Detailed information for compound 822012

Basic information

Technical information
  • TDR Targets ID: 822012
  • Name: methyl 2-(1-adamantyl)-2-(butylcarbamoylamino )acetate
  • MW: 322.442 | Formula: C18H30N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.48 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)NC(C12CC3CC(C2)CC(C1)C3)C(=O)OC
  • InChi: 1S/C18H30N2O3/c1-3-4-5-19-17(22)20-15(16(21)23-2)18-9-12-6-13(10-18)8-14(7-12)11-18/h12-15H,3-11H2,1-2H3,(H2,19,20,22)
  • InChiKey: YSGIOGYRVWQLRA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(1-adamantyl)-2-[(butylamino-oxomethyl)amino]acetic acid methyl ester
  • 2-(1-adamantyl)-2-(butylcarbamoylamino)acetic acid methyl ester
  • methyl 2-(1-adamantyl)-2-(butylcarbamoylamino)ethanoate
  • T0513-3281
  • BIM-0007087.P001
  • CBMicro_007337
  • MLS000684222
  • SMR000268038
  • methyl 1-adamantyl{[(butylamino)carbonyl]amino}acetate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis voltage dependent calcium channel 0.01 0.0507 0.0507
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0168 0.0893 0.0934
Echinococcus granulosus potassium voltage gated channel protein 0.01 0.0507 0.0531
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.01 0.0507 0.0531
Schistosoma mansoni ap endonuclease 0.002 0.0049 0.0048
Schistosoma mansoni 60S ribosomal protein L21 0.01 0.0507 0.0527
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0392 0.1883
Echinococcus granulosus calcium activated potassium channel 0.01 0.0507 0.0531
Brugia malayi acetyltransferase, GNAT family protein 0.047 0.2621 0.2741
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0049 0.0699
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0021
Echinococcus multilocularis two pore calcium channel protein 1 0.01 0.0507 0.0507
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0309 0.032
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0392 0.1883
Loa Loa (eye worm) hypothetical protein 0.0147 0.0776 0.0812
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.01 0.0507 0.0507
Schistosoma mansoni bromodomain containing protein 0.0015 0.002 0.0017
Plasmodium vivax importin-beta 2, putative 0.0064 0.0301 0.3141
Brugia malayi TAR-binding protein 0.0066 0.0312 0.0327
Echinococcus multilocularis voltage gated potassium channel 0.01 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0216 0.1166 0.122
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0178 0.095 0.4808
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.01 0.0507 0.0531
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.01 0.0507 0.0531
Echinococcus granulosus histone acetyltransferase KAT2B 0.0457 0.2546 0.2663
Schistosoma mansoni carbonic anhydrase 0.0168 0.0893 0.0931
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.0168 0.0893 0.0934
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.01 0.0507 0.0507
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Brugia malayi Carboxylesterase family protein 0.0285 0.1561 0.1632
Echinococcus multilocularis voltage gated hydrogen channel 1 0.01 0.0507 0.0507
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.01 0.0507 0.5322
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0357 0.1976 1
Schistosoma mansoni carbonic anhydrase-related 0.0168 0.0893 0.0931
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0357 0.1976 0.2064
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0178 0.095 0.4743
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.01 0.0507 0.0531
Onchocerca volvulus 0.0285 0.1561 1
Echinococcus multilocularis sodium leak channel non selective protein 0.01 0.0507 0.0507
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0507 0.0527
Schistosoma mansoni carbonic anhydrase-related 0.0168 0.0893 0.0931
Echinococcus multilocularis cpg binding protein 0.0064 0.0302 0.0302
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0307 0.464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0678 0.0705
Echinococcus multilocularis short transient receptor potential channel 6 0.01 0.0507 0.0507
Echinococcus granulosus hypothetical protein 0.01 0.0507 0.0531
Plasmodium falciparum importin beta, putative 0.0064 0.0301 0.3141
Echinococcus multilocularis potassium voltage gated channel protein 0.01 0.0507 0.0507
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0507 0.0527
Schistosoma mansoni hypothetical protein 0.0036 0.0139 0.0142
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.01 0.0507 0.0531
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0285 0.1561 0.1561
Plasmodium vivax SET domain protein, putative 0.0031 0.0111 0.1131
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0096 0.0974
Brugia malayi Importin beta-1 subunit 0.0064 0.0301 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0111 0.0112
Entamoeba histolytica acetyltransferase, GNAT family 0.0127 0.0658 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.01 0.0507 0.0531
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0307 0.0307
