Detailed information for compound 82102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.237 | Formula: C11H14F2N2O4
  • H donors: 3 H acceptors: 4 LogP: -0.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CC(C(C1O)(F)F)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C11H14F2N2O4/c1-5-3-15(10(19)14-9(5)18)7-2-6(4-16)8(17)11(7,12)13/h3,6-8,16-17H,2,4H2,1H3,(H,14,18,19)
  • InChiKey: FIGPROBREMXEOO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.007 0.1029 0.101
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.094 0.196
Onchocerca volvulus Putative organic anion transporter 0.0055 0.066 0.1271
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0028 0.0026 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4198 0.6236
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1029 0.2116
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0898 0.1333
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Mycobacterium tuberculosis Conserved protein 0.007 0.1029 0.101
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1869 0.1852
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0058 0.0139
Toxoplasma gondii protease inhibitor PI2 0.0037 0.0249 0.0824
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0099 0.0192
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0079 0.0189
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0718 0.1725
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0225 0.076
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2149 0.2132
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0047 0.0091
Trypanosoma cruzi monoglyceride lipase, putative 0.0141 0.27 1
Plasmodium falciparum lysophospholipase, putative 0.0144 0.2782 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0028 0.0026 0.0055
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.066 0.1585
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0094 0.0226
Schistosoma mansoni hypothetical protein 0.0166 0.33 0.7928
Echinococcus multilocularis sodium channel protein 0.0121 0.2229 0.5355
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1029 0.2116
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0225 0.0334
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Mycobacterium tuberculosis Possible lysophospholipase 0.0141 0.27 0.2684
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Trypanosoma brucei monoglyceride lipase, putative 0.0141 0.27 1
Echinococcus multilocularis follistatin 0.0037 0.0249 0.0598
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1029 0.101
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1889 0.6972
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0099 0.0192
Giardia lamblia Sugar-proton symporter 0.0029 0.0047 0.0022
Brugia malayi hypothetical protein 0.0029 0.0047 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.02 0.0481
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0202 0.4162 1
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0189
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0028 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0094 0.0226
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.4162 1
Echinococcus multilocularis 0.0028 0.0021 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0139
Trichomonas vaginalis taga, putative 0.0031 0.0099 0.0204
Brugia malayi ABC transporter family protein 0.0031 0.0099 0.0207
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Schistosoma mansoni agrin 0.0037 0.0249 0.0598
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0079 0.0189
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0091 0.0219
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Loa Loa (eye worm) sugar transporter 0.0029 0.0047 0.007
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0225 0.0334
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0091 0.0219
Leishmania major glucose transporter/membrane transporter D2, putative 0.0029 0.0047 0.0096
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.4162 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0202 0.4162 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2149 0.2132
Loa Loa (eye worm) hypothetical protein 0.0072 0.1063 0.1579
Toxoplasma gondii hypothetical protein 0.0144 0.2782 1
Onchocerca volvulus 0.0037 0.0249 0.0419
Trichomonas vaginalis abcb9, putative 0.0031 0.0099 0.0204
Brugia malayi follicle stimulating hormone receptor 0.0229 0.4798 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni organic anion transporter 0.0055 0.066 0.1585
Schistosoma mansoni glucose transport protein 0.0029 0.0047 0.0113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.066 0.1375
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis conserved hypothetical protein 0.0045 0.0437 0.1049
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0079 0.0189
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.2513 0.6037
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Schistosoma mansoni multidrug resistance protein 0.0033 0.0157 0.0377
Brugia malayi SPARC precursor 0.0037 0.0249 0.0518
Brugia malayi Cytochrome P450 family protein 0.0036 0.0225 0.0468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Giardia lamblia DINP protein human, muc B family 0.0039 0.0298 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0099 0.0147
Echinococcus granulosus sodium channel protein 0.0091 0.1517 0.3644
Brugia malayi Cytochrome P450 family protein 0.0028 0.0021 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0225 0.076
Plasmodium falciparum hexose transporter 0.0029 0.0047 0.0002
Mycobacterium ulcerans sugar transporter 0.0029 0.0047 0.0096
Toxoplasma gondii facilitative glucose transporter GT1 0.0029 0.0047 0.0093
Schistosoma mansoni hypothetical protein 0.0029 0.0047 0.0113
Brugia malayi multidrug resistance protein 3 0.0031 0.0099 0.0207
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0718 0.1725
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.4162 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1029 0.2473
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1869 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1029 0.101
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0145 0.0461
