TDR Targets

Basic information

Technical information

TDR Targets ID: 819487
Name: CBMicro_015995
MW: 302.414 | Formula: C15H14N2OS2
H donors: 0 H acceptors: 1 LogP: 3.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C#CCSc1nc2sc3c(c2c(=O)n1CC=C)CCC3
InChi: 1S/C15H14N2OS2/c1-3-8-17-14(18)12-10-6-5-7-11(10)20-13(12)16-15(17)19-9-4-2/h2-3H,1,5-9H2
InChiKey: RQAQETALVXQPPT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Oprea1_357179
EU-0073925
Oprea1_804449
STOCK1S-30477
ZINC02694763
BIM-0015861.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	peptidase, putative	0.0028	0.0117	0.0233
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0028	0.0117	0.0233
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0028	0.0117	0.0292
Mycobacterium tuberculosis	Probable cytoplasmic peptidase PepQ	0.0028	0.0117	0.0292
Brugia malayi	intermediate filament protein	0.0032	0.0157	0.057
Mycobacterium ulcerans	dipeptidase	0.0028	0.0117	0.0292
Toxoplasma gondii	creatinase domain-containing protein	0.0028	0.0117	0.0233
Schistosoma mansoni	cellular tumor antigen P53	0.0058	0.044	0.1811
Trypanosoma cruzi	aminopeptidase P1, putative	0.0028	0.0117	0.0233
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Giardia lamblia	Xaa-Pro dipeptidase	0.0028	0.0117	1
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0028	0.0117	0.0062
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.022	0.218	0.7956
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0028	0.0117	0.0292
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Entamoeba histolytica	hypothetical protein	0.0042	0.027	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0157	0.057
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0028	0.0117	0.0233
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0028	0.0117	0.0062
Giardia lamblia	Xaa-Pro dipeptidase	0.0028	0.0117	1
Entamoeba histolytica	methionine aminopeptidase, putative	0.0028	0.0117	0.2882
Onchocerca volvulus		0.0032	0.0157	0.125
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0365	0.116
Echinococcus multilocularis	xaa Pro dipeptidase	0.0028	0.0117	0.0062
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0365	0.116
Schistosoma mansoni	lamin	0.0032	0.0157	0.0482
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0271	0.2726	0.2686
Echinococcus multilocularis	neuropeptide s receptor	0.0544	0.5645	0.5621
Leishmania major	hypothetical protein, conserved	0.0051	0.0365	0.116
Mycobacterium ulcerans	dipeptidase PepE	0.0028	0.0117	0.0292
Echinococcus multilocularis	FACT complex subunit SPT16	0.0028	0.0117	0.0062
Brugia malayi	follicle stimulating hormone receptor	0.0274	0.2756	1
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0028	0.0117	0.0292
Echinococcus granulosus	xaa pro aminopeptidase	0.0028	0.0117	0.0111
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0028	0.0117	0.0233
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.022	0.218	1
Schistosoma mansoni	hypothetical protein	0.0042	0.027	0.1015
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0028	0.0117	0.0292
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.022	0.218	1
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.022	0.218	1
Echinococcus granulosus	Proliferation associated protein 2G4	0.0028	0.0117	0.0111
Entamoeba histolytica	hypothetical protein	0.0042	0.027	1
Trypanosoma cruzi	aminopeptidase P, putative	0.0028	0.0117	0.0233
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.0365	0.116
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.022	0.218	1
Entamoeba histolytica	peptidase, putative	0.0028	0.0117	0.2882
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0028	0.0117	0.0233
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0271	0.2726	0.4778
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0028	0.0117	0.0233
Echinococcus granulosus	FACT complex subunit SPT16	0.0028	0.0117	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0058	0.044	0.1595
Echinococcus multilocularis	musashi	0.0032	0.0157	0.0103
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0157	0.057
Plasmodium falciparum	aminopeptidase P	0.0028	0.0117	0.0233
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0271	0.2726	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.027	0.0217
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0271	0.2726	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0274	0.2756	1
Echinococcus granulosus	neuropeptide s receptor	0.0544	0.5645	1
Echinococcus multilocularis	lamin	0.0032	0.0157	0.0103
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.027	0.1015
Leishmania major	transcription factor-like protein	0.0028	0.0117	0.0233
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0117	0.0424
Entamoeba histolytica	hypothetical protein, conserved	0.0028	0.0117	0.2882
Plasmodium falciparum	HP12 protein homolog, putative	0.0051	0.0365	0.116
Onchocerca volvulus		0.0032	0.0157	0.125
Leishmania major	methionine aminopeptidase 2, putative	0.0028	0.0117	0.0233
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Mycobacterium ulcerans	aminopeptidase	0.0028	0.0117	0.0292
Toxoplasma gondii	methionine aminopeptidase	0.0271	0.2726	1
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0117	0.0424
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0271	0.2726	1
Echinococcus multilocularis	xaa pro aminopeptidase	0.0028	0.0117	0.0062
Giardia lamblia	Methionine aminopeptidase	0.0028	0.0117	1
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0028	0.0117	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0117	0.0424
Echinococcus granulosus	xaa Pro dipeptidase	0.0028	0.0117	0.0111
Leishmania major	hypothetical protein, conserved	0.0028	0.0117	0.0233
