Detailed information for compound 820490

Basic information

Technical information
  • TDR Targets ID: 820490
  • Name: (5E)-1-(2,3-dichlorophenyl)-2-sulfanylidene-5 -[(1,2,5-trimethylpyrrol-3-yl)methylidene]-1, 3-diazinane-4,6-dione
  • MW: 408.302 | Formula: C18H15Cl2N3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)C(=Cc2cc(n(c2C)C)C)C(=O)N1c1cccc(c1Cl)Cl
  • InChi: 1S/C18H15Cl2N3O2S/c1-9-7-11(10(2)22(9)3)8-12-16(24)21-18(26)23(17(12)25)14-6-4-5-13(19)15(14)20/h4-8H,1-3H3,(H,21,24,26)/b12-8+
  • InChiKey: DNGXZUNKRHKDHZ-XYOKQWHBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,3-dichlorophenyl)-2-sulfanylidene-5-[(1,2,5-trimethylpyrrol-3-yl)methylidene]-1,3-diazinane-4,6-dione
  • (5E)-1-(2,3-dichlorophenyl)-2-thioxo-5-[(1,2,5-trimethylpyrrol-3-yl)methylene]hexahydropyrimidine-4,6-dione
  • 1-(2,3-dichlorophenyl)-2-thioxo-5-[(1,2,5-trimethylpyrrol-3-yl)methylene]hexahydropyrimidine-4,6-dione
  • 1-(2,3-dichlorophenyl)-2-thioxo-5-[(1,2,5-trimethyl-3-pyrrolyl)methylene]hexahydropyrimidine-4,6-dione
  • (5E)-1-(2,3-dichlorophenyl)-2-thioxo-5-[(1,2,5-trimethyl-3-pyrrolyl)methylene]hexahydropyrimidine-4,6-dione
  • 1-(2,3-dichlorophenyl)-2-thioxo-5-[(1,2,5-trimethylpyrrol-3-yl)methylene]hexahydropyrimidine-4,6-quinone
  • (5E)-1-(2,3-dichlorophenyl)-2-thioxo-5-[(1,2,5-trimethylpyrrol-3-yl)methylene]hexahydropyrimidine-4,6-quinone
  • 6174-26-1
  • ZINC02262610
  • CBMicro_010778
  • BIM-0010685.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Loa Loa (eye worm) hypothetical protein 0.0071 0.011 0.0078
Echinococcus granulosus 7tm_1 domain containing protein 0.012 0.0348 0.014
Mycobacterium ulcerans dehydrogenase 0.0101 0.0256 0.0774
Schistosoma mansoni neuropeptide receptor 0.012 0.0348 0.0348
Schistosoma mansoni furin-1 (S08 family) 0.09 0.4145 0.4145
Brugia malayi ORL1-like opioid receptor 0.012 0.0348 0.014
Schistosoma mansoni cyclin B 0.0147 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Trypanosoma cruzi cyclin, putative 0.0147 0.048 1
Echinococcus multilocularis neuropeptide s receptor 0.0569 0.2533 0.3042
Echinococcus multilocularis cyclin B 0.0147 0.048 0.0352
Schistosoma mansoni tyrosine kinase 0.0288 0.1164 0.1164
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus neuropeptide s receptor 0.0569 0.2533 0.2372
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.012 0.0348 0.0179
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus tm gpcr rhodopsin 0.012 0.0348 0.014
Schistosoma mansoni alpha-1 adrenergic receptor 0.012 0.0348 0.0348
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Onchocerca volvulus 0.012 0.0348 0.1129
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0101 0.0256 0.0451
Schistosoma mansoni neuropeptide F-like receptor 0.012 0.0348 0.0348
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.012 0.0348 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus lysine specific histone demethylase 1A 0.0497 0.2184 0.2015
Echinococcus granulosus serotonin receptor 0.012 0.0348 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus fmrfamide receptor 0.012 0.0348 0.014
Brugia malayi follicle stimulating hormone receptor 0.012 0.0348 0.014
Echinococcus multilocularis g protein coupled receptor 0.012 0.0348 0.0179
Echinococcus granulosus neuroendocrine convertase 2 0.1343 0.6301 0.6221
Echinococcus multilocularis serotonin receptor 0.012 0.0348 0.0179
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0098 0.024 0.024
Schistosoma mansoni serine-type protease inhibitor 0.1748 0.8273 0.8273
Loa Loa (eye worm) neuropeptide F receptor 0.012 0.0348 0.0317
Echinococcus granulosus G protein coupled receptor 139 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.0101 0.0256 0.0224
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0096 0.0232 0.0021
Onchocerca volvulus 0.0098 0.024 0.066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus multilocularis neuropeptide receptor 0.012 0.0348 0.0179
Echinococcus granulosus furin 0.2102 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0118 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0541 0.2396 0.3788
