Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0035 | 0.261 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0016 | 0.0952 | 0.3152 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0035 | 0.261 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0016 | 0.0952 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0189 | 0.0724 |
Brugia malayi | nuclear receptor RXR | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0189 | 0.0189 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0018 | 0.113 | 0.3885 |
Onchocerca volvulus | 0.0035 | 0.261 | 1 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.1548 | 0.5929 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0645 | 0.365 |
Schistosoma mansoni | smad | 0.0008 | 0.0189 | 0.0724 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.1174 | 0.6637 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.1174 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0016 | 0.0952 | 0.3648 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.1174 | 0.6637 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.113 | 0.113 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0035 | 0.261 | 0.261 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.113 | 0.113 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.1768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.1768 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0016 | 0.0952 | 0.3648 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0035 | 0.261 | 0.261 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.1174 | 0.1174 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.1174 | 0.4496 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.1174 | 0.4066 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0016 | 0.0952 | 0.3152 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.1174 | 0.6637 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0018 | 0.113 | 0.4328 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0016 | 0.0952 | 0.0952 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0189 | 0.0189 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0035 | 0.261 | 0.261 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Brugia malayi | conserved hypotetical protein | 0.0016 | 0.0952 | 0.0952 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0016 | 0.0952 | 0.3152 |
Brugia malayi | nuclear receptor NHR-67 | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.1174 | 0.1174 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0189 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.1768 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0035 | 0.261 | 0.261 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1174 | 0.6637 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0018 | 0.113 | 0.113 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.1768 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0035 | 0.261 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0016 | 0.0952 | 0.3152 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.1768 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0035 | 0.261 | 0.261 |
Brugia malayi | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.1174 | 0.4066 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.0952 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.1174 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0016 | 0.0952 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0189 | 0.0189 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0016 | 0.0952 | 0.0952 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0035 | 0.261 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0645 | 0.365 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.1174 | 0.6637 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0035 | 0.261 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0035 | 0.261 | 0.261 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0016 | 0.0952 | 0.0952 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1174 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0016 | 0.0952 | 0.3152 |
Brugia malayi | tailless protein | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.113 | 0.4328 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0645 | 0.365 |
Brugia malayi | ecdysone receptor | 0.0016 | 0.0952 | 0.0952 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0035 | 0.261 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0035 | 0.261 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0035 | 0.261 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0035 | 0.261 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0645 | 0.365 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0035 | 0.261 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0018 | 0.113 | 0.3885 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0016 | 0.0952 | 0.0952 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.1174 | 0.6637 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.1174 | 0.4066 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0952 | 0.3648 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0035 | 0.261 | 0.261 |
Brugia malayi | nuclear receptor NHR-88 | 0.0016 | 0.0952 | 0.0952 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0189 | 0.0724 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0035 | 0.261 | 0.261 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.1768 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.1174 | 0.1174 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.1768 | 0.1768 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0016 | 0.0952 | 0.3152 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.1174 | 0.6637 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0189 | 0.0189 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0035 | 0.261 | 0.261 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.1174 | 0.4066 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.1174 | 0.4066 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1174 | 0.6637 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | nuclear receptor RXR | 0.0018 | 0.113 | 0.113 |
Schistosoma mansoni | nuclear hormone receptor | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0189 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1174 | 0.1174 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.1768 | 0.1768 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0189 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0189 | 0.0724 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0016 | 0.0952 | 0.3648 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0189 | 0.0724 |
Schistosoma mansoni | coup transcription factor | 0.0035 | 0.261 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0016 | 0.0952 | 0.0952 |
Schistosoma mansoni | nuclear receptor | 0.0016 | 0.0952 | 0.3648 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0035 | 0.261 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0035 | 0.261 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0035 | 0.261 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.1174 | 0.4496 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | thyroid hormone receptor | 0.0035 | 0.261 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.1768 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.1768 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0035 | 0.261 | 0.261 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0035 | 0.261 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0016 | 0.0952 | 0.0952 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0035 | 0.261 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.1174 | 0.4496 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0035 | 0.261 | 0.261 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0035 | 0.261 | 0.261 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1174 | 0.6637 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | thyroid hormone receptor | 0.0035 | 0.261 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0016 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0035 | 0.261 | 0.261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0645 | 0.365 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0016 | 0.0952 | 0.0952 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.1768 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0035 | 0.261 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0952 | 0.0952 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.1768 | 0.6522 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1174 | 0.6637 |
Brugia malayi | steroid hormone receptor | 0.0035 | 0.261 | 0.261 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0035 | 0.261 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0035 | 0.261 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0016 | 0.0952 | 0.3152 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.0952 | 0.3152 |
Brugia malayi | Smad1 | 0.0008 | 0.0189 | 0.0189 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0035 | 0.261 | 0.261 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0189 | 0.0724 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0016 | 0.0952 | 0.3152 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.1174 | 0.4066 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 0.0952 | 0.3648 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0016 | 0.0952 | 0.3648 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 0.0952 | 0.3648 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.261 | 0.261 |
Brugia malayi | hypothetical protein | 0.0018 | 0.113 | 0.113 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.1768 | 0.6522 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.