Echinococcus granulosus potassium voltage gated channel protein 0.0103 0.1813 0.4356
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0202 0.4162 1
Schistosoma mansoni multidrug resistance protein 0.0031 0.0099 0.0238
Loa Loa (eye worm) carboxylesterase 0.0133 0.2513 0.3733
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0047 0.007
Schistosoma mansoni smdr2 0.0031 0.0099 0.0238
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0898 0.1871
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0056 0.0687 0.1651
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Schistosoma mansoni follistatin 0.0037 0.0249 0.0598
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0762 0.2767
Loa Loa (eye worm) hypothetical protein 0.0094 0.1585 0.2355
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus acetylcholinesterase 0.0133 0.2513 0.6037
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.4162 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Plasmodium falciparum esterase, putative 0.0144 0.2782 1
Echinococcus multilocularis expressed protein 0.0037 0.0249 0.0598
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0202 0.4162 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0898 0.2156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Echinococcus multilocularis shaker cognate 0.0028 0.0026 0.0063
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0898 0.3271
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.0215
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0099 0.0238
Echinococcus granulosus voltage gated potassium channel 0.0028 0.0026 0.0063
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0099 0.0192
Onchocerca volvulus 0.0031 0.0099 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0028 0.0026 0.0063
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1889 0.6972
Trypanosoma brucei unspecified product 0.0052 0.0609 0.2195
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi polk-prov protein 0.0036 0.0224 0.0467
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.4162 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0898 0.2156
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0437 0.0649
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0099 0.0192
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1869 0.1852
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus follistatin 0.0037 0.0249 0.0598
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0132 0.0415
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0225 0.0334
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1889 0.4538
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Leishmania major glucose transporter, lmgt1 0.0029 0.0047 0.0096
Brugia malayi major facilitator superfamily protein 0.0029 0.0047 0.0098
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1889 1
Brugia malayi hypothetical protein 0.0029 0.0047 0.0098
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0047 0.0096
Schistosoma mansoni glucose transporter 0.0029 0.0047 0.0113
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Trypanosoma brucei monoglyceride lipase, putative 0.0141 0.27 1
Brugia malayi Carboxylesterase family protein 0.0133 0.2513 0.5237
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0047 0.0113
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0202 0.4162 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Mycobacterium leprae conserved hypothetical protein 0.007 0.1029 0.3763
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) acetylcholinesterase 1 0.0133 0.2513 0.3733
Loa Loa (eye worm) hypothetical protein 0.0202 0.4162 0.6183
Echinococcus granulosus shaker cognate 0.0028 0.0026 0.0063
Plasmodium falciparum lysophospholipase, putative 0.0141 0.27 0.9701
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Plasmodium vivax hexose transporter 0.0029 0.0047 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Echinococcus granulosus agrin 0.0037 0.0249 0.0598
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1029 0.3763
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Leishmania major DNA polymerase kappa, putative 0.0039 0.0298 0.1033
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.066 0.1375
Brugia malayi hypothetical protein 0.0119 0.2191 0.4567
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi Cytochrome P450 family protein 0.0028 0.0021 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0898 0.3271
Leishmania major p-glycoprotein 0.0031 0.0099 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Schistosoma mansoni inositol monophosphatase 0.0036 0.0222 0.0534
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0252 0.0605
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0775 0.2729
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.037
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1029 0.3763
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0766 0.184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0086
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0762 0.2767
Schistosoma mansoni thyroid hormone receptor 0.0141 0.2699 0.6484
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0145 0.0215
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.066 0.1375
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0099 1
Mycobacterium ulcerans hypothetical protein 0.007 0.1029 0.3763
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0311 0.6731 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0157 0.0506
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0099 0.0238
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0047 0.0096
Echinococcus granulosus potassium voltage gated channel protein 0.0028 0.0026 0.0063
Onchocerca volvulus Putative organic anion transporter 0.0055 0.066 0.1271
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0094 0.014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0145 0.0348
Leishmania major hypothetical protein, conserved 0.0029 0.0047 0.0096
Brugia malayi hypothetical protein 0.0099 0.1723 0.359
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0056 0.0129
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Plasmodium falciparum thioredoxin reductase 0.0046 0.0463 0.1521
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1869 0.1852
