TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.436 | Formula: C21H23F2N5O2
H donors: 1 H acceptors: 3 LogP: 1.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)CN1CCn2c(CC1)nnc2CNC(=O)c1cc(oc1C)C
InChi: 1S/C21H23F2N5O2/c1-13-9-17(14(2)30-13)21(29)24-11-20-26-25-19-5-6-27(7-8-28(19)20)12-15-3-4-16(22)10-18(15)23/h3-4,9-10H,5-8,11-12H2,1-2H3,(H,24,29)
InChiKey: FXRYVFPSSUFLFQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	DNA helicase recq1, putative	0.0047	0.0891	0.9594
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0122	0.0122
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0337	0.1175
Echinococcus multilocularis	dnaJ subfamily B	0.0467	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0004	0.0007
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0027	0.0451	0.2031
Schistosoma mansoni	alpha-glucosidase	0.0149	0.31	0.31
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0122	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0122	0.0229
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0027	0.0451	0.2027
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0000000032684
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0337	0.0337
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0122	0.0229
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0122	0.0122
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0704	0.7505
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0014	0.0182	0.0311
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0075	0.1506	0.1506
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0095	0.193	0.3631
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.138	0.138
Entamoeba histolytica	recQ family DNA helicase	0.0017	0.0233	0.0387
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0583	0.1096
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0122	0.0122
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0122	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0122	0.0229
Echinococcus granulosus	bloom syndrome protein	0.0047	0.0891	0.0891
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0122	0.0122
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0014	0.0182	0.0341
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0048	0.0048
Schistosoma mansoni	alpha-glucosidase	0.0149	0.31	0.31
Onchocerca volvulus		0.0033	0.0583	0.2402
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0704	0.7505
Schistosoma mansoni	ap endonuclease	0.0021	0.0337	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Giardia lamblia	Histone acetyltransferase GCN5	0.0045	0.0839	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0004	0.0004
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0704	0.7505
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0704	0.7505
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0122	0.0229
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Schistosoma mansoni	thyroid hormone receptor	0.0155	0.3239	0.3239
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0704	0.3943
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0004	0.0007
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0982	0.0982
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0704	0.7505
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0704	0.3943
Echinococcus granulosus	cpg binding protein	0.0035	0.0623	0.0623
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0075	0.1506	0.1506
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0028	0.0479	0.3671
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0027	0.0451	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0122	0.0229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.0927	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0166	0.3461	0.3461
Brugia malayi	hypothetical protein	0.0006	0.0004	0.0007
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0048	0.0048
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0000000032684
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0092	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0122	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0122	0.0229
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0704	0.1324
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0337	0.4794
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.0839	0.4964
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0075	0.1506	0.1506
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0014	0.0182	0.1665
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0033	0.0000000032684
Brugia malayi	nuclear receptor RXR	0.0006	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0007
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0337	0.1175
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0004	0.0007
Echinococcus granulosus	survival motor neuron protein 1	0.0251	0.5316	0.5316
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0122	0.0122
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0027	0.0451	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.1506	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.1307	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0337	0.0337
Schistosoma mansoni	cpg binding protein	0.0035	0.0623	0.0623
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0075	0.1506	0.2833
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0161	0.336	0.336
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0007
Trichomonas vaginalis	DNA helicase recq, putative	0.0047	0.0891	0.9594
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0704	0.7505
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0122	0.0229
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0048	0.0048
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0033	0.058	0.1092
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0818	0.0818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0000000032684
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0173	0.3622	0.6815
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0036	0.0645	0.3496
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0122	0.0122
Echinococcus granulosus	L aminoadipate semialdehyde	0.0095	0.193	0.193
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0144	0.2989	0.2989
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0122	0.0229
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0075	0.1506	0.2833
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0704	0.3943
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0122	0.0229
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0704	0.0704
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0017	0.0233	0.0387
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0173	0.3622	0.3622
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0122	0.0122
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0704	0.3943
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0000000032684
Schistosoma mansoni	hypothetical protein	0.0051	0.0982	0.0982
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0122	0.0229
Brugia malayi	Bloom's syndrome protein homolog	0.0047	0.0891	0.1676
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0122	0.0229
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0033	0.058	0.058
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0044	0.0827	0.975
Schistosoma mansoni	DNA helicase recq1	0.0033	0.058	0.058
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0122	0.0229
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0122	0.0122
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0004	0.0004
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0033	0.058	0.058
Trypanosoma brucei	glucosidase, putative	0.0038	0.0704	0.3943
Entamoeba histolytica	recQ family helicase, putative	0.0016	0.0219	0.0284
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0704	0.0704
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0095	0.193	0.193
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0036	0.0645	0.3496
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0337	0.3406
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0122	0.0122
Brugia malayi	acetyltransferase, GNAT family protein	0.0166	0.3461	0.651
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0337	0.1175
