Detailed information for compound 82102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.237 | Formula: C11H14F2N2O4
  • H donors: 3 H acceptors: 4 LogP: -0.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CC(C(C1O)(F)F)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C11H14F2N2O4/c1-5-3-15(10(19)14-9(5)18)7-2-6(4-16)8(17)11(7,12)13/h3,6-8,16-17H,2,4H2,1H3,(H,14,18,19)
  • InChiKey: FIGPROBREMXEOO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.066 0.1375
Loa Loa (eye worm) hypothetical protein 0.0099 0.1723 0.2559
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0047 0.0096
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0028 0.0026 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0058 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1029 0.3763
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0202 0.4162 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0145 0.0302
Giardia lamblia Hexose transporter 0.0029 0.0047 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Schistosoma mansoni multidrug resistance protein 0.0031 0.0099 0.0238
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0225 0.076
Leishmania major glucose transporter, lmgt2 0.0029 0.0047 0.0096
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0718 0.1725
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Loa Loa (eye worm) calcium channel 0.0202 0.4162 0.6183
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi ABC transporter family protein 0.0031 0.0099 0.0207
Brugia malayi hypothetical protein 0.0099 0.1723 0.359
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1889 0.6972
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0094 0.014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.0437 0.1049
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1029 0.101
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Leishmania major glucose transporter, lmgt1 0.0029 0.0047 0.0096
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0047 0.0097
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0099 0.0291
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Echinococcus multilocularis acetylcholinesterase 0.0133 0.2513 0.6037
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0051 0.0576 0.1384
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0718 0.1067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0147
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0021 0.0051
Leishmania major trypanothione reductase 0.0046 0.0463 0.1648
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0189
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1029 0.101
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.066 0.098
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Schistosoma mansoni voltage-gated potassium channel 0.0105 0.1858 0.4463
Schistosoma mansoni voltage-gated potassium channel 0.0103 0.1813 0.4356
Plasmodium falciparum esterase, putative 0.0144 0.2782 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0463 0.1599
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.0249 0.0518
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1889 0.6736
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.2782 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0105 0.1858 0.4463
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0141 0.27 0.9701
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Echinococcus multilocularis sodium channel protein 0.0121 0.2229 0.5355
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis potassium voltage gated channel protein 0.0103 0.1813 0.4356
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0222 0.0457
Loa Loa (eye worm) cytochrome P450 0.0028 0.0021 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1029 0.3763
Loa Loa (eye worm) hypothetical protein 0.0133 0.2513 0.3733
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Mycobacterium leprae conserved hypothetical protein 0.007 0.1029 0.3763
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1029 0.2473
Echinococcus multilocularis conserved hypothetical protein 0.0045 0.0437 0.1049
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0145 0.0348
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.0437 0.1049
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.094 0.196
Loa Loa (eye worm) hypothetical protein 0.0094 0.1585 0.2355
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0762 0.2767
Echinococcus granulosus dna polymerase eta 0.0033 0.0145 0.0348
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0028 0.0026 0.0055
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Giardia lamblia Sugar-proton symporter 0.0029 0.0047 0.0022
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Plasmodium vivax lysophospholipase, putative 0.0144 0.2782 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Echinococcus multilocularis 0.0028 0.0021 0.0051
Onchocerca volvulus 0.0055 0.066 0.1271
Loa Loa (eye worm) hypothetical protein 0.0072 0.1063 0.1579
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0252 0.0605
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1889 0.4538
Brugia malayi 6-phosphofructokinase 0.0106 0.1889 0.3936
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.066 0.1375
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0094 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0099 0.0204
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0056 0.0687 0.1432
Schistosoma mansoni smdr2 0.0031 0.0099 0.0238
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Brugia malayi Sugar transporter family protein 0.0029 0.0047 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1029 0.2473
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1029 0.101
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1029 0.1529
Echinococcus granulosus potassium voltage gated channel protein 0.0028 0.0026 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0094 0.0226
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0081 0.1291 0.2691
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1889 0.6972
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0047 0.0098
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0099 0.0282
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.037
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0157 0.0506
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0718 0.1725
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0099 0.0204
