Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0247 | 0.9895 | 1 |
Treponema pallidum | NADH oxidase | 0.0067 | 0.1221 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0247 | 0.9895 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0247 | 0.9895 | 0.5 |
Leishmania major | trypanothione reductase | 0.0247 | 0.9895 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0247 | 0.9895 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.1221 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0067 | 0.1221 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0247 | 0.9895 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0067 | 0.1221 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0067 | 0.1221 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0247 | 0.9895 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0247 | 0.9895 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0247 | 0.9895 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0247 | 0.9895 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0067 | 0.1221 | 0.1234 |
Loa Loa (eye worm) | glutathione reductase | 0.0247 | 0.9895 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0249 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0247 | 0.9895 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0067 | 0.1221 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0067 | 0.1221 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.1221 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0247 | 0.9895 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0067 | 0.1221 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0067 | 0.1221 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0067 | 0.1221 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.