Detailed information for compound 82211

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 310.43 | Formula: C21H26O2
  • H donors: 1 H acceptors: 2 LogP: 3.82 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=Cc1ccc2c(cc1=O)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C
  • InChi: 1S/C21H26O2/c1-3-13-4-6-15-14(12-19(13)22)5-7-17-16(15)10-11-21(2)18(17)8-9-20(21)23/h3-4,6,12,16-18,20,23H,1,5,7-11H2,2H3/t16-,17-,18+,20+,21+/m1/s1
  • InChiKey: WZWXMELSRJQVED-SACAXFFCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0012 0.0261 0.073
Mycobacterium tuberculosis Possible lysophospholipase 0.0067 0.3578 0.5148
Loa Loa (eye worm) tubulin gamma chain 0.0012 0.0261 0.0377
Schistosoma mansoni tubulin subunit beta 0.0012 0.0261 0.0261
Entamoeba histolytica tubulin family protein 0.0012 0.0261 0.073
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.058 0.1621
Plasmodium vivax tubulin gamma chain, putative 0.0012 0.0261 0.073
Echinococcus granulosus beta tubulin 0.0012 0.0261 0.0261
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0261 0.073
Plasmodium vivax glutathione reductase, putative 0.0049 0.2482 0.6935
Brugia malayi AMP-binding enzyme family protein 0.0025 0.1031 0.149
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.3578 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0012 0.0261 0.0261
Mycobacterium tuberculosis Probable reductase 0.0112 0.621 0.8934
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0067 0.3578 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.1031 0.288
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0853 0.0853
Brugia malayi beta-tubulin, identical 0.0012 0.0261 0.0377
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.3578 1
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0553 0.08
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.6919 1
Leishmania major beta tubulin 0.0012 0.0261 0.073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.058 0.1621
Schistosoma mansoni smad 0.0008 0.0072 0.0072
Plasmodium falciparum tubulin beta chain 0.0012 0.0261 0.073
Echinococcus multilocularis tubulin epsilon chain 0.0012 0.0261 0.0261
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.0853 0.0853
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0853 0.0853
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0853 0.2383
Trypanosoma brucei beta tubulin 0.0012 0.0261 0.073
Schistosoma mansoni tubulin subunit beta 0.0012 0.0261 0.0261
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0072 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.2387 0.2387
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.2387 0.2387
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.1031 0.1483
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.1031 0.288
Brugia malayi Tubulin beta-1 chain 0.0012 0.0261 0.0377
Schistosoma mansoni hypothetical protein 0.0175 1 1
Toxoplasma gondii beta-tubulin, putative 0.0012 0.0261 0.1052
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0853 0.0853
Echinococcus granulosus tubulin subunit beta 0.0012 0.0261 0.0261
Schistosoma mansoni smad1 5 8 and 0.0008 0.0072 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2482 0.6935
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.695 1
Leishmania major beta tubulin 0.0012 0.0261 0.073
Leishmania major beta tubulin 0.0012 0.0261 0.073
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0853 0.2383
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0853 0.0853
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0853 0.0853
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0853 0.0853
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.621 0.8934
Echinococcus granulosus tubulin alpha 0.0012 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.0957
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.1031 0.1483
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.0957
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.058 0.1621
Trypanosoma cruzi beta tubulin, putative 0.0012 0.0261 0.073
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.058 0.539
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.695 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.2482 0.2482
Loa Loa (eye worm) TAR-binding protein 0.0066 0.347 0.5015
Toxoplasma gondii beta tubulin 0.0012 0.0261 0.1052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0553 0.08
Plasmodium falciparum alpha tubulin 1 0.0022 0.0853 0.2383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2387 0.2387
Schistosoma mansoni Smad4 0.0008 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0066 0.347 0.347
Echinococcus granulosus tubulin alpha chain 0.0022 0.0853 0.0853
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0662 0.185
Loa Loa (eye worm) tubulin beta chain 0.0012 0.0261 0.0377
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.0853 0.2383
Trypanosoma brucei monoglyceride lipase, putative 0.0067 0.3578 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0312 0.0451
Leishmania major epsilon tubulin, putative 0.0012 0.0261 0.073
Echinococcus multilocularis tubulin gamma 1 chain 0.0012 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0015 0.0463 0.0669
Onchocerca volvulus 0.0025 0.1031 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0662 0.185
Leishmania major beta tubulin 0.0012 0.0261 0.073
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.347 0.5015
Plasmodium falciparum lysophospholipase, putative 0.0067 0.3578 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0261 0.0261
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.1031 0.288
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.3578 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.1031 0.1483
Loa Loa (eye worm) hypothetical protein 0.0022 0.0853 0.1232
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.058 0.058