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0047 0.0091
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Onchocerca volvulus Putative organic anion transporter 0.0055 0.066 0.1271
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis transfer RNA-Gly 0.0028 0.0026 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0099 0.0192
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Brugia malayi jmjC domain containing protein 0.0057 0.0718 0.1497
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0051 0.0576 0.1384
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0036 0.0086
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0141 0.27 0.9701
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0028 0.0026 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.0249 0.037
Brugia malayi Sugar transporter family protein 0.0029 0.0047 0.0098
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0222 0.0728
Echinococcus multilocularis potassium voltage gated channel protein 0.0028 0.0026 0.0063
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0099 0.0238
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Leishmania major hypothetical protein, conserved 0.007 0.1029 0.3763
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trypanosoma brucei sugar transporter, putative 0.0029 0.0047 0.0096
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0047 0.0096
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Trypanosoma cruzi MFS transporter, putative 0.0055 0.066 0.2383
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1889 0.6972
Schistosoma mansoni glucose transport protein 0.0029 0.0047 0.0113
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Mycobacterium ulcerans lipase LipD 0.007 0.1029 0.3763
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1029 0.101
Mycobacterium ulcerans beta-lactamase 0.007 0.1029 0.3763
Brugia malayi Thioredoxin reductase 0.0046 0.0463 0.0964
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0099 0.0204
Mycobacterium ulcerans hypothetical protein 0.0141 0.27 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1029 0.3763
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0762 0.2767
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi Cytochrome P450 family protein 0.0036 0.0225 0.0468
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.066 0.1585
Echinococcus granulosus GPCR family 2 0.0031 0.0094 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0029 0.0054 0.008
Plasmodium vivax SET domain protein, putative 0.0029 0.0058 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0145 0.0302
Onchocerca volvulus 0.0029 0.0058 0.0022
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) hypothetical protein 0.0133 0.2513 0.3733
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Plasmodium falciparum esterase, putative 0.0144 0.2782 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0718 0.1725
Schistosoma mansoni voltage-gated cation channel 0.0202 0.4162 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.0437 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Schistosoma mansoni hypothetical protein 0.0123 0.2288 0.5497
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0141 0.27 0.9701
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0033 0.0157 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.27 0.5549
Loa Loa (eye worm) glutathione reductase 0.0046 0.0463 0.0687
Plasmodium falciparum lysophospholipase, putative 0.0141 0.27 0.9701
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0117
Onchocerca volvulus 0.0055 0.066 0.1271
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Echinococcus multilocularis potassium voltage gated channel protein 0.0103 0.1813 0.4356
Schistosoma mansoni hypothetical protein 0.0028 0.0021 0.0051
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0091 0.1517 0.5582
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0139
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0463 0.1521
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Trypanosoma cruzi membrane transporter protein, putative 0.0033 0.0157 0.0506
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0718 0.1725
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0094 0.0226
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0047 0.0026
Plasmodium vivax sugar transporter, putative 0.0029 0.0047 0.0002
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2149 0.2132
Trichomonas vaginalis esterase, putative 0.007 0.1029 0.2116
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0099 0.0238
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.2782 1
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0141 0.27 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0047 0.0096
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1029 0.101
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1889 0.2806
Onchocerca volvulus 0.007 0.1029 0.2039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.0026 0.0063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1029 0.1529
Schistosoma mansoni DNA polymerase eta 0.0033 0.0145 0.0348
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0124 0.2297 0.8498
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0047 0.0098
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Schistosoma mansoni cytochrome P450 0.0028 0.0021 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0775 0.2813
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Onchocerca volvulus 0.007 0.1029 0.2039
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium tuberculosis Conserved protein 0.007 0.1029 0.101
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0762 0.1567
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0047 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0224 0.0758
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.1291 0.3102
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0298 0.1033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.02 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0105 0.1858 0.4463
Schistosoma mansoni voltage-gated potassium channel 0.0103 0.1813 0.4356
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0222 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) inositol-1 0.0036 0.0222 0.033
