Detailed information for compound 81799

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.504 | Formula: C23H28F2N6O3
  • H donors: 1 H acceptors: 2 LogP: 1.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)CN1CCN(CC1)c1nc(Oc2cccc(c2)C(=N)N)c(c(c1F)C)F
  • InChi: 1S/C23H28F2N6O3/c1-15-19(24)22(28-23(20(15)25)34-17-4-2-3-16(13-17)21(26)27)31-7-5-29(6-8-31)14-18(32)30-9-11-33-12-10-30/h2-4,13H,5-12,14H2,1H3,(H3,26,27)
  • InChiKey: MGPQKMLCRPUMJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Grp94/Hsp90 0.0025 0.0079 0.0654
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0027 0.009 0.077
Brugia malayi isocitrate dehydrogenase 0.0017 0.0017 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0237 0.0492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0223 0.1481 0.7401
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0033 0.0136 0.0282
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0045 0.0028
Trypanosoma brucei DNA topoisomerase III, putative 0.0016 0.0014 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.4621 0.9608
Brugia malayi DNA topoisomerase III beta-1 0.0016 0.0014 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0132 0.0413
Echinococcus multilocularis lamin dm0 0.0027 0.0091 0.0189
Toxoplasma gondii heat shock protein HSP90 0.0043 0.0202 0.1346
Echinococcus granulosus tyrosine protein kinase Lyn 0.0037 0.0161 0.0335
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0461 0.4109
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0568
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0082 0.0479 0.2397
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0101 0.0209
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0045 0.0093
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0017 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.0326 0.1629
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0178 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0105 0.0636
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0386 0.0802
Mycobacterium tuberculosis Probable two component sensor kinase 0.0017 0.0023 0.0006
Schistosoma mansoni pyruvate dehydrogenase 0.0017 0.0023 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0624
Brugia malayi hypothetical protein 0.0032 0.0125 0.0391
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0205 0.1352 0.281
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0409 0.0851
Plasmodium vivax amine transporter, putative 0.003 0.0114 0.0675
Plasmodium falciparum DNA topoisomerase 2 0.0172 0.1118 0.8045
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0027 0.009 0.0534
Mycobacterium ulcerans DNA gyrase subunit B 0.021 0.1386 0.2468
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Brugia malayi ecdysone receptor 0.0028 0.0101 0.0314
Entamoeba histolytica heat shock protein 90, putative 0.0043 0.0202 0.1784
Echinococcus granulosus zinc finger protein 0.0028 0.0101 0.021
Treponema pallidum sodium- and chloride- dependent transporter 0.0178 0.116 0.835
Leishmania major hypothetical protein, conserved 0.0017 0.0023 0.0099
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0017 0.0023 0.0006
Echinococcus granulosus heat shock protein 90 0.0025 0.0079 0.0163
Giardia lamblia DINP protein human, muc B family 0.0039 0.0178 0.1664
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0034 0.0137 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.0326 0.1629
Onchocerca volvulus 0.0223 0.1481 0.9331
Toxoplasma gondii DNA topoisomerase 2, putative 0.0172 0.1118 0.7544
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0034 0.0137 0.0286
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0771 0.1604
Echinococcus granulosus beta LACTamase domain containing family member 0.0223 0.1481 0.3079
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0114 0.0236
Brugia malayi GRF zinc finger family protein 0.0016 0.0014 0.0039
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0101 0.0504
Entamoeba histolytica heat shock protein 90, putative 0.0043 0.0202 0.1784
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.011 0.0695
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0137 0.0783
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0034 0.0137 0.0896
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0161 0.0335
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0237 0.0492
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0017 0.0094
Schistosoma mansoni hypothetical protein 0.0035 0.0146 0.0303
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0435 0.0905
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0205 0.1352 0.281
Mycobacterium ulcerans proteasome PrcA 0.0801 0.5571 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.011 0.0228
Schistosoma mansoni cpg binding protein 0.0032 0.0123 0.0256
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0056 0.0281
Trypanosoma brucei P-type H+-ATPase, putative 0.0021 0.0051 0.0279
Loa Loa (eye worm) hypothetical protein 0.0223 0.1481 0.7401
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0213 0.0442
Mycobacterium leprae conserved hypothetical protein 0.0223 0.1481 0.2638
Onchocerca volvulus 0.0223 0.1481 0.9331
Schistosoma mansoni ap endonuclease 0.0056 0.0299 0.0621
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.0114 0.0236
Brugia malayi acetyltransferase, GNAT family protein 0.0297 0.2 0.6367
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.1208
Leishmania major UDP-galactopyranose mutase 0.0021 0.0045 0.024
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0017 0.0023 0.0016
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0034 0.0137 0.0286
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0046 0.023
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0027 0.009 0.0563
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Echinococcus multilocularis tyrosine protein kinase Srms 0.0033 0.0136 0.0282
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0014 0.0029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0299 0.0621
Schistosoma mansoni amine oxidase 0.0021 0.0045 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0098 0.0492
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0027 0.009 0.0187
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0132 0.0274
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0062 0.0393
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0045 0.0222
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.032 0.0303
Plasmodium vivax SET domain protein, putative 0.0031 0.0116 0.0691
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0101 0.0314
Trypanosoma cruzi Heat shock protein 83, putative 0.0043 0.0202 0.1295
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0137 0.0783
Entamoeba histolytica hypothetical protein 0.0023 0.0062 0.0521
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0333 0.0692
Echinococcus multilocularis endoplasmin 0.0025 0.0079 0.0163
Brugia malayi Endoplasmin precursor 0.0043 0.0202 0.0638
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0023 0.0061 0.0044
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0079 0.0408
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0475 0.0988
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0034 0.0137 0.1202
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0014 0.0072
Echinococcus multilocularis serotonin transporter 0.0178 0.116 0.2411
Schistosoma mansoni zinc finger protein 0.0028 0.0101 0.021
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0291 0.1963 0.3506
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0101 0.0314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0326 0.0678
Schistosoma mansoni heat shock protein 0.0043 0.0202 0.0421
