TDR Targets

Basic information

Technical information

TDR Targets ID: 819481
Name: N-(3-bromophenyl)-2-[(2-ethylphenyl)-methylsu lfonylamino]acetamide
MW: 411.313 | Formula: C17H19BrN2O3S
H donors: 1 H acceptors: 3 LogP: 3.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1N(S(=O)(=O)C)CC(=O)Nc1cccc(c1)Br
InChi: 1S/C17H19BrN2O3S/c1-3-13-7-4-5-10-16(13)20(24(2,22)23)12-17(21)19-15-9-6-8-14(18)11-15/h4-11H,3,12H2,1-2H3,(H,19,21)
InChiKey: KWLNLHLCSAZVDI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-bromophenyl)-2-[(2-ethylphenyl)-methylsulfonyl-amino]acetamide
N-(3-bromophenyl)-2-[(2-ethylphenyl)-mesyl-amino]acetamide
N-(3-bromophenyl)-2-[(2-ethylphenyl)-methylsulfonyl-amino]ethanamide
CBMicro_015985
Oprea1_640598
BIM-0015916.P001
ZINC01168097

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	oxidoreductase	0.0227	0.8574	0.8574
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0227	0.8574	0.8574
Leishmania major	aldo-keto reductase-like protein	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Trypanosoma cruzi	aldo-keto reductase	0.0227	0.8574	1
Loa Loa (eye worm)	oxidoreductase	0.0227	0.8574	0.8574
Echinococcus multilocularis	aldo keto reductase	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase	0.0227	0.8574	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Entamoeba histolytica	aldose reductase, putative	0.0227	0.8574	0.5
Echinococcus granulosus	voltage gated potassium channel subunit	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Brugia malayi	NADH-dependent xylose reductase	0.0227	0.8574	0.8574
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0227	0.8574	0.8574
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0523	0.061
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Onchocerca volvulus		0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0523
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0227	0.8574	1
Onchocerca volvulus		0.0227	0.8574	1
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0227	0.8574	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0227	0.8574	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0523	0.0523
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0523	0.061
Brugia malayi	beta-lactamase family protein	0.004	0.0523	0.0523
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0227	0.8574	1
Onchocerca volvulus		0.0227	0.8574	1
Loa Loa (eye worm)	oxidoreductase	0.0227	0.8574	0.8574
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0227	0.8574	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0523	0.061
Schistosoma mansoni	potassium channel beta	0.0227	0.8574	1
Trypanosoma brucei	aldo/keto reductase, putative	0.0227	0.8574	1
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0523	0.061
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0227	0.8574	0.8574
Echinococcus multilocularis	aldo keto reductase	0.0227	0.8574	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0227	0.8574	1
Schistosoma mansoni	aldo-keto reductase	0.0227	0.8574	1
Schistosoma mansoni	lipoxygenase	0.0062	0.1453	0.1156
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0062	0.1453	0.1156
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0227	0.8574	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0227	0.8574	1
Brugia malayi	beta-lactamase	0.004	0.0523	0.0523
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.026	1	1
Loa Loa (eye worm)	beta-lactamase	0.004	0.0523	0.0523
Entamoeba histolytica	aldose reductase, putative	0.0227	0.8574	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase	0.0227	0.8574	1
Leishmania major	hypothetical protein, conserved	0.004	0.0523	0.061
Brugia malayi	beta-lactamase family protein	0.004	0.0523	0.0523
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0523
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0523	0.0523
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Giardia lamblia	Aldose reductase	0.0227	0.8574	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Schistosoma mansoni	aldo-keto reductase	0.0227	0.8574	1
Trypanosoma brucei	prostaglandin f synthase	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase	0.0227	0.8574	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0227	0.8574	0.8574
Loa Loa (eye worm)	oxidoreductase	0.0227	0.8574	0.8574
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0258	0.9923	1
Schistosoma mansoni	pol-related	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.0227	0.8574	0.8574
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Giardia lamblia	Aldose reductase	0.0227	0.8574	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Mycobacterium leprae	Possible oxidoreductase	0.0227	0.8574	1
Toxoplasma gondii	aldo-keto reductase	0.0227	0.8574	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0227	0.8574	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0523
Leishmania major	prostaglandin f synthase, putative	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Mycobacterium ulcerans	hypothetical protein	0.0227	0.8574	1
Toxoplasma gondii	ABC1 family protein	0.004	0.0523	0.061
Onchocerca volvulus		0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0523
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0227	0.8574	1
Loa Loa (eye worm)	oxidoreductase	0.0227	0.8574	0.8574
Trichomonas vaginalis	conserved hypothetical protein	0.0227	0.8574	1
Onchocerca volvulus		0.0227	0.8574	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0227	0.8574	1
Entamoeba histolytica	aldose reductase, putative	0.0227	0.8574	0.5
Echinococcus granulosus	hypothetical protein	0.0227	0.8574	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0227	0.8574	1
Toxoplasma gondii	aldose reductase, putative	0.0227	0.8574	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0227	0.8574	0.8574
Onchocerca volvulus		0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Onchocerca volvulus		0.0227	0.8574	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0227	0.8574	0.8574
Plasmodium vivax	aldehyde reductase, putative	0.0227	0.8574	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0227	0.8574	1
Mycobacterium ulcerans	oxidoreductase	0.0227	0.8574	1
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0523
Mycobacterium tuberculosis	Probable oxidoreductase	0.0227	0.8574	0.8564
Mycobacterium tuberculosis	Conserved protein	0.0227	0.8574	0.8564
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0227	0.8574	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0227	0.8574	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0062	0.1453	0.1156
Plasmodium falciparum	aldehyde reductase, putative	0.0227	0.8574	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0227	0.8574	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0523
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0227	0.8574	0.5
Plasmodium falciparum	aldo-keto reductase, putative	0.0227	0.8574	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0227	0.8574	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 819481