TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.446 | Formula: C23H23N3O5
H donors: 3 H acceptors: 4 LogP: 1.92 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1O)C1N(CC2CCCO2)C(=O)c2c1c(n[nH]2)c1ccccc1O
InChi: 1S/C23H23N3O5/c1-30-18-11-13(8-9-17(18)28)22-19-20(15-6-2-3-7-16(15)27)24-25-21(19)23(29)26(22)12-14-5-4-10-31-14/h2-3,6-9,11,14,22,27-28H,4-5,10,12H2,1H3,(H,24,25)
InChiKey: LBNGANKQKIIDBA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0231	0.1348	0.4014
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0726	0.171
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0299	0.2074
Schistosoma mansoni	serine/threonine protein kinase	0.0244	0.1429	0.4157
Brugia malayi	diacylglycerol kinase	0.0132	0.0726	0.2112
Loa Loa (eye worm)	CAMKK/META protein kinase	0.0066	0.0315	0.0743
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0149	0.0832	0.0832
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0003	0.0009
Echinococcus granulosus	NDR protein kinase	0.0149	0.0832	0.2419
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0149	0.0832	0.0832
Schistosoma mansoni	protein kinase C mu	0.0132	0.0726	0.2112
Echinococcus multilocularis	N chimaerin	0.0132	0.0726	0.0726
Onchocerca volvulus		0.004	0.0155	0.0389
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0141	0.0783	0.5469
Echinococcus granulosus	serine:threonine protein kinase N2	0.0149	0.0832	0.2419
Entamoeba histolytica	protein kinase, putative	0.0157	0.0882	0.5152
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0422	0.2538	0.2538
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0237	0.1381	0.1381
Echinococcus multilocularis	unc 13 (munc13)	0.0144	0.0804	0.0804
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0208	0.0489
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0381	0.228	0.6632
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0198	0.0576
Schistosoma mansoni	serine/threonine kinase	0.0149	0.0832	0.2419
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.1429
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0132	0.0726	0.171
Loa Loa (eye worm)	hypothetical protein	0.0381	0.2282	0.5377
Loa Loa (eye worm)	hypothetical protein	0.0244	0.1429	0.3367
Schistosoma mansoni	serine/threonine protein kinase	0.0149	0.0832	0.2419
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0254	0.1493	0.3517
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0068	0.0161
Brugia malayi	protein kinase C3,putative	0.0303	0.1794	0.5218
Onchocerca volvulus		0.0026	0.0068	0.0125
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0149	0.0832	0.0832
Giardia lamblia	Kinase, AGC PKA	0.0244	0.1429	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0726	0.171
Echinococcus granulosus	protein kinase c epsilon type	0.0566	0.3438	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0063	0.0299	0.2074
Schistosoma mansoni	diacylglycerol kinase theta	0.0132	0.0726	0.2112
Brugia malayi	Protein kinase domain containing protein	0.0139	0.0775	0.2253
Echinococcus granulosus	raf serine:threonine protein kinase	0.0132	0.0726	0.2112
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0244	0.1429	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0521	0.1228
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0244	0.1429	0.3367
Echinococcus multilocularis	protein kinase c eta type	0.0132	0.0726	0.0726
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0112	0.0325
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0315	0.1869	0.4403
Echinococcus granulosus	myotubularin protein 13	0.014	0.0777	0.2259
Loa Loa (eye worm)	hypothetical protein	0.0547	0.3317	0.7815
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0132	0.0726	0.2112
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0149	0.0832	0.1959
Brugia malayi	Protein kinase domain containing protein	0.002	0.0027	0.0079
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.4157
Schistosoma mansoni	vav2	0.014	0.0777	0.2259
Brugia malayi	C1-like domain containing protein	0.0381	0.228	0.6632
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0244	0.1429	1
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0003	0.0007
Echinococcus multilocularis	rac serine:threonine kinase	0.0016	0.0003	0.0003
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0244	0.1429	1
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0149	0.0832	0.1959
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1367	0.322
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0252	0.148	0.8654
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0157	0.0882	0.6165
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0149	0.0832	0.1959
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0129	0.0303
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0123	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0629
Brugia malayi	intermediate filament protein	0.0026	0.0068	0.0198
Toxoplasma gondii	diacylglycerol kinase, putative	0.0132	0.0726	0.5069
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0144	0.0804	0.2338
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0112	0.0263
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0149	0.0832	0.1959
Echinococcus multilocularis	protein kinase c epsilon type	0.0566	0.3438	0.3438
Brugia malayi	Protein kinase domain containing protein	0.0149	0.0832	0.2419
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Brugia malayi	hypothetical protein	0.0099	0.0521	0.1516
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0132	0.0726	0.171
Echinococcus granulosus	intermediate filament protein	0.0026	0.0068	0.0198
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0244	0.1429	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0149	0.0832	0.1959
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.1345	0.1345
Schistosoma mansoni	serine/threonine protein kinase	0.0527	0.3194	0.9291
Loa Loa (eye worm)	hypothetical protein	0.0547	0.3317	0.7815