Loa Loa (eye worm) ryanodine receptor 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus granulosus two pore calcium channel protein 2 0.01 0.0507 0.0531
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0392 0.4102
Brugia malayi mbt repeat family protein 0.0058 0.0263 0.0275
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0301 0.3141
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0324 0.0339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0049 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.006
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4696 0.4912
Echinococcus multilocularis two pore calcium channel protein 2 0.01 0.0507 0.0507
Brugia malayi Animal haem peroxidase family protein 0.0025 0.008 0.0084
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0204 0.0921
Plasmodium falciparum carbonic anhydrase 0.0168 0.0893 0.9401
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4696 0.4911
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Echinococcus multilocularis peroxidasin 0.0025 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Brugia malayi ion channel NompC 0.01 0.0507 0.0531
Trichomonas vaginalis ran, putative 0.0047 0.0204 0.1288
Schistosoma mansoni cpg binding protein 0.0064 0.0302 0.0312
Loa Loa (eye worm) hepatopoietin HPO2 0.0178 0.095 0.0994
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0315
Echinococcus multilocularis carbonic anhydrase 0.0168 0.0893 0.0893
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Echinococcus granulosus snurportin 1 0.0685 0.3849 0.4026
Entamoeba histolytica hypothetical protein 0.0052 0.0232 0.3481
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.01 0.0507 0.0531
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0028 0.0096 0.0366
Brugia malayi Carboxylesterase family protein 0.0285 0.1561 0.1632
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Leishmania major GTP-binding protein, putative 0.0047 0.0204 0.0228
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0111 0.0116
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0263 0.0272
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0028 0.0096 0.0366
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0111 0.0111
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.008 0.0084
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.0392 0.4102
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0678 0.4255
Echinococcus granulosus voltage gated potassium channel 0.01 0.0507 0.0531
Brugia malayi Cytochrome P450 family protein 0.0016 0.0024 0.0025
Brugia malayi PHD-finger family protein 0.0015 0.002 0.0021
Brugia malayi Muscleblind-like protein 0.0148 0.0779 0.0815
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus granulosus voltage dependent calcium channel 0.01 0.0507 0.0531
Leishmania major hypothetical protein, conserved 0.01 0.0507 0.0573
Loa Loa (eye worm) histone methyltransferase 0.002 0.0048 0.005
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0049 0.0294
Schistosoma mansoni two-pore calcium channel 0.01 0.0507 0.0527
Echinococcus granulosus potassium voltage gated channel subfamily A 0.01 0.0507 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Echinococcus granulosus sulfhydryl oxidase 1 0.0028 0.0096 0.01
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0028 0.0096 0.0107
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0678 0.0709
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1684 0.956 1
Loa Loa (eye worm) carboxylesterase 0.0285 0.1561 0.1632
Loa Loa (eye worm) hypothetical protein 0.0066 0.0309 0.0323
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0324 0.0339
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0204 0.0204
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.01 0.0507 0.0531
Loa Loa (eye worm) carboxylesterase 0.1684 0.956 1
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0028 0.0096 0.0107
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.01 0.0507 0.0531
Echinococcus granulosus zinc finger protein 0.0015 0.002 0.0021
Brugia malayi Pre-SET motif family protein 0.0031 0.0111 0.0116
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0024 0.0123
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0028 0.0096 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0013 0.006
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Onchocerca volvulus 0.0061 0.0282 0.1363
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Leishmania major hypothetical protein, conserved 0.008 0.0392 0.0442
Schistosoma mansoni hypothetical protein 0.0416 0.2314 0.2417
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0301 0.1523
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0263 0.0272
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.01 0.0507 0.0507
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0678 0.0706
Onchocerca volvulus 0.0058 0.0263 0.1239
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0779 0.0779
Echinococcus multilocularis translational activator gcn1 0.0012 0.0004 0.0004
