TDR Targets

Basic information

Technical information

TDR Targets ID: 822733
Name: 4-butoxy-N-(phenylmethyl)-N-pyridin-2-ylbenza mide
MW: 360.449 | Formula: C23H24N2O2
H donors: 0 H acceptors: 2 LogP: 4.92 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOc1ccc(cc1)C(=O)N(c1ccccn1)Cc1ccccc1
InChi: 1S/C23H24N2O2/c1-2-3-17-27-21-14-12-20(13-15-21)23(26)25(22-11-7-8-16-24-22)18-19-9-5-4-6-10-19/h4-16H,2-3,17-18H2,1H3
InChiKey: JUBFXQKPXWZGEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-butoxy-N-(phenylmethyl)-N-(2-pyridyl)benzamide
N-(benzyl)-4-butoxy-N-(2-pyridyl)benzamide
4-butoxy-N-(phenylmethyl)-N-pyridin-2-yl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0018	0.0054
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0043	0.0364	0.4375
Loa Loa (eye worm)	hypothetical protein	0.0184	0.2139	0.5067
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.0733	0.2154
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Brugia malayi	intermediate filament protein	0.0027	0.0163	0.0479
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0598	0.526
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Entamoeba histolytica	protein kinase, putative	0.0078	0.0808	0.39
Echinococcus granulosus	lamin	0.0027	0.0163	0.0479
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0074	0.0757	0.1792
Echinococcus multilocularis	musashi	0.0027	0.0163	0.0163
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.0364
Entamoeba histolytica	diacylglycerol kinase, putative	0.0066	0.0654	0.2781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0598	0.7334
Schistosoma mansoni	serine/threonine protein kinase	0.0284	0.3403	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0598	1
Echinococcus granulosus	protein kinase c iota type	0.0222	0.2627	0.7718
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0598	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0043	0.0364	0.5966
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0757	0.2224
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.107
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0003	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0364	0.107
Loa Loa (eye worm)	hypothetical protein	0.0275	0.3285	0.778
Brugia malayi	RhoGAP domain containing protein	0.0066	0.0654	0.1923
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0598	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0066	0.0654	0.1923
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0066	0.0654	0.155
Echinococcus multilocularis	myotubularin protein 13	0.007	0.0706	0.0706
Echinococcus multilocularis	lamin	0.0027	0.0163	0.0163
Brugia malayi	diacylglycerol kinase	0.0066	0.0654	0.1923
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0074	0.0757	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0064	0.0633	0.1859
Echinococcus multilocularis	unc 13 (munc13)	0.0072	0.0733	0.0733
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.0654	0.1923
Leishmania major	protein kinase A catalytic subunit	0.0043	0.0364	0.5966
Echinococcus granulosus	protein kinase c eta type	0.0066	0.0654	0.1923
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.0364
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0271	0.0797
Brugia malayi	Protein kinase c protein 2	0.0194	0.2263	0.665
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0598	1
Loa Loa (eye worm)	hypothetical protein	0.0341	0.412	0.9757
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0733	0.1736
Brugia malayi	Protein kinase domain containing protein	0.007	0.0699	0.2054
Onchocerca volvulus		0.0191	0.2234	0.6802
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0043	0.0364	0.0862
Schistosoma mansoni	serine/threonine protein kinase	0.0264	0.3156	0.9273
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0043	0.0364	0.5966
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.0364
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0043	0.0364	0.5966
Brugia malayi	diacylglycerol kinase	0.0066	0.0654	0.1923
Brugia malayi	Pleckstrin Homology Domain	0.007	0.0706	0.2074
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0074	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0654	0.155
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0074	0.0757	0.0757
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0757	0.884
Schistosoma mansoni	serine/threonine protein kinase	0.0264	0.3156	0.9273
Loa Loa (eye worm)	hypothetical protein	0.0275	0.3285	0.778
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.000000010465	0.000000010465
Entamoeba histolytica	hypothetical protein	0.0066	0.0654	0.2781
Echinococcus multilocularis	protein kinase c epsilon type	0.0284	0.3403	0.3403
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0043	0.0364	0.107
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0072	0.0733	0.2154
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0654	0.1923
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0598	0.1756
Schistosoma mansoni	protein kinase C	0.0072	0.0733	0.2154
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0163	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0004
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0043	0.0364	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0066	0.0654	0.1923
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0191	0.2227	0.6545
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.0699	0.2054
Schistosoma mansoni	protein kinase C mu	0.0066	0.0654	0.1923
Echinococcus granulosus	RNA directed DNA polymerase	0.0118	0.1305	0.3834
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0074	0.0757	0.2224
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0078	0.0808	0.1914
Schistosoma mansoni	diacylglycerol kinase theta	0.0066	0.0654	0.1923
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.0364
