Detailed information for compound 82033

Basic information

Technical information
  • TDR Targets ID: 82033
  • Name: [(5S)-1-azabicyclo[2.2.1]heptan-5-yl] N-methy lcarbamate
  • MW: 170.209 | Formula: C8H14N2O2
  • H donors: 1 H acceptors: 1 LogP: 0.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)O[C@@H]1CN2CC1CC2
  • InChi: 1S/C8H14N2O2/c1-9-8(11)12-7-5-10-3-2-6(7)4-10/h6-7H,2-5H2,1H3,(H,9,11)/t6?,7-/m1/s1
  • InChiKey: RMGQCZQEHAVQDV-COBSHVIPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-methylcarbamic acid [(5S)-1-azabicyclo[2.2.1]heptan-5-yl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.302 0.8151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus g-protein coupled receptor 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1616 0.1519
Brugia malayi Dopamine receptor protein 2 0.0093 0.0835 0.0511
Brugia malayi Serotonin receptor 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0093 0.0835 0.0835
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus multilocularis G protein coupled receptor 139 0.0093 0.0835 0.0511
Echinococcus multilocularis G-protein coupled receptor, putative 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptide receptor A26 0.0093 0.0835 0.0511
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.0835 0.0511
Brugia malayi sulfakinin receptor protein 0.0093 0.0835 0.0511
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni histamine h1 receptor 0.0093 0.0835 0.0835
Trypanosoma brucei ingi protein (ORF1) 0.0107 0.1072 0.0969
Echinococcus granulosus allatostatin A receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Leishmania major thymidine kinase, putative 0.0266 0.3679 0.5099
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0093 0.0835 0.0835
Brugia malayi follicle stimulating hormone receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0112 0.115 0.0987
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) melatonin receptor type 1A 0.0093 0.0835 0.0511
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0093 0.0835 0.0511
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.0835 0.0511
Schistosoma mansoni neuropeptide f receptor 76f 0.0093 0.0835 0.0835
Loa Loa (eye worm) thymidylate synthase 0.0475 0.7106 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0093 0.0835 0.0511
Trypanosoma brucei thymidylate kinase, putative 0.0072 0.0497 0.0388
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0475 0.7106 1
Echinococcus multilocularis neuropeptide receptor 0.0093 0.0835 0.0511
Schistosoma mansoni phosphoglucomutase 0.0093 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Trichomonas vaginalis thymidine kinase, putative 0.0266 0.3679 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni hypothetical protein 0.0072 0.0497 0.0497
Schistosoma mansoni biogenic amine receptor 0.0093 0.0835 0.0835
Toxoplasma gondii thymidylate kinase 0.0072 0.0497 0.0571
Trypanosoma brucei ribonuclease H1 0.0093 0.083 0.0724
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.0835 0.0511
Trypanosoma brucei unspecified product 0.0107 0.1072 0.0969
Schistosoma mansoni DNA polymerase gamma 0.0097 0.0902 0.0902
Schistosoma mansoni amine GPCR 0.0093 0.0835 0.0835
Onchocerca volvulus Ribonuclease H1 homolog 0.0093 0.083 0.0503
Brugia malayi thymidylate synthase 0.0475 0.7106 1
Echinococcus multilocularis g protein coupled receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Trypanosoma cruzi ribonuclease H1, putative 0.0093 0.083 0.1023
Onchocerca volvulus 0.0093 0.0835 0.0511
Giardia lamblia Ribonuclease H 0.0093 0.083 0.1044
Echinococcus granulosus g protein coupled receptor 0.0093 0.0835 0.0511
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.0835 0.0835
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0093 0.0835 0.0511
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4181 0.5816
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0475 0.7106 0.7106
Echinococcus granulosus DNA polymerase subunit gamma 0.0097 0.0902 0.0612
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.0835 0.0511
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.0835 0.0511
Trypanosoma brucei ingi protein (ORF1) 0.0107 0.1072 0.0969
Echinococcus multilocularis serotonin receptor 0.0093 0.0835 0.0511
Schistosoma mansoni hypothetical protein 0.0093 0.0835 0.0835
Plasmodium vivax DNA polymerase alpha, putative 0.0091 0.0802 0.0462
Echinococcus granulosus peptide allatostatin:somatostatin 0.0093 0.0835 0.0511