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.024 0.0168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus g protein coupled receptor 0.012 0.0348 0.014
Echinococcus granulosus peptide allatostatin:somatostatin 0.012 0.0348 0.014
Echinococcus granulosus aminopeptidase N 0.0121 0.0352 0.0143
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0443 0.192 0.2988
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0098 0.024 0.0264
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0098 0.024 0.0264
Schistosoma mansoni neuropeptide receptor 0.012 0.0348 0.0348
Onchocerca volvulus 0.012 0.0348 0.1129
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0541 0.2396 0.3788
Echinococcus multilocularis tachykinin peptides receptor 99D 0.012 0.0348 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Brugia malayi putative neuropeptide receptor NPR1 0.012 0.0348 0.014
Schistosoma mansoni peptide (allatostatin)-like receptor 0.012 0.0348 0.0348
Trichomonas vaginalis hypothetical protein 0.0443 0.192 0.2988
Mycobacterium ulcerans oxidoreductase 0.0101 0.0256 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Schistosoma mansoni histamine h1 receptor 0.012 0.0348 0.0348
Onchocerca volvulus 0.012 0.0348 0.1129
Loa Loa (eye worm) hypothetical protein 0.0101 0.0256 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.024 0.0168
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0098 0.024 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Schistosoma mansoni biogenic amine (dopamine) receptor 0.012 0.0348 0.0348
Echinococcus granulosus neuropeptides capa receptor 0.012 0.0348 0.014
Echinococcus granulosus neuropeptide receptor 0.012 0.0348 0.014
Echinococcus multilocularis epidermal growth factor receptor 0.0288 0.1164 0.1248
Trichomonas vaginalis cyclins, putative 0.0092 0.0211 0.012
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) follicle stimulating hormone receptor 0.012 0.0348 0.0317
Schistosoma mansoni adenoreceptor 0.012 0.0348 0.0348
Onchocerca volvulus 0.012 0.0348 0.1129
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Entamoeba histolytica cyclin, putative 0.0147 0.048 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.024 0.0168
Toxoplasma gondii subtilisin SUB12 0.0098 0.024 0.2844
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.012 0.0348 0.0317
Toxoplasma gondii subtilisin SUB2 0.0098 0.024 0.2844
Mycobacterium tuberculosis Possible oxidoreductase 0.0101 0.0256 0.0774
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Toxoplasma gondii cathepsin CPC2 0.0169 0.0584 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Loa Loa (eye worm) peptidase family M13 containing protein 0.0071 0.011 0.0078
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.13 0.6095 0.7709
Loa Loa (eye worm) hypothetical protein 0.0073 0.0118 0.0086
Onchocerca volvulus 0.012 0.0348 0.1129
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0541 0.2396 0.2396
Schistosoma mansoni neuropeptide receptor 0.012 0.0348 0.0348
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.012 0.0348 0.0348
Loa Loa (eye worm) TK/EGFR protein kinase 0.0288 0.1164 0.1135
Brugia malayi RE15519p 0.012 0.0348 0.014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0541 0.2396 0.3788
Echinococcus granulosus neuropeptide FF receptor 2 0.0355 0.149 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.024 0.0168
Trypanosoma brucei RNA helicase, putative 0.01 0.0252 0.0482
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0098 0.024 0.0038
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Onchocerca volvulus 0.012 0.0348 0.1129
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.012 0.0348 0.014
Echinococcus multilocularis orexin receptor type 2 0.012 0.0348 0.0179
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus multilocularis neuropeptides capa receptor 0.012 0.0348 0.0179
Toxoplasma gondii aspartyl protease ASP5 0.0117 0.0334 0.4801
Echinococcus multilocularis g protein coupled receptor 0.012 0.0348 0.0179