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0204 0.2119
Echinococcus granulosus TRP transient receptor potential channel 0.01 0.0507 0.0531
Echinococcus granulosus tar DNA binding protein 0.0066 0.0312 0.0327
Loa Loa (eye worm) ion channel NompC 0.01 0.0507 0.0531
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0204 0.0213
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0312 0.0327
Schistosoma mansoni voltage-gated ion channel 0.01 0.0507 0.0527
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1062 0.1062
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.015 0.015
Echinococcus multilocularis carbonic anhydrase II 0.0357 0.1976 0.1976
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0357 0.1976 0.2067
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus multilocularis muscleblind protein 0.0148 0.0779 0.0779
Brugia malayi hypothetical protein 0.01 0.0507 0.0531
Echinococcus granulosus cyclic nucleotide gated cation channel 0.01 0.0507 0.0531
Brugia malayi Cytochrome P450 family protein 0.0026 0.0083 0.0087
Echinococcus granulosus transient receptor potential cation channel 0.01 0.0507 0.0531
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.008 0.0084
Echinococcus multilocularis para nitrobenzyl esterase 0.0285 0.1561 0.1561
Trichomonas vaginalis bromodomain-containing protein, putative 0.0138 0.0724 0.4629
Brugia malayi kap beta 3 protein 0.0012 0.0004 0.0004
Brugia malayi RNA, U transporter 1 0.0182 0.0977 0.1022
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.01 0.0507 0.2475
Brugia malayi Blistered cuticle protein 3 0.0025 0.008 0.0084
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.01 0.0507 0.0531
Loa Loa (eye worm) acetyltransferase 0.047 0.2621 0.2741
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0309 0.0309
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0024 0.0025
Echinococcus granulosus dnaJ subfamily B 0.0416 0.2314 0.242
Echinococcus granulosus potassium voltage gated channel subfamily D 0.01 0.0507 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Echinococcus multilocularis potassium voltage gated channel protein 0.01 0.0507 0.0507
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0665 0.6985
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0263 0.0275
Echinococcus granulosus short transient receptor potential channel 6 0.01 0.0507 0.0531
Brugia malayi cation channel family protein 0.01 0.0507 0.0531
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0204 0.254
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0049 0.0052
Echinococcus granulosus carbonic anhydrase 0.0168 0.0893 0.0934
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0507 0.0527
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.01 0.0507 0.0531
Echinococcus granulosus carboxylesterase 5A 0.1684 0.956 1
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0678 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Echinococcus granulosus sodium leak channel non selective protein 0.01 0.0507 0.0531
Trypanosoma brucei carbonic anhydrase-like protein 0.0357 0.1976 1
Onchocerca volvulus 0.0031 0.0111 0.0207
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.01 0.0507 0.2567
Echinococcus granulosus importin 5 0.0012 0.0004 0.0004
Echinococcus granulosus hyperpolarization activated cyclic 0.01 0.0507 0.0531
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0285 0.1561 0.1629
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0049 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0083 0.0087
Echinococcus multilocularis calcium activated potassium channel 0.01 0.0507 0.0507
Schistosoma mansoni peroxidasin 0.0025 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0027 0.0027
Brugia malayi Animal haem peroxidase family protein 0.0025 0.008 0.0084
Toxoplasma gondii transporter, cation channel family protein 0.01 0.0507 0.5322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1062 0.1108
Echinococcus multilocularis hyperpolarization activated cyclic 0.01 0.0507 0.0507
Echinococcus multilocularis hyperpolarization activated cyclic 0.01 0.0507 0.0507
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0013 0.006
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0168 0.0893 0.0934
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0307 0.0318
Loa Loa (eye worm) hypothetical protein 0.0168 0.0893 0.0934
Echinococcus multilocularis zinc finger protein 0.0015 0.002 0.002
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0049 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.01 0.0507 0.0527
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.01 0.0507 0.0507
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0047 0.0049
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0049 0.0052
Schistosoma mansoni transient receptor potential channel 0.01 0.0507 0.0527
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0678 0.0767
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus granulosus carbonic anhydrase 0.0168 0.0893 0.0934
