Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thymidylate synthase | 0.0457 | 0.2293 | 0.1634 |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.0424 | 0.0424 |
Brugia malayi | N-terminal motif family protein | 0.0178 | 0.0709 | 0.0709 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1265 | 0.6884 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0117 | 0.0364 | 0.0364 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0457 | 0.2293 | 0.2293 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1265 | 0.6884 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1814 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0064 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | thymidylate synthase | 0.0457 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0065 | 0.0065 |
Brugia malayi | hypothetical protein | 0.0217 | 0.0934 | 0.0934 |
Onchocerca volvulus | 0.0075 | 0.0125 | 0.0545 | |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0709 | 0.0709 |
Echinococcus multilocularis | thymidylate synthase | 0.0457 | 0.2293 | 0.1634 |
Mycobacterium ulcerans | thymidylate synthase | 0.0457 | 0.2293 | 0.2243 |
Onchocerca volvulus | Matrilysin homolog | 0.0117 | 0.0364 | 0.1587 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0457 | 0.2293 | 0.2243 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0457 | 0.2293 | 0.2243 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0217 | 0.0934 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1265 | 0.6884 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0178 | 0.0709 | 0.3092 |
Schistosoma mansoni | dihydrofolate reductase | 0.1814 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1265 | 0.6884 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0117 | 0.0364 | 0.1587 |
Brugia malayi | thymidylate synthase | 0.0457 | 0.2293 | 0.2293 |
Brugia malayi | Matrixin family protein | 0.0127 | 0.0424 | 0.0424 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1265 | 0.6884 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0217 | 0.0934 | 0.0875 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1265 | 0.6884 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1814 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1814 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1814 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1814 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0125 | 0.0125 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1814 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1814 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1814 | 1 | 0.5 |
Onchocerca volvulus | 0.0457 | 0.2293 | 1 | |
Brugia malayi | Hemopexin family protein | 0.0075 | 0.0125 | 0.0125 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM l-1 | Inhibition of human neutrophil collagenase [Matrix Metalloproteinase-8, MMP-8] | ChEMBL. | 10354399 |
IC50 (binding) | = 10 nM l-1 | Inhibition of human neutrophil collagenase [Matrix Metalloproteinase-8, MMP-8] | ChEMBL. | 10354399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.