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Schistosoma mansoni growth hormone secretagogue receptor 0.012 0.0348 0.0348
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.012 0.0348 0.0179
Plasmodium vivax plasmepsin V, putative 0.0129 0.039 0.4353
Brugia malayi G protein-coupled receptor 0.012 0.0348 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.012 0.0348 0.0348
Toxoplasma gondii subtilisin SUB11 0.0098 0.024 0.2844
Echinococcus multilocularis fmrfamide receptor 0.012 0.0348 0.0179
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.012 0.0348 0.0348
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.012 0.0348 0.0348
Echinococcus multilocularis neuropeptide receptor 0.012 0.0348 0.0179
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus granulosus neuropeptide Y receptor 0.012 0.0348 0.014
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0098 0.024 0.0264
Trypanosoma cruzi CYC2-like cyclin, putative 0.0147 0.048 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0101 0.0256 0.0256
Toxoplasma gondii peptidase family M13 protein 0.0096 0.0232 0.2677
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.0098 0.024 0.0209
Brugia malayi Myb-like DNA-binding domain containing protein 0.0169 0.0585 0.0382
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Toxoplasma gondii subtilisin SUB4 0.0098 0.024 0.2844
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0226 0.0863 0.0834
Onchocerca volvulus CoRest homolog 0.0174 0.0609 0.2263
Echinococcus granulosus hypothetical protein 0.012 0.0348 0.014
Loa Loa (eye worm) melatonin receptor type 1A 0.012 0.0348 0.0317
Schistosoma mansoni amine oxidase 0.0101 0.0256 0.0256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.012 0.0348 0.0348
Brugia malayi proprotein convertase 2 0.1343 0.6301 0.6221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0541 0.2396 0.3788
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0443 0.192 0.2988
Echinococcus granulosus allatostatin A receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.0096 0.0232 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Echinococcus granulosus neuropeptide receptor A26 0.0569 0.2533 0.2372
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0169 0.0584 1
Onchocerca volvulus 0.0121 0.0352 0.1145
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Brugia malayi Dopamine receptor protein 2 0.012 0.0348 0.014
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0147 0.048 1
Schistosoma mansoni serine/threonine protein kinase 0.0226 0.0863 0.0863
Onchocerca volvulus 0.0539 0.2389 1
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Schistosoma mansoni hypothetical protein 0.01 0.0252 0.0252
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0256 0.0774
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Echinococcus multilocularis g-protein coupled receptor 0.012 0.0348 0.0179
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Echinococcus multilocularis biogenic amine (5HT) receptor 0.012 0.0348 0.0179
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.012 0.0348 0.014
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0169 0.0584 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0497 0.2184 0.2585
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0159 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0232 0.0201
Brugia malayi larval opioid receptor 0.012 0.0348 0.014
Echinococcus multilocularis fmrfamide receptor 0.012 0.0348 0.0179
Mycobacterium leprae Possible secreted protease 0.0098 0.024 0.3406
Mycobacterium ulcerans epoxide hydrolase EphA 0.0159 0.0536 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Schistosoma mansoni biogenic amine receptor 0.012 0.0348 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Brugia malayi neuropeptide F receptor 0.012 0.0348 0.014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.012 0.0348 0.0348
Brugia malayi AKH receptor 0.012 0.0348 0.014
Toxoplasma gondii subtilisin SUB9 0.0098 0.024 0.2844
Echinococcus multilocularis aminopeptidase N 0.0121 0.0352 0.0184
Onchocerca volvulus 0.012 0.0348 0.1129