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.022	0.218	0.2137
Onchocerca volvulus		0.0058	0.044	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0055	0.0199
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0271	0.2726	0.9888
Loa Loa (eye worm)	DNA-binding protein	0.0028	0.0117	0.0424
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.027	0.0386
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0028	0.0117	0.0233
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0028	0.0117	0.0424
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0028	0.0117	0.0233
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Echinococcus multilocularis	neuropeptide receptor A26	0.0544	0.5645	0.5621
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0271	0.2726	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.022	0.218	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0157	0.057
Mycobacterium ulcerans	cytoplasmic peptidase PepQ	0.0028	0.0117	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0117	0.0424
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0055	0.0199
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.022	0.218	1
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.0028	0.0117	0.2882
Chlamydia trachomatis	methionine aminopeptidase	0.022	0.218	1
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0028	0.0117	0.0233
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0028	0.0117	0.0424
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0028	0.0117	0.0233
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0028	0.0117	0.0233
Brugia malayi	initiation factor 2-associated protein.	0.0028	0.0117	0.0424
Mycobacterium tuberculosis	Dipeptidase PepE	0.0028	0.0117	0.0292
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0028	0.0117	0.0233
Plasmodium falciparum	methionine aminopeptidase 2	0.0028	0.0117	0.0233
Schistosoma mansoni	lamin	0.0032	0.0157	0.0482
Echinococcus granulosus	lamin dm0	0.0032	0.0157	0.0183
Echinococcus granulosus	lamin	0.0032	0.0157	0.0183
Echinococcus granulosus	tumor protein p63	0.0396	0.4061	0.7167
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.022	0.218	1
Trypanosoma brucei	methionine aminopeptidase, putative	0.0271	0.2726	1
Brugia malayi	Methionine aminopeptidase protein type I	0.0271	0.2726	0.9888
Toxoplasma gondii	hypothetical protein	0.0051	0.0365	0.116
Echinococcus granulosus	methionine aminopeptidase type I	0.0028	0.0117	0.0111
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0028	0.0117	0.0233
Treponema pallidum	methionine aminopeptidase (map)	0.022	0.218	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0117	0.0424
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.057
Wolbachia endosymbiont of Brugia malayi	Xaa-Pro aminopeptidase	0.0028	0.0117	0.0292
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0157	0.0482
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Mycobacterium ulcerans	methionine aminopeptidase	0.022	0.218	1
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0117	0.0424
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0028	0.0117	0.0233
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0028	0.0117	0.0424
Trypanosoma brucei	hypothetical protein, conserved	0.0051	0.0365	0.116
Schistosoma mansoni	peptidase	0.0028	0.0117	0.0292
Entamoeba histolytica	aminopeptidase, putative	0.0028	0.0117	0.2882
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0271	0.2726	1
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0028	0.0117	0.0292
Toxoplasma gondii	peptidase D, putative	0.0028	0.0117	0.0233
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Brugia malayi	hypothetical protein	0.0042	0.027	0.0981
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0028	0.0117	0.0233
Echinococcus granulosus	xaa Pro dipeptidase	0.0028	0.0117	0.0111
Echinococcus multilocularis	lamin dm0	0.0032	0.0157	0.0103
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0028	0.0117	0.0233
Echinococcus granulosus	intermediate filament protein	0.0032	0.0157	0.0183
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0117	0.0233
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0028	0.0117	0.0233
Echinococcus granulosus	neuropeptide receptor A26	0.0544	0.5645	1
Echinococcus granulosus	methionyl aminopeptidase 2	0.0028	0.0117	0.0111
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.022	0.218	0.7956
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.022	0.218	0.7956
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0028	0.0117	0.0111
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Toxoplasma gondii	methionine aminopeptidase	0.022	0.218	0.7956
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0271	0.2726	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0271	0.2726	1
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0028	0.0117	0.0292
Echinococcus multilocularis	tumor protein p63	0.0396	0.4061	0.4028
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0151	0.0548
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0028	0.0117	0.0233
Entamoeba histolytica	hypothetical protein	0.0042	0.027	1
Entamoeba histolytica	hypothetical protein	0.0042	0.027	1
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0028	0.0117	0.0062
Echinococcus multilocularis	xaa Pro dipeptidase	0.0028	0.0117	0.0062
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0028	0.0117	0.0062
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0028	0.0117	0.0233
Treponema pallidum	aminopeptidase P	0.0028	0.0117	0.0292
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0028	0.0117	0.0292
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.022	0.218	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 819487