Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0649 | 0.1173 |
Onchocerca volvulus | 0.0076 | 0.0649 | 0.2322 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.0929 | 0.0929 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0464 | 0.0464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0464 | 0.0597 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0.0128 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0649 | 0.0834 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0329 | 0.3972 | 0.3972 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0128 | 0.9325 |
Echinococcus multilocularis | acetylcholinesterase | 0.0449 | 0.5532 | 0.5532 |
Echinococcus granulosus | acetylcholinesterase | 0.0449 | 0.5532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.5532 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0449 | 0.5532 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0128 | 0.0128 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0128 | 0.9325 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0076 | 0.0649 | 0.1173 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0724 | 0.1309 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.0128 | 0.0231 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0076 | 0.0649 | 1 |
Onchocerca volvulus | 0.0093 | 0.0868 | 0.3106 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.0929 | 0.1195 |
Echinococcus granulosus | carboxylesterase 5A | 0.0449 | 0.5532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0128 | 0.0231 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0101 | 0.0984 | 0.1779 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0048 | 0.0284 | 0.0513 |
Echinococcus granulosus | alkaline phosphatase | 0.0329 | 0.3972 | 0.718 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.0437 | 0.079 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0044 | 0.023 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0984 | 0.1779 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0076 | 0.0649 | 0.0649 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0076 | 0.0649 | 0.0834 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Echinococcus multilocularis | alkaline phosphatase | 0.0329 | 0.3972 | 0.3972 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.1751 | 0.3166 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0121 | 0.0219 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0128 | 0.0128 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.0929 | 0.168 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0121 | 0.7951 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.2794 | 0.5051 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0121 | 0.0219 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0464 | 0.0839 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0036 | 0.0131 | 0.0131 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0329 | 0.3972 | 0.3972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0128 | 0.0128 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.0722 | 0.1305 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0121 | 0.0156 |
Onchocerca volvulus | 0.0076 | 0.0649 | 0.2322 | |
Echinococcus multilocularis | zinc finger protein | 0.0042 | 0.0201 | 0.0201 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0121 | 0.7951 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.5532 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0076 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1168 | 0.2111 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1625 | 0.2937 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.1751 | 0.3166 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0101 | 0.0984 | 0.1265 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0128 | 0.9325 |
Loa Loa (eye worm) | MBCTL1 | 0.0115 | 0.1168 | 0.2111 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0464 | 0.0839 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0101 | 0.0984 | 0.1779 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0048 | 0.0284 | 0.0365 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0403 | 0.4937 | 0.4937 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0449 | 0.5532 | 0.5532 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0449 | 0.5532 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0649 | 0.0834 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0076 | 0.0649 | 0.0649 |
Brugia malayi | Carboxylesterase family protein | 0.0449 | 0.5532 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.023 | 0.0296 |
Loa Loa (eye worm) | carboxylesterase | 0.0449 | 0.5532 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.024 | 0.2794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0076 | 0.0649 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0238 | 0.2777 | 0.5021 |
Onchocerca volvulus | 0.0101 | 0.0984 | 0.3521 | |
Onchocerca volvulus | Huntingtin homolog | 0.024 | 0.2794 | 1 |
Brugia malayi | mbt repeat family protein | 0.0101 | 0.0984 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0843 | 0.1524 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0329 | 0.3972 | 0.3972 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0076 | 0.0649 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0131 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.0929 | 0.168 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0115 | 0.1168 | 0.2111 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.0929 | 0.0929 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0101 | 0.0984 | 0.1265 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0131 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0038 | 0.0148 | 0.0267 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0.0128 | 0.129 |
Brugia malayi | Bromodomain containing protein | 0.0159 | 0.1744 | 0.3152 |
Brugia malayi | hypothetical protein | 0.024 | 0.2794 | 0.5051 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.0929 | 0.168 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0464 | 0.0597 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0048 | 0.0284 | 0.0284 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0131 | 0.0236 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.146 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 0.0128 | 0.0164 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0082 | 0.0105 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0131 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0449 | 0.5532 | 0.7113 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 0.0128 | 0.0164 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0131 | 0.0168 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0081 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0115 | 0.1168 | 0.1168 |