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0222 0.075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0718 0.1725
Toxoplasma gondii transporter, cation channel family protein 0.0094 0.1585 0.5666
Trypanosoma brucei monoglyceride lipase, putative 0.0141 0.27 1
Plasmodium vivax unspecified product 0.0144 0.2782 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Plasmodium vivax sugar transporter, putative 0.0029 0.0047 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.4798 0.7128
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0099 0.0238
Trypanosoma brucei glucose transporter 1E 0.0029 0.0047 0.0096
Brugia malayi Sugar transporter family protein 0.0029 0.0047 0.0098
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.003 0.0087 0.021
Plasmodium falciparum lysophospholipase, putative 0.0144 0.2782 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0165 0.0339
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0032 0.0078
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0141 0.27 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0099 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.066 0.1375
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0222 0.0728
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium tuberculosis Possible lysophospholipase 0.0141 0.27 0.2684
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi SPARC precursor 0.0037 0.0249 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi beta-lactamase family protein 0.007 0.1029 0.2145
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.003 0.0079 0.0164
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0079 0.0189
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Brugia malayi Inositol-1 0.0036 0.0222 0.0463
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.066 0.1585
Leishmania major hypothetical protein, conserved 0.0033 0.0157 0.0506
Trypanosoma brucei monoglyceride lipase, putative 0.0141 0.27 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.4162 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0029 0.0047 0.0093
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0718 0.1725
Brugia malayi cytochrome P450 0.0028 0.0021 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0099 0.0238
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0029 0.0047 0.0113
Plasmodium falciparum lysophospholipase, putative 0.0141 0.27 0.9701
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Brugia malayi hypothetical protein 0.0035 0.02 0.0417
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0058 0.0139
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0202 0.4162 1
Plasmodium vivax hypothetical protein, conserved 0.007 0.1029 0.3593
Schistosoma mansoni multidrug resistance protein 0.0033 0.0157 0.0377
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0762 0.2767
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.1291 0.3102
Plasmodium vivax SET domain protein, putative 0.0029 0.0058 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0056 0.0129
Brugia malayi hypothetical protein 0.0029 0.0047 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium ulcerans hypothetical protein 0.007 0.1029 0.3763
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1029 0.2116
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Leishmania major DNA polymerase kappa, putative 0.0039 0.0298 0.1033
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0047 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Echinococcus multilocularis potassium voltage gated channel protein 0.0028 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.0105 0.1858 0.276
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0775 0.2813
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0047 0.0091
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Schistosoma mansoni thyroid hormone receptor 0.0141 0.2699 0.6484
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1889 0.4538
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0157 0.0506
Echinococcus multilocularis follistatin 0.0037 0.0249 0.0598
Loa Loa (eye worm) hypothetical protein 0.0045 0.0437 0.0649
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0058 0.0139
Trypanosoma brucei unspecified product 0.0052 0.0609 0.2195
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0775 0.2813
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1889 0.2806
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.1718 0.4128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.167 0.348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Schistosoma mansoni inositol monophosphatase 0.0036 0.0222 0.0534
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0225 0.0334
Giardia lamblia DINP protein human, muc B family 0.0039 0.0298 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0047 0.007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Onchocerca volvulus Putative organic anion transporter 0.0055 0.066 0.1271
Echinococcus granulosus potassium voltage gated channel protein 0.0103 0.1813 0.4356
Onchocerca volvulus 0.0031 0.0099 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1029 0.2473
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0141 0.27 0.9701
Onchocerca volvulus 0.007 0.1029 0.2039
Brugia malayi follicle stimulating hormone receptor 0.0229 0.4798 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0775 0.1861
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0086
Brugia malayi Thioredoxin reductase 0.0046 0.0463 0.0964
Plasmodium falciparum lysophospholipase, putative 0.0141 0.27 0.9701
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0028 0.0026 0.0063
Toxoplasma gondii sugar transporter ST3 0.0029 0.0047 0.0093
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0036 0.0086
Schistosoma mansoni glucose transport protein 0.0029 0.0047 0.0113
Plasmodium vivax glutathione reductase, putative 0.0046 0.0463 0.1521
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Onchocerca volvulus Putative organic anion transporter 0.0055 0.066 0.1271
Toxoplasma gondii sugar transporter ST2 0.0029 0.0047 0.0093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi hypothetical protein 0.0055 0.066 0.1375
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0029 0.0054 0.008
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0058 0.0139
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1029 0.2145
Plasmodium falciparum lysophospholipase, putative 0.0141 0.27 0.9701
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0762 0.1567
