Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.2949 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2949 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0982 | 0.0982 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.0016 | 0.0016 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.0016 | 0.0016 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2949 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2949 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Onchocerca volvulus | 0.007 | 0.052 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.007 | 0.052 | 0.052 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.105 | 0.105 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2949 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2949 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 11 uM | In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | > 11 uM | In vitro inhibitory concentration against rat liver dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | > 11 uM | In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | > 11 uM | In vitro inhibitory concentration against rat liver dihydrofolate reductase | ChEMBL. | 9191966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.