Detailed information for compound 821819

Basic information

Technical information
  • TDR Targets ID: 821819
  • Name: 4-[(4Z)-4-[[3-methoxy-4-(phenylmethoxy)phenyl ]methylidene]-3-methyl-5-oxopyrazol-1-yl]benz enesulfonamide
  • MW: 477.532 | Formula: C25H23N3O5S
  • H donors: 1 H acceptors: 3 LogP: 3.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OCc1ccccc1)C=C1C(=NN(C1=O)c1ccc(cc1)S(=O)(=O)N)C
  • InChi: 1S/C25H23N3O5S/c1-17-22(25(29)28(27-17)20-9-11-21(12-10-20)34(26,30)31)14-19-8-13-23(24(15-19)32-2)33-16-18-6-4-3-5-7-18/h3-15H,16H2,1-2H3,(H2,26,30,31)/b22-14-
  • InChiKey: QIBSFCIGMLOVRE-HMAPJEAMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4Z)-4-[[3-methoxy-4-(phenylmethoxy)phenyl]methylene]-3-methyl-5-oxo-pyrazol-1-yl]benzenesulfonamide
  • 4-[(4Z)-4-[[3-methoxy-4-(phenylmethoxy)phenyl]methylene]-3-methyl-5-oxo-1-pyrazolyl]benzenesulfonamide
  • 4-[(4Z)-4-[4-(benzyloxy)-3-methoxy-benzylidene]-5-keto-3-methyl-pyrazol-1-yl]benzenesulfonamide
  • 4-[(4Z)-4-[[3-methoxy-4-(phenylmethoxy)phenyl]methylidene]-3-methyl-5-oxo-pyrazol-1-yl]benzenesulfonamide
  • BIM-0007057.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0576 0.0576
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0024 0.0052
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.044 0.1933
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0228 0.099
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0158 0.2236 1
Schistosoma mansoni tar DNA-binding protein 0.02 0.2846 0.2846
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0228 0.0999
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0283 0.2475
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.3392 0.8055
Echinococcus multilocularis smad 0.0016 0.0134 0.0134
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0132 0.0637
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0002 0.0002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0189 0.0813
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.001 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0576 0.1365
Entamoeba histolytica hypothetical protein 0.0071 0.0937 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0283 0.1244
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.044 0.195
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.026 0.1133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0576 0.1365
Schistosoma mansoni cpg binding protein 0.003 0.034 0.034
Schistosoma mansoni microtubule-associated protein tau 0.0684 1 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.044 0.195
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0134 0.0134
Schistosoma mansoni smad 0.0007 0.0002 0.0002
Loa Loa (eye worm) carboxylesterase 0.0292 0.421 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0021 0.0069
Schistosoma mansoni Smad4 0.0007 0.0002 0.0002
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0158 0.2236 1
Echinococcus multilocularis neuroligin 0.0049 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0008 0.0013
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0228 0.0228
Mycobacterium ulcerans carboxylesterase, LipT 0.0049 0.0625 0.2769
Brugia malayi TAR-binding protein 0.02 0.2846 0.6758
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0199 0.085
Onchocerca volvulus 0.0043 0.053 0.8481
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0023 0.0228 0.098
Echinococcus multilocularis tar DNA binding protein 0.02 0.2846 0.2846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0576 0.0576
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0008 0.0008 0.001
Schistosoma mansoni Smad4 0.0016 0.0134 0.0134
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.026 0.1142
Loa Loa (eye worm) hypothetical protein 0.0041 0.0508 0.1202
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0228 0.0999
Brugia malayi Methyltransferase-like protein 4 0.0007 0.0005 0.0008
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0283 0.1235
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0283 0.1244
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0283 0.1244
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0049 0.0625 0.0625
Brugia malayi MH2 domain containing protein 0.0016 0.0134 0.0313
Echinococcus granulosus neuroligin 0.0049 0.0625 0.0625
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0788 0.0788
Echinococcus multilocularis acetylcholinesterase 0.0292 0.421 0.421
Schistosoma mansoni tar DNA-binding protein 0.02 0.2846 0.2846
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0937 0.0937
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0228 0.0999
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0316 0.0746
Echinococcus granulosus Smad4 0.0016 0.0134 0.0134
Mycobacterium tuberculosis Probable aminotransferase 0.0158 0.2236 1
Echinococcus granulosus geminin 0.0341 0.4926 0.4926
Echinococcus multilocularis acetylcholinesterase 0.0292 0.421 0.421
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0016 0.0134 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0576 0.0576
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0063 0.0145
Brugia malayi hypothetical protein 0.0049 0.0625 0.1479
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0137 0.0579
Schistosoma mansoni cpg binding protein 0.0028 0.0316 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.09 0.4003
