Detailed information for compound 82169

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 397.3 | Formula: C21H18Cl2N4
  • H donors: 0 H acceptors: 1 LogP: 3.56 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C=C/1\c2ccc(cc2C(=Nc2c1ccc(c2)Cl)N1CCN(CC1)C)Cl
  • InChi: 1S/C21H18Cl2N4/c1-26-8-10-27(11-9-26)21-19-12-14(22)2-4-16(19)17(6-7-24)18-5-3-15(23)13-20(18)25-21/h2-6,12-13H,8-11H2,1H3/b17-6+
  • InChiKey: ZAWDLOTYWSLZKT-UBKPWBPPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Schistosoma mansoni organic anion transporter 0.0027 0.0238 0.0327
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0029
Brugia malayi 6-phosphofructokinase 0.0106 0.1245 0.1743
Brugia malayi Cathepsin L-like precursor 0.0016 0.0095 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.002 0.002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0095 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0095 0.0568
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0095 0.0126
Brugia malayi hypothetical protein 0.0019 0.0125 0.0168
Echinococcus granulosus cathepsin l1 0.0016 0.0095 0.0133
Onchocerca volvulus 0.0016 0.0095 0.0126
Leishmania major cathepsin L-like protease 0.0062 0.0681 0.5385
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0153 0.1034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0153 0.1051
Onchocerca volvulus 0.0016 0.0095 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Schistosoma mansoni hypothetical protein 0.0165 0.1999 0.2803
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0139 0.0188
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0027 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0463
Echinococcus multilocularis cysteine protease 0.0016 0.0095 0.0095
Brugia malayi ABC transporter family protein 0.0016 0.0097 0.0129
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1241 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0139 0.0188
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0066 0.0085
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0139 0.0188
Onchocerca volvulus 0.0027 0.0238 0.0327
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.203
Onchocerca volvulus 0.0016 0.0097 0.0129
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.1005
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0125 0.0168
Loa Loa (eye worm) ctsf protein 0.0016 0.0095 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0097 0.0784
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0238 0.0327
Plasmodium vivax multidrug resistance protein 1, putative 0.0016 0.0097 0.1176
Brugia malayi nuclear receptor NHR-88 0.002 0.0139 0.0188
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0125 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0139 0.0188
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0335 0.0894
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0139 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.1005
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0095 0.0133
Echinococcus granulosus lamin dm0 0.0026 0.0222 0.0312
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0153 0.3311
Brugia malayi nuclear receptor RXR 0.001 0.002 0.002
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0335 0.047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0335 0.0463
Leishmania major hypothetical protein, conserved 0.0035 0.0335 0.2529
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0335 0.0894
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0095 0.0126
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0252 0.1863
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0005 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0139 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0139 0.0195
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0153 0.1034
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0097 0.0137
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0095 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Brugia malayi ecdysteroid receptor 0.002 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Loa Loa (eye worm) hypothetical protein 0.0564 0.7119 1
Schistosoma mansoni lamin 0.0026 0.0222 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0139 0.0188
Onchocerca volvulus 0.0035 0.0335 0.0463
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0125 0.0175
Brugia malayi Sodium Bile acid symporter family protein 0.0564 0.7119 1
Onchocerca volvulus 0.0027 0.0238 0.0327
Trichomonas vaginalis ABC transporter, putative 0.0016 0.0097 0.0784
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.002 0.002
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1241 0.1738
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0097 0.0097
Echinococcus granulosus cathepsin l1 0.0011 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0463
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.002 0.002
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0126 0.017
Entamoeba histolytica hypothetical protein 0.0019 0.0125 0.0817
Onchocerca volvulus 0.0027 0.0238 0.0327
Trichomonas vaginalis ABC transporter, putative 0.0016 0.0097 0.0784
Brugia malayi hypothetical protein 0.0027 0.0238 0.0327
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0222 0.0305
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.002 0.002
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0125 0.0125
Schistosoma mansoni multidrug resistance protein 0.0021 0.0153 0.0208
Echinococcus multilocularis cysteine protease 0.0016 0.0095 0.0095
Brugia malayi Cathepsin L-like precursor 0.0011 0.0026 0.0029
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Echinococcus multilocularis musashi 0.0026 0.0222 0.0222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0139 0.0195
Trichomonas vaginalis abcb9, putative 0.0016 0.0097 0.0784
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0139 0.0188
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1241 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0139 0.0188
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0335 0.0894
Brugia malayi intermediate filament protein 0.0026 0.0222 0.0305
Leishmania major p-glycoprotein 0.0016 0.0097 0.0572
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0016 0.0094 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0126 0.017
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0431 0.5409 0.7596
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0139 0.0188
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0097 0.0137