Echinococcus multilocularis beta tubulin 0.0012 0.0261 0.0261
Trypanosoma brucei alpha tubulin 0.0022 0.0853 0.2383
Brugia malayi MH2 domain containing protein 0.0008 0.0072 0.0104
Schistosoma mansoni tubulin subunit epsilon 0.0012 0.0261 0.0261
Echinococcus multilocularis tar DNA binding protein 0.0066 0.347 0.347
Loa Loa (eye worm) glutathione reductase 0.0049 0.2482 0.3587
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0312 0.0451
Brugia malayi Tubulin alpha chain 0.0022 0.0853 0.1232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.0867
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0853 0.2383
Trypanosoma brucei monoglyceride lipase, putative 0.0067 0.3578 1
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0067 0.3578 0.5148
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.6919 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Trichomonas vaginalis tubulin, putative 0.0012 0.0261 0.073
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0261 0.0377
Echinococcus granulosus tubulin alpha chain 0.0022 0.0853 0.0853
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0853 0.2383
Mycobacterium ulcerans lysophospholipase 0.0067 0.3578 1
Plasmodium falciparum glutathione reductase 0.0049 0.2482 0.6935
Echinococcus multilocularis tubulin alpha 0.0012 0.0261 0.0261
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.3578 1
Giardia lamblia Alpha-tubulin 0.0022 0.0853 1
Brugia malayi tubulin alpha chain - mouse 0.0022 0.0853 0.1232
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.058 0.0834
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.2387 0.345
Loa Loa (eye worm) hypothetical protein 0.0025 0.1031 0.149
Leishmania major beta tubulin 0.0012 0.0261 0.073
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0853 0.0853
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.695 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.621 0.8934
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.2482 0.357
Schistosoma mansoni smad1 5 8 and 0.0008 0.0072 0.0072
Trypanosoma brucei epsilon tubulin 0.0012 0.0261 0.073
Brugia malayi MH2 domain containing protein 0.0124 0.6919 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.058 0.1621
Plasmodium vivax tubulin beta chain, putative 0.0012 0.0261 0.073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Plasmodium vivax PST-A protein 0.0067 0.3578 1
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.0853 0.3436
Brugia malayi glutathione reductase 0.0049 0.2482 0.3587
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.0957
Trypanosoma brucei alpha tubulin 0.0022 0.0853 0.2383
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0853 0.0853
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Loa Loa (eye worm) tubulin alpha 2 0.001 0.0163 0.0236
Plasmodium falciparum thioredoxin reductase 0.0049 0.2482 0.6935
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0072 0.0072
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.058 0.1621
Echinococcus granulosus tubulin gamma 1 chain 0.0012 0.0261 0.0261
Echinococcus multilocularis beta tubulin 0.0012 0.0261 0.0261
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0067 0.3578 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.1031 0.149
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0072 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.0867
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.058 0.1621
Echinococcus granulosus beta tubulin 0.0012 0.0261 0.0261
Trypanosoma brucei beta tubulin 0.0012 0.0261 0.073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.058 0.0838
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.058 0.2337
Trypanosoma brucei trypanothione reductase 0.0049 0.2482 0.6935
Echinococcus multilocularis smad 0.0008 0.0072 0.0072
Plasmodium falciparum thioredoxin reductase 0.0017 0.058 0.1621
Toxoplasma gondii beta-1 tubulin, putative 0.0012 0.0261 0.1052
Schistosoma mansoni alpha tubulin 0.0022 0.0853 0.0853
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.3578 1
Schistosoma mansoni tubulin subunit beta 0.0012 0.0261 0.0261
Loa Loa (eye worm) beta-tubulin 0.0012 0.0261 0.0377
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0261 0.0261
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.058 0.058
Plasmodium falciparum alpha tubulin 2 0.0022 0.0853 0.2383
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.058 0.1621
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.1031 0.288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.2387 0.2387
Plasmodium falciparum lysophospholipase, putative 0.0067 0.3578 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0012 0.0261 0.0377
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0261 0.0261
Plasmodium falciparum esterase, putative 0.0067 0.3578 1
Leishmania major beta tubulin 0.0012 0.0261 0.073
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.621 0.8934
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.058 0.1621
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.058 0.1621
Loa Loa (eye worm) tubulin beta-4 chain 0.0012 0.0261 0.0377
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0853 0.2383
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0853 0.2383
Mycobacterium ulcerans hypothetical protein 0.0025 0.1031 0.288
Echinococcus granulosus tubulin alpha chain 0.0022 0.0853 0.0853
Leishmania major beta tubulin 0.0012 0.0261 0.073
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0853 0.1232
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0853 0.0853
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Echinococcus granulosus smad 0.0008 0.0072 0.0072
Plasmodium falciparum glutathione reductase 0.0017 0.058 0.1621
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0662 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0853 0.2383
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.621 0.8934