Brugia malayi Carboxylesterase family protein 0.0049 0.0625 0.1479
Brugia malayi Carboxylesterase family protein 0.0049 0.0625 0.1479
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0692 0.7471
Brugia malayi RNA recognition motif domain containing protein 0.02 0.2846 0.6758
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.026 0.1123
Echinococcus granulosus cpg binding protein 0.003 0.034 0.034
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0283 0.1225
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0283 0.1225
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0189 0.0813
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0158 0.2236 1
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0228 0.0228
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0228 0.5
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0228 0.099
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0228 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0292 0.421 0.421
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.09 0.4003
Onchocerca volvulus 0.0049 0.0625 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0576 0.0576
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0228 0.099
Schistosoma mansoni Smad4 0.0007 0.0002 0.0002
Trichomonas vaginalis spcc417.12 protein, putative 0.0049 0.0625 0.2776
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0228 0.099
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0236 0.0556
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0283 0.1225
Schistosoma mansoni hypothetical protein 0.0341 0.4926 0.4926
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0023 0.0228 0.098
Echinococcus granulosus para nitrobenzyl esterase 0.0049 0.0625 0.0625
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0236 0.1035
Schistosoma mansoni tar DNA-binding protein 0.02 0.2846 0.2846
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.006
Brugia malayi Smad1 0.0016 0.0134 0.0313
Loa Loa (eye worm) RNA binding protein 0.02 0.2846 0.6758
Schistosoma mansoni acetylcholinesterase 0.0049 0.0625 0.0625
Schistosoma mansoni smad1 5 8 and 0.0016 0.0134 0.0134
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0002 0.0002
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0228 0.0228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0576 0.0576
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0292 0.421 0.421
Loa Loa (eye worm) TAR-binding protein 0.02 0.2846 0.6758
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0249 0.1092
Loa Loa (eye worm) hypothetical protein 0.0292 0.421 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0189 0.0803
Echinococcus granulosus smad 0.0016 0.0134 0.0134
Mycobacterium ulcerans polyketide synthase 0.0025 0.026 0.1133
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0049 0.0625 0.2776
Loa Loa (eye worm) carboxylesterase 0.0049 0.0625 0.1479
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.006
Schistosoma mansoni hypothetical protein 0.0341 0.4926 0.4926
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.09 0.09
Schistosoma mansoni smad 0.0016 0.0134 0.0134
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0134 0.0313
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.09 0.09
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0576 0.0576
Onchocerca volvulus 0.0049 0.0625 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0049 0.0625 0.0625
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0228 0.099
Schistosoma mansoni smad1 5 8 and 0.0016 0.0134 0.0134
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0255 0.0602
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0228 0.0228
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0157 0.0682
Brugia malayi RNA binding protein 0.02 0.2846 0.6758
Schistosoma mansoni cpg binding protein 0.003 0.034 0.034
Echinococcus granulosus Aminotransferase class III 0.0023 0.0228 0.0228
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0586 0.1389
Brugia malayi MH2 domain containing protein 0.0016 0.0134 0.0313
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.026 0.1123
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.026 0.1133
Loa Loa (eye worm) hypothetical protein 0.0014 0.01 0.0232
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0625 0.0625
Schistosoma mansoni gliotactin 0.0049 0.0625 0.0625
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0553 0.8845
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0228 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0228 0.1811
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0049 0.0625 0.2776
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.026 0.1133
Mycobacterium ulcerans hypothetical protein 0.0158 0.2236 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0316 0.0746
Onchocerca volvulus 0.0049 0.0625 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Loa Loa (eye worm) nuclear factor I 0.0009 0.0027 0.006
Echinococcus granulosus tar DNA binding protein 0.02 0.2846 0.2846
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0249 0.1092
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Brugia malayi Carboxylesterase family protein 0.0049 0.0625 0.1479
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.09 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0134 0.0134
