TDR Targets

Basic information

Technical information

TDR Targets ID: 82272
Name: 5-methoxy-1-[3-[4-[3-(trifluoromethyl)phenyl] piperazin-1-yl]propyl]quinolin-2-one
MW: 445.477 | Formula: C24H26F3N3O2
H donors: 0 H acceptors: 1 LogP: 4.36 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc2c1ccc(=O)n2CCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
InChi: 1S/C24H26F3N3O2/c1-32-22-8-3-7-21-20(22)9-10-23(31)30(21)12-4-11-28-13-15-29(16-14-28)19-6-2-5-18(17-19)24(25,26)27/h2-3,5-10,17H,4,11-16H2,1H3
InChiKey: UPMTXQBFGGSRSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-methoxy-1-[3-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]propyl]-2-quinolinone
5-methoxy-1-[3-[4-[3-(trifluoromethyl)phenyl]piperazino]propyl]carbostyril
5-methoxy-1-[3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propyl]carbostyril

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Sigma opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0093	0.1785	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0181	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Onchocerca volvulus		0.0028	0.026	0.0663
Schistosoma mansoni	acetylcholinesterase	0.0023	0.0152	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.026	0.0506
Onchocerca volvulus		0.0028	0.026	0.0663
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0734	0.2112
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.026	0.026
Echinococcus granulosus	allatostatin A receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Onchocerca volvulus		0.0093	0.1785	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.026	0.0506
Schistosoma mansoni	myosin xvIII	0.0028	0.026	0.0748
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.026	0.0506
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.047	1
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0028	0.026	0.0748
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0023	0.0152	0.0295
Onchocerca volvulus		0.0028	0.026	0.0663
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	Carboxylesterase family protein	0.0023	0.0152	0.0152
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0152	0.0152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.026	0.0506
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0152	0.0436
Echinococcus granulosus	neuropeptide receptor	0.0028	0.026	0.0506
Echinococcus granulosus	serotonin receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.026	0.0748
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.026	0.0506
Echinococcus granulosus	GPCR family 2	0.0034	0.0393	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	sex peptide receptor	0.0028	0.026	0.0506
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.1131
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.026	0.026
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.026	0.0506
Schistosoma mansoni	biogenic amine receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.047	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0023	0.0152	0.0295
Echinococcus multilocularis	acetylcholinesterase	0.0138	0.2836	0.5521
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.026	0.026
Echinococcus multilocularis	somatostatin receptor	0.0028	0.026	0.0506
Brugia malayi	Dopamine receptor protein 2	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1785	0.1785
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0075	0.4142
Onchocerca volvulus		0.0028	0.026	0.0663
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.026	0.0506
Brugia malayi	sulfakinin receptor protein	0.0028	0.026	0.026
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.047	0.047
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0075	0.0075
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.026	0.0748
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.026	0.0506
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0429	0.9641	0.9641
Brugia malayi	Carboxylesterase family protein	0.0138	0.2836	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1785	0.1785
Echinococcus multilocularis	geminin	0.0166	0.3475	0.6764
Echinococcus multilocularis	serotonin receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.2094	0.2094
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0152	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.026	0.026
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.026	0.0506
Leishmania major	hypothetical protein, conserved	0.0025	0.0181	0.0181
Brugia malayi	neuropeptide F receptor	0.0028	0.026	0.026
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.026	0.0748
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.047	1
Echinococcus granulosus	BC026374 protein S09 family	0.0023	0.0152	0.0295
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.026	0.0506
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0181	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.026	0.0506
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0023	0.0152	0.3997
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.026	0.0748
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.026	0.0506
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.026	0.0748
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.026	0.0506
Echinococcus multilocularis	acetylcholinesterase	0.0138	0.2836	0.5521
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.047	0.047
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.026	0.0506
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.047	0.047
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.026	0.0506
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0393	0.0765
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Schistosoma mansoni	BC026374 protein (S09 family)	0.0023	0.0152	0.0436
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Schistosoma mansoni	histamine h1 receptor	0.0028	0.026	0.0748
Schistosoma mansoni	neuropeptide receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	hypothetical protein	0.0023	0.0152	0.0152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Onchocerca volvulus		0.0028	0.026	0.0663
Brugia malayi	larval opioid receptor	0.0028	0.026	0.026
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.026	0.0506
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.026	0.0506
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Echinococcus granulosus	g protein coupled receptor	0.0028	0.026	0.0506
Echinococcus granulosus	somatostatin receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Schistosoma mansoni	amine GPCR	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.5137	1
Brugia malayi	hypothetical protein	0.0025	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0237	0.5137	0.5137
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.1307	0.1307
Brugia malayi	G protein-coupled receptor	0.0028	0.026	0.026
Brugia malayi	Serotonin receptor	0.0028	0.026	0.026
Schistosoma mansoni	biogenic amine receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.026	0.0748