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0016 0.0014 0.0072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0223 0.1481 0.2638
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0034 0.0137 0.0873
Brugia malayi Pre-SET motif family protein 0.0209 0.1381 0.4393
Mycobacterium ulcerans beta-lactamase 0.0223 0.1481 0.2638
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0034 0.0137 0.0286
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.032 0.0665
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0017 0.0023 0.0016
Onchocerca volvulus 0.0016 0.0014 0.0004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0101 0.0209
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0299 0.2649
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0156 0.0965
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.0326 0.0678
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0014 0.007
Schistosoma mansoni alpha-glucosidase 0.0135 0.0859 0.1786
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0027 0.009 0.028
Loa Loa (eye worm) norepinephrine transporter 0.0178 0.116 0.5797
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0475 0.1507
Plasmodium vivax P-type ATPase4, putative 0.0034 0.0137 0.0838
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0017 0.0023 0.0016
Leishmania major DNA polymerase eta, putative 0.0033 0.0132 0.0808
Loa Loa (eye worm) hypothetical protein 0.0223 0.1481 0.7401
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0045 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0105 0.0636
Brugia malayi kinase, mitochondrial precursor 0.0017 0.0023 0.0067
Echinococcus granulosus Na:K ATPase alpha subunit 0.0075 0.0432 0.0898
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0125 0.026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0455
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0161 0.0335
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.0326 0.1032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0213 0.1063
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.1481 0.9625
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0529 0.356
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0017 0.0023 0.0006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0128 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0333 0.0692
Trypanosoma brucei developmentally regulated phosphoprotein 0.0017 0.0023 0.0099
Onchocerca volvulus 0.0027 0.0091 0.0491
Brugia malayi hypothetical protein 0.0035 0.0146 0.0458
Plasmodium vivax hypothetical protein, conserved 0.003 0.0114 0.0675
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0147 0.0844
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0079 0.0115
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0091 0.0455
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0316 0.0542
Trypanosoma brucei DNA topoisomerase IA, putative 0.0016 0.0014 0.0041
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0045 0.0055
Loa Loa (eye worm) serotonin transporter b 0.0178 0.116 0.5797
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0101 0.0504
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0132 0.1152
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0223 0.1481 0.1466
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0299 0.1939
Trypanosoma brucei unspecified product 0.0052 0.027 0.1713
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0147 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Brugia malayi nuclear receptor NHR-88 0.0028 0.0101 0.0314
Trypanosoma brucei unspecified product 0.0023 0.006 0.0337
Echinococcus granulosus dna polymerase kappa 0.0059 0.0316 0.0657
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0333 0.0692
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0225
Trypanosoma cruzi ISWI complex protein 0.0015 0.0008 0.0031
Trichomonas vaginalis heat shock protein, putative 0.003 0.0115 0.0642
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0045 0.0208
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Chlamydia trachomatis DNA gyrase subunit B 0.021 0.1386 1
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0202 0.1295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0326 0.1032
Leishmania major calcium-transporting ATPase, putative 0.0027 0.009 0.0534
Onchocerca volvulus Bile acid receptor homolog 0.006 0.0326 0.1985
Trypanosoma brucei calcium-translocating P-type ATPase 0.0027 0.009 0.0534
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0101 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0017
Schistosoma mansoni ap endonuclease 0.0056 0.0299 0.0621
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0132 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.0326 0.0678
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0023 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0101 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.0326 0.1032
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0034 0.0137 0.1255
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0299 0.181
Echinococcus multilocularis tyrosine protein kinase Blk 0.0033 0.0136 0.0282
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0178 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0225
Toxoplasma gondii exonuclease III APE 0.0056 0.0299 0.1999
Entamoeba histolytica DNA topoisomerase III, putative 0.0016 0.0014 0.0099
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0078 0.0453 0.0789
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.4621 0.9608
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0034 0.0137 0.0286
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0297 0.2 0.416
Giardia lamblia DNA topoisomerase II 0.0155 0.0994 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0568
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0161 0.0335
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0014 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0101 0.0209
Trichomonas vaginalis receptor histidine kinase, putative 0.0017 0.0023 0.0056
Echinococcus granulosus Tolloid protein 1 0.0016 0.0014 0.0029
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0101 0.0209
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0068
Echinococcus multilocularis nervana 2 0.0126 0.0792 0.1647
Echinococcus multilocularis dnaJ subfamily B 0.04 0.2731 0.5679
Loa Loa (eye worm) TK protein kinase 0.003 0.011 0.0548
Mycobacterium ulcerans putative regultory protein 0.0017 0.0023 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.1481 0.9626
Brugia malayi hypothetical protein 0.0032 0.0125 0.0391
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0202 0.1295
Mycobacterium leprae Probable two component sensor kinase MprB 0.0017 0.0023 0.0016
Mycobacterium ulcerans lipase LipD 0.0223 0.1481 0.2638
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0017 0.0036
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0017 0.0023 0.0134
Brugia malayi nuclear hormone receptor 0.006 0.0326 0.1032
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0114 0.0236
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0131 0.0825 0.7373
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0014 0.0069
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.0114 0.0355
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.006
Echinococcus multilocularis nervana 2 0.0205 0.1352 0.281
Plasmodium vivax DNA gyrase subunit A, putative 0.0029 0.0108 0.0636
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0023 0.0061 0.0084
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0034 0.0137 0.0845
Loa Loa (eye worm) hypothetical protein 0.0223 0.1481 0.7401
Brugia malayi beta-lactamase 0.0223 0.1481 0.4711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0213 0.0442