Echinococcus multilocularis geminin 0.0166 0.33 0.7928
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi hypothetical protein 0.0055 0.066 0.1375
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0718 0.1725
Loa Loa (eye worm) beta-lactamase 0.007 0.1029 0.1529
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Schistosoma mansoni glucose transport protein 0.0029 0.0047 0.0113
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Plasmodium falciparum esterase, putative 0.0141 0.27 0.9701
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1889 0.4538
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) sugar transporter 0.0029 0.0047 0.007
Leishmania major cytochrome p450-like protein 0.0036 0.0225 0.076
Toxoplasma gondii sugar transporter ST3 0.0029 0.0047 0.0093
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0898 0.3271
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.0249 0.0518
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0094 0.0226
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0165 0.0339
Brugia malayi beta-lactamase 0.007 0.1029 0.2145
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1029 0.2473
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.0437 0.1049
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 0.1858 0.4463
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.167 0.348
Schistosoma mansoni multidrug resistance protein 0.0031 0.0099 0.0238
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0762 0.1832
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.27 0.5549
Echinococcus granulosus acetylcholinesterase 0.0133 0.2513 0.6037
Brugia malayi Carboxylesterase family protein 0.0133 0.2513 0.5237
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0224 0.0758
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0132 0.0111
Echinococcus granulosus geminin 0.0166 0.33 0.7928
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0056 0.0687 0.1021
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0047 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0139
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Schistosoma mansoni organic anion transporter 0.0055 0.066 0.1585
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.003 0.0079 0.0164
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.066 0.2312
Echinococcus granulosus dna polymerase kappa 0.0059 0.0762 0.1832
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Trypanosoma brucei MATE efflux family protein, putative 0.0033 0.0157 0.0506
Echinococcus granulosus voltage gated potassium channel 0.003 0.0079 0.0189
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0047 0.0026
Toxoplasma gondii sugar transporter ST1 0.0029 0.0047 0.0093
Trichomonas vaginalis abcb9, putative 0.0031 0.0099 0.0204
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0898 0.3111
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0047 0.0091
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Plasmodium vivax lysophospholipase, putative 0.0144 0.2782 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0775 0.2813
Plasmodium falciparum glutathione reductase 0.0046 0.0463 0.1521
Trypanosoma brucei trypanothione reductase 0.0046 0.0463 0.1648
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0135
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Brugia malayi major facilitator superfamily protein 0.0029 0.0047 0.0098
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0775 0.1861
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0099 0.0192
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0145 0.0302
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0463 0.1648
Echinococcus multilocularis GPCR, family 2 0.0031 0.0094 0.0226
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0775 0.1861
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2782 0.5717
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0298 0.1033
Plasmodium falciparum lysophospholipase, putative 0.0141 0.27 0.9701
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2288 0.5497
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0094 0.0196
Mycobacterium leprae Probable lipase LipE 0.007 0.1029 0.3763
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0898 0.2156
Trypanosoma cruzi hexose transporter 0.0029 0.0047 0.0096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0222 0.0457
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0718 0.1725
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0775 0.1861
Loa Loa (eye worm) hypothetical protein 0.0072 0.1063 0.1579
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1889 0.6736
Loa Loa (eye worm) cytochrome P450 0.0028 0.0021 0.0032
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.066 0.1585
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0222 0.075
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0124 0.2297 0.8498
Mycobacterium tuberculosis Probable reductase 0.0106 0.1869 0.1852
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni lipoxygenase 0.0115 0.2103 0.5054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.014
Onchocerca volvulus 0.0232 0.4865 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0047 0.0002
Brugia malayi Sugar transporter family protein 0.0029 0.0047 0.0098
Leishmania major hypothetical protein, conserved 0.0033 0.0157 0.0506
Loa Loa (eye worm) hypothetical protein 0.0133 0.2513 0.3733
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0718 0.1067
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0021 0.0032
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0298 0.0277
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1889 0.4538
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2103 0.5054
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0099 0.0282
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0099 0.0147
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0222 0.0457
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Trypanosoma brucei glucose transporter 1E 0.0029 0.0047 0.0096
Brugia malayi hypothetical protein 0.0035 0.02 0.0417
Leishmania major glucose transporter, lmgt2 0.0029 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0097 0.167 0.248
