Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0787 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.0232 | 0.0738 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Echinococcus multilocularis | acetylcholinesterase | 0.0282 | 0.3141 | 0.3141 |
Brugia malayi | phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.0232 | 0.0738 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.0232 | 0.0738 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0787 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0232 | 0.0738 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.2486 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Echinococcus granulosus | 6 phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.0232 | 0.0738 |
Loa Loa (eye worm) | phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.0623 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0107 | 0.0787 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.2486 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0107 | 0.0787 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.2486 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0107 | 0.0787 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0232 | 0.0738 |
Echinococcus granulosus | acetylcholinesterase | 0.0282 | 0.3141 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.0787 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0282 | 0.3141 | 0.3141 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0107 | 0.0787 | 0.0787 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3141 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0.0787 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0232 | 0.0738 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.2486 |
Echinococcus granulosus | carboxylesterase 5A | 0.0282 | 0.3141 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.0232 | 0.0738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0232 | 0.0738 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0196 | 0.0623 |
Echinococcus granulosus | acetylcholinesterase | 0.0282 | 0.3141 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0107 | 0.0787 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.0787 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Brugia malayi | RNA binding protein | 0.0065 | 0.0232 | 0.0738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0232 | 0.0738 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0787 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0282 | 0.3141 | 1 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0787 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0787 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0196 | 0.0196 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0282 | 0.3141 | 0.3141 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.0232 | 0.0738 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0196 | 0.0623 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0282 | 0.3141 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0282 | 0.3141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3141 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0282 | 0.3141 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0282 | 0.3141 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.0787 | 0.2507 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0787 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.