
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0014 0.0029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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