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0098 0.024 0.024
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0101 0.0256 0.0774
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0101 0.0256 0.0774
Brugia malayi Dopamine receptor 0.012 0.0348 0.014
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0256 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.012 0.0348 0.0179
Plasmodium falciparum subtilisin-like protease 3 0.0098 0.024 0.0771
Trichomonas vaginalis cyclin B, putative 0.0147 0.048 0.057
Echinococcus multilocularis expressed protein 0.0361 0.1523 0.1719
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Trichomonas vaginalis cyclins, putative 0.0147 0.048 0.057
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.012 0.0348 0.1129
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0098 0.024 0.0264
Echinococcus granulosus g protein coupled receptor 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Onchocerca volvulus 0.012 0.0348 0.1129
Onchocerca volvulus 0.012 0.0348 0.1129
Onchocerca volvulus 0.012 0.0348 0.1129
Brugia malayi hypothetical protein 0.0101 0.0256 0.0045
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0541 0.2396 0.3788
Loa Loa (eye worm) peptidase family M1 containing protein 0.0098 0.0239 0.0208
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Plasmodium falciparum subtilisin-like protease 2 0.0098 0.024 0.0771
Loa Loa (eye worm) subtilase 0.0098 0.024 0.0209
Loa Loa (eye worm) proprotein convertase 2 0.0541 0.2396 0.2371
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0256 0.0647
Onchocerca volvulus 0.012 0.0348 0.1129
Onchocerca volvulus 0.012 0.0348 0.1129
Brugia malayi Peptidase family M13 containing protein 0.0096 0.0232 0.0021
Schistosoma mansoni amine oxidase 0.0101 0.0256 0.0256
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0098 0.024 0.3406
Echinococcus granulosus biogenic amine 5HT receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni site-1 peptidase (S08 family) 0.0098 0.024 0.024
Schistosoma mansoni biogenic amine receptor 0.012 0.0348 0.0348
Brugia malayi Peptidase family M1 containing protein 0.0121 0.0352 0.0143
Schistosoma mansoni opsin-like receptor 0.012 0.0348 0.0348
Schistosoma mansoni serine-type protease inhibitor 0.1748 0.8273 0.8273
Loa Loa (eye worm) hypothetical protein 0.0169 0.0585 0.0554
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.012 0.0348 0.014
Schistosoma mansoni hypothetical protein 0.012 0.0348 0.0348
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.13 0.6095 0.6011
Schistosoma mansoni neuropeptide f receptor 76f 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.012 0.0348 0.0179
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Loa Loa (eye worm) cyclin domain-containing protein 0.0092 0.0211 0.018
Echinococcus granulosus dro:myosuppressin receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Brugia malayi GnHR receptor homolog 0.012 0.0348 0.014
Schistosoma mansoni neuropeptide F-like receptor 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni amine GPCR 0.012 0.0348 0.0348
Trypanosoma cruzi cyclin 6, putative 0.0147 0.048 1
Brugia malayi G protein-coupled receptor F59B2.13 0.012 0.0348 0.014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.0073 0.0118 0.0086
Trichomonas vaginalis cyclin A, putative 0.0147 0.048 0.057
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.012 0.0348 0.0179
Echinococcus granulosus tachykinin peptides receptor 99D 0.012 0.0348 0.014
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0497 0.2184 0.2184
Echinococcus multilocularis 0.166 0.7844 1
Schistosoma mansoni hypothetical protein 0.012 0.0348 0.0348
Echinococcus granulosus membrane bound transcription factor site 1 0.0098 0.024 0.0029
Schistosoma mansoni amine GPCR 0.012 0.0348 0.0348
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.012 0.0348 0.0317
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Echinococcus multilocularis Furin 1 0.0541 0.2396 0.2862
Loa Loa (eye worm) hypothetical protein 0.0071 0.011 0.0078