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0071 0.0147
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.0326 0.0678
Echinococcus granulosus nervana 2 0.0205 0.1352 0.281
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0019 0.0034 0.027
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0017 0.0023 0.0134
Brugia malayi hypothetical protein 0.0028 0.0101 0.0314
Schistosoma mansoni intermediate filament proteins 0.0027 0.0091 0.0189
Plasmodium vivax DNA gyrase subunit B, putative 0.021 0.1386 0.9355
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0326 0.0678
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0045 0.0208
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0316 0.2012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1381 0.6903
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.0114 0.0236
Loa Loa (eye worm) RNA binding protein 0.0061 0.0333 0.1665
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0017 0.0023 0.0056
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0027 0.009 0.0187
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0071 0.0403 0.1278
Schistosoma mansoni endoplasmin 0.0043 0.0202 0.0421
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0316 0.2036
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0014 0.007
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0202 0.1295
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0114 0.0236
Toxoplasma gondii hypothetical protein 0.003 0.0114 0.0745
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0172 0.1118 0.3555
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.032 0.0665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0237 0.0492
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0071 0.0147
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.0326 0.0678
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0624
Leishmania major DNA polymerase kappa, putative 0.0039 0.0178 0.1107
Schistosoma mansoni ATPase 0.0034 0.0137 0.0286
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0017 0.0023 0.0006
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0016 0.0014 0.0072
Mycobacterium tuberculosis Probable esterase LipL 0.0223 0.1481 0.1466
Mycobacterium ulcerans DNA gyrase subunit A 0.0029 0.0108 0.0168
Plasmodium falciparum heat shock protein 90 0.0043 0.0202 0.1369
Brugia malayi protein-tyrosine kinase 0.0033 0.0136 0.0426
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0017 0.0023 0.0006
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0034 0.0137 0.0845
Loa Loa (eye worm) hypothetical protein 0.0223 0.1481 0.7401
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.032 0.0665
Mycobacterium ulcerans two component regulator - sensor kinase 0.0017 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0027 0.009 0.0585
Brugia malayi RNA binding protein 0.0061 0.0333 0.1054
Plasmodium vivax heat shock protein 86, putative 0.0043 0.0202 0.1281
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0034 0.0137 0.0845
Echinococcus granulosus nervana 2 0.0205 0.1352 0.281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0326 0.0678
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0147 0.0844
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0114 0.0236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0163
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0016 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0081 0.0475 0.2376
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.021 0.1386 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.0825 0.5354
Brugia malayi calcium ATPase 0.0015 0.0003 0.0004
Echinococcus multilocularis geminin 0.0693 0.4809 1
Echinococcus multilocularis heat shock protein 90 0.0043 0.0202 0.0421
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.0114 0.0236
Treponema pallidum heat shock protein 90 0.0025 0.0079 0.0467
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0114 0.0236
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.0326 0.0678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.0326 0.1629
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0126 0.0792 0.1647
Schistosoma mansoni alpha-glucosidase 0.0135 0.0859 0.1786
Toxoplasma gondii ABC1 family protein 0.0223 0.1481 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0435 0.0905
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1014 0.507
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.0114 0.0722
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0114 0.0236
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0161 0.0335
Echinococcus granulosus dnaJ subfamily B 0.04 0.2731 0.5679
Loa Loa (eye worm) hypothetical protein 0.0205 0.1352 0.6757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0213 0.0442
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1277
Loa Loa (eye worm) hypothetical protein 0.0038 0.0172 0.0859
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.0326 0.0678
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0016 0.0014 0.0037
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0205 0.1352 0.281
Toxoplasma gondii heat shock protein 90, putative 0.0043 0.0202 0.1346
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0017 0.0023 0.0048
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0075 0.0432 0.4262
Brugia malayi E1-E2 ATPase family protein 0.0021 0.0051 0.0155
Trypanosoma brucei DNA topoisomerase III, putative 0.0016 0.0014 0.0041
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0017 0.0023 0.0064
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0029 0.0108 0.0706
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0101 0.0209
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0062 0.0343
Onchocerca volvulus 0.0238 0.1586 1
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0017 0.0023 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0101 0.0209
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0299 0.1899
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0161 0.0335
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0075 0.0432 0.0898
Brugia malayi beta-lactamase family protein 0.0223 0.1481 0.4711
Loa Loa (eye worm) hypothetical protein 0.0178 0.116 0.5797
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0076 0.038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.0326 0.0678
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0017 0.0023 0.0016
Schistosoma mansoni cpg binding protein 0.0032 0.0123 0.0256
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0071 0.0403 0.2016
Trichomonas vaginalis sensor histidine kinase, putative 0.0017 0.0023 0.0056
Leishmania major DNA topoisomerase III, putative 0.0016 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0163
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0131 0.0825 0.1716
Echinococcus multilocularis dna polymerase eta 0.0033 0.0132 0.0274
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0016 0.0014 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.032 0.055
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.021 0.1386 1
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.011 0.0228
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0045 0.0281
Mycobacterium tuberculosis Probable lipase LipD 0.0223 0.1481 0.1466
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.0783
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0132 0.0413
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0529 0.1101
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0075 0.0432 0.0898
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0062 0.0393
Onchocerca volvulus 0.0031 0.0116 0.0649
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Schistosoma mansoni nuclear hormone receptor 0.006 0.0326 0.0678