Loa Loa (eye worm) hypothetical protein 0.0045 0.0437 0.0649
Loa Loa (eye worm) calcium channel 0.0202 0.4162 0.6183
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0775 0.0755
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0047 0.0096
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0047 0.0096
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0033 0.0157 0.0377
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1869 0.69
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0145 0.0348
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0463 0.1112
Brugia malayi Pre-SET motif family protein 0.0029 0.0058 0.0121
Toxoplasma gondii thioredoxin reductase 0.0046 0.0463 0.1599
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1889 0.6972
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1889 0.6972
Schistosoma mansoni lipoxygenase 0.0081 0.1279 0.3074
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0145 0.0461
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1889 0.2806
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1029 0.101
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Trypanosoma brucei glucose transporter 2A 0.0029 0.0047 0.0096
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0145 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1889 0.6736
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) hypothetical protein 0.0051 0.0574 0.0853
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1029 0.101
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0898 0.3271
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi cytochrome P450 0.0028 0.0021 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Loa Loa (eye worm) hypothetical protein 0.0105 0.1858 0.276
Echinococcus granulosus dna polymerase eta 0.0033 0.0145 0.0348
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0105 0.1858 0.4463
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0775 0.2813
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi prostaglandin transporter 0.0055 0.066 0.1375
Echinococcus granulosus voltage dependent calcium channel 0.0094 0.1585 0.3809
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2103 0.5054
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0047 0.0113
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0047 0.0113
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Echinococcus granulosus voltage dependent calcium channel 0.0202 0.4162 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0222 0.0534
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Brugia malayi Pre-SET motif family protein 0.0204 0.4198 0.8748
Toxoplasma gondii sugar transporter ST2 0.0029 0.0047 0.0093
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1029 0.101
Giardia lamblia Hexose transporter 0.0029 0.0047 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1029 0.2116
Plasmodium vivax hypothetical protein, conserved 0.007 0.1029 0.3593
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1029 0.3763
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0225 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0222 1
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0766 0.184
Echinococcus multilocularis carboxylesterase 5A 0.0133 0.2513 0.6037
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0028 0.0026 0.0063
Schistosoma mansoni hypothetical protein 0.0166 0.33 0.7928
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0222 0.0534
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0028 0.0026 0.0063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0145 0.0348
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0775 0.2813
Brugia malayi Inositol-1 0.0036 0.0222 0.0463
Brugia malayi phosphofructokinase 0.0106 0.1889 0.3936
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0051 0.0576 0.1384
Plasmodium vivax unspecified product 0.0144 0.2782 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0058 0.0139
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0718 0.1725
Echinococcus multilocularis acetylcholinesterase 0.0133 0.2513 0.6037
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.0437 0.1049
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0121 0.2229 0.5355
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.02 0.0481
Brugia malayi glutathione reductase 0.0046 0.0463 0.0964
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Schistosoma mansoni hypothetical protein 0.0035 0.02 0.0481
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2288 0.5497
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0094 0.0196
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0058 0.0139
Echinococcus granulosus potassium voltage gated channel protein 0.0105 0.1858 0.4463
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1029 0.2116
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1889 0.6736
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1029 0.2116
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.066 0.098
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.4162 1
Onchocerca volvulus 0.007 0.1029 0.2039
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.003 0.0087 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0775 0.1861
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0463 0.1112
Toxoplasma gondii ABC1 family protein 0.007 0.1029 0.3652
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Onchocerca volvulus 0.0055 0.066 0.1271
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1889 0.4538
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0056 0.0687 0.1651
Plasmodium vivax PST-A protein 0.0141 0.27 0.9701
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0021 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) voltage-gated potassium channel 0.0028 0.0026 0.0039
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Brugia malayi beta-lactamase family protein 0.007 0.1029 0.2145
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0047 0.0098
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0099 0.0078
Loa Loa (eye worm) hypothetical protein 0.0066 0.094 0.1397
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0047 0.0113
Brugia malayi beta-lactamase family protein 0.007 0.1029 0.2145
