Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase | 0.0026 | 0.1069 | 0.0586 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0399 | 0.0313 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0399 | 0.3737 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.6918 | 0.8897 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0399 | 0.3737 |
Brugia malayi | glutathione reductase | 0.0048 | 0.2601 | 0.2535 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0017 | 0.0399 | 0.1535 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0399 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0026 | 0.1069 | 0.1374 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.2601 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.2601 | 0.2201 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0026 | 0.1069 | 0.3684 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.2601 | 1 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.7739 | 0.7719 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Leishmania major | trypanothione reductase | 0.0048 | 0.2601 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.6918 | 0.8897 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.6918 | 0.8897 |
Leishmania major | pyruvate kinase | 0.0026 | 0.1069 | 0.4108 |
Onchocerca volvulus | 0.0153 | 1 | 1 | |
Plasmodium falciparum | pyruvate kinase | 0.0026 | 0.1069 | 0.3684 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0399 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0017 | 0.0399 | 0.0927 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.7776 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0026 | 0.1069 | 0.0586 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0026 | 0.1069 | 0.4108 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.2601 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0026 | 0.1069 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.6918 | 0.8897 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.6918 | 0.8897 |
Schistosoma mansoni | pyruvate kinase | 0.0026 | 0.1069 | 0.0912 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.0682 | 0.2089 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0399 | 0.3737 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0399 | 0.3737 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0026 | 0.1069 | 0.4108 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0399 | 0.1535 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.7739 | 0.7617 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.7776 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0026 | 0.1069 | 0.3684 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.7776 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.2601 | 0.2535 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.6918 | 0.8897 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0026 | 0.1069 | 0.4108 |
Giardia lamblia | Pyruvate kinase | 0.0026 | 0.1069 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.2601 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0399 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.2601 | 0.2201 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.1069 | 0.3684 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0026 | 0.1069 | 0.0988 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0399 | 0.0927 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0399 | 0.3737 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0017 | 0.0399 | 0.1535 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.2601 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0026 | 0.1069 | 0.1374 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0399 | 0.1535 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.7739 | 0.7617 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.2601 | 0.3345 |
Chlamydia trachomatis | pyruvate kinase | 0.0026 | 0.1069 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0018 | 0.0513 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0399 | 0.3737 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0017 | 0.0399 | 0.1535 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0017 | 0.0399 | 0.0927 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0017 | 0.0399 | 0.0927 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0017 | 0.0399 | 0.1535 |
Mycobacterium ulcerans | pyruvate kinase | 0.0026 | 0.1069 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0017 | 0.0399 | 0.0927 |
Plasmodium falciparum | thioredoxin reductase | 0.0017 | 0.0399 | 0.0927 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.1069 | 0.3684 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.2601 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0399 | 0.3737 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.6918 | 0.8897 |
Loa Loa (eye worm) | pyruvate kinase | 0.0026 | 0.1069 | 0.0586 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.7776 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0026 | 0.1069 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0017 | 0.0399 | 0.0927 |
Plasmodium vivax | pyruvate kinase, putative | 0.0026 | 0.1069 | 0.3684 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1069 | 0.0586 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0017 | 0.0399 | 0.0514 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0399 | 0.1535 |
Echinococcus granulosus | pyruvate kinase | 0.0026 | 0.1069 | 0.3684 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0399 | 0.0229 |
Giardia lamblia | Pyruvate kinase | 0.0013 | 0.0174 | 0.1633 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0026 | 0.1069 | 0.0988 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.2601 | 1 |
Leishmania major | pyruvate kinase | 0.0026 | 0.1069 | 0.4108 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0026 | 0.1069 | 0.4108 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.2601 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0026 | 0.1069 | 0.0912 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0399 | 0.0927 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.2601 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0017 | 0.0399 | 0.0927 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0017 | 0.0399 | 0.1535 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0017 | 0.0399 | 0.0927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.