Loa Loa (eye worm) endoprotease bli-4 0.2102 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Echinococcus multilocularis neuropeptide Y receptor 0.012 0.0348 0.0179
Schistosoma mansoni hypothetical protein 0.0443 0.192 0.192
Chlamydia trachomatis protoporphyrinogen oxidase 0.0101 0.0256 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0256 0.1187
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Echinococcus multilocularis allatostatin A receptor 0.012 0.0348 0.0179
Brugia malayi Stress-activated protein kinase jnk-1 0.0226 0.0863 0.0666
Loa Loa (eye worm) hypothetical protein 0.0096 0.0232 0.0201
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.012 0.0348 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.012 0.0348 0.0348
Brugia malayi amine oxidase, flavin-containing family protein 0.0143 0.046 0.0254
Schistosoma mansoni opsin-like receptor 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus multilocularis neuropeptide receptor A26 0.0569 0.2533 0.3042
Schistosoma mansoni biogenic amine (5HT) receptor 0.012 0.0348 0.0348
Trichomonas vaginalis cyclin D, putative 0.0092 0.0211 0.012
Onchocerca volvulus 0.0147 0.048 0.1701
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0101 0.0256 0.1187
Schistosoma mansoni cyclin B3 0.0092 0.0211 0.0211
Onchocerca volvulus 0.012 0.0348 0.1129
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0101 0.0256 0.0774
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.012 0.0348 0.0348
Brugia malayi Serotonin receptor 0.012 0.0348 0.014
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.012 0.0348 0.0179
Echinococcus multilocularis alpha 1A adrenergic receptor 0.012 0.0348 0.0179
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0098 0.024 0.0264
Loa Loa (eye worm) hypothetical protein 0.0147 0.048 0.0449
Toxoplasma gondii subtilisin SUB7 0.0098 0.024 0.2844
Loa Loa (eye worm) hypothetical protein 0.0071 0.011 0.0078
Loa Loa (eye worm) G-protein coupled receptor 0.012 0.0348 0.0317
Trichomonas vaginalis cyclin B, putative 0.0147 0.048 0.057
Brugia malayi neuroendocrine convertase 1 precursor 0.1343 0.6301 0.6221
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1132 0.5276 0.6635
Echinococcus granulosus cyclin B 0.0147 0.048 0.0274
Echinococcus multilocularis 0.0101 0.0256 0.0058
Loa Loa (eye worm) hypothetical protein 0.0174 0.0609 0.0579
Onchocerca volvulus Neuropeptide F receptor homolog 0.012 0.0348 0.1129
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0101 0.0256 1
Echinococcus multilocularis serotonin receptor 0.012 0.0348 0.0179
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus multilocularis somatostatin receptor 0.012 0.0348 0.0179
Echinococcus granulosus neuropeptides capa receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0118 0.0086
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.0497 0.2184 0.2159
Brugia malayi G-protein coupled receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Leishmania major UDP-galactopyranose mutase 0.0101 0.0256 0.0647
Plasmodium falciparum protoporphyrinogen oxidase 0.0101 0.0256 0.1187
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0256 0.0647
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Brugia malayi SWIRM domain containing protein 0.0539 0.2389 0.2225
Schistosoma mansoni site-1 peptidase (S08 family) 0.0098 0.024 0.024
Brugia malayi Cyclin, N-terminal domain containing protein 0.0147 0.048 0.0274
Loa Loa (eye worm) hypothetical protein 0.0802 0.3669 0.3648
Echinococcus granulosus alpha 1A adrenergic receptor 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Schistosoma mansoni biogenic amine receptor 0.012 0.0348 0.0348
Onchocerca volvulus 0.012 0.0348 0.1129
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.012 0.0348 0.0179
Toxoplasma gondii subtilisin SUB10 0.0098 0.024 0.2844
Echinococcus granulosus 7TM GPCR rhodopsin 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.0143 0.046 0.043
Toxoplasma gondii subtilisin SUB8 0.0098 0.024 0.2844
Trichomonas vaginalis cyclin B3, putative 0.0092 0.0211 0.012