Schistosoma mansoni | zinc finger protein | 0.0033 | 0.0082 | 0.0105 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0036 | 0.0131 | 0.0236 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.1751 | 0.1751 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0121 | 0.0121 |
Schistosoma mansoni | zinc finger protein | 0.0042 | 0.0201 | 0.0258 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0131 | 0.0131 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0131 | 0.0236 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0464 | 0.0839 |
Brugia malayi | Carboxylesterase family protein | 0.0449 | 0.5532 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0649 | 0.1173 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0131 | 0.0168 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0131 | 0.0168 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0101 | 0.0984 | 0.1779 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.006 | 0.0437 | 1 |
Onchocerca volvulus | 0.0076 | 0.0649 | 0.2322 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0131 | 0.0168 |
Brugia malayi | follicle stimulating hormone receptor | 0.0238 | 0.2777 | 0.5021 |
Loa Loa (eye worm) | carboxylesterase | 0.0076 | 0.0649 | 0.1173 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.0437 | 0.5909 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0076 | 0.0649 | 0.1173 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0121 | 0.7951 |
Loa Loa (eye worm) | carboxylesterase | 0.0076 | 0.0649 | 0.1173 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0115 | 0.1168 | 0.2111 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0115 | 0.1168 | 0.1502 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.0437 | 0.079 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0101 | 0.0984 | 0.3521 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0329 | 0.3972 | 0.718 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.0929 | 0.168 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0131 | 0.0168 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0329 | 0.3972 | 0.718 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 0.0128 | 0.6704 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0464 | 0.0839 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0131 | 0.0237 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.0929 | 0.1195 |
Schistosoma mansoni | hypothetical protein | 0.062 | 0.7777 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0464 | 0.0597 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0127 | 0.1318 | 0.1318 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.1751 | 0.1751 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0339 | 0.0612 |
Onchocerca volvulus | 0.0076 | 0.0649 | 0.2322 | |
Echinococcus granulosus | zinc finger protein | 0.0042 | 0.0201 | 0.0363 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.006 | 0.0437 | 0.6268 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0076 | 0.0649 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0131 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0076 | 0.0649 | 0.0834 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0076 | 0.0656 | 0.0656 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0076 | 0.0649 | 0.1173 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0649 | 0.1173 |
Echinococcus granulosus | neuroligin | 0.0076 | 0.0649 | 0.1173 |
Echinococcus multilocularis | neuroligin | 0.0076 | 0.0649 | 0.0649 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0101 | 0.0984 | 0.1265 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0076 | 0.0649 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0131 | 0.0191 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0121 | 0.11 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0076 | 0.0649 | 0.0834 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0131 | 0.0237 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0131 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0131 | 0.0191 |
Echinococcus multilocularis | acetylcholinesterase | 0.0449 | 0.5532 | 0.5532 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0101 | 0.0984 | 0.0984 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0127 | 0.1318 | 0.2382 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0464 | 0.0839 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0076 | 0.0649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.079 | 0.1428 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0128 | 0.0231 |
Schistosoma mansoni | alkaline phosphatase | 0.0329 | 0.3972 | 0.5107 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.0929 | 0.1195 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0464 | 0.0839 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.0649 | 0.1173 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.146 | 0.1877 |
Onchocerca volvulus | 0.0076 | 0.0649 | 0.2322 | |
Schistosoma mansoni | bromodomain containing protein | 0.0134 | 0.1418 | 0.1823 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0101 | 0.0984 | 0.0984 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0115 | 0.1168 | 0.1168 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.1751 | 0.3166 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0329 | 0.3972 | 0.718 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0076 | 0.0656 | 0.1186 |
Schistosoma mansoni | acetylcholinesterase | 0.0076 | 0.0649 | 0.0834 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0131 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 0.0128 | 0.0231 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0403 | 0.4937 | 0.8925 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0121 | 0.0219 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0131 | 0.0237 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0649 | 0.0834 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0464 | 0.0597 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0464 | 0.0597 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0128 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.1173 |
Brugia malayi | mbt repeat family protein | 0.0101 | 0.0984 | 0.1779 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.0437 | 0.0437 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 0.0128 | 0.0128 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0115 | 0.1168 | 0.2111 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.0437 | 0.5909 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.2794 | 0.5051 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1899 | 0.2441 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0131 | 0.1384 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.0437 | 0.0562 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0131 | 0.0168 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0464 | 0.0839 |
Brugia malayi | PHD-finger family protein | 0.0053 | 0.0349 | 0.0632 |
Schistosoma mansoni | alkaline phosphatase | 0.0329 | 0.3972 | 0.5107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.