Brugia malayi Tachykinin-like peptides receptor 99D 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus granulosus ribonuclease H1 0.0093 0.083 0.0503
Schistosoma mansoni neuropeptide receptor 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0093 0.0835 0.0511
Schistosoma mansoni hypothetical protein 0.0093 0.0835 0.0835
Brugia malayi Dopamine receptor 0.0093 0.0835 0.0511
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4181 0.5816
Leishmania major ribonuclease H1, putative 0.0093 0.083 0.1023
Schistosoma mansoni adenoreceptor 0.0093 0.0835 0.0835
Brugia malayi Melatonin receptor type 1A 0.0093 0.0835 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Trypanosoma brucei RNA helicase, putative 0.0651 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.4181 0.5816
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.0835 0.0511
Entamoeba histolytica thymidine kinase, putative 0.0266 0.3679 1
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Trypanosoma cruzi thymidylate kinase, putative 0.0072 0.0497 0.0548
Trypanosoma cruzi ribonuclease H1, putative 0.0093 0.083 0.1023
Schistosoma mansoni myosin xvIII 0.0093 0.0835 0.0835
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0093 0.0835 0.0511
Schistosoma mansoni phosphoglucomutase 0.0093 0.083 0.083
Brugia malayi RNase H family protein 0.0093 0.083 0.0503
Echinococcus granulosus alpha 1A adrenergic receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus multilocularis dro:myosuppressin receptor 0.0093 0.0835 0.0511
Brugia malayi G protein-coupled receptor F59B2.13 0.0093 0.0835 0.0511
Giardia lamblia Thymidine kinase 0.0266 0.3679 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0093 0.0835 0.0511
Brugia malayi G protein-coupled receptor 0.0093 0.0835 0.0511
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0093 0.0835 0.0511
Schistosoma mansoni biogenic amine receptor 0.0093 0.0835 0.0835
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0226 0.302 0.4156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Echinococcus multilocularis neuropeptide receptor A26 0.0093 0.0835 0.0511
Echinococcus multilocularis g protein coupled receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Echinococcus granulosus biogenic amine 5HT receptor 0.0093 0.0835 0.0511
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0093 0.0835 0.0835
Schistosoma mansoni biogenic amine (5HT) receptor 0.0093 0.0835 0.0835
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus granulosus thymidylate synthase 0.0475 0.7106 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Echinococcus multilocularis g protein coupled receptor 0.0093 0.0835 0.0511
Echinococcus granulosus G protein coupled receptor 139 0.0093 0.0835 0.0511
Echinococcus granulosus 7tm_1 domain containing protein 0.0093 0.0835 0.0511
Trypanosoma brucei thymidylate kinase, putative 0.0072 0.0497 0.0388
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Trichomonas vaginalis thymidylate kinase, putative 0.0072 0.0497 0.1075
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Mycobacterium ulcerans hypothetical protein 0.0156 0.1876 0.2087
Mycobacterium tuberculosis Hypothetical protein 0.0226 0.302 0.3817
Echinococcus multilocularis g-protein coupled receptor 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus multilocularis sex peptide receptor 0.0093 0.0835 0.0511
Trichomonas vaginalis thymidylate kinase, putative 0.0072 0.0497 0.1075
Trypanosoma brucei thymidine kinase 0.0266 0.3679 0.3606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus sex peptide receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.0835 0.0511
Echinococcus granulosus biogenic amine 5HT receptor 0.0093 0.0835 0.0511
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Treponema pallidum ribonuclease H (rnhA) 0.0093 0.083 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptide FF receptor 2 0.0093 0.0835 0.0511
Trypanosoma cruzi thymidine kinase, putative 0.0266 0.3679 0.5099
Echinococcus multilocularis thymidylate synthase 0.0475 0.7106 1
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Brugia malayi neuropeptide F receptor 0.0093 0.0835 0.0511
Trypanosoma cruzi thymidine kinase, putative 0.0266 0.3679 0.5099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0097 0.0902 0.0612
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi Dopamine receptor protein 1 0.0093 0.0835 0.0511
Mycobacterium ulcerans thymidylate synthase 0.0475 0.7106 1