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0757	0.884
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Entamoeba histolytica	protein kinase, putative	0.0078	0.0808	0.39
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0074	0.0757	0.1792
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0066	0.0654	0.1923
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0127	0.1428	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0588	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0654	0.155
Onchocerca volvulus		0.0275	0.3285	1
Schistosoma mansoni	hypothetical protein	0.0066	0.0654	0.1923
Schistosoma mansoni	diacylglycerol kinase theta	0.0066	0.0654	0.1923
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0125	0.1393	0.3298
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0163	0.0386
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0598	0.1756
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0598	0.526
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0757	0.884
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0633	0.6048
Echinococcus granulosus	protein kinase c epsilon type	0.0284	0.3403	1
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0018	0.0054
Schistosoma mansoni	protein kinase C mu	0.0191	0.2227	0.6545
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0018	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Echinococcus multilocularis	protein kinase c eta type	0.0066	0.0654	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.3193
Schistosoma mansoni	rac gtpase activating protein	0.0066	0.0654	0.1923
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Echinococcus granulosus	serine:threonine protein kinase N2	0.0074	0.0757	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0191	0.2234	0.5292
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0633	0.6048
Brugia malayi	Uncoordinated protein 44	0.0014	0.000000010465	0.000000030753
Echinococcus granulosus	N chimaerin	0.0066	0.0654	0.1923
Echinococcus multilocularis	N chimaerin	0.0066	0.0654	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0588	0.1393
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0074	0.0757	0.1792
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0066	0.0654	0.0654
Loa Loa (eye worm)	hypothetical protein	0.007	0.0706	0.1672
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0211	0.2489	0.2489
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0364	0.107
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.107
Echinococcus granulosus	unc 13 munc13	0.0072	0.0733	0.2154
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0633	0.6048
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0163	0.0386
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0118	0.1305	0.1305
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0598	0.526
Echinococcus granulosus	myotubularin protein 13	0.007	0.0706	0.2074
Loa Loa (eye worm)	raf kinase	0.0066	0.0654	0.155
Echinococcus granulosus	Diacylglycerol kinase theta	0.0066	0.0654	0.1923
Echinococcus granulosus	NDR protein kinase	0.0074	0.0757	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0364	0.0862
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0043	0.0364	0.0862
Onchocerca volvulus		0.0027	0.0163	0.0496
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0598	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0066	0.0654	0.155
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0757	0.2224
Echinococcus granulosus	serine:threonine protein kinase N2	0.0141	0.1597	0.4692
Entamoeba histolytica	protein kinase, putative	0.0074	0.0757	0.3526
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.004	0.0319	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0654	0.155
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0066	0.0654	0.155
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0264	0.3156	0.3156
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.000000010465	0.000000030753
Onchocerca volvulus		0.0027	0.0163	0.0496
Schistosoma mansoni	lamin	0.0027	0.0163	0.0479
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0016	0.0018	0.5
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0074	0.0757	0.2224
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Onchocerca volvulus		0.0072	0.0733	0.2232
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0757	0.2224
Brugia malayi	protein kinase C3,putative	0.0152	0.1734	0.5095
Toxoplasma gondii	AGC kinase	0.0074	0.0757	1
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0757	0.2224
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0047	0.0416	0.1048
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0066	0.0654	0.0654
Schistosoma mansoni	serine/threonine kinase	0.0074	0.0757	0.2224
Trypanosoma brucei	protein kinase, putative	0.0062	0.0598	0.7334
Echinococcus multilocularis	protein kinase c iota type	0.0222	0.2627	0.2627
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0598	1
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0633	0.6048
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0163	0.0479
Echinococcus multilocularis	serine threonine protein kinase	0.0198	0.2321	0.2321
Schistosoma mansoni	vav2	0.007	0.0706	0.2074
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0757	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0654	0.155
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0074	0.0757	0.2224
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0047	0.0416	0.1048
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0045	0.0131
Onchocerca volvulus		0.0187	0.2183	0.6645
Brugia malayi	Ras association domain family 1 isoform A	0.0066	0.0654	0.1923
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1305	0.309
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0598	0.526
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0043	0.0364	0.4375