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0312 0.0327
Leishmania major hypothetical protein, conserved 0.0178 0.095 0.1077
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0027 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0049 0.0294
Echinococcus granulosus cyclic nucleotide gated cation channel 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0263 0.0275
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.01 0.0507 0.0531
Schistosoma mansoni voltage-gated cation channel 0.01 0.0507 0.0527
Echinococcus multilocularis voltage gated potassium channel 0.01 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0068 0.0324 0.0335
Brugia malayi Animal haem peroxidase family protein 0.0025 0.008 0.0084
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.0815
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.01 0.0507 0.0531
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0204 0.2119
Echinococcus granulosus potassium voltage gated channel subfamily H 0.01 0.0507 0.0531
Echinococcus granulosus voltage gated potassium channel 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0138 0.0724 0.7615
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0685 0.3849 0.4026
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0204 0.0213
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.01 0.0507 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0048 0.0048
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.01 0.0507 0.0531
Echinococcus granulosus carbonic anhydrase II 0.0357 0.1976 0.2067
Brugia malayi mbt repeat family protein 0.0058 0.0263 0.0275
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.01 0.0507 0.0527
Echinococcus granulosus acetylcholinesterase 0.1684 0.956 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0168 0.0893 0.0934
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0309 0.0323
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0301 0.0301
Trichomonas vaginalis importin beta-1, putative 0.0052 0.0232 0.1464
Echinococcus multilocularis transient receptor potential cation channel 0.01 0.0507 0.0507
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0027 0.0028
Brugia malayi Animal haem peroxidase family protein 0.0025 0.008 0.0084
Toxoplasma gondii Erv1 / Alr family protein 0.0178 0.095 1
Schistosoma mansoni hypothetical protein 0.0354 0.1959 0.2046
Echinococcus granulosus potassium voltage gated channel subfamily D 0.01 0.0507 0.0531
Echinococcus multilocularis transient receptor potential cation channel 0.01 0.0507 0.0507
Loa Loa (eye worm) voltage-gated potassium channel 0.01 0.0507 0.0531
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.01 0.0507 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1062 0.1111
Echinococcus granulosus para nitrobenzyl esterase 0.0285 0.1561 0.1632
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0357 0.1976 0.2067
Echinococcus granulosus transient receptor potential cation channel 0.01 0.0507 0.0531
Toxoplasma gondii transporter, cation channel family protein 0.01 0.0507 0.5322
Echinococcus granulosus muscleblind protein 0.0148 0.0779 0.0815
Echinococcus granulosus voltage gated hydrogen channel 1 0.01 0.0507 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0312 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0111 0.0112
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0507 0.0527
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0263 0.1239
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0216 0.1166 0.122
Echinococcus multilocularis transportin 1 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.01
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.01 0.0507 0.0527
Echinococcus granulosus acetylcholinesterase 0.1684 0.956 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0138 0.0724 0.4629
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0724 0.0758
Toxoplasma gondii hypothetical protein 0.01 0.0507 0.5322
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Leishmania major cytochrome p450-like protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0312 0.0323
Echinococcus multilocularis carbonic anhydrase 0.0168 0.0893 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.01 0.0507 0.0531
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.1062 0.1111
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0507 0.0527
Schistosoma mansoni gliotactin 0.0285 0.1561 0.1629
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0312 0.0323
Loa Loa (eye worm) Erv1/Alr family protein 0.0028 0.0096 0.01
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0111 0.1131
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0263 0.0263
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0312 0.0327
Loa Loa (eye worm) hypothetical protein 0.1684 0.956 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0285 0.1561 0.1629
Echinococcus multilocularis ryanodine receptor 44f 0.01 0.0507 0.0507
Echinococcus multilocularis BC026374 protein (S09 family) 0.0285 0.1561 0.1561
