Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9606 | 0.9606 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | neuropeptide F receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | AKH receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Brugia malayi | RE15519p | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Dopamine receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Serotonin receptor | 0.0031 | 0.8849 | 0.8849 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | G protein-coupled receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | GnHR receptor homolog | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | sulfakinin receptor protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Melatonin receptor type 1A | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | follicle stimulating hormone receptor | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | putative neuropeptide receptor | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | G-protein coupled receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | G-protein coupled receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0031 | 0.8849 | 0.8849 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | ORL1-like opioid receptor | 0.0031 | 0.8849 | 0.8849 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | neuropeptide F receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | Dopamine receptor protein 1 | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 2 | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | larval opioid receptor | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Brugia malayi | hypothetical protein | 0.0031 | 0.8849 | 0.8849 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0398 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.