Onchocerca volvulus 0.0093 0.0835 0.0511
Schistosoma mansoni opsin-like receptor 0.0093 0.0835 0.0835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.0835 0.0835
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0475 0.7106 0.7073
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus dro:myosuppressin receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus multilocularis neuropeptide s receptor 0.0093 0.0835 0.0511
Brugia malayi DNA polymerase I family protein 0.0097 0.0902 0.0612
Schistosoma mansoni amine GPCR 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0093 0.0835 0.0835
Onchocerca volvulus 0.0093 0.0835 0.0511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.0835 0.0511
Brugia malayi larval opioid receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis neuropeptide receptor 0.0093 0.0835 0.0511
Schistosoma mansoni amine GPCR 0.0093 0.0835 0.0835
Brugia malayi AKH receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis fmrfamide receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis serotonin receptor 0.0093 0.0835 0.0511
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.0835 0.0835
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0475 0.7106 1
Chlamydia trachomatis thymidylate kinase 0.0072 0.0497 0.5
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptide receptor 0.0093 0.0835 0.0511
Schistosoma mansoni phosphoglucomutase 0.0093 0.083 0.083
Echinococcus granulosus orexin receptor type 2 0.0093 0.0835 0.0511
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.0835 0.0511
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0093 0.0835 0.0835
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0093 0.0835 0.0511
Brugia malayi RNase H family protein 0.0093 0.083 0.0503
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0112 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi GnHR receptor homolog 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0475 0.7106 1
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0112 0.115 0.0987
Echinococcus granulosus neuropeptide s receptor 0.0093 0.0835 0.0511
Echinococcus granulosus g protein coupled receptor 0.0093 0.0835 0.0511
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0475 0.7106 1
Brugia malayi putative neuropeptide receptor NPR1 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.4181 0.4113
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.0835 0.0511
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0093 0.0835 0.0511
Schistosoma mansoni hypothetical protein 0.0093 0.0835 0.0835
Schistosoma mansoni opsin-like receptor 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni opsin-like receptor 0.0093 0.0835 0.0835
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0154 0.1838 0.2029
Trichomonas vaginalis thymidine kinase, putative 0.0266 0.3679 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0093 0.0835 0.0511
Schistosoma mansoni thymidylate kinase 0.0072 0.0497 0.0497
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0093 0.0835 0.0835
Schistosoma mansoni biogenic amine receptor 0.0093 0.0835 0.0835
Echinococcus granulosus neuropeptide receptor 0.0093 0.0835 0.0511
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0093 0.0835 0.0511
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi DNA polymerase alpha catalytic subunit 0.0091 0.0802 0.0462
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0093 0.0835 0.0511
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0107 0.1072 0.0969
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.0835 0.0511
Schistosoma mansoni amine GPCR 0.0093 0.0835 0.0835
Echinococcus granulosus expressed protein 0.0377 0.549 0.7555
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0093 0.083 1
Trichomonas vaginalis ribonuclease H1, putative 0.0093 0.083 0.2007
Schistosoma mansoni neuropeptide receptor 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0093 0.0835 0.0835
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0475 0.7106 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0093 0.0835 0.0511
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0091 0.0802 0.1007
Echinococcus multilocularis orexin receptor type 2 0.0093 0.0835 0.0511
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1072 0.0969
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1876 0.2087
Brugia malayi RNase H family protein 0.0093 0.083 0.0503
Schistosoma mansoni biogenic amine (5HT) receptor 0.0093 0.0835 0.0835