Treponema pallidum NADH oxidase 0.0017 0.058 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.1031 0.288
Schistosoma mansoni tubulin subunit gamma 0.0012 0.0261 0.0261
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0.0553 0.1546
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0261 0.0261
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0072 0.0072
Echinococcus granulosus tubulin beta 1 chain 0.0012 0.0261 0.0261
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.0853 0.0853
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.058 0.5
Leishmania major monoglyceride lipase, putative 0.0067 0.3578 1
Leishmania major beta tubulin 0.0012 0.0261 0.073
Trypanosoma cruzi tubulin gamma chain 0.0012 0.0261 0.073
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.1031 0.288
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0012 0.0261 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0066 0.347 0.347
Brugia malayi Tubulin gamma chain 0.0012 0.0261 0.0377
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0853 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.0867
Brugia malayi Smad1 0.0008 0.0072 0.0104
Brugia malayi alpha-tubulin 0.0022 0.0853 0.1232
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.0553 0.08
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0261 0.073
Leishmania major beta tubulin 0.0012 0.0261 0.073
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.1031 0.288
Echinococcus granulosus Smad4 0.0008 0.0072 0.0072
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.0853 0.1232
Brugia malayi MH1 domain containing protein 0.0008 0.0072 0.0104
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.0957
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Schistosoma mansoni tubulin subunit beta 0.0012 0.0261 0.0261
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0853 0.0853
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0853 0.1232
Echinococcus granulosus tubulin alpha chain 0.0022 0.0853 0.0853
Schistosoma mansoni tar DNA-binding protein 0.0066 0.347 0.347
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.3578 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.058 0.2337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.2387 0.2387
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Loa Loa (eye worm) RNA binding protein 0.0066 0.347 0.5015
Schistosoma mansoni alpha tubulin 0.0022 0.0853 0.0853
Echinococcus multilocularis geminin 0.0175 1 1
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0853 0.0853
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0072 0.0072
Brugia malayi MH1 domain containing protein 0.0008 0.0072 0.0104
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.695 1
Plasmodium vivax tubulin epsilon chain, putative 0.0012 0.0261 0.073
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0072 0.0104
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0261 0.0377
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.058 0.1621
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0853 0.0853
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.2482 0.2482
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.1031 0.288
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0853 0.0853
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0261 0.073
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.058 0.1621
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.347 0.5015
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.058 0.1621
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0261 0.0261
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0853 0.1232
Leishmania major beta tubulin 0.0012 0.0261 0.073
Leishmania major beta tubulin 0.0012 0.0261 0.073
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0067 0.3578 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0012 0.0261 0.073
Schistosoma mansoni hypothetical protein 0.0175 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2387 0.2387
Trypanosoma brucei beta tubulin 0.0012 0.0261 0.073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.1031 0.1483
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0261 0.073
Leishmania major beta tubulin 0.0012 0.0261 0.073
Loa Loa (eye worm) hypothetical protein 0.0025 0.1031 0.149
Entamoeba histolytica tubulin alpha-1 chain 0.0022 0.0853 0.2383
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Entamoeba histolytica tubulin alpha chain, putative 0.0022 0.0853 0.2383
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Trichomonas vaginalis tubulin epsilon chain, putative 0.0012 0.0261 0.073
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0853 0.0853
Schistosoma mansoni tubulin subunit beta 0.0012 0.0261 0.0261
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.0853 0.3436
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.621 0.8934
Trypanosoma brucei epsilon tubulin 0.0012 0.0261 0.073
Echinococcus multilocularis tubulin beta 1 chain 0.0012 0.0261 0.0261
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0853 0.1232
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.058 0.1621
Schistosoma mansoni tubulin subunit beta 0.0012 0.0261 0.0261
Leishmania major gamma-tubulin 0.0012 0.0261 0.073
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0015 0.0463 0.1293
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Trypanosoma brucei alpha tubulin 0.0022 0.0853 0.2383
Trypanosoma brucei beta tubulin 0.0012 0.0261 0.073
Brugia malayi tubulin alpha-2 chain 0.0022 0.0853 0.1232
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2387 0.2387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Echinococcus multilocularis tubulin subunit beta 0.0012 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.0957
Schistosoma mansoni tar DNA-binding protein 0.0066 0.347 0.347
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0853 0.2383