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.155 0.8793 0.9197
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.01 0.0507 0.0507
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0678 0.416
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Schistosoma mansoni cpg binding protein 0.0064 0.0302 0.0312
Loa Loa (eye worm) hypothetical protein 0.1684 0.956 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0204 0.1033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0678 0.0678
Echinococcus multilocularis snurportin 1 0.0685 0.3849 0.3849
Leishmania major importin beta-1 subunit, putative 0.0052 0.0232 0.0259
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0678 0.4255
Schistosoma mansoni importin beta-1 0.0064 0.0301 0.0311
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0013 0.001 0.0039
Loa Loa (eye worm) MBCTL1 0.0066 0.0309 0.0323
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.1062 0.1111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.006
Echinococcus granulosus carbonic anhydrase 0.0168 0.0893 0.0934
Brugia malayi Carboxylesterase family protein 0.0285 0.1561 0.1632
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.01 0.0507 0.0507
Onchocerca volvulus 0.0285 0.1561 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0285 0.1561 0.1629
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Echinococcus granulosus potassium voltage gated channel protein 0.01 0.0507 0.0531
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0309 0.0323
Schistosoma mansoni ran 0.0047 0.0204 0.021
Schistosoma mansoni ran 0.0047 0.0204 0.021
Plasmodium falciparum histone acetyltransferase GCN5 0.0127 0.0658 0.6919
Entamoeba histolytica Ran family GTPase 0.0047 0.0204 0.3062
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.01 0.0507 0.0527
Echinococcus granulosus transient receptor potential cation channel 0.01 0.0507 0.0531
Echinococcus multilocularis carboxylesterase 5A 0.1684 0.956 0.956
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0021
Schistosoma mansoni hypothetical protein 0.0068 0.0324 0.0335
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1118 0.117
Echinococcus multilocularis transient receptor potential cation channel 0.01 0.0507 0.0507
Loa Loa (eye worm) voltage-gated potassium channel 0.01 0.0507 0.0531
Loa Loa (eye worm) quiescin Q6 0.0028 0.0096 0.01
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.0392 0.1983
Loa Loa (eye worm) hypothetical protein 0.0058 0.0263 0.0275
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0357 0.1976 1
Echinococcus multilocularis transient receptor potential cation channel 0.01 0.0507 0.0507
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0178 0.095 0.0994
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.008 0.0084
Echinococcus granulosus potassium voltage gated channel subfamily C 0.01 0.0507 0.0531
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.0232 0.1062
Brugia malayi hypothetical protein 0.0052 0.023 0.024
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.047 0.2621 0.2621
Echinococcus granulosus ryanodine receptor 44f 0.01 0.0507 0.0531
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.01 0.0507 0.0507
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.01 0.0507 0.0507
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.01 0.0507 0.3235
Schistosoma mansoni inositol 145-trisphosphate receptor 0.01 0.0507 0.0527
Brugia malayi hypothetical protein 0.008 0.0392 0.041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0285 0.1561 0.1629
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0004 0.0004
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0168 0.0893 0.0934
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0307 0.0346
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0178 0.095 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0049 0.5
Leishmania major hypothetical protein, unknown function 0.01 0.0507 0.0573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.006
Echinococcus multilocularis voltage dependent calcium channel 0.01 0.0507 0.0507
Toxoplasma gondii hypothetical protein 0.01 0.0507 0.5322
Plasmodium vivax SET domain containing protein 0.0014 0.0014 0.0109
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0168 0.0893 0.0934
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0178 0.095 0.4743
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.2314 0.2314
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0307 0.0322
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0263 0.0263
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0049 0.0163
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.01 0.0507 0.0527
Schistosoma mansoni peroxidasin 0.0025 0.008 0.008
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.01 0.0507 0.0507
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Echinococcus granulosus transient receptor potential cation channel 0.01 0.0507 0.0531
Echinococcus multilocularis acetylcholinesterase 0.1684 0.956 0.956