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Brugia malayi follicle stimulating hormone receptor 0.0237 0.1576 0.5016
Schistosoma mansoni alpha glucosidase 0.0035 0.0147 0.0306
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1277
Onchocerca volvulus 0.0091 0.0544 0.3375
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.0326 0.0678
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0017 0.0023 0.0129
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0333 0.1054
Brugia malayi MH2 domain containing protein 0.0115 0.0716 0.2276
Loa Loa (eye worm) hypothetical protein 0.0036 0.0156 0.0779
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0223 0.1481 0.1466
Brugia malayi intermediate filament protein 0.0027 0.0091 0.0283
Loa Loa (eye worm) hypothetical protein 0.0178 0.116 0.5797
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0029 0.0108 0.068
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0132 0.0837
Toxoplasma gondii DNA topoisomerase family protein 0.0016 0.0014 0.0075
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0014 0.0069
Schistosoma mansoni tyrosine kinase 0.0037 0.0161 0.0335
Echinococcus multilocularis cpg binding protein 0.0032 0.0123 0.0256
Schistosoma mansoni sodium/chloride dependent transporter 0.0178 0.116 0.2411
Mycobacterium ulcerans hypothetical protein 0.0223 0.1481 0.2638
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0237 0.0492
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0158 0.1016 0.6856
Onchocerca volvulus 0.003 0.0114 0.0634
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.0326 0.0678
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0147 0.0935
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0062 0.0349
Echinococcus multilocularis heat shock protein 0.0043 0.0202 0.0421
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0231 0.1538 1
Echinococcus multilocularis lamin 0.0027 0.0091 0.0189
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.0114 0.0236
Echinococcus multilocularis thyroid hormone receptor alpha 0.0183 0.1197 0.249
Loa Loa (eye worm) solute carrier family 6 member 4 0.0178 0.116 0.5797
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0299 0.0282
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0045 0.0055
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0017 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0017 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0326 0.1032
Entamoeba histolytica protein kinase, putative 0.003 0.011 0.0952
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0062 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0326 0.1032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1014 0.2109
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0529 0.3278
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0091 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0316 0.2036
Trypanosoma cruzi ISWI complex protein 0.0015 0.0008 0.0031
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0017 0.0036
Brugia malayi nuclear receptor NHR-88 0.006 0.0326 0.1032
Echinococcus granulosus calcium transporting atpase 0.0027 0.009 0.0187
Echinococcus granulosus cpg binding protein 0.0032 0.0123 0.0256
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0202 0.1295
Loa Loa (eye worm) hypothetical protein 0.0178 0.116 0.5797
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0801 0.5571 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0461 0.3259
Echinococcus granulosus dna polymerase eta 0.0033 0.0132 0.0274
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0316 0.192
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.0326 0.1032
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0062 0.0044
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0101 0.0314
Echinococcus granulosus microtubule associated protein 2 0.0667 0.4621 0.9608
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0161 0.0335
Giardia lamblia Pms1-like protein 0.0017 0.0023 0.009
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0045 0.0222
Mycobacterium tuberculosis Probable hydrolase 0.0223 0.1481 0.1466
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0101 0.0209
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0128 0.0804 0.5028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0146 0.0303
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0147 0.0844
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0131 0.0825 0.1716
Echinococcus granulosus histone acetyltransferase KAT2B 0.0286 0.1925 0.4003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0223 0.1481 0.3079
Loa Loa (eye worm) hypothetical protein 0.0082 0.0479 0.2397
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0027 0.009 0.048
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0079 0.049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0223 0.1481 0.3079
Echinococcus multilocularis heat shock protein 90 0.0025 0.0079 0.0163
Echinococcus granulosus geminin 0.0693 0.4809 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0082 0.0479 0.0997
Schistosoma mansoni hypothetical protein 0.04 0.2731 0.5679
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0101 0.0209
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0202 0.1196
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0021 0.0043
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0027 0.009 0.0187
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Schistosoma mansoni zinc finger protein 0.0015 0.0008 0.0017
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0205 0.1352 0.281
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0437
Onchocerca volvulus 0.0028 0.0098 0.0538
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0128 0.0804 0.5028
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0161 0.0335
Plasmodium falciparum endoplasmin, putative 0.003 0.0115 0.0736
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0045 0.0093
Schistosoma mansoni endoplasmin 0.0043 0.0202 0.0421
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0386 0.0802
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0132 0.0274
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0045 0.0093
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0045 0.0222
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0017 0.0023 0.0056
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.021 0.1386 0.1371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0326 0.0678
Loa Loa (eye worm) hypothetical protein 0.0223 0.1481 0.7401
Plasmodium falciparum DNA gyrase subunit B 0.021 0.1386 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0101 0.0209
Plasmodium vivax DNA topoisomerase II, putative 0.0172 0.1118 0.7526
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0045 0.0208
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0017 0.0087
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Brugia malayi Fibulin-1 precursor 0.0016 0.0014 0.0037
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.0783
Loa Loa (eye worm) hypothetical protein 0.0092 0.0554 0.2772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.0326 0.1629
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0017 0.0023 0.0048
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0801 0.5571 0.5564
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0771 0.1604
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0316 0.192
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0147 0.0844
Mycobacterium tuberculosis Conserved protein 0.0017 0.0023 0.0006
Echinococcus multilocularis nervana 2 0.0126 0.0792 0.1647
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0147 0.0844
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0147 0.1288
Onchocerca volvulus 0.0027 0.0091 0.0491