Plasmodium falciparum hexose transporter 0.0029 0.0047 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0222 0.0534
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0099 0.0282
Schistosoma mansoni hypothetical protein 0.0166 0.33 0.7928
Mycobacterium tuberculosis Conserved protein 0.007 0.1029 0.101
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0047 0.0026
Loa Loa (eye worm) inositol-1 0.0036 0.0222 0.033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1869 0.1852
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1029 0.101
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1029 0.101
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Toxoplasma gondii hypothetical protein 0.0144 0.2782 1
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0047 0.0093
Onchocerca volvulus 0.0037 0.0249 0.0419
Onchocerca volvulus 0.0055 0.066 0.1271
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Mycobacterium ulcerans beta-lactamase 0.007 0.1029 0.3763
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.014
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0718 0.1725
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0047 0.0097
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0222 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0224 0.0758
Brugia malayi Sugar transporter family protein 0.0029 0.0047 0.0098
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1889 0.4538
Echinococcus multilocularis agrin 0.0037 0.0249 0.0598
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0139
Echinococcus granulosus voltage dependent calcium channel 0.0094 0.1585 0.3809
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0099 0.0192
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0099 0.0192
Trypanosoma cruzi hexose transporter 0.0029 0.0047 0.0096
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0099 1
Plasmodium falciparum esterase, putative 0.0141 0.27 0.9701
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0132 0.0415
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.066 0.1585
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.2699 0.6484
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0056 0.0129
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0222 0.0643
Plasmodium vivax PST-A protein 0.0141 0.27 0.9701
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0775 0.2729
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0124 0.2297 0.8498
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1869 0.1852
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0766 0.184
Brugia malayi jmjC domain containing protein 0.0057 0.0718 0.1497
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0145 0.0302
Plasmodium falciparum glutathione reductase 0.0046 0.0463 0.1521
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0091 0.1517 0.5582
Schistosoma mansoni follistatin 0.0037 0.0249 0.0598
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1029 0.3763
Loa Loa (eye worm) beta-lactamase 0.007 0.1029 0.1529
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0047 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.4162 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1889 0.6972
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0047 0.0113
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) hypothetical protein 0.0045 0.0437 0.0649
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Schistosoma mansoni agrin 0.0037 0.0249 0.0598
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0056 0.0687 0.1021
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.066 0.1585
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0775 0.0755
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.02 0.0481
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Schistosoma mansoni multidrug resistance protein 0.0031 0.0099 0.0238
Schistosoma mansoni hypothetical protein 0.0166 0.33 0.7928
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0762 0.1832
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis abcb9, putative 0.0031 0.0099 0.0204
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0047 0.0098
Mycobacterium ulcerans hypothetical protein 0.0141 0.27 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0463 0.0687
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1889 0.1871
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0051 0.0574 0.0853
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0058 0.0132
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Leishmania major p-glycoprotein 0.0031 0.0099 0.0291
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.167 0.248
Leishmania major DNA polymerase eta, putative 0.0033 0.0145 0.0461
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0202 0.4162 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Brugia malayi major facilitator superfamily protein 0.0029 0.0047 0.0098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0222 0.0457
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0775 0.2813
Brugia malayi glutathione reductase 0.0046 0.0463 0.0964
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0898 0.3111
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0099 0.0078
Echinococcus granulosus sodium channel protein 0.0091 0.1517 0.3644
Brugia malayi major facilitator superfamily protein 0.0029 0.0047 0.0098
Onchocerca volvulus 0.007 0.1029 0.2039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0145 0.0461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0775 0.2813
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0139
Toxoplasma gondii protease inhibitor PI2 0.0037 0.0249 0.0824
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0099 0.0192
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0094 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2782 0.5717
Schistosoma mansoni hypothetical protein 0.0029 0.0047 0.0113
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1889 0.6972
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0463 0.0687
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0033 0.0157 0.0377
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0898 0.2156
Loa Loa (eye worm) hypothetical protein 0.0311 0.6731 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0047 0.0096
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0252 0.0605
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0775 0.1861
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0766 0.184