Brugia malayi Augmenter of liver regeneration 0.0178 0.095 0.0994
Echinococcus granulosus GPCR family 2 0.0068 0.0324 0.0339
Echinococcus multilocularis carbonic anhydrase 0.0168 0.0893 0.0893
Brugia malayi voltage-dependent calcium channel 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Schistosoma mansoni ryanodine receptor related 0.01 0.0507 0.0527
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.01 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Brugia malayi Carboxylesterase family protein 0.0285 0.1561 0.1632
Schistosoma mansoni hypothetical protein 0.0147 0.0776 0.0809
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0678 0.7126
Echinococcus multilocularis transient receptor potential cation channel 0.01 0.0507 0.0507
Echinococcus granulosus transient receptor potential cation channel 0.01 0.0507 0.0531
Echinococcus granulosus transportin 1 0.0012 0.0004 0.0004
Brugia malayi Carboxylesterase family protein 0.1684 0.956 1
Brugia malayi RNA binding protein 0.0066 0.0312 0.0327
Echinococcus multilocularis transfer RNA-Gly 0.01 0.0507 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.006
Loa Loa (eye worm) hypothetical protein 0.0068 0.0324 0.0339
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0216 0.1166 0.122
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.01 0.0507 0.0531
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0307 0.1556
Echinococcus granulosus potassium voltage gated channel protein 0.01 0.0507 0.0531
Echinococcus multilocularis sodium channel protein 0.155 0.8793 0.8793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1062 0.1062
Brugia malayi CXXC zinc finger family protein 0.0061 0.0282 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0168 0.0893 0.0934
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.01 0.0507 0.0531
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0232 0.1464
Loa Loa (eye worm) voltage-gated calcium channel 0.01 0.0507 0.0531
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0178 0.095 0.095
Loa Loa (eye worm) carboxylesterase 0.0285 0.1561 0.1632
Echinococcus granulosus potassium voltage gated channel subfamily D 0.01 0.0507 0.0531
Schistosoma mansoni cpg binding protein 0.0061 0.0282 0.0291
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0049 0.0484
Echinococcus multilocularis conserved hypothetical protein 0.01 0.0507 0.0507
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.047 0.2621 0.2739
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.01 0.0507 0.0531
Echinococcus granulosus transient receptor potential cation channel 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Mycobacterium tuberculosis Carboxylesterase LipT 0.0285 0.1561 1
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0028 0.0096 0.0484
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0049 0.0484
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.0392 0.4102
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0138 0.0724 0.7615
Onchocerca volvulus 0.0285 0.1561 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.006
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.01 0.0507 0.0527
Echinococcus multilocularis transient receptor potential cation channel 0.01 0.0507 0.0507
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0015 0.002 0.002
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.01 0.0507 0.0507
Brugia malayi olfactory channel protein osm-9 0.01 0.0507 0.0531
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.1255 0.1312
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0309 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0312 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1062 0.1108
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.01 0.0507 0.3235
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.01 0.0507 0.0527
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0357 0.1976 0.2067
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0285 0.1561 0.1632
Loa Loa (eye worm) voltage-dependent calcium channel 0.01 0.0507 0.0531
Echinococcus granulosus BC026374 protein S09 family 0.0285 0.1561 0.1632
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0116
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0307 0.0322
Echinococcus multilocularis potassium voltage gated channel protein 0.01 0.0507 0.0507
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0049 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0324 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.01 0.0507 0.0527
Schistosoma mansoni transient receptor potential channel 0.01 0.0507 0.0527
Schistosoma mansoni carbonic anhydrase-related 0.0168 0.0893 0.0931
Trichomonas vaginalis helicase, putative 0.0014 0.0013 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0027 0.0028
Schistosoma mansoni transient receptor potential channel 0.01 0.0507 0.0527
Mycobacterium ulcerans carboxylesterase, LipT 0.0285 0.1561 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.015 0.0157