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0553 0.08
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0853 0.1232
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.0853 0.0853
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0261 0.0261
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0853 0.0853
Trypanosoma brucei beta tubulin 0.0012 0.0261 0.073
Trypanosoma cruzi epsilon tubulin, putative 0.0012 0.0261 0.073
Loa Loa (eye worm) Smad1 0.0008 0.0072 0.0104
Echinococcus granulosus alpha tubulin 0.0022 0.0853 0.0853
Leishmania major trypanothione reductase 0.0049 0.2482 0.6935
Mycobacterium ulcerans hypothetical protein 0.0067 0.3578 1
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0853 0.0853
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0072 0.0072
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0662 0.0952
Leishmania major beta tubulin 0.0012 0.0261 0.073
Trypanosoma cruzi monoglyceride lipase, putative 0.0067 0.3578 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.058 0.1621
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.2482 0.3587
Brugia malayi MH2 domain containing protein 0.0008 0.0072 0.0104
Loa Loa (eye worm) tubulin alpha-3 chain 0.0015 0.0463 0.0669
Leishmania major alpha tubulin 0.0022 0.0853 0.2383
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0853 0.2383
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.2482 0.6935
Echinococcus multilocularis Smad4 0.0008 0.0072 0.0072
Schistosoma mansoni smad1 5 8 and 0.0008 0.0072 0.0072
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.058 0.1621
Giardia lamblia Alpha-tubulin 0.0022 0.0853 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0012 0.0261 0.1052
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0261 0.0261
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0853 0.1232
Trichomonas vaginalis tubulin beta chain, putative 0.0012 0.0261 0.073
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0853 0.2383
Trypanosoma brucei alpha tubulin 0.0022 0.0853 0.2383
Brugia malayi TAR-binding protein 0.0066 0.347 0.5015
Entamoeba histolytica tubulin gamma chain 0.0012 0.0261 0.073
Trypanosoma brucei epsilon tubulin 0.0012 0.0261 0.073
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.621 0.8934
Leishmania major beta tubulin 0.0012 0.0261 0.073
Loa Loa (eye worm) tubulin beta-1 chain 0.0012 0.0261 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.3578 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.2387 0.345
Schistosoma mansoni tar DNA-binding protein 0.0066 0.347 0.347
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.058 0.1621
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.058 0.5
Brugia malayi Thioredoxin reductase 0.0049 0.2482 0.3587
Plasmodium falciparum tubulin gamma chain 0.0012 0.0261 0.073
Echinococcus granulosus tar DNA binding protein 0.0066 0.347 0.347
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0261 0.0261
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0261 0.073
Trypanosoma brucei tubulin gamma chain 0.0012 0.0261 0.073
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0853 0.0853
Plasmodium falciparum tubulin epsilon chain, putative 0.0012 0.0261 0.073
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.1031 0.288
Entamoeba histolytica tubulin family protein 0.0012 0.0261 0.073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.1031 0.288
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0853 0.0853
Echinococcus multilocularis hypothetical protein 0.0022 0.0853 0.0853
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.1031 0.288
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.058 0.058
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.0853 0.2383
Leishmania major beta tubulin 0.0012 0.0261 0.073
Loa Loa (eye worm) hypothetical protein 0.0025 0.1031 0.149
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0261 0.0261
Leishmania major beta tubulin 0.0012 0.0261 0.073
Trypanosoma cruzi epsilon tubulin, putative 0.0012 0.0261 0.073
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0853 0.0853
Schistosoma mansoni alpha tubulin 0.0022 0.0853 0.0853
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.1031 0.288
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.058 0.1621
Echinococcus granulosus tubulin epsilon chain 0.0012 0.0261 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.058 0.1621
Leishmania major beta tubulin 0.0012 0.0261 0.073
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.058 0.1621
Toxoplasma gondii thioredoxin reductase 0.0049 0.2482 1
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0261 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0025 0.1031 0.149
Echinococcus granulosus tubulin subunit TubB 0.0022 0.0853 0.0853
Plasmodium falciparum lysophospholipase, putative 0.0067 0.3578 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0853 0.0853
Brugia malayi RNA binding protein 0.0066 0.347 0.5015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.0867
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0662 0.185
Echinococcus granulosus tubulin alpha chain 0.0022 0.0853 0.0853
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.1031 0.288

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 14.2 uM Compound was evaluated for inhibition of tubulin polymerization using purified bovine brain tubulin, activity expressed as IC50 ChEMBL. No reference
IC50 (functional) = 14.2 uM Compound was evaluated for inhibition of tubulin polymerization using purified bovine brain tubulin, activity expressed as IC50 ChEMBL. No reference
Relative activity (functional) = 0.79 Inhibition of tubulin polymerization using purified bovine brain tubulin relative to estratropone, activity expressed as relative activity (IC50colchicine /IC50 estratropone). ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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