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0205 0.1352 0.281
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0745
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0019 0.0034 0.027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0329 0.0684
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0017 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.0326 0.1032
Loa Loa (eye worm) hypothetical protein 0.0052 0.0265 0.1323
Brugia malayi beta-lactamase family protein 0.0223 0.1481 0.4711
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0062 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0333 0.0692
Mycobacterium tuberculosis Conserved protein 0.0223 0.1481 0.1466
Loa Loa (eye worm) DNA topoisomerase III 0.0016 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0205 0.1352 0.6757
Entamoeba histolytica DNA topoisomerase III, putative 0.0016 0.0014 0.0099
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0045 0.0136
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0016 0.0014 0.0068
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0223 0.1481 0.4711
Plasmodium falciparum DNA gyrase subunit A 0.0029 0.0108 0.068
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0017 0.0023 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.0326 0.0678
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0045 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0069
Schistosoma mansoni coup transcription factor 0.006 0.0326 0.0678
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0155 0.0321
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0079 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Toxoplasma gondii P-type ATPase4, putative 0.0034 0.0137 0.0907
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0131 0.0825 0.1716
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.0825 0.5339
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0137 0.0783
Echinococcus granulosus hypothetical protein 0.0683 0.4739 0.9854
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0299 0.2072
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0205 0.1352 0.281
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.0114 0.0236
Trypanosoma cruzi DNA topoisomerase II, putative 0.0156 0.1003 0.6513
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0017 0.0036
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0079 0.0408
Echinococcus granulosus lamin dm0 0.0027 0.0091 0.0189
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0316 0.2012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0529 0.3511
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0205 0.1352 0.281
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.032 0.2143
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0062 0.0349
Trichomonas vaginalis endoplasmin, putative 0.003 0.0115 0.0642
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1014 0.2109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0213 0.0442
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0079 0.046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0132 0.0115
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0116
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0299 0.0621
Plasmodium falciparum transporter, putative 0.003 0.0114 0.0722
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0045 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0163
Echinococcus multilocularis rho GTPase activating protein 20 0.0016 0.0014 0.003
Echinococcus granulosus heat shock protein 0.0043 0.0202 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.0326 0.1032
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0021 0.0043
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0101 0.0314
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0019 0.0034 0.01
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0069
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0017 0.0023 0.0016
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Echinococcus granulosus heat shock protein 90 0.0043 0.0202 0.0421
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0021 0.0043
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0017 0.0023 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0223 0.1481 0.9336
Trypanosoma brucei calcium-transporting ATPase, putative 0.0016 0.0014 0.0036
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0034 0.0137 0.0907
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0147 0.0972
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0062 0.0343
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.0783
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0017 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0048 0.024 0.1199
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0156 0.0965
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0125 0.026
Trypanosoma brucei unspecified product 0.0023 0.006 0.0337
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.006
Brugia malayi hypothetical protein 0.0021 0.0045 0.0136
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0352 0.2359
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0016 0.0014 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.1481 0.9336
Leishmania major P-type H -ATPase, putative 0.0021 0.0051 0.0279
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0016 0.0014 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0225
Trypanosoma cruzi DNA topoisomerase II, putative 0.0156 0.1003 0.6513
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0461 0.4562
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0147 0.0844
Brugia malayi Bromodomain containing protein 0.0084 0.0494 0.1568
Brugia malayi hypothetical protein 0.0028 0.0101 0.0314
Echinococcus granulosus tyrosine protein kinase Blk 0.0033 0.0136 0.0282
Brugia malayi heat shock protein 90 0.0043 0.0202 0.0638
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0017 0.0023 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.0326 0.1985
Schistosoma mansoni lamin 0.0027 0.0091 0.0189
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0015 0.0003 0.0017
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0045 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.0326 0.1032
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0027 0.009 0.0187
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0147 0.0306
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0271 0.1818 0.1803
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0333 0.1665
Trypanosoma brucei heat shock protein 90, putative 0.0043 0.0202 0.1269
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0299 0.2072
Schistosoma mansoni hypothetical protein 0.0021 0.0046 0.0096
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0079 0.0115
Schistosoma mansoni bromodomain containing protein 0.0072 0.0411 0.0855
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.032 0.055
Brugia malayi Steroid receptor seven-up type 2 0.006 0.0326 0.1032
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0131 0.0825 0.2622
Echinococcus granulosus FTZ F1 alpha 0.006 0.0326 0.0678
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0104 0.0216
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0016 0.0014 0.003
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1014 0.3225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0069
Brugia malayi Serotonin receptor 0.0458 0.314 1
Schistosoma mansoni thyroid hormone receptor 0.0183 0.1197 0.249
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0125 0.0391
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0745
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0146 0.0303
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0161 0.0335