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.008 0.0084
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0285 0.1561 1
Echinococcus granulosus two pore calcium channel protein 1 0.01 0.0507 0.0531
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0138 0.0724 0.7615
Onchocerca volvulus 0.0285 0.1561 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0204 0.0921
Brugia malayi Pre-SET motif family protein 0.0207 0.1118 0.117
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.01 0.0507 0.0531
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0068 0.0324 0.0335
Echinococcus granulosus potassium large conductance calcium activated 0.01 0.0507 0.0531
Schistosoma mansoni zinc finger protein 0.0015 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0004 0.0004
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1281 0.8204
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0324 0.0339
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.006
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.01 0.0507 0.0531
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.01 0.0507 0.0507
Schistosoma mansoni calcium-activated potassium channel 0.01 0.0507 0.0527
Echinococcus granulosus peroxidasin 0.0025 0.008 0.0084
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.01 0.0507 0.0531
Brugia malayi Erv1 / Alr family protein 0.0028 0.0096 0.01
Trypanosoma brucei RNA helicase, putative 0.01 0.0507 0.2567
Loa Loa (eye worm) blistered cuticle protein 3 0.0025 0.008 0.0084
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.01 0.0507 0.0531
Echinococcus granulosus importin subunit beta 1 0.0064 0.0301 0.0315
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0013 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.0815
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0307 0.1451
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4696 0.4696
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Echinococcus multilocularis acetylcholinesterase 0.1684 0.956 0.956
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.01 0.0507 0.2886
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0678 0.4255
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Brugia malayi Bromodomain containing protein 0.0015 0.002 0.0021
Echinococcus multilocularis neuroligin 0.0285 0.1561 0.1561
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0139 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1062 0.1108
Loa Loa (eye worm) RNA binding protein 0.0066 0.0312 0.0327
Brugia malayi Cytochrome P450 family protein 0.0016 0.0024 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.006
Leishmania major calcium channel protein, putative,ion transporter, putative 0.155 0.8793 1
Giardia lamblia Histone acetyltransferase GCN5 0.0127 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Echinococcus multilocularis GPCR, family 2 0.0068 0.0324 0.0324
Loa Loa (eye worm) carbonic anhydrase 3 0.0357 0.1976 0.2067
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.01 0.0507 0.2567
Echinococcus granulosus short transient receptor potential channel 6 0.01 0.0507 0.0531
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0263 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0111 0.0112
Schistosoma mansoni vesicular amine transporter 0.01 0.0507 0.0527
Schistosoma mansoni acetylcholinesterase 0.0285 0.1561 0.1629
Toxoplasma gondii Erv1 / Alr family protein 0.0028 0.0096 0.0974
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.1255 0.1255
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.01 0.0507 0.0531
Schistosoma mansoni ap endonuclease 0.002 0.0049 0.0048
Onchocerca volvulus 0.0285 0.1561 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Echinococcus granulosus voltage dependent calcium channel 0.01 0.0507 0.0531
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0282 0.0295
Onchocerca volvulus 0.01 0.0507 0.2886
Toxoplasma gondii Erv1 / Alr family protein 0.0178 0.095 1
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.0776 0.0812
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0111 0.0112
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0204 0.2119
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0263 0.0272
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0015 0.002 0.0021
Schistosoma mansoni voltage-dependent calcium channel 0.01 0.0507 0.0527
Loa Loa (eye worm) hypothetical protein 0.01 0.0507 0.0531
Toxoplasma gondii exonuclease III APE 0.002 0.0049 0.0484
Leishmania major carbonic anhydrase-like protein 0.0357 0.1976 0.2244
Echinococcus granulosus potassium voltage gated channel subfamily H 0.01 0.0507 0.0531
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0204 0.0213
Brugia malayi cation channel family protein 0.01 0.0507 0.0531
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.01 0.0507 0.5322
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0357 0.1976 0.2064
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.01 0.0507 0.0531
