Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0372 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0412 | 1 |
Echinococcus granulosus | caspase | 0.012 | 0.2891 | 0.2801 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0022 | 0.0125 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.018 | 0.459 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.049 | 0.0187 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0022 | 0.0125 | 0.0272 |
Onchocerca volvulus | 0.0033 | 0.0427 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0412 | 0.0412 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0427 | 0.0306 |
Echinococcus granulosus | caspase 8 | 0.0032 | 0.0412 | 0.0291 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.018 | 0.459 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0412 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0032 | 0.0412 | 0.0251 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.012 | 0.2891 | 0.2801 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.018 | 0.459 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.018 | 0.459 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0427 | 0.093 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0035 | 0.049 | 0.037 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0427 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0412 | 0.0412 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0427 | 0.0306 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0022 | 0.0125 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0022 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0372 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0032 | 0.0412 | 0.0291 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.018 | 0.459 | 0.4521 |
Trypanosoma cruzi | metacaspase, putative | 0.0032 | 0.0412 | 0.0251 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0022 | 0.0125 | 0.0272 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.049 | 0.0187 |
Echinococcus granulosus | lamin | 0.0033 | 0.0427 | 0.0306 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.018 | 0.459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.049 | 0.049 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0305 | 0.6252 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0427 | 0.0427 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0035 | 0.049 | 0.0187 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.018 | 0.459 | 0.4521 |
Echinococcus granulosus | caspase 3 | 0.0088 | 0.1986 | 0.1885 |
Brugia malayi | Cell death protein 3 precursor | 0.0032 | 0.0412 | 0.0898 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.018 | 0.459 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.012 | 0.2891 | 0.2801 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.049 | 0.0187 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0032 | 0.0412 | 0.0291 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.018 | 0.459 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0035 | 0.049 | 0.037 |
Schistosoma mansoni | lamin | 0.0033 | 0.0427 | 0.0306 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0427 | 0.0306 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.012 | 0.2891 | 0.2801 |
Schistosoma mansoni | lamin | 0.0033 | 0.0427 | 0.0306 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0032 | 0.0412 | 0.0291 |
Trichomonas vaginalis | importin beta-1, putative | 0.0028 | 0.0305 | 0.6252 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.012 | 0.2891 | 0.2801 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0032 | 0.0412 | 0.0251 |
Echinococcus multilocularis | caspase 2 | 0.0032 | 0.0412 | 0.0291 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0427 | 0.0427 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0022 | 0.0125 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0412 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0412 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0032 | 0.0412 | 0.0251 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0022 | 0.0125 | 0.0272 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0427 | 0.0306 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.018 | 0.459 | 1 |
Onchocerca volvulus | 0.0033 | 0.0427 | 1 | |
Echinococcus multilocularis | caspase 3 | 0.0088 | 0.1986 | 0.1885 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0412 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.018 | 0.459 | 0.459 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.018 | 0.459 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.018 | 0.459 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.018 | 0.459 | 0.4521 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.018 | 0.459 | 0.4521 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0427 | 0.093 |
Trypanosoma cruzi | metacaspase, putative | 0.0032 | 0.0412 | 0.0251 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0305 | 0.6252 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0035 | 0.049 | 0.0187 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.018 | 0.459 | 0.4521 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0125 | 0.0125 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0412 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0022 | 0.0125 | 0.0272 |
Leishmania major | importin beta-1 subunit, putative | 0.0028 | 0.0305 | 0.0402 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0305 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0032 | 0.0412 | 0.0291 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0022 | 0.0125 | 0.0272 |
Echinococcus multilocularis | caspase | 0.012 | 0.2891 | 0.2801 |
Brugia malayi | RNA, U transporter 1 | 0.0099 | 0.2303 | 0.5017 |
Echinococcus multilocularis | snurportin 1 | 0.0372 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0032 | 0.0412 | 1 |
Leishmania major | metacaspase, putative | 0.0032 | 0.0412 | 0.0644 |
Echinococcus granulosus | importin subunit beta 1 | 0.0035 | 0.049 | 0.037 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0427 | 0.0306 |
Brugia malayi | Importin beta-1 subunit | 0.0035 | 0.049 | 0.1069 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.018 | 0.459 | 0.4521 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.018 | 0.459 | 0.4521 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.018 | 0.459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.041 | 0.041 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0032 | 0.0412 | 0.0898 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.018 | 0.459 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0032 | 0.0412 | 0.0251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.