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0927	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0033	0.058	0.058
Loa Loa (eye worm)	hypothetical protein	0.0251	0.5316	1
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0027	0.0451	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0122	0.0229
Schistosoma mansoni	cpg binding protein	0.0035	0.0623	0.0623
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0451	0.2031
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0122	0.0229
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0033	0.058	0.1092
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0033	0.058	0.058
Loa Loa (eye worm)	RecQ helicase	0.0047	0.0891	0.1676
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0027	0.0451	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.0839	1
Entamoeba histolytica	recQ family helicase, putative	0.0036	0.0645	0.3496
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0173	0.3622	0.3622
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0166	0.3461	0.3461
Onchocerca volvulus		0.01	0.2041	1
Loa Loa (eye worm)	acetyltransferase	0.0166	0.3461	0.651
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0122	0.0122
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0122	0.0229
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0122	0.0122
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0122	0.0122
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0233	0.0233
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0033	0.058	0.4846
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0122	0.0122
Toxoplasma gondii	exonuclease III APE	0.0021	0.0337	0.0972
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0337	0.3406
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0122	0.0122
Brugia malayi	ecdysteroid receptor	0.0012	0.0122	0.0229
Schistosoma mansoni	hypothetical protein	0.0144	0.2989	0.2989
Trichomonas vaginalis	DNA helicase recq, putative	0.0036	0.0645	0.6842
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0033	0.058	0.3236
Schistosoma mansoni	hypothetical protein	0.0467	1	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.003	0.0529	0.0529
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0033	0.058	0.1092
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0048	0.0048
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0017	0.0233	0.0387
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0182	0.1665
Echinococcus multilocularis	bloom syndrome protein	0.0047	0.0891	0.0891
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0155	0.3239	0.3239
Schistosoma mansoni	alpha glucosidase	0.0038	0.0704	0.0704
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0122	0.0122
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Brugia malayi	hypothetical protein	0.0006	0.0004	0.0007
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0122	0.0122
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0173	0.3622	0.6815
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0182	0.1665
Leishmania major	phosphopantetheinyl transferase-like protein	0.0027	0.0451	0.2031
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Schistosoma mansoni	cpg binding protein	0.0033	0.0583	0.0583
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0982	0.1847
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0704	0.7505
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0092	0.0092
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0092	0.0092
Schistosoma mansoni	coup transcription factor	0.0012	0.0122	0.0122
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0122	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0543	0.1022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0122	0.0229
Brugia malayi	hypothetical protein	0.0251	0.5316	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0004	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0122	0.0229
Schistosoma mansoni	DNA helicase recq5	0.0033	0.058	0.058
Loa Loa (eye worm)	hypothetical protein	0.0095	0.193	0.3631
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0182	0.1665
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0000000032684
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0182	0.0341
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0036	0.0645	0.3496
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0122	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0122	0.0122
Brugia malayi	steroid hormone receptor	0.0012	0.0122	0.0229
Echinococcus multilocularis	cpg binding protein	0.0035	0.0623	0.0623
Onchocerca volvulus		0.0051	0.0982	0.4482
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0229
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0033	0.0000000032684
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0122	0.0229
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0583	0.1096
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0337	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0033	0.058	0.1092
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0004	0.0004
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0337	0.0634
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0182	0.1665
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0027	0.0451	1
Brugia malayi	nuclear hormone receptor	0.0012	0.0122	0.0229
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0704	0.7505
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0337	0.1175
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0033	0.058	0.3236
Schistosoma mansoni	thyroid hormone receptor	0.0155	0.3239	0.3239
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0007
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0095	0.193	0.193
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0007
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0451	0.2259
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0075	0.1506	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0927	0.0927
Onchocerca volvulus		0.0095	0.193	0.9423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0122	0.0229
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0704	0.1324
Mycobacterium leprae	conserved hypothetical protein	0.0027	0.0451	0.5
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0027	0.0451	0.2027
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.1506	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0182	0.1665
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0089	0.0167
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0122	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0122	0.0229
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0182	0.1665
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0704	0.3943
Echinococcus multilocularis	survival motor neuron protein 1	0.0251	0.5316	0.5316
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0182	0.1665
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0704	0.7505
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0122	0.0122
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.0927	0.6463
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0818	0.0818
Schistosoma mansoni	ap endonuclease	0.0021	0.0337	0.0337
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0122	0.0122
Echinococcus granulosus	lysosomal alpha glucosidase	0.0173	0.3622	0.3622
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0233	0.0438
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0075	0.1506	1
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0027	0.0451	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.0927	0.6463
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0144	0.2989	0.2989
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0027	0.0465	0.2164
Giardia lamblia	Sgs1 DNA helicase, putative	0.0033	0.058	0.4846
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0704	0.4386
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0451	0.327
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.1506	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.0927	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0000000032684
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0122	0.0229
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0337	0.0634

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 822306