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.0699	0.2054
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0271	0.0271
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0364	0.107
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Echinococcus granulosus	protein kinase C gamma type	0.0198	0.2321	0.682
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0066	0.0654	0.1923
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0043	0.0364	0.5966
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0043	0.0364	0.4375
Echinococcus multilocularis	lamin dm0	0.0027	0.0163	0.0163
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0066	0.0654	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0588	0.1393
Brugia malayi	hypothetical protein	0.0036	0.0271	0.0797
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0633	0.6048
Brugia malayi	p70 ribosomal S6 kinase beta	0.0074	0.0757	0.2224
Onchocerca volvulus		0.0121	0.1348	0.4104
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0271	0.0797
Brugia malayi	RhoGAP domain containing protein	0.0066	0.0654	0.1923
Loa Loa (eye worm)	hypothetical protein	0.0349	0.4222	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0002	0.0005
Entamoeba histolytica	diacylglycerol kinase, putative	0.0066	0.0654	0.2781
Echinococcus granulosus	lamin dm0	0.0027	0.0163	0.0479
Echinococcus granulosus	Protein kinase C brain isozyme	0.0264	0.3156	0.9273
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0043	0.0364	0.107
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0066	0.0654	0.155
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0654	0.155
Echinococcus granulosus	Ankyrin	0.0014	0.0002	0.0005
Brugia malayi	Protein kinase domain containing protein	0.0078	0.0808	0.2375
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0757	0.2224
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0598	1
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.0733	0.2154
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0598	0.1756
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.007	0.0699	0.2054
Echinococcus multilocularis	Ankyrin	0.0014	0.0002	0.0002
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0191	0.2227	0.5276
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.000000010465	0.000000030753
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0074	0.0757	0.0757
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase	0.0064	0.0633	0.0633
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0074	0.0757	0.0757
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0073	0.0744	0.2186
Toxoplasma gondii	diacylglycerol kinase, putative	0.0066	0.0654	0.739
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.004	0.0319	0.0319
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Schistosoma mansoni	lamin	0.0027	0.0163	0.0479
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0078	0.0808	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0271	0.0797
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0071	0.0712	0.7836
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0633	0.6048
Brugia malayi	C1-like domain containing protein	0.0191	0.2227	0.6545
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0074	0.0757	0.1792
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0158	0.181	0.4287
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0598	0.0598
Entamoeba histolytica	protein kinase, putative	0.0074	0.0757	0.3526
Brugia malayi	MAP kinase sur-1	0.0062	0.0598	0.1756
Brugia malayi	RhoGEF domain containing protein	0.0066	0.0654	0.1923
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0598	0.1416
Loa Loa (eye worm)	hypothetical protein	0.0275	0.3285	0.778
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0074	0.0757	0.1792
Brugia malayi	Hr1 repeat family protein	0.0074	0.0757	0.2224
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.007	0.0699	0.0699
Echinococcus granulosus	intermediate filament protein	0.0027	0.0163	0.0479
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0073	0.0744	0.0744
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0284	0.3403	0.806
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0043	0.0364	0.5
Loa Loa (eye worm)	hypothetical protein	0.0187	0.2183	0.517
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0145	0.1648	1
Schistosoma mansoni	atypical protein kinase C	0.0228	0.2703	0.7942
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0598	0.0598
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0808	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0018	0.0043
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0598	0.595
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0074	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0157	0.0371
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0043	0.0364	0.5966
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0654	0.155
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.3193
Echinococcus multilocularis	RNA directed DNA polymerase	0.0118	0.1305	0.1305
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0066	0.0654	0.0654
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0072	0.0733	0.0733
Loa Loa (eye worm)	CAMKK/META protein kinase	0.0064	0.0633	0.1499
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0163	0.0479
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0018	0.0043
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0043	0.0364	0.5966
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0003	0.0008
Echinococcus granulosus	Rac GTPase activating protein 1	0.0066	0.0654	0.1923
Brugia malayi	Death domain containing protein	0.0014	0.000000010465	0.000000030753
Brugia malayi	protein kinase C II.	0.0284	0.3403	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 822733