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0228 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.09 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0625 0.0625
Echinococcus multilocularis BC026374 protein (S09 family) 0.0049 0.0625 0.0625
Loa Loa (eye worm) carboxylesterase 0.0049 0.0625 0.1479
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0937 0.0937
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Echinococcus granulosus BC026374 protein S09 family 0.0049 0.0625 0.0625
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0937 0.0937
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.006
Entamoeba histolytica hypothetical protein 0.0071 0.0937 0.5
Echinococcus multilocularis geminin 0.0341 0.4926 0.4926
Loa Loa (eye worm) hypothetical protein 0.0292 0.421 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0134 0.0313
Onchocerca volvulus 0.0049 0.0625 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0002 0.0002
Echinococcus granulosus acetylcholinesterase 0.0292 0.421 0.421
Brugia malayi Carboxylesterase family protein 0.0049 0.0625 0.1479
Schistosoma mansoni tar DNA-binding protein 0.02 0.2846 0.2846
Onchocerca volvulus 0.0023 0.0236 0.376
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0236 0.0556
Onchocerca volvulus 0.0028 0.0316 0.5045
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0134 0.0134
Brugia malayi hypothetical protein 0.0071 0.0937 0.2221
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0199 0.087
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0155 0.0918
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.026 0.0613
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0228 0.0538
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.001 0.0021
Schistosoma mansoni tar DNA-binding protein 0.02 0.2846 0.2846
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.2846 0.6758
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0026 0.0056
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.09 0.09
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0103 0.0437
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0023 0.0228 0.098
Entamoeba histolytica hypothetical protein 0.0071 0.0937 0.5
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.044 0.1942
Loa Loa (eye worm) Smad1 0.0016 0.0134 0.0313
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0137 0.0569
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0049 0.0625 0.0625
Echinococcus multilocularis cpg binding protein 0.003 0.034 0.034
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.3392 0.8055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0576 0.0576
Mycobacterium ulcerans polyketide synthase 0.0026 0.0283 0.1235
Brugia malayi Carboxylesterase family protein 0.0292 0.421 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0134 0.0134
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0228 0.099
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.09 0.09
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0158 0.2236 1
Brugia malayi MH1 domain containing protein 0.0016 0.0134 0.0313
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0049 0.0625 0.2776
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0199 0.086
Brugia malayi Carboxylesterase family protein 0.0292 0.421 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0049 0.0625 0.0625
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.09 0.4009
Loa Loa (eye worm) acetylcholinesterase 1 0.0292 0.421 1
Brugia malayi MH2 domain containing protein 0.0237 0.3392 0.8055
Echinococcus multilocularis microtubule associated protein 2 0.0684 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0043 0.0169
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.09 0.4003
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0137 0.0579
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.026 0.1133
Entamoeba histolytica hypothetical protein 0.0071 0.0937 0.5
Mycobacterium tuberculosis Carboxylesterase LipT 0.0049 0.0625 0.2776
Echinococcus multilocularis Smad4 0.0016 0.0134 0.0134
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0228 0.0999
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.026 0.1142
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0625 0.0625
Schistosoma mansoni hypothetical protein 0.0071 0.0937 0.0937
Schistosoma mansoni methyltransferase-related 0.0007 0.0005 0.0005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.026 0.1142
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0134 0.0134
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0194 0.0844
Loa Loa (eye worm) hypothetical protein 0.0049 0.0625 0.1479
Echinococcus granulosus carboxylesterase 5A 0.0292 0.421 0.421
Mycobacterium ulcerans thioesterase 0.0021 0.0199 0.086
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0283 0.1235
Giardia lamblia Methyltransferase like 2 0.0007 0.0005 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0134 0.0134
Echinococcus granulosus acetylcholinesterase 0.0292 0.421 0.421
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0228 0.0228
Onchocerca volvulus 0.0049 0.0625 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0049 0.0625 0.0625

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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