Toxoplasma gondii transporter, cation channel family protein 0.0094 0.1585 0.5666
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0463 0.0442
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Brugia malayi hypothetical protein 0.0029 0.0047 0.0098
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0222 0.0534
Echinococcus multilocularis dna polymerase eta 0.0033 0.0145 0.0348
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1029 0.2145
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Mycobacterium ulcerans lysophospholipase 0.0141 0.27 1
Schistosoma mansoni multidrug resistance protein 0.0031 0.0099 0.0238
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.167 0.248
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0058 0.0139
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Echinococcus granulosus carboxylesterase 5A 0.0133 0.2513 0.6037
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0029 0.0047 0.0113
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0165 0.0339
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1889 0.1871
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Schistosoma mansoni thyroid hormone receptor 0.0141 0.2699 0.6484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1029 0.2473
Trichomonas vaginalis set domain proteins, putative 0.0232 0.4865 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.4798 0.7128
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0225 0.076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0762 0.2767
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0099 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Toxoplasma gondii hypothetical protein 0.0072 0.1063 0.3774
Onchocerca volvulus 0.0055 0.066 0.1271
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0157 0.0506
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni vesicular amine transporter 0.0028 0.0026 0.0063
Echinococcus multilocularis agrin 0.0037 0.0249 0.0598
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0099 0.0282
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0099 0.0192
Brugia malayi hypothetical protein 0.0055 0.066 0.1375
Brugia malayi 6-phosphofructokinase 0.0106 0.1889 0.3936
Schistosoma mansoni voltage-gated potassium channel 0.0105 0.1858 0.4463
Brugia malayi 6-phosphofructokinase 0.0107 0.1897 0.3953
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1869 0.1852
Schistosoma mansoni hypothetical protein 0.0066 0.094 0.2259
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1029 0.2473
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2149 0.7943
Leishmania major glucose transporter, lmgt3 0.0029 0.0047 0.0096
Plasmodium vivax glutathione reductase, putative 0.0046 0.0463 0.1521
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.066 0.1585
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0056 0.0129
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0039
Trichomonas vaginalis abcb9, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0099 0.0238
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0081 0.1291 0.2691
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.167 0.348
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0762 0.1567
Leishmania major trypanothione reductase 0.0046 0.0463 0.1648
Brugia malayi jmjC domain containing protein 0.0057 0.0718 0.1497
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0463 0.0687
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0058 0.0132
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0252 0.0605
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0145 0.0124
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0105 0.1858 0.3872
Loa Loa (eye worm) voltage-dependent calcium channel 0.0094 0.1585 0.2355
Onchocerca volvulus 0.0055 0.066 0.1271
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0099 0.0192
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0047 0.0113
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0147
Onchocerca volvulus 0.0055 0.066 0.1271
Leishmania major monoglyceride lipase, putative 0.0141 0.27 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1889 0.2806
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0047 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.1718 0.4128
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0056 0.0129
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0056 0.0687 0.1432
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Echinococcus multilocularis acetylcholinesterase 0.0133 0.2513 0.6037
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0202 0.4162 0.8674
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0145 0.036
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1029 0.3763
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0032 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0141 0.27 0.5549
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0157 0.0506
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0099 0.0291
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Brugia malayi Sugar transporter family protein 0.0029 0.0047 0.0098
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0099 0.0192
Leishmania major DNA polymerase eta, putative 0.0033 0.0145 0.0461
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0222 0.0457
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0099 0.1723 0.2559
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0609 0.2195
Leishmania major hypothetical protein, conserved 0.0033 0.0157 0.0506
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.2699 0.6484

Activities

Activity type Activity value Assay description Source Reference
Cytotoxicity (functional) > 100 Cytotoxic effect on Vero cells was determined in mock infected cell monolayers incubated with the compound for 48 h at 37 degree celsius. ChEMBL. 2153201
ID50 (functional) > 100 ug ml-1 Antiherpes activity was measured in a plaque reduction assay in Vero cells, against HSV-1 strain KOS. ChEMBL. 2153201
ID50 (functional) > 100 ug ml-1 Antiherpes activity was measured in a plaque reduction assay in Vero cells, against HSV-2 strain 186. ChEMBL. 2153201

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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