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0298 0.1033
Brugia malayi hypothetical protein 0.0029 0.0047 0.0098
Schistosoma mansoni organic anion transporter 0.0055 0.066 0.1585
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Onchocerca volvulus 0.007 0.1029 0.2039
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0028 0.0026 0.0063
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.0437 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi jmjC domain containing protein 0.0057 0.0718 0.1497
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0051 0.0576 0.1384
Loa Loa (eye worm) voltage-dependent calcium channel 0.0094 0.1585 0.2355
Echinococcus granulosus shaker cognate 0.0028 0.0026 0.0063
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1889 0.6736
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Leishmania major hypothetical protein, conserved 0.007 0.1029 0.3763
Plasmodium falciparum esterase, putative 0.0144 0.2782 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Onchocerca volvulus 0.0055 0.066 0.1271
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0762 0.2767
Echinococcus granulosus geminin 0.0166 0.33 0.7928
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0056 0.0687 0.1651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.02 0.0481
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0099 0.0192
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0094 0.0226
Mycobacterium ulcerans lipase LipD 0.007 0.1029 0.3763
Loa Loa (eye worm) hypothetical protein 0.0097 0.167 0.248
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Brugia malayi Carboxylesterase family protein 0.0133 0.2513 0.5237
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0165 0.0339
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0222 0.0457
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1889 0.2806
Trichomonas vaginalis abcb9, putative 0.0031 0.0099 0.0204
Brugia malayi hypothetical protein 0.0119 0.2191 0.4567
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0121 0.2229 0.5355
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Echinococcus granulosus acetylcholinesterase 0.0133 0.2513 0.6037
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 0.1858 0.4463
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0157 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Onchocerca volvulus 0.0029 0.0058 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1869 0.1852
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0145 0.0348
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0047 0.0097
Trichomonas vaginalis set domain proteins, putative 0.0232 0.4865 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1029 0.2473
Echinococcus multilocularis expressed protein 0.0037 0.0249 0.0598
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0091 0.0219
Brugia malayi beta-lactamase family protein 0.007 0.1029 0.2145
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0099 0.0192
Trypanosoma brucei MATE efflux family protein, putative 0.0033 0.0157 0.0506
Leishmania major hypothetical protein, conserved 0.0029 0.0047 0.0096
Trypanosoma cruzi MFS transporter, putative 0.0055 0.066 0.2383
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1029 0.3763
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Schistosoma mansoni cytochrome P450 0.0028 0.0021 0.0051
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0202 0.4162 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1029 0.101
Brugia malayi Pre-SET motif family protein 0.0204 0.4198 0.8748
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.2513 0.6037
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0099 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1029 0.2116
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.4162 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0099 0.0204
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0099 0.0204
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.4162 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0124 0.2297 0.8498
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1029 0.2116
Brugia malayi Cytochrome P450 family protein 0.0028 0.0021 0.0044
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0047 0.0113
Toxoplasma gondii ABC1 family protein 0.007 0.1029 0.3652
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0099 0.0204
Schistosoma mansoni hypothetical protein 0.0028 0.0021 0.0051
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0047 0.0096
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0099 0.0147
Schistosoma mansoni organic anion transporter 0.0055 0.066 0.1585
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Loa Loa (eye worm) carboxylesterase 0.0133 0.2513 0.3733
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Schistosoma mansoni hypothetical protein 0.0123 0.2288 0.5497
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0047 0.0096
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2149 0.2132
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1029 0.2116
Loa Loa (eye worm) hypothetical protein 0.0066 0.094 0.1397
Schistosoma mansoni glucose transporter 0.0029 0.0047 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0145 0.0124
Loa Loa (eye worm) voltage-gated potassium channel 0.0028 0.0026 0.0039
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0099 0.0192
Trypanosoma brucei trypanothione reductase 0.0046 0.0463 0.1648
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1869 0.69
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0145 0.036
Trypanosoma cruzi membrane transporter protein, putative 0.0033 0.0157 0.0506
Plasmodium falciparum thioredoxin reductase 0.0046 0.0463 0.1521
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2103 0.5054
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0775 0.1861
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0762 0.2767
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0047 0.0097
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2149 0.2132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0039
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.066 0.1585
Loa Loa (eye worm) hypothetical protein 0.0133 0.2513 0.3733
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0222 0.0534
Mycobacterium ulcerans lysophospholipase 0.0141 0.27 1
Onchocerca volvulus 0.0055 0.066 0.1271
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1889 0.3882
