Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0484 | 0.2534 | 0.2421 |
Echinococcus granulosus | acetylcholinesterase | 0.0659 | 0.3651 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.0149 | 0.0224 |
Onchocerca volvulus | 0.0111 | 0.0149 | 1 | |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0169 | 0.052 | 0.0377 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0111 | 0.0149 | 0.5 |
Schistosoma mansoni | alkaline phosphatase | 0.0169 | 0.052 | 0.1425 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.0149 | 0.0224 |
Schistosoma mansoni | survival motor neuron protein | 0.0099 | 0.0069 | 0.0189 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0136 | 0.031 | 0.0458 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0069 | 0.0189 |
Echinococcus multilocularis | alkaline phosphatase | 0.0169 | 0.052 | 0.0377 |
Schistosoma mansoni | amine GPCR | 0.0339 | 0.1607 | 0.4402 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0169 | 0.052 | 0.0377 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.0149 | 0.0224 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0111 | 0.0149 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.0149 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0111 | 0.0149 | 0.0409 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0169 | 0.052 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.2534 | 0.681 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0169 | 0.052 | 0.1059 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0111 | 0.0149 | 0.0409 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0111 | 0.0149 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0111 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.031 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.031 | 0.0458 |
Echinococcus granulosus | alkaline phosphatase | 0.0169 | 0.052 | 0.1059 |
Echinococcus multilocularis | serotonin receptor | 0.0136 | 0.031 | 0.0163 |
Echinococcus multilocularis | acetylcholinesterase | 0.0659 | 0.3651 | 0.3555 |
Echinococcus granulosus | acetylcholinesterase | 0.0659 | 0.3651 | 1 |
Onchocerca volvulus | 0.0111 | 0.0149 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.3651 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0659 | 0.3651 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0659 | 0.3651 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0659 | 0.3651 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0111 | 0.0149 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0659 | 0.3651 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0111 | 0.0149 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0111 | 0.0149 | 0.0409 |
Schistosoma mansoni | gliotactin | 0.0111 | 0.0149 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.3651 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.0149 | 0.0224 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0111 | 0.0149 | 0.0409 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0169 | 0.052 | 0.1059 |
Onchocerca volvulus | 0.0111 | 0.0149 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0659 | 0.3651 | 0.3555 |
Echinococcus granulosus | carboxylesterase 5A | 0.0659 | 0.3651 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0169 | 0.052 | 0.1425 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0111 | 0.0149 | 0.0409 |
Onchocerca volvulus | 0.0111 | 0.0149 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0659 | 0.3651 | 0.3555 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0111 | 0.0149 | 0.0409 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0136 | 0.031 | 0.0848 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0149 | 0.0224 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0484 | 0.2534 | 0.681 |
Echinococcus multilocularis | serotonin receptor | 0.0136 | 0.031 | 0.0163 |
Brugia malayi | Carboxylesterase family protein | 0.0659 | 0.3651 | 1 |
Brugia malayi | hypothetical protein | 0.0484 | 0.2534 | 0.6882 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0169 | 0.052 | 0.1059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.