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0129	0.0374
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0149	0.0832	0.1959
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.1429
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0521	0.1228
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0527	0.3194	0.3194
Onchocerca volvulus		0.0381	0.2282	0.6855
Echinococcus multilocularis	myotubularin protein 13	0.014	0.0777	0.0777
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Onchocerca volvulus		0.0099	0.0521	0.1502
Echinococcus granulosus	Ankyrin repeat domain containing protein	0.0088	0.0452	0.1314
Schistosoma mansoni	serine/threonine protein kinase	0.0149	0.0832	0.2419
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0315	0.0917
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0315	0.219
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0804	0.1893
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Loa Loa (eye worm)	hypothetical protein	0.0678	0.4139	0.9751
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1173	0.2762
Schistosoma mansoni	serine/threonine protein kinase	0.0149	0.0832	0.2419
Brugia malayi	Protein kinase c protein 2	0.0386	0.2315	0.6734
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0123	0.0358
Echinococcus granulosus	N chimaerin	0.0132	0.0726	0.2112
Toxoplasma gondii	AGC kinase	0.0149	0.0832	0.5809
Brugia malayi	Hr1 repeat family protein	0.0149	0.0832	0.2419
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0086	0.058
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0775	0.2253
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0021	0.0032	0.0076
Toxoplasma gondii	AGC kinase	0.0244	0.1429	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0132	0.0726	0.171
Echinococcus granulosus	mitogen activated protein kinase	0.0063	0.0299	0.0869
Echinococcus granulosus	serine/threonine protein kinase	0.0016	0.0003	0.0009
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Onchocerca volvulus		0.0047	0.0198	0.0519
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0315	0.219
Entamoeba histolytica	protein kinase, putative	0.002	0.003	0.0158
Onchocerca volvulus		0.0547	0.3317	1
Echinococcus multilocularis	protein kinase c iota type	0.0444	0.2673	0.2673
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0244	0.1429	0.4157
Brugia malayi	Variant SH3 domain containing protein	0.0132	0.0726	0.2112
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Trichomonas vaginalis	AGC family protein kinase	0.0149	0.0832	0.5809
Schistosoma mansoni	rac gtpase activating protein	0.0132	0.0726	0.2112
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0149	0.0832	0.0832
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0132	0.0726	0.171
Brugia malayi	hypothetical protein	0.0231	0.1345	0.3913
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0063	0.0299	0.2074
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0068	0.0198
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0063	0.0299	0.2074
Schistosoma mansoni	serine/threonine-protein kinase	0.0016	0.0003	0.0009
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0003	0.0007
Entamoeba histolytica	hypothetical protein	0.0035	0.0123	0.0704
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0244	0.1429	1
Schistosoma mansoni	serine/threonine protein kinase	0.0566	0.3438	1
Brugia malayi	RhoGAP domain containing protein	0.0132	0.0726	0.2112
Echinococcus multilocularis	Ankyrin repeat domain containing protein	0.0088	0.0452	0.0452
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0149	0.0832	0.2419
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0726	0.171
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0726	0.171
Loa Loa (eye worm)	hypothetical protein	0.0366	0.2189	0.5157
Entamoeba histolytica	protein kinase, putative	0.0157	0.0882	0.5152
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0208	0.0489
Brugia malayi	M-phase phosphoprotein, mpp8	0.0099	0.0521	0.1516
Plasmodium vivax	SET domain protein, putative	0.0029	0.0086	0.058
Echinococcus granulosus	Rac GTPase activating protein 1	0.0132	0.0726	0.2112
Schistosoma mansoni	hypothetical protein	0.0035	0.0123	0.0358
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0775	0.2253
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0032	0.0094
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0299	0.2074
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0299	0.2074
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0208	0.0604
Entamoeba histolytica	hypothetical protein	0.0035	0.0123	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0086	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0726	0.171
Brugia malayi	protein kinase C II.	0.0566	0.3438	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0144	0.0804	0.0804
Schistosoma mansoni	hypothetical protein	0.0047	0.0198	0.0576
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0149	0.0434
Brugia malayi	p70 ribosomal S6 kinase beta	0.0149	0.0832	0.2419
Echinococcus granulosus	lamin dm0	0.0026	0.0068	0.0198
Echinococcus granulosus	serine:threonine protein kinase N2	0.0281	0.1659	0.4826
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0088	0.0452	0.1314
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0249	0.1458	0.3435
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0086	0.025
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Schistosoma mansoni	protein kinase C	0.0144	0.0804	0.2338
Echinococcus multilocularis	geminin	0.0338	0.2014	0.2014
Schistosoma mansoni	atypical protein kinase C	0.0456	0.2748	0.7993
Echinococcus multilocularis	mitogen activated protein kinase	0.0063	0.0299	0.0299
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0114	0.0777
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0244	0.1429	1
Brugia malayi	RhoGAP domain containing protein	0.0132	0.0726	0.2112
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0629