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Brugia malayi	Inositol-1	0.0037	0.047	0.047
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1635	0.1635
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0023	0.0152	0.3997
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0023	0.0152	0.1938
Onchocerca volvulus		0.0028	0.026	0.0663
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.1131
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.026	0.0506
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0393	0.0765
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.026	0.0748
Onchocerca volvulus		0.0093	0.1785	1
Echinococcus granulosus	geminin	0.0166	0.3475	0.6764
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2836	0.2836
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.026	0.0506
Onchocerca volvulus		0.0028	0.026	0.0663
Echinococcus granulosus	hypothetical protein	0.0028	0.026	0.0506
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.026	0.0748
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.026	0.0506
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	AKH receptor	0.0028	0.026	0.026
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.026	0.0748
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Schistosoma mansoni	ap endonuclease	0.002	0.0075	0.0216
Loa Loa (eye worm)	acetylcholinesterase 1	0.0138	0.2836	0.2836
Trichomonas vaginalis	spcc417.12 protein, putative	0.0023	0.0152	0.1938
Schistosoma mansoni	amine GPCR	0.0028	0.026	0.0748
Schistosoma mansoni	adenoreceptor	0.0028	0.026	0.0748
Echinococcus multilocularis	neuroligin	0.0023	0.0152	0.0295
Brugia malayi	Carboxylesterase family protein	0.0023	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.1131
Echinococcus granulosus	orexin receptor type 2	0.0028	0.026	0.0506
Schistosoma mansoni	gliotactin	0.0023	0.0152	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2836	0.2836
Schistosoma mansoni	neuropeptide receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.026	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1307	0.1307
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.047	1
Echinococcus granulosus	neuroligin	0.0023	0.0152	0.0295
Onchocerca volvulus		0.0028	0.026	0.0663
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.026	0.026
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.047	0.0914
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	1	1
Toxoplasma gondii	exonuclease III APE	0.002	0.0075	0.1598
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0023	0.0152	0.0295
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0152	0.0152
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.026	0.0748
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.026	0.0506
Echinococcus multilocularis	carboxylesterase 5A	0.0138	0.2836	0.5521
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.026	0.0748
Schistosoma mansoni	amine GPCR	0.0028	0.026	0.0748
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Leishmania major	C-8 sterol isomerase-like protein	0.0445	1	1
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.026	0.0506
Schistosoma mansoni	amine GPCR	0.0028	0.026	0.0748
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	neuropeptide receptor	0.0028	0.026	0.0506
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.026	0.0506
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0181	0.0181
Schistosoma mansoni	neuropeptide receptor	0.0028	0.026	0.0748
Schistosoma mansoni	amine GPCR	0.0028	0.026	0.0748
Brugia malayi	Carboxylesterase family protein	0.0138	0.2836	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0075	0.5
Echinococcus granulosus	g protein coupled receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2331	0.2331
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Onchocerca volvulus		0.0028	0.026	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0075	0.0146
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0393	0.0765
Echinococcus granulosus	fmrfamide receptor	0.0028	0.026	0.0506
Schistosoma mansoni	inositol monophosphatase	0.0037	0.047	0.1352
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0023	0.0152	0.0436
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.026	0.0506
Brugia malayi	putative neuropeptide receptor	0.0028	0.026	0.026
Onchocerca volvulus		0.0028	0.026	0.0663
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.2094	0.2094
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	sex peptide receptor	0.0028	0.026	0.0506
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0075	0.0075
Echinococcus granulosus	carboxylesterase 5A	0.0138	0.2836	0.5521
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.026	0.026
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.026	0.0506
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.026	0.0748
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.026	0.026
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.026	0.0506
Schistosoma mansoni	opsin-like receptor	0.0028	0.026	0.0748
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.026	0.0506
Onchocerca volvulus		0.0028	0.026	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0445	1	1
Schistosoma mansoni	inositol monophosphatase	0.0037	0.047	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0075	0.4142
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.026	0.0506
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0075	0.0075
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Onchocerca volvulus		0.0028	0.026	0.0663
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0181	0.0181
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2331	0.2331
Brugia malayi	Melatonin receptor type 1A	0.0028	0.026	0.026
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0393	0.0765
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.047	1
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0393	0.0393
Brugia malayi	Dopamine receptor	0.0028	0.026	0.026
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.026	0.0663
Brugia malayi	GnHR receptor homolog	0.0028	0.026	0.026
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0181	0.3859
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0393	0.0393
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.026	0.0506
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.026	0.026
Schistosoma mansoni	biogenic amine receptor	0.0028	0.026	0.0748
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0093	0.1785	0.5138
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2094	0.2094
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.026	0.0506
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.026	0.0506
Brugia malayi	ORL1-like opioid receptor	0.0028	0.026	0.026
Schistosoma mansoni	neuropeptide receptor	0.0028	0.026	0.0748
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.026	0.026
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0734	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0393	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0429	0.9641	0.9641