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0232 0.0232
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0098 0.024 0.0029
Echinococcus multilocularis sex peptide receptor 0.012 0.0348 0.0179
Loa Loa (eye worm) hypothetical protein 0.0497 0.2184 0.2159
Echinococcus granulosus epidermal growth factor receptor 0.0288 0.1164 0.0973
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus granulosus c-Jun N-terminal kinases 0.0226 0.0863 0.0666
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.012 0.0348 0.0348
Onchocerca volvulus 0.012 0.0348 0.1129
Schistosoma mansoni amine GPCR 0.012 0.0348 0.0348
Giardia lamblia G2/mitotic-specific cyclin B 0.0147 0.048 0.0825
Schistosoma mansoni neuropeptide receptor 0.012 0.0348 0.0348
Echinococcus granulosus g protein coupled receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni biogenic amine (dopamine) receptor 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni myosin xvIII 0.012 0.0348 0.0348
Giardia lamblia High cysteine membrane protein Group 2 0.076 0.3463 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0355 0.149 0.1306
Echinococcus multilocularis endothelin converting enzyme 1 0.0096 0.0232 0.0027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.012 0.0348 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0211 0.012
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0443 0.192 0.2988
Loa Loa (eye worm) neuropeptide F receptor 0.012 0.0348 0.0317
Loa Loa (eye worm) hypothetical protein 0.0108 0.0291 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.1132 0.5276 0.5174
Leishmania major cyclin 0.0147 0.048 1
Plasmodium falciparum plasmepsin V 0.0129 0.039 0.4788
Giardia lamblia Furin precursor putative serine protease 0.0443 0.192 0.5253
Schistosoma mansoni hypothetical protein 0.012 0.0348 0.0348
Brugia malayi Cyclin, N-terminal domain containing protein 0.0147 0.048 0.0274
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni opsin-like receptor 0.012 0.0348 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.13 0.6095 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0179 0.0147
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0098 0.024 0.0264
Trypanosoma cruzi cyclin, putative 0.0147 0.048 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.0348 0.0179
Echinococcus multilocularis G-protein coupled receptor, putative 0.012 0.0348 0.0179
Echinococcus granulosus neuropeptide Y receptor 0.012 0.0348 0.014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0118 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.012 0.0348 0.014
Echinococcus granulosus expressed protein 0.0361 0.1523 0.134
Brugia malayi neuropeptide F receptor 0.012 0.0348 0.014
Onchocerca volvulus 0.012 0.0348 0.1129
Brugia malayi Melatonin receptor type 1A 0.012 0.0348 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Brugia malayi Furin-like cysteine rich region family protein 0.0288 0.1164 0.0973
Loa Loa (eye worm) peptidase family M13 containing protein 0.0071 0.011 0.0078
Brugia malayi putative neuropeptide receptor 0.012 0.0348 0.014
Schistosoma mansoni amine GPCR 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.2102 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.012 0.0348 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.024 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni cyclins 0.0092 0.0211 0.0211
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0226 0.0863 0.0854
Brugia malayi Subtilase family protein 0.0098 0.024 0.0029
Trichomonas vaginalis cyclins, putative 0.0147 0.048 0.057
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.012 0.0348 0.014
Brugia malayi celfurPC protein 0.166 0.7844 0.7798
Loa Loa (eye worm) G-protein coupled receptor 0.012 0.0348 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.13 0.6095 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.012 0.0348 0.0179
Loa Loa (eye worm) TYRA-2 protein 0.012 0.0348 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.0348 0.014
Brugia malayi gonadotropin-releasing hormone receptor 2 0.012 0.0348 0.014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.012 0.0348 0.0179