Giardia lamblia MRP-like ABC transporter 0.0021 0.0153 0.0344
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.203
Onchocerca volvulus 0.0027 0.0238 0.0327
Echinococcus multilocularis lamin dm0 0.0026 0.0222 0.0222
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0252 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.012 0.1587
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0066 0.0085
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0016 0.0097 0.1245
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0335 0.2529
Schistosoma mansoni agrin 0.0019 0.0126 0.017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0095 0.0095
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0125 0.0125
Trypanosoma cruzi hypothetical protein 0.0013 0.0053 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Brugia malayi phosphofructokinase 0.0106 0.1241 0.1738
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0139 0.0188
Brugia malayi Cathepsin L-like precursor 0.0016 0.0095 0.0126
Onchocerca volvulus 0.0035 0.0335 0.0463
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 0.0894
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0335 0.2697
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0095 0.0549
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0126 0.2313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0139 0.0188
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1241 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0168
Loa Loa (eye worm) multidrug resistance-associated protein 0.0013 0.0056 0.0071
Echinococcus multilocularis lamin 0.0026 0.0222 0.0222
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0126 0.017
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0612 0.4816
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0139 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0126 0.2313
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0153 0.0344
Brugia malayi 6-phosphofructokinase 0.0106 0.1241 0.1738
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0305
Echinococcus granulosus bloom syndrome protein 0.0021 0.0152 0.0213
Schistosoma mansoni sodium-bile acid cotransporter related 0.0326 0.4066 0.5709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Echinococcus multilocularis sodium bile acid cotransporter 0.0564 0.7119 0.7119
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0153 0.0153
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.1005
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0139 0.0188
Echinococcus granulosus multidrug resistance associated protein 4 0.0013 0.0053 0.0074
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0463
Echinococcus granulosus Solute carrier organic anion transporter family 0.0027 0.0238 0.0334
Schistosoma mansoni multidrug resistance protein 0.0016 0.0097 0.0129
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0252 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0125 0.0175
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0139 0.0139
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0097 0.0097
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0153 0.1034
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0139 0.0195
Entamoeba histolytica hypothetical protein 0.0021 0.0153 0.1051
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0153 0.1051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0296
Trichomonas vaginalis ABC transporter, putative 0.0016 0.0097 0.0784
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0252 0.6947
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0126
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0252 1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0252 0.6947
Leishmania major cathepsin L-like protease 0.0016 0.0095 0.0549
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0238 0.0327
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0335 0.0463
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0095 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0168
Toxoplasma gondii ABC1 family protein 0.0035 0.0335 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0095 0.0126
Onchocerca volvulus 0.0035 0.0335 0.0463
Schistosoma mansoni multidrug resistance protein 0.0016 0.0097 0.0129
Onchocerca volvulus 0.0019 0.0126 0.017
Echinococcus multilocularis geminin 0.0165 0.1999 0.1999
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0168
Onchocerca volvulus 0.0027 0.0238 0.0327
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Entamoeba histolytica P-glycoprotein-2 0.0016 0.0097 0.0591
Leishmania major pentamidine resistance protein 1 0.0021 0.0153 0.1034
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0125 0.0168
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0016 0.0097 0.0572
Toxoplasma gondii cathepsin CPL 0.0016 0.0095 0.1143
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0096 0.0127
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0125 0.0168
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0028 0.0225
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0463
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0252 0.6947
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0125 0.0125
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0048 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0681 0.5385
Leishmania major cathepsin L-like protease 0.0016 0.0095 0.0549
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0335 0.2697
Leishmania major cathepsin L-like protease 0.0016 0.0095 0.0549
Onchocerca volvulus 0.0564 0.7119 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0335 0.2529
Trichomonas vaginalis esterase, putative 0.0035 0.0335 0.2697
Brugia malayi beta-lactamase family protein 0.0035 0.0335 0.0463
Trypanosoma cruzi MFS transporter, putative 0.0027 0.0238 0.1732
Entamoeba histolytica hypothetical protein 0.0019 0.0125 0.0817
Schistosoma mansoni coup transcription factor 0.002 0.0139 0.0188
Entamoeba histolytica P-glycoprotein-2, putative 0.0016 0.0097 0.0591
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0153 0.0208
Onchocerca volvulus 0.002 0.0139 0.0188
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0153 0.1034
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0125 0.0175
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1241 0.1738
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0126 0.017
Brugia malayi steroid hormone receptor 0.002 0.0139 0.0188
