Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0025 | 0.1527 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0311 | 0.1028 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.3077 | 0.3077 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0043 | 0.3077 | 0.3077 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0311 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.2492 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0311 | 0.1145 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0025 | 0.1527 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0123 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0025 | 0.1527 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.2715 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.3026 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0025 | 0.1527 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.1527 | 0.1527 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0025 | 0.1527 | 0.5626 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0025 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0025 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0025 | 0.1527 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0311 | 0.0311 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0311 | 0.1145 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0025 | 0.1527 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2268 | 0.2268 |
Loa Loa (eye worm) | cytochrome P450 | 0.0025 | 0.1527 | 0.1527 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.1527 | 0.5048 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0025 | 0.1527 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0043 | 0.3077 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0025 | 0.1527 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.2492 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0025 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0025 | 0.1527 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.3026 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0025 | 0.1527 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.2715 | 0.2715 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0025 | 0.1527 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.2715 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0025 | 0.1527 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0025 | 0.1527 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.3077 | 0.3077 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.088 | 0.088 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0025 | 0.1527 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0311 | 0.1145 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0043 | 0.3077 | 1 |
Brugia malayi | cytochrome P450 | 0.0025 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0043 | 0.3077 | 0.3077 |
Mycobacterium leprae | putative cytochrome p450 | 0.0025 | 0.1527 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0043 | 0.3077 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.2715 | 0.2715 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0311 | 0.1028 |
Trypanosoma brucei | cytochrome P450, putative | 0.0043 | 0.3077 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0025 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0025 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0025 | 0.1527 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0043 | 0.3077 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0025 | 0.1527 | 0.5048 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0043 | 0.3077 | 0.3077 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0311 | 0.0311 |
Echinococcus multilocularis | 0.0025 | 0.1527 | 0.5626 | |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0025 | 0.1527 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0025 | 0.1527 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.