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0056 0.0687 0.1651
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0047 0.0096
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0099 0.0238
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0079 0.0189
Trypanosoma brucei glucose transporter 2A 0.0029 0.0047 0.0096
Echinococcus granulosus potassium voltage gated channel protein 0.0105 0.1858 0.4463
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus follistatin 0.0037 0.0249 0.0598
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0225 0.0334
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0298 0.0277
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0145 0.0215
Leishmania major glucose transporter, lmgt3 0.0029 0.0047 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trichomonas vaginalis taga, putative 0.0031 0.0099 0.0204
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0898 0.2156
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1869 0.1852
Trypanosoma cruzi monoglyceride lipase, putative 0.0141 0.27 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.0249 0.037
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0047 0.0091
Echinococcus multilocularis geminin 0.0166 0.33 0.7928
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0898 0.3271
Plasmodium vivax hexose transporter 0.0029 0.0047 0.0002
Entamoeba histolytica hypothetical protein 0.0035 0.02 0.0561
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Loa Loa (eye worm) acetylcholinesterase 1 0.0133 0.2513 0.3733
Mycobacterium tuberculosis Conserved protein 0.007 0.1029 0.101
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0047 0.0026
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0047 0.0096
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2149 0.7943
Trichomonas vaginalis esterase, putative 0.007 0.1029 0.2116
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0898 0.2156
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.066 0.2312
Mycobacterium leprae Probable lipase LipE 0.007 0.1029 0.3763
Loa Loa (eye worm) hypothetical protein 0.0072 0.1063 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.27 0.5549
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Trichomonas vaginalis abcb9, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4198 0.6236
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0898 0.1871
Onchocerca volvulus 0.0055 0.066 0.1271
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0147
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0145 0.0348
Mycobacterium tuberculosis Probable reductase 0.0106 0.1869 0.1852
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0099 0.0192
Brugia malayi Cytochrome P450 family protein 0.0036 0.0225 0.0468
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.167 0.348
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Echinococcus granulosus voltage dependent calcium channel 0.0202 0.4162 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0091 0.0219
Brugia malayi phosphofructokinase 0.0106 0.1889 0.3936
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0298 0.1033
Echinococcus multilocularis GPCR, family 2 0.0031 0.0094 0.0226
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0226
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1029 0.3763
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus dna polymerase kappa 0.0059 0.0762 0.1832
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0463 0.1112
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.27 0.5549
Brugia malayi polk-prov protein 0.0036 0.0224 0.0467
Schistosoma mansoni multidrug resistance protein 0.0031 0.0099 0.0238
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1889 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0047 0.0113
Schistosoma mansoni hypothetical protein 0.0035 0.02 0.0481
Echinococcus granulosus agrin 0.0037 0.0249 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0099 0.0238
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0225 0.076
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0463 0.1112
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2103 0.5054
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0117
Echinococcus granulosus acetylcholinesterase 0.0133 0.2513 0.6037
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0249 0.0824
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0099 0.0238
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0775 0.1861
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0225 0.076
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0141 0.27 0.5549
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0047 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0047 0.0096
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0898 0.3271
Echinococcus granulosus voltage gated potassium channel 0.003 0.0079 0.0189
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0028 0.0026 0.0063
Toxoplasma gondii hypothetical protein 0.0072 0.1063 0.3774
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1889 0.4538
Mycobacterium tuberculosis Conserved protein 0.007 0.1029 0.101
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0021 0.0032
Schistosoma mansoni lipoxygenase 0.0081 0.1279 0.3074
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0898 0.1333
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.4162 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0202 0.4162 0.8674
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0047 0.0113
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.037
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1889 0.6972
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0094 0.0226
Echinococcus granulosus carboxylesterase 5A 0.0133 0.2513 0.6037
Schistosoma mansoni glucose transport protein 0.0029 0.0047 0.0113
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0762 0.1567
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1029 0.2116
Leishmania major monoglyceride lipase, putative 0.0141 0.27 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Echinococcus granulosus voltage gated potassium channel 0.0028 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.007 0.1029 0.1529
Schistosoma mansoni voltage-gated cation channel 0.0202 0.4162 1
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.0026 0.0063
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0463 0.1648
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0028 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0097