Brugia malayi G-protein coupled receptor 0.012 0.0348 0.014
Echinococcus multilocularis membrane bound transcription factor site 1 0.0098 0.024 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.012 0.0348 0.0179
Trypanosoma brucei mitotic cyclin 6 0.0147 0.048 1
Trichomonas vaginalis cyclin B, putative 0.0147 0.048 0.057
Loa Loa (eye worm) hypothetical protein 0.0147 0.048 0.0449
Loa Loa (eye worm) hypothetical protein 0.0073 0.0118 0.0086
Onchocerca volvulus 0.012 0.0348 0.1129
Echinococcus granulosus neuropeptide receptor 0.012 0.0348 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Plasmodium falciparum subtilisin-like protease 1 0.0098 0.024 0.0771
Echinococcus granulosus somatostatin receptor 0.012 0.0348 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Echinococcus multilocularis neuroendocrine convertase 2 0.1343 0.6301 0.7978
Echinococcus granulosus Furin 1 0.0541 0.2396 0.2232
Trichomonas vaginalis cyclin D, putative 0.0092 0.0211 0.012
Loa Loa (eye worm) hypothetical protein 0.0355 0.149 0.1463
Trichomonas vaginalis cyclin B, putative 0.0092 0.0211 0.012
Echinococcus multilocularis G protein coupled receptor 139 0.012 0.0348 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0256 0.0451
Trichomonas vaginalis cyclins, putative 0.0147 0.048 0.057
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Echinococcus granulosus lysine specific histone demethylase 1A 0.0101 0.0256 0.0045
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0101 0.0256 0.3167
Toxoplasma gondii subtilisin SUB5 0.0098 0.024 0.2844
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0098 0.024 0.0168
Toxoplasma gondii subtilisin SUB6 0.0098 0.024 0.2844
Toxoplasma gondii histone lysine-specific demethylase 0.0101 0.0256 0.3167
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.012 0.0348 0.014
Toxoplasma gondii subtilisin SUB1 0.0098 0.024 0.2844
Echinococcus multilocularis neuropeptide FF receptor 2 0.0355 0.149 0.1675
Echinococcus granulosus endothelin converting enzyme 1 0.0096 0.0232 0.0021
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0098 0.024 0.3406
Loa Loa (eye worm) hypothetical protein 0.0071 0.011 0.0078
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0098 0.024 0.0264
Trichomonas vaginalis cyclins, putative 0.0147 0.048 0.057
Brugia malayi sulfakinin receptor protein 0.012 0.0348 0.014
Trichomonas vaginalis cyclin B, putative 0.0147 0.048 0.057
Echinococcus multilocularis dro:myosuppressin receptor 0.012 0.0348 0.0179
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0098 0.024 0.0029
Brugia malayi Dopamine receptor protein 1 0.012 0.0348 0.014
Echinococcus multilocularis neuropeptide Y receptor 0.012 0.0348 0.0179
Echinococcus multilocularis g protein coupled receptor 0.012 0.0348 0.0179
Echinococcus granulosus g-protein coupled receptor 0.012 0.0348 0.014
Brugia malayi Serotonin receptor 0.012 0.0348 0.014
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0101 0.0256 0.0451
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Mycobacterium ulcerans monoamine oxidase 0.0101 0.0256 0.0774
Schistosoma mansoni biogenic amine (dopamine) receptor 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0539 0.2389 0.2364
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Schistosoma mansoni amine GPCR 0.012 0.0348 0.0348
Echinococcus multilocularis protoporphyrinogen oxidase 0.0101 0.0256 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.192 0.2988
Brugia malayi hypothetical protein 0.012 0.0348 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.012 0.0348 0.0317
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2102 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0541 0.2396 0.3788
Echinococcus granulosus orexin receptor type 2 0.012 0.0348 0.014
Schistosoma mansoni hypothetical protein 0.012 0.0348 0.0348
Echinococcus granulosus sex peptide receptor 0.012 0.0348 0.014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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