Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0652 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.038 | 0.035 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.038 | 0.035 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.2495 | 0.8342 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0697 | 0.0893 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.0908 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.4114 | 0.6259 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.0908 | 0.1382 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0697 | 0.033 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0652 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0652 | 0.0622 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.014 | 0.3603 | 0.335 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.2033 | 0.3093 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0697 | 0.033 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.038 | 0.5 |
Schistosoma mansoni | lamin | 0.0054 | 0.0908 | 0.0549 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0173 | 0.4634 | 0.4617 |
Schistosoma mansoni | thyroid hormone receptor | 0.0173 | 0.4634 | 0.4422 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0235 | 0.6573 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0173 | 0.4634 | 0.4422 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0235 | 0.6573 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.2861 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.2495 | 0.8342 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0697 | 0.0668 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.038 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.038 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0121 | 0.0184 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0652 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3903 | 0.5938 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0697 | 0.0893 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0697 | 0.0668 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0129 | 0.325 | 0.3229 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.015 | 0.3903 | 0.5862 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0697 | 0.106 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2033 | 0.2008 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.014 | 0.3603 | 0.3583 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2033 | 0.1718 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.0908 | 0.088 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0652 | 0.5 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0652 | 0.0822 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0652 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.2861 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.3966 | 0.3947 |
Brugia malayi | hypothetical protein | 0.0157 | 0.4114 | 0.6189 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.015 | 0.3903 | 0.5938 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0697 | 0.033 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0652 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0697 | 0.0668 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2033 | 0.2008 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2419 | 0.212 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0652 | 0.0822 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.2033 | 0.2963 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0652 | 0.0622 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.2495 | 0.8342 |
Echinococcus multilocularis | geminin | 0.0345 | 1 | 1 |
Onchocerca volvulus | 0.0157 | 0.4114 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2033 | 0.2008 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0908 | 0.1382 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0697 | 0.0668 |
Brugia malayi | MH2 domain containing protein | 0.0235 | 0.6573 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0652 | 0.0991 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.0908 | 0.1382 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0697 | 0.106 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.0908 | 0.088 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.0908 | 0.0549 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2033 | 0.2008 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.3966 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2419 | 0.368 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.2495 | 0.8342 |
Echinococcus granulosus | lamin | 0.0054 | 0.0908 | 0.088 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.038 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2033 | 0.1718 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0652 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.0908 | 0.122 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.2861 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.2861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0031 | 0.0047 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0697 | 0.0668 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0652 | 0.0991 |
Echinococcus multilocularis | musashi | 0.0054 | 0.0908 | 0.088 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0697 | 0.033 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.2419 | 0.3562 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.015 | 0.3903 | 0.5862 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.0908 | 0.122 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0652 | 0.5 |
Schistosoma mansoni | lamin | 0.0054 | 0.0908 | 0.0549 |
Echinococcus multilocularis | lamin | 0.0054 | 0.0908 | 0.088 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.2495 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0877 | 0.1334 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2033 | 0.1718 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.2495 | 0.8342 |
Brugia malayi | hypothetical protein | 0.0037 | 0.038 | 0.0401 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.3966 | 0.3947 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0697 | 0.0668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.