Echinococcus multilocularis FTZ F1 alpha 0.006 0.0326 0.0678
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0125 0.026
Schistosoma mansoni lamin 0.0027 0.0091 0.0189
Mycobacterium ulcerans oxidoreductase 0.0021 0.0045 0.0055
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.032 0.0665
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0029 0.0108 0.068
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0155 0.0321
Brugia malayi nuclear hormone receptor 0.0028 0.0101 0.0314
Mycobacterium tuberculosis Conserved protein 0.0223 0.1481 0.1466
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Loa Loa (eye worm) hypothetical protein 0.0061 0.0328 0.164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0225
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0205 0.1352 0.281
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0051 0.0232
Brugia malayi DNA topoisomerase III 0.0016 0.0014 0.0039
Mycobacterium ulcerans dehydrogenase 0.0021 0.0045 0.0055
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0316 0.0657
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0016 0.0014 0.0075
Onchocerca volvulus 0.0021 0.0045 0.0198
Onchocerca volvulus 0.003 0.0114 0.0634
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0213 0.0442
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0333 0.1665
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0299 0.1493
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0079 0.049
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.032 0.2038
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0125 0.0624
Toxoplasma gondii P-type ATPase PMA1 0.0021 0.0051 0.0321
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0016 0.0014 0.003
Trichomonas vaginalis receptor histidine kinase, putative 0.0017 0.0023 0.0056
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0114 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0178 0.1107
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0172 0.1118 0.2324
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1014 0.2109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0624
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0624
Onchocerca volvulus 0.0028 0.0101 0.0553
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0101 0.0209
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0101 0.0504
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0131 0.0825 0.4124
Brugia malayi hypothetical protein 0.003 0.0114 0.0355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0316 0.2036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.0326 0.0678
Trypanosoma cruzi P-type H+-ATPase, putative 0.0021 0.0051 0.0309
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0034 0.0137 0.0286
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0017 0.0023 0.0016
Echinococcus granulosus serotonin transporter 0.0178 0.116 0.2411
Schistosoma mansoni heat shock protein 0.0043 0.0202 0.0421
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0333 0.0692
Mycobacterium leprae Probable lipase LipE 0.0223 0.1481 0.2638
Echinococcus multilocularis calcium transporting atpase 0.0027 0.009 0.0187
Echinococcus multilocularis musashi 0.0027 0.0091 0.0189
Trypanosoma cruzi P-type H+-ATPase, putative 0.0021 0.0051 0.0309
Echinococcus granulosus tar DNA binding protein 0.0061 0.0333 0.0692
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0172 0.1118 0.3555
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0062 0.0321
Schistosoma mansoni DNA polymerase eta 0.0033 0.0132 0.0274
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0299 0.2901
Onchocerca volvulus 0.0205 0.1352 0.851
Loa Loa (eye worm) heat shock protein 90 0.0043 0.0202 0.1011
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0475 0.0988
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1585 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0223 0.1481 0.9336
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0101 0.0314
Loa Loa (eye worm) TK protein kinase 0.0033 0.0136 0.0678
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0034 0.0137 0.0286
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0071 0.0403 0.07
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0299 0.181
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0114 0.0236
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.0825 0.5354
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.0326 0.0678
Brugia malayi polk-prov protein 0.0036 0.0156 0.049
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0126 0.0792 0.1647
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0299 0.1899
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0231 0.1538 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0062 0.0343
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0045 0.027
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0355
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0082 0.0481 0.2405
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0022 0.0057 0.0363
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0079 0.0163
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0114 0.0236
Loa Loa (eye worm) hypothetical protein 0.0082 0.0481 0.2405
Loa Loa (eye worm) hypothetical protein 0.0071 0.0401 0.2007
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Schistosoma mansoni amine oxidase 0.0021 0.0045 0.0093
Echinococcus granulosus tyrosine kinase 0.0033 0.0136 0.0282
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.006 0.0326 0.1985
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0034 0.0137 0.0873
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0475 0.0988
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0114 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.1481 0.9626
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0128 0.0804 0.5028
Schistosoma mansoni hypothetical protein 0.0693 0.4809 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0071 0.0147
Schistosoma mansoni DNA topoisomerase II 0.0172 0.1118 0.2324
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0017 0.0023 0.0006
Brugia malayi Pre-SET motif family protein 0.0031 0.0116 0.0362
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0147 0.0844
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Trichomonas vaginalis esterase, putative 0.0223 0.1481 0.9336
Schistosoma mansoni retinoic acid receptor RXR 0.006 0.0326 0.0678
Leishmania major DNA topoisomerase 1A 0.0016 0.0014 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.0326 0.1629
Echinococcus multilocularis laminin 0.0016 0.0014 0.0029
Toxoplasma gondii hypothetical protein 0.003 0.0114 0.0745
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0033 0.0136 0.0282
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0034 0.0137 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.0326 0.1629
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0128 0.0267
Brugia malayi tailless protein 0.0028 0.0101 0.0314
Brugia malayi nuclear receptor RXR 0.0032 0.0125 0.0391
Brugia malayi Membrane calcium atpase protein 3 0.0027 0.009 0.028
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0568
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.0326 0.0678
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.1481 0.9336
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.027 0.1713
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0101 0.0209
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0014 0.0037
Plasmodium falciparum amino acid transporter, putative 0.003 0.0114 0.0722
Brugia malayi PHD-finger family protein 0.0034 0.0139 0.0435
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0213 0.0442
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0034 0.0137 0.0783