Schistosoma mansoni hypothetical protein 0.01 0.0507 0.0527
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.01 0.0507 0.0527
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0178 0.095 1
Echinococcus granulosus shaker cognate 0.01 0.0507 0.0531
Brugia malayi Calcitonin receptor-like protein seb-1 0.0216 0.1166 0.122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0232 0.1464
Loa Loa (eye worm) acetylcholinesterase 1 0.1684 0.956 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0309 0.0323
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0312 0.0323
Echinococcus granulosus cpg binding protein 0.0064 0.0302 0.0315
Schistosoma mansoni hypothetical protein 0.01 0.0507 0.0527
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0097 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0024 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0392 0.4102
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.01
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0004 0.0018
Toxoplasma gondii transporter, cation channel family protein 0.01 0.0507 0.5322
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0285 0.1561 1
Echinococcus granulosus sodium channel protein 0.155 0.8793 0.9197
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.01 0.0507 0.0527
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0049 0.0249
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0012 0.0004 0.0018
Brugia malayi hypothetical protein 0.0285 0.1561 0.1632
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.01 0.0507 0.0527
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0285 0.1561 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0048 0.005
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.01 0.0507 0.2475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0324 0.0324
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.01 0.0507 0.0507
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0028 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0068 0.0324 0.0335
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.01 0.0507 0.0527
Brugia malayi Animal haem peroxidase family protein 0.0025 0.008 0.0084
Loa Loa (eye worm) hypothetical protein 0.008 0.0392 0.041
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0096 0.0974
Brugia malayi hypothetical protein 0.0025 0.008 0.0084
Brugia malayi Transient-receptor-potential like protein 0.01 0.0507 0.0531
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0324 0.0339
Echinococcus granulosus neuroligin 0.0285 0.1561 0.1632
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.01 0.0507 0.2886
Schistosoma mansoni hypothetical protein 0.0685 0.3849 0.4023
Toxoplasma gondii hypothetical protein 0.0168 0.0893 0.9401
Brugia malayi quiescin Q6 0.0028 0.0096 0.01
Brugia malayi Carboxylesterase family protein 0.1684 0.956 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0324 0.0339
Echinococcus granulosus potassium voltage gated channel protein 0.01 0.0507 0.0531
Brugia malayi Peroxidasin 0.0025 0.008 0.0084
Schistosoma mansoni BC026374 protein (S09 family) 0.0285 0.1561 0.1629
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0507 0.0527
Loa Loa (eye worm) calcium channel 0.01 0.0507 0.0531
Echinococcus multilocularis TRP (transient receptor potential) channel 0.01 0.0507 0.0507
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0307 0.0322
Echinococcus multilocularis shaker cognate 0.01 0.0507 0.0507
Echinococcus granulosus hyperpolarization activated cyclic 0.01 0.0507 0.0531
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0301 0.1523
Echinococcus granulosus translational activator gcn1 0.0012 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0312 0.0323
Echinococcus multilocularis short transient receptor potential channel 6 0.01 0.0507 0.0507
Onchocerca volvulus 0.0236 0.1281 0.8112
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0178 0.095 0.4743
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0049 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.01 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0168 0.0893 0.0931
Schistosoma mansoni bromodomain containing protein 0.0015 0.002 0.0017
Echinococcus multilocularis potassium voltage gated channel protein 0.01 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1062 0.1111
Echinococcus multilocularis importin 5 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0285 0.1561 0.1632
Echinococcus granulosus potassium voltage gated channel protein 0.01 0.0507 0.0531
Loa Loa (eye worm) hypothetical protein 0.0168 0.0893 0.0934
Echinococcus multilocularis sulfhydryl oxidase 1 0.0028 0.0096 0.0096
Echinococcus multilocularis potassium large conductance calcium activated 0.01 0.0507 0.0507
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0111 0.0111
Trichomonas vaginalis spcc417.12 protein, putative 0.0285 0.1561 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0307 0.1451

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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