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0047 0.0113
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0718 0.1725
Schistosoma mansoni DNA polymerase eta 0.0033 0.0145 0.0348
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2149 0.2132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0139
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0249 0.0518
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0047 0.0096
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0222 1
Brugia malayi hypothetical protein 0.0029 0.0047 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0718 0.1725
Loa Loa (eye worm) sugar transporter 0.0029 0.0047 0.007
Onchocerca volvulus Putative organic anion transporter 0.0055 0.066 0.1271
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1869 0.1852
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Schistosoma mansoni vesicular amine transporter 0.0028 0.0026 0.0063
Schistosoma mansoni lipoxygenase 0.0115 0.2103 0.5054
Brugia malayi Pre-SET motif family protein 0.0029 0.0058 0.0121
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.066 0.098
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1889 0.2806
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0047 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0105 0.1858 0.3872
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Brugia malayi beta-lactamase 0.007 0.1029 0.2145
Schistosoma mansoni thyroid hormone receptor 0.0141 0.2699 0.6484
Echinococcus granulosus solute carrier family 22 0.0029 0.0047 0.0113
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0094 0.0196
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2288 0.5497
Brugia malayi hypothetical protein 0.0055 0.066 0.1375
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0099 0.0238
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0079 0.0189
Schistosoma mansoni voltage-gated potassium channel 0.0105 0.1858 0.4463
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0145 0.0348
Loa Loa (eye worm) hypothetical protein 0.0202 0.4162 0.6183
Echinococcus multilocularis solute carrier family 22 0.0029 0.0047 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0224 0.0758
Echinococcus multilocularis carboxylesterase 5A 0.0133 0.2513 0.6037
Toxoplasma gondii sugar transporter ST1 0.0029 0.0047 0.0093
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.02 0.0481
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0609 0.2195
Brugia malayi multidrug resistance protein 3 0.0031 0.0099 0.0207
Echinococcus multilocularis transfer RNA-Gly 0.0028 0.0026 0.0063
Trypanosoma brucei sugar transporter, putative 0.0029 0.0047 0.0096
Brugia malayi prostaglandin transporter 0.0055 0.066 0.1375
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1029 0.101
Echinococcus multilocularis shaker cognate 0.0028 0.0026 0.0063
Schistosoma mansoni glucose transport protein 0.0029 0.0047 0.0113
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0099 0.0204
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0898 0.3271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Echinococcus multilocularis dna polymerase eta 0.0033 0.0145 0.0348
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0047 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0762 0.2767
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0145 0.0461
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0463 0.0442
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0047 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0189
Leishmania major glucose transporter/membrane transporter D2, putative 0.0029 0.0047 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0157 0.0506
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0026 0.0063
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0028 0.0026 0.0055
Brugia malayi Cytochrome P450 family protein 0.0036 0.0225 0.0468
Echinococcus multilocularis acetylcholinesterase 0.0133 0.2513 0.6037
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0463 0.1521
Leishmania major hypothetical protein, conserved 0.0033 0.0157 0.0506
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1889 0.6736
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.4162 1
Loa Loa (eye worm) sugar transporter 0.0029 0.0047 0.007
Schistosoma mansoni hypothetical protein 0.0066 0.094 0.2259
Onchocerca volvulus 0.0232 0.4865 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0099 0.0192
Brugia malayi 6-phosphofructokinase 0.0107 0.1897 0.3953
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0898 0.3271
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0033 0.0157 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0047 0.0097
Trypanosoma brucei glucose transporter, putative 0.0029 0.0047 0.0096
Mycobacterium ulcerans sugar transporter 0.0029 0.0047 0.0096
Leishmania major cytochrome p450-like protein 0.0036 0.0225 0.076
Echinococcus granulosus GPCR family 2 0.0031 0.0094 0.0226
Brugia malayi Cytochrome P450 family protein 0.0028 0.0021 0.0044
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0099 0.0147
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0132 0.0111
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0202 0.4162 1
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0225 0.076
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2288 0.5497
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0225 0.0334
Schistosoma mansoni sugar transporter 0.0029 0.0047 0.0113
Brugia malayi Carboxylesterase family protein 0.0133 0.2513 0.5237
Schistosoma mansoni inositol monophosphatase 0.0036 0.0222 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.27 0.5549
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0047 0.0096
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0047 0.0098

Activities

Activity type Activity value Assay description Source Reference
Cytotoxicity (functional) > 100 Cytotoxic effect on Vero cells was determined in mock infected cell monolayers incubated with the compound for 48 h at 37 degree celsius. ChEMBL. 2153201
ID50 (functional) > 100 ug ml-1 Antiherpes activity was measured in a plaque reduction assay in Vero cells, against HSV-1 strain KOS. ChEMBL. 2153201
ID50 (functional) > 100 ug ml-1 Antiherpes activity was measured in a plaque reduction assay in Vero cells, against HSV-2 strain 186. ChEMBL. 2153201

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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