Schistosoma mansoni	opsin-like receptor	0.0028	0.026	0.0748
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.026	0.0506
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0075	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.026	0.0506
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Schistosoma mansoni	hypothetical protein	0.0166	0.3475	1
Echinococcus granulosus	acetylcholinesterase	0.0138	0.2836	0.5521
Loa Loa (eye worm)	hypothetical protein	0.0227	0.4918	0.4918
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0393	0.0393
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0075	0.0146
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.026	0.026
Loa Loa (eye worm)	carboxylesterase	0.0138	0.2836	0.2836
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.026	0.026
Brugia malayi	RE15519p	0.0028	0.026	0.026
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Onchocerca volvulus		0.0028	0.026	0.0663
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.026	0.0506
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.2094	0.2094
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0023	0.0152	0.0295
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.026	0.026
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0093	0.1785	0.5138
Onchocerca volvulus		0.0028	0.026	0.0663
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.026	0.0506
Schistosoma mansoni	opsin-like receptor	0.0028	0.026	0.0748
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.047	1
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	neuropeptide F receptor	0.0028	0.026	0.026
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0393	0.0393
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Brugia malayi	Carboxylesterase family protein	0.0023	0.0152	0.0152
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.026	0.0506
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	g protein coupled receptor	0.0028	0.026	0.0506
Onchocerca volvulus		0.0048	0.0734	0.3564
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Onchocerca volvulus		0.0028	0.026	0.0663
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0075	0.0075
Brugia malayi	MH2 domain containing protein	0.0117	0.2331	0.2331
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0028	0.026	0.0748
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.026	0.0506
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.026	0.0748
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	1	1
Brugia malayi	Cation transporter family protein	0.0093	0.1785	0.1785
Mycobacterium ulcerans	carboxylesterase, LipT	0.0023	0.0152	0.1938
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.047	0.047
Onchocerca volvulus		0.0028	0.026	0.0663
Brugia malayi	G-protein coupled receptor	0.0028	0.026	0.026
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.026	0.026
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0379	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.1131
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.5137	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.026	0.0506
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.026	0.0748
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0075	0.198
Loa Loa (eye worm)	inositol-1	0.0037	0.047	0.047
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.026	0.0506
Schistosoma mansoni	ap endonuclease	0.002	0.0075	0.0216
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.026	0.0506
Brugia malayi	Serotonin receptor	0.0028	0.026	0.026
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0379	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.026	0.0506
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0181	1
Brugia malayi	G-protein coupled receptor	0.0028	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0073	0.1307	0.376
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0023	0.0152	0.3997
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.047	0.0914
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.026	0.0748
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0138	0.2836	0.8162
Brugia malayi	hypothetical protein	0.0028	0.026	0.026
Brugia malayi	Carboxylesterase family protein	0.0023	0.0152	0.0152
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.026	0.0506
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0181	0.0181
Onchocerca volvulus		0.0028	0.026	0.0663
Brugia malayi	Dopamine receptor protein 1	0.0028	0.026	0.026
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0075	0.0075
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.026	0.0506
Schistosoma mansoni	hypothetical protein	0.0028	0.026	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.026	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0166	0.3475	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0152	0.0436
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.026	0.0748
Echinococcus multilocularis	para nitrobenzyl esterase	0.0023	0.0152	0.0295
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.026	0.0506
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.026	0.0506
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.026	0.0506
Schistosoma mansoni	hypothetical protein	0.0048	0.0734	0.2112
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.026	0.0506
Echinococcus multilocularis	serotonin receptor	0.0028	0.026	0.0506
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.026	0.0506
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0075	0.0075
Echinococcus granulosus	acetylcholinesterase	0.0138	0.2836	0.5521
Brugia malayi	hypothetical protein	0.0237	0.5137	0.5137
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.047	1
Brugia malayi	hypothetical protein	0.0028	0.026	0.026

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 820 nM	Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]-DTG to rat whole brain membranes	ChEMBL.	10649973
IC50 (binding)	= 820 nM	Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]-DTG to rat whole brain membranes	ChEMBL.	10649973
NT (functional)	0	Effect on the sleeping time of mice before halothane load (control group);NT means not tested	ChEMBL.	10649973
NT (functional)	0	Effect on the sleeping time of mice anesthetized with halothane (treated group);NT means not tested	ChEMBL.	10649973
RRT (functional)	< 65 s	Effect on recovery time for coma induced in mice by cerebral concussion (treated group)	ChEMBL.	10649973
RRT (functional)	< 65 s	Effect on recovery time for coma induced in mice by cerebral concussion (treated group)	ChEMBL.	10649973
RRT (functional)	= 128 s	Effect on recovery time for coma induced in mice by cerebral concussion (control group)	ChEMBL.	10649973
RRT (functional)	= 128 s	Effect on recovery time for coma induced in mice by cerebral concussion (control group)	ChEMBL.	10649973

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL53951
PubChem: 11797587

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 82272