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Plasmodium vivax vivapain-2 0.0016 0.0095 0.1073
Onchocerca volvulus 0.0026 0.0222 0.0305
Loa Loa (eye worm) multidrug resistance protein 3 0.0016 0.0097 0.0129
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0126 0.2313
Brugia malayi Cathepsin L-like precursor 0.0016 0.0095 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0139 0.0188
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0125 0.0125
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0005 0.0005
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0125 0.0168
Plasmodium vivax vivapain-2 0.0016 0.0095 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.1005
Echinococcus multilocularis follistatin 0.0019 0.0126 0.0126
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0139 0.0188
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0095 0.0095
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1241 0.1738
Leishmania major p-glycoprotein e 0.0021 0.0153 0.1034
Brugia malayi multidrug resistance protein 3 0.0016 0.0097 0.0129
Loa Loa (eye worm) hypothetical protein 0.0016 0.0094 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Loa Loa (eye worm) cysteine protease 0.0016 0.0095 0.0126
Brugia malayi cathepsin L-like precursor 0.0011 0.0026 0.0029
Entamoeba histolytica P-glycoprotein-5 0.0016 0.0097 0.0591
Brugia malayi beta-lactamase 0.0035 0.0335 0.0463
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0153 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0139 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0139 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0153 0.1034
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0097 0.0137
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0139 0.0139
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0095 0.0549
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0097 0.0784
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0252 0.203
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0125 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0139 0.0188
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0139 0.0188
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0016 0.0097 0.1245
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1241 1
Leishmania major cathepsin L-like protease 0.0062 0.0681 0.5385
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0168
Onchocerca volvulus Phospholipase A2 homolog 0.0091 0.1048 0.1467
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0681 0.5385
Entamoeba histolytica hypothetical protein 0.0019 0.0125 0.0817
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0335 0.2697
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0139 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0027 0.0238 0.0334
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.1005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Loa Loa (eye worm) hypothetical protein 0.0019 0.0126 0.017
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0252 0.6923
Onchocerca volvulus 0.0026 0.0222 0.0305
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0222 0.0305
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0026 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0168
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0153 0.1034
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0125 0.0168
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0238 0.0327
Schistosoma mansoni multidrug resistance protein 0.0016 0.0097 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.203
Brugia malayi SPARC precursor 0.0019 0.0126 0.017
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0681 0.5385
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0125 0.0175
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0126 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0139 0.0188
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0005 0.0007
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1241 0.1241
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0238 0.0327
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0125 0.0175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0168
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0016 0.0097 0.0129
Schistosoma mansoni multidrug resistance protein 0.0021 0.0153 0.0208
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0168
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0152 0.1223
Trypanosoma brucei multidrug resistance protein E 0.0021 0.0153 0.1034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0335 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0203
Loa Loa (eye worm) fibroinase 0.0016 0.0095 0.0126
Giardia lamblia ABC transporter, putative 0.0021 0.0153 0.0344
Entamoeba histolytica ABC transporter, putative 0.0021 0.0153 0.1051
Brugia malayi Cathepsin L-like precursor 0.0016 0.0095 0.0126
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0335 0.0894
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0153 0.1051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0139 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1241 0.1744
Loa Loa (eye worm) hypothetical protein 0.0016 0.0097 0.0129
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0463
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0139 0.0139
Onchocerca volvulus 0.0016 0.0095 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0026 0.0206
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.1005
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0125 0.0125
Onchocerca volvulus 0.0016 0.0095 0.0126
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0027 0.0238 0.0327
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0125 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Echinococcus multilocularis expressed protein 0.0019 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0097 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Toxoplasma gondii transporter, major facilitator family protein 0.0027 0.0238 0.6434
Trichomonas vaginalis abcb9, putative 0.0016 0.0097 0.0784
Echinococcus granulosus FTZ F1 alpha 0.002 0.0139 0.0195
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0097 0.0137
Schistosoma mansoni sodium-bile acid cotransporter 0.0238 0.2938 0.4123
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0125 0.0168
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1241 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0126 0.017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0139 0.0188