Echinococcus multilocularis ribonuclease H1 0.0093 0.083 0.0503
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0154 0.1838 0.2029
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.0835 0.0835
Echinococcus multilocularis neuropeptide FF receptor 2 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Schistosoma mansoni amine GPCR 0.0093 0.0835 0.0835
Brugia malayi G-protein coupled receptor 0.0093 0.0835 0.0511
Echinococcus granulosus g protein coupled receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0093 0.0835 0.0511
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.0835 0.0835
Onchocerca volvulus 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Brugia malayi putative neuropeptide receptor 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi ORL1-like opioid receptor 0.0093 0.0835 0.0511
Schistosoma mansoni neuropeptide receptor 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Leishmania major thymidylate kinase-like protein 0.0072 0.0497 0.0548
Schistosoma mansoni thymidylate kinase 0.0072 0.0497 0.0497
Schistosoma mansoni neuropeptide receptor 0.0093 0.0835 0.0835
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0475 0.7106 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.0835 0.0511
Echinococcus granulosus somatostatin receptor 0.0093 0.0835 0.0511
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1616 0.2148
Loa Loa (eye worm) TYRA-2 protein 0.0093 0.0835 0.0511
Echinococcus multilocularis allatostatin A receptor 0.0093 0.0835 0.0511
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.0835 0.0511
Brugia malayi RE15519p 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Giardia lamblia DNA polymerase alpha subunit A 0.0095 0.0868 0.1164
Schistosoma mansoni hypothetical protein 0.0093 0.0835 0.0835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0146 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.0835 0.0835
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0475 0.7106 1
Echinococcus multilocularis expressed protein 0.0377 0.549 0.7555
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0475 0.7106 1
Echinococcus multilocularis fmrfamide receptor 0.0093 0.0835 0.0511
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1616 0.2148
Brugia malayi Serotonin receptor 0.0093 0.0835 0.0511
Onchocerca volvulus 0.0093 0.0835 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0835 0.0511
Echinococcus granulosus tachykinin peptides receptor 99D 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Echinococcus granulosus fmrfamide receptor 0.0093 0.0835 0.0511
Echinococcus granulosus serotonin receptor 0.0093 0.0835 0.0511
Echinococcus multilocularis somatostatin receptor 0.0093 0.0835 0.0511
Trypanosoma cruzi thymidylate kinase, putative 0.0072 0.0497 0.0548
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0093 0.0835 0.0511
Brugia malayi hypothetical protein 0.0226 0.302 0.3817
Schistosoma mansoni growth hormone secretagogue receptor 0.0093 0.0835 0.0835
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Brugia malayi G-protein coupled receptor 0.0093 0.0835 0.0511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Toxoplasma gondii ribonuclease HI protein 0.0093 0.083 0.1045
Trichomonas vaginalis thymidine kinase, putative 0.0266 0.3679 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0093 0.0835 0.0835
Echinococcus multilocularis hypothetical protein 0.0097 0.0902 0.0612
Brugia malayi neuropeptide F receptor 0.0093 0.0835 0.0511
Loa Loa (eye worm) hypothetical protein 0.0093 0.0835 0.0511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0835 0.0835
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.0835 0.0511

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 26000 nM Affinity towards human M1 receptor expressed in CHO cells using [3H]-QNB as radioligand ChEMBL. 10450949
Ki (binding) = 26000 nM Affinity towards human M1 receptor expressed in CHO cells using [3H]-QNB as radioligand ChEMBL. 10450949
MED (functional) = 1 mg kg-1 Compound was evaluated for minimum effective dose in the rat radial arm maze model ChEMBL. 10450949
PI (functional) = 100 % Efficacy expressed as PI (percentage of carbachol) against human M1 receptor expressed in CHO cells ChEMBL. 10450949
PI (functional) = 100 % Efficacy expressed as PI (percentage of carbachol) against human M1 receptor expressed in CHO cells ChEMBL. 10450949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.