Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.3156 | 0.4519 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0022 | 0.1383 | 0.3037 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.104 | 0.7911 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.4434 | 0.5711 |
Plasmodium falciparum | DNA (cytosine-5)-methyltransferase | 0.0021 | 0.1314 | 0.0306 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.104 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1383 | 0.3037 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.1383 | 0.1012 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0022 | 0.1383 | 0.0578 |
Toxoplasma gondii | hypothetical protein | 0.009 | 1 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0022 | 0.1383 | 0.0578 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0022 | 0.1383 | 0.0578 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4434 | 0.6349 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0022 | 0.1383 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.104 | 0.7418 |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0021 | 0.1314 | 0.1882 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0022 | 0.1383 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.104 | 0.7516 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0053 | 0.0000000025538 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0022 | 0.1383 | 1 |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0021 | 0.1314 | 0.0462 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.3156 | 0.3561 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0022 | 0.1383 | 0.0578 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.6983 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0022 | 0.1383 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.6983 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0036 | 0.3156 | 0.7083 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.6983 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.1383 | 0.1383 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0021 | 0.1314 | 0.9501 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.104 | 0.5 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0021 | 0.1314 | 0.1314 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4434 | 0.6349 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.6983 | 0.6983 |
Echinococcus granulosus | bloom syndrome protein | 0.0022 | 0.1383 | 0.0578 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.3156 | 0.3561 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.4434 | 0.5711 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0022 | 0.1383 | 1 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0041 | 0.3827 | 0.8213 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3827 | 0.8615 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0053 | 0.0381 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0021 | 0.1314 | 0.1314 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0053 | 0.0401 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0053 | 0.0053 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.1383 | 0.1012 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0022 | 0.1383 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0036 | 0.3156 | 0.6235 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0022 | 0.1383 | 0.0578 |
Entamoeba histolytica | recQ family helicase, putative | 0.0022 | 0.1383 | 1 |
Echinococcus granulosus | disco interacting protein 2 | 0.0041 | 0.3827 | 0.469 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0053 | 0.0075 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.4434 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.4434 | 0.5711 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.104 | 0.7418 |
Schistosoma mansoni | DNA helicase recq5 | 0.0022 | 0.1383 | 0.1981 |
Loa Loa (eye worm) | RecQ helicase | 0.0022 | 0.1383 | 0.3037 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0021 | 0.1314 | 0.0462 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.104 | 0.1489 |
Leishmania major | modification methylase-like protein | 0.0021 | 0.1314 | 0.0462 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.6983 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.6983 | 1 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0021 | 0.1314 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.1383 | 0.0383 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0041 | 0.3827 | 0.469 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0041 | 0.3827 | 0.5481 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.3156 | 0.4519 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.6983 | 1 |
Onchocerca volvulus | 0.0041 | 0.3827 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.6983 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.104 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4434 | 0.6349 |
Schistosoma mansoni | DNA helicase recq1 | 0.0022 | 0.1383 | 0.1981 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.6983 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0022 | 0.1383 | 0.0578 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0022 | 0.1383 | 0.0383 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.104 | 0.2253 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0022 | 0.1383 | 0.1012 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.6983 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.1383 | 0.1383 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0021 | 0.1314 | 0.7991 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.4434 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.4434 | 0.5711 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.104 | 0.1489 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.3156 | 0.4519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.