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0335 0.0894
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1241 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0005 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0511 0.3982
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0029
Leishmania major cathepsin L-like protease 0.0016 0.0095 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0125 0.0175
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0095 0.0568
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0125 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0125 0.0168
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0153 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1241 1
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.0097 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0139 0.0188
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0097 0.0784
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0153 0.0215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0335 0.0463
Brugia malayi PXA domain containing protein 0.0019 0.0125 0.0168
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0222 0.0305
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0153 0.1051
Brugia malayi Cathepsin L-like precursor 0.0011 0.0026 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0139 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0125 0.0168
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Echinococcus granulosus intermediate filament protein 0.0026 0.0222 0.0312
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0152 0.0206
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0095 0.0095
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0125 0.0168
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1241 0.1738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0125 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0139 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Schistosoma mansoni multidrug resistance protein 0.0021 0.0153 0.0208
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0005 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0139 0.0195
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0005 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0026 0.0206
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0095 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Echinococcus multilocularis agrin 0.0019 0.0126 0.0126
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0126 0.2313
Onchocerca volvulus 0.0016 0.0095 0.0126
Trichomonas vaginalis taga, putative 0.0016 0.0097 0.0784
Entamoeba histolytica P-glycoprotein-2 0.0016 0.0097 0.0591
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0028 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0139 0.0195
Onchocerca volvulus 0.0016 0.0095 0.0126
Brugia malayi Cathepsin L-like precursor 0.0016 0.0095 0.0126
Loa Loa (eye worm) RecQ helicase 0.0021 0.0152 0.0206
Trichomonas vaginalis ABC transporter, putative 0.0016 0.0097 0.0784
Schistosoma mansoni thyroid hormone receptor 0.002 0.0139 0.0188
Brugia malayi Cathepsin L-like precursor 0.0016 0.0095 0.0126
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0005 0.0007
Schistosoma mansoni sodium-bile acid cotransporter related 0.0564 0.7119 1
Onchocerca volvulus 0.0011 0.0026 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0139 0.0188
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0238 0.0327
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0125 0.0168
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0095 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Brugia malayi Phospholipase A2 family protein 0.0091 0.1048 0.1467
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0208
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0095 0.0762
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0139 0.0188
Echinococcus granulosus follistatin 0.0019 0.0126 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0139 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0335 0.2697
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0139 0.0188
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Leishmania major ABC-thiol transporter 0.0021 0.0153 0.1034
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0125 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0125 0.0175
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0208
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0681 0.5385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Echinococcus granulosus sodium bile acid cotransporter 0.0564 0.7119 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0335 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1241 0.4305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.013
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0153 0.0215
Schistosoma mansoni thyroid hormone receptor 0.002 0.0139 0.0188
Schistosoma mansoni hypothetical protein 0.0165 0.1999 0.2803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0029
Brugia malayi hypothetical protein 0.001 0.002 0.002
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0005 0.0005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Entamoeba histolytica P-glycoprotein-1 0.0016 0.0097 0.0591
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0252 0.6923
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0126 0.017
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0097 0.0784
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 0.0894
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0126 0.017
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0095 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0125 0.0168
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0125 0.0168
Brugia malayi multidrug resistance related protein 1 0.0021 0.0153 0.0208
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0048 0.0048
Trypanosoma brucei p-glycoprotein 0.0021 0.0153 0.1034
Onchocerca volvulus Phospholipase A2 homolog 0.0431 0.5409 0.7596
Brugia malayi beta-lactamase family protein 0.0035 0.0335 0.0463
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0139 0.0195
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0153 0.1034
Leishmania major cathepsin L-like protease 0.0016 0.0095 0.0549
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0153 0.1034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0463
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0125 0.0125