Schistosoma mansoni hypothetical protein 0.0693 0.4809 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0114 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0223 0.1481 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0017 0.0023 0.0016
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0161 0.0335
Schistosoma mansoni cpg binding protein 0.0028 0.0098 0.0205
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Loa Loa (eye worm) steroid hormone receptor 0.006 0.0326 0.1629
Leishmania major mitochondrial DNA topoisomerase II 0.0231 0.1538 1
Leishmania major P-type ATPase, putative 0.0027 0.009 0.0534
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.1202
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0017 0.0023 0.0006
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0114 0.0236
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0108 0.068
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0014 0.0037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0101 0.0209
Leishmania major developmentally regulated phosphoprotein-like protein 0.0017 0.0023 0.0099
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.0114 0.0236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0146 0.0303
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0156 0.1003 0.6503
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0716 0.3581
Schistosoma mansoni hypothetical protein 0.0123 0.0771 0.1604
Trypanosoma brucei glucosidase, putative 0.0035 0.0147 0.0907
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Loa Loa (eye worm) SRC-1 0.0037 0.0161 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.0326 0.1032
Leishmania major P-type H -ATPase, putative 0.0021 0.0051 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0105 0.0636
Trypanosoma brucei Heat shock protein 83, putative 0.0043 0.0202 0.1269
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0101 0.0314
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0147 0.0461
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0126 0.0792 0.1647
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0223 0.1481 0.1466
Brugia malayi Bromodomain containing protein 0.0046 0.0222 0.0702
Leishmania major hypothetical protein, conserved 0.0223 0.1481 0.9625
Leishmania major DNA topoisomerase ii 0.0156 0.1003 0.6503
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.0326 0.1032
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1277
Echinococcus granulosus lamin 0.0027 0.0091 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0326 0.1032
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0045 0.0093
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.0202 0.1917
Echinococcus multilocularis nervana 2 0.0205 0.1352 0.281
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0108 0.068
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0034 0.0137 0.0845
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.1583
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0021 0.0043
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0017 0.0036
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.0783
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0225
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0147 0.0306
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0291 0.1963 0.3506
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0147 0.0935
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0034 0.0137 0.0873
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0147 0.1288
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.1481 0.9336
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0132 0.0659
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0014 0.0069
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0017 0.0023 0.0056
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0316 0.0542
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0114 0.0236
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0062 0.0343
Onchocerca volvulus 0.003 0.0114 0.0634
Brugia malayi conserved hypotetical protein 0.0028 0.0101 0.0314
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0027 0.009 0.0187
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0355
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0529 0.356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0213 0.0442
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0062 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0326 0.1032
Chlamydia trachomatis DNA gyrase subunit B 0.0151 0.0966 0.6936
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0045 0.0028
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0017 0.006
Plasmodium vivax calcium-transporting ATPase, putative 0.0034 0.0137 0.0838
Loa Loa (eye worm) hypothetical protein 0.0034 0.0137 0.0687
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0126 0.0792 0.1647
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Mycobacterium leprae Probable two-component sensor kinase 0.0017 0.0023 0.0016
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0017 0.0023 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0125 0.0391
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0017 0.0023 0.0048
Brugia malayi nuclear receptor RXR 0.0028 0.0101 0.0314
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0299 0.2072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.0326 0.0678
Echinococcus granulosus nervana 2 0.0126 0.0792 0.1647
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.1202
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.1202
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0101 0.0209
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0045 0.0055
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0017 0.0023 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0624
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0299 0.1924
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0014 0.0029
Echinococcus multilocularis zinc finger protein 0.0028 0.0101 0.021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0116 0.0241
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0299 0.0511
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0223 0.1481 0.3079
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0147 0.0844
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0326 0.1032
Leishmania major calcium motive p-type ATPase, putative 0.0027 0.009 0.0534
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0101 0.0209
Echinococcus multilocularis conserved hypothetical protein 0.0677 0.4694 0.9762
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0017 0.0023 0.0099
Schistosoma mansoni nuclear receptor 0.0028 0.0101 0.0209
Trypanosoma brucei heat shock protein 90, putative 0.0043 0.0202 0.1269
Loa Loa (eye worm) beta-lactamase 0.0223 0.1481 0.7401
Echinococcus multilocularis fibrillin 1 0.0016 0.0014 0.0029
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0529 0.3278
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0161 0.0335
Mycobacterium ulcerans two component sensor kinase MprB 0.0017 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0034 0.0137 0.0845
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0027 0.009 0.0187
Onchocerca volvulus 0.006 0.0326 0.1985
Onchocerca volvulus 0.0126 0.0792 0.4951
Schistosoma mansoni ATPase 0.0034 0.0137 0.0286
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0079 0.0408
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0161 0.0335
Leishmania major DNA topoisomerase III, putative 0.0016 0.0014 0.0041
Schistosoma mansoni tyrosine kinase 0.0037 0.0161 0.0335
Trypanosoma brucei P-type H+-ATPase, putative 0.0021 0.0051 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0326 0.1032
Onchocerca volvulus 0.0028 0.0101 0.0553