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1241 0.1738
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0139 0.0188
Brugia malayi nuclear hormone receptor 0.002 0.0139 0.0188
Schistosoma mansoni organic anion transporter 0.0027 0.0238 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0139 0.0188
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0125 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0152 0.0152
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0335 0.2697
Schistosoma mansoni lamin 0.0026 0.0222 0.0305
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0016 0.0097 0.0784
Echinococcus multilocularis expressed protein 0.0363 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0327
Onchocerca volvulus 0.0016 0.0095 0.0126
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0153 0.1051
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0568
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.006
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0168
Brugia malayi hypothetical protein 0.0027 0.0238 0.0327
Plasmodium falciparum multidrug resistance protein 1 0.0016 0.0097 0.0175
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0125 0.0125
Trichomonas vaginalis abcb9, putative 0.0016 0.0097 0.0784
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0097 0.0097
Echinococcus multilocularis sodium bile acid cotransporter 0.0564 0.7119 0.7119
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0139 0.0139
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0005 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0335 0.0335
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0097 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.002 0.002
Echinococcus granulosus agrin 0.0019 0.0126 0.0177
Schistosoma mansoni smdr2 0.0016 0.0097 0.0129
Brugia malayi hypothetical protein 0.0019 0.0125 0.0168
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0139 0.0188
Echinococcus granulosus lamin 0.0026 0.0222 0.0312
Entamoeba histolytica P-glyco protein 6, putative 0.0016 0.0097 0.0591
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0126 0.017
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Echinococcus granulosus sodium bile acid cotransporter 0.0564 0.7119 1
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0126 0.017
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1241 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0027 0.0238 0.0238
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0026 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0139 0.0188
Echinococcus granulosus expressed protein 0.0363 0.4541 0.6379
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.002 0.0028
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1241 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0335 1
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0126 0.2313
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0125 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1241 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0097 0.0784
Entamoeba histolytica P-glycoprotein 5, putative 0.0016 0.0097 0.0591
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0097 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0125 0.0168
Brugia malayi hypothetical protein 0.001 0.002 0.002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0095 0.0126
Echinococcus multilocularis sodium bile acid cotransporter 0.0564 0.7119 0.7119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0097 0.0784
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0335 0.0463
Schistosoma mansoni intermediate filament proteins 0.0026 0.0222 0.0305
Echinococcus multilocularis ATP binding cassette sub family B 0.0016 0.0094 0.0094
Echinococcus granulosus geminin 0.0165 0.1999 0.2808
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0005 0.0005
Schistosoma mansoni follistatin 0.0019 0.0126 0.017
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0125 0.0175
Brugia malayi PXA domain containing protein 0.0019 0.0125 0.0168
Leishmania major cathepsin L-like protease 0.0062 0.0681 0.5385
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0016 0.0097 0.0784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0681 0.5385
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1241 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0095 0.0762
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0139 0.0188
Brugia malayi prostaglandin transporter 0.0027 0.0238 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0335 0.2529
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0016 0.0097 0.0784
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0125 0.0168
Loa Loa (eye worm) beta-lactamase 0.0035 0.0335 0.0463
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0125 0.0168
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.1048 0.1467
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0125 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0762
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0097 0.0137
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0153 0.0153
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0238 0.0327
Echinococcus multilocularis multidrug resistance associated protein 4 0.0013 0.0053 0.0053
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0252 1
Schistosoma mansoni multidrug resistance protein 0.0021 0.0153 0.0208
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0188
Trypanosoma cruzi multidrug resistance protein E, putative 0.0021 0.0153 0.1034
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0152 0.1223
Echinococcus granulosus sodium bile acid cotransporter 0.0564 0.7119 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0005 0.0007
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.0097 0.0097

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) ~ 1 mg kg-1 Sedative activity in mice ChEMBL. 2876098
ED50 (functional) ~ 1 mg kg-1 Sedative activity in mice ChEMBL. 2876098
ED50 (functional) > 10 mg kg-1 Anticholinergic activity in mice. ChEMBL. 2876098
ED50 (functional) > 10 mg kg-1 Anticholinergic activity in mice. ChEMBL. 2876098
Relative activity (functional) < 1.4 Anticholinergic activity relative with respect to clozapine. ChEMBL. 2876098
Relative activity (functional) = 4.74 Sedative activity relative with respect to clozapine. ChEMBL. 2876098

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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