Brugia malayi nuclear receptor NHR-67 0.0028 0.0101 0.0314
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0016 0.0014 0.003
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0027 0.009 0.0187
Loa Loa (eye worm) hypothetical protein 0.0223 0.1481 0.7401
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.0326 0.0678
Schistosoma mansoni zinc finger protein 0.0028 0.0101 0.0209
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0137 0.0783
Loa Loa (eye worm) E1-E2 ATPase 0.0021 0.0051 0.0255
Leishmania major calcium-translocating P-type ATPase 0.0034 0.0137 0.0845
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0297 0.2 0.416
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0082 0.0479 0.0837
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0014 0.0072
Brugia malayi CXXC zinc finger family protein 0.0028 0.0098 0.0307
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0114 0.0236
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0147 0.0907
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0116 0.0241
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Plasmodium vivax endoplasmin, putative 0.0043 0.0202 0.1281
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0161 0.0335
Trichomonas vaginalis DNA topoisomerase II, putative 0.0172 0.1118 0.7026
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0659
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0147 0.0844
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0015 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0132 0.0808
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0101 0.0553
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0079 0.0654
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1629
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0101 0.0553
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0409 0.0851
Loa Loa (eye worm) calcium ATPase 0.0019 0.0034 0.0168
Brugia malayi SWIRM domain containing protein 0.0021 0.0045 0.0136
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0161 0.0335
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1277
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0045 0.0208
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0161 0.0335
Loa Loa (eye worm) TOPoisomerase family member 0.0172 0.1118 0.5588
Schistosoma mansoni thyroid hormone receptor 0.0183 0.1197 0.249
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0114 0.0236
Loa Loa (eye worm) acetyltransferase 0.0297 0.2 1
Schistosoma mansoni egf-like domain protein 0.0016 0.0014 0.0029
Schistosoma mansoni nuclear receptor 0.0028 0.0101 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0213 0.067
Plasmodium falciparum calcium-transporting ATPase 0.0027 0.009 0.055
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0079 0.0467
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0132 0.0274
Brugia malayi steroid hormone receptor 0.006 0.0326 0.1032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0116 0.0241
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0114 0.0236
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.1576 0.7879
Onchocerca volvulus 0.0082 0.0479 0.2962
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Loa Loa (eye worm) DR-78 0.0028 0.0101 0.0504
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0091 0.0455
Trypanosoma brucei heat shock protein, putative 0.0043 0.0202 0.1269
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0017 0.002
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0333 0.0692
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0017 0.0094
Onchocerca volvulus 0.0081 0.0475 0.2935
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0027 0.009 0.0187
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0017 0.0023 0.0006
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0156 0.1003 0.6503
Brugia malayi TAR-binding protein 0.0061 0.0333 0.1054
Brugia malayi Cytochrome P450 family protein 0.0022 0.0056 0.0172
Echinococcus multilocularis 0.0021 0.0045 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Leishmania major heat shock protein 83-1 0.0043 0.0202 0.1269
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0116 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0316 0.2012
Loa Loa (eye worm) endoplasmin 0.0043 0.0202 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.0326 0.1629
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0017 0.0023 0.0056
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0114 0.0745
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0161 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0316 0.2036
Echinococcus granulosus intermediate filament protein 0.0027 0.0091 0.0189
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0178 0.116 0.2411
Schistosoma mansoni transmemberane protein 0.0205 0.1352 0.281
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0017 0.0023 0.0129
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0017 0.0023 0.0064
Echinococcus granulosus endoplasmin 0.0025 0.0079 0.0163
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0027 0.009 0.0563
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.0326 0.0678
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0131 0.0825 0.5339
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0299 0.0945
Echinococcus granulosus retinoic acid receptor rxr beta a 0.006 0.0326 0.0678
Onchocerca volvulus 0.0223 0.1481 0.9331
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.032 0.055
Brugia malayi ecdysteroid receptor 0.006 0.0326 0.1032
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0178 0.116 0.3688
Brugia malayi Probable DNA topoisomerase II 0.0172 0.1118 0.3555
Mycobacterium tuberculosis Probable lipase LipE 0.0223 0.1481 0.1466
Mycobacterium tuberculosis Conserved protein 0.0223 0.1481 0.1466
Onchocerca volvulus 0.0178 0.116 0.729
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0125 0.026
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0029 0.0108 0.009
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0172 0.1118 0.2324
Trypanosoma brucei DNA topoisomerase ii 0.0231 0.1538 1
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0027 0.009 0.0187
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0017 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.0326 0.0678
Echinococcus granulosus laminin 0.0016 0.0014 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0299 0.1924
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0326 0.0678
Loa Loa (eye worm) hypothetical protein 0.0092 0.0554 0.2772
Echinococcus granulosus nervana 2 0.0126 0.0792 0.1647
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0017 0.0094
Brugia malayi Na,K-ATPase alpha subunit 0.0082 0.0479 0.1521
Entamoeba histolytica DNA topoisomerase II, putative 0.0172 0.1118 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0237 0.1184
Mycobacterium ulcerans esterase/lipase LipP 0.0223 0.1481 0.2638
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0504
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0716 0.3581
Brugia malayi SRC-1 0.0037 0.0161 0.0507
Mycobacterium tuberculosis Possible two component sensor kinase 0.0017 0.0023 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0101 0.0209
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0017 0.0023 0.0056
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0161 0.0335

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 5000 nM Binding affinity of the compound was evaluated against Coagulation factor X ChEMBL. 9873451
Ki (binding) > 5000 nM Binding affinity of the compound was evaluated against Coagulation factor X ChEMBL. 9873451

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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