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0068	0.0197
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0086	0.0086
Schistosoma mansoni	serine/threonine-protein kinase	0.0016	0.0003	0.0009
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0234	0.1367	0.1367
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0132	0.0726	0.0726
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0244	0.1429	1
Trichomonas vaginalis	AGC family protein kinase	0.0149	0.0832	0.5809
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0315	0.219
Onchocerca volvulus		0.0373	0.2232	0.67
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0003	0.0009
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0063	0.0299	0.0704
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.1348	0.9429
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0566	0.3438	0.8099
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0244	0.1429	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.0132	0.0726	0.2112
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.002	0.0027	0.0064
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0381	0.228	0.5371
Trichomonas vaginalis	AGC family protein kinase	0.0244	0.1429	1
Schistosoma mansoni	hypothetical protein	0.0338	0.2014	0.5857
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0132	0.0726	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1409	0.332
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0139	0.0775	0.2253
Entamoeba histolytica	diacylglycerol kinase, putative	0.0132	0.0726	0.4236
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0016	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0547	0.3317	0.7815
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0244	0.1429	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0099	0.0233
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0063	0.0299	0.2074
Schistosoma mansoni	lamin	0.0026	0.0068	0.0198
Brugia malayi	Pre-SET motif family protein	0.0029	0.0086	0.025
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0132	0.0726	0.0726
Trypanosoma brucei	protein kinase, putative	0.0063	0.0299	0.2074
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0244	0.1429	1
Brugia malayi	RhoGEF domain containing protein	0.0132	0.0726	0.2112
Schistosoma mansoni	hypothetical protein	0.0033	0.0112	0.0325
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0157	0.0882	0.2078
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0149	0.0434
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0244	0.1429	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0132	0.0726	0.4236
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Schistosoma mansoni	serine/threonine protein kinase	0.0149	0.0832	0.2419
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase	0.0066	0.0315	0.0315
Schistosoma mansoni	protein kinase C mu	0.0381	0.228	0.6632
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.1429
Echinococcus granulosus	RNA directed DNA polymerase	0.0234	0.1367	0.3975
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0129	0.0129
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0139	0.0775	0.0775
Brugia malayi	Pre-SET motif family protein	0.0203	0.1173	0.3411
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0086	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0527	0.3194	0.9291
Brugia malayi	Pleckstrin Homology Domain	0.014	0.0777	0.2259
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0129	0.0374
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0149	0.0832	0.2419
Toxoplasma gondii	AGC kinase	0.0244	0.1429	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0123	0.0123
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0315	0.219
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0068	0.0198
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0063	0.0299	0.2074
Onchocerca volvulus		0.0144	0.0804	0.236
Echinococcus multilocularis	musashi	0.0026	0.0068	0.0068
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.4157
Echinococcus multilocularis	lamin dm0	0.0026	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0068	0.0161
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.004	0.0155	0.0452
Trichomonas vaginalis	AGC family protein kinase	0.0149	0.0832	0.5809
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0063	0.0299	0.2074
Entamoeba histolytica	hypothetical protein	0.0035	0.0123	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0695	0.4245	1
Entamoeba histolytica	protein kinase, putative	0.0149	0.0832	0.4854
Entamoeba histolytica	protein kinase, putative	0.002	0.003	0.0158
Schistosoma mansoni	hypothetical protein	0.0132	0.0726	0.2112
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0088	0.0452	0.1314
Schistosoma mansoni	unc-13 (munc13)	0.0144	0.0804	0.2338
Echinococcus multilocularis	lamin	0.0026	0.0068	0.0068
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0299	0.2074
Echinococcus granulosus	protein kinase C gamma type	0.0395	0.2372	0.6899
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0289	0.171	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0086	0.025
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0086	0.025
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0063	0.0299	0.0299
Schistosoma mansoni	diacylglycerol kinase theta	0.0132	0.0726	0.2112
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0726	0.171
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1345	0.317
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0252	0.148	0.8654
Loa Loa (eye worm)	hypothetical protein	0.014	0.0777	0.183
Brugia malayi	diacylglycerol kinase	0.0132	0.0726	0.2112
Onchocerca volvulus		0.0099	0.0521	0.1502
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0149	0.0832	0.0832
Echinococcus granulosus	lamin	0.0026	0.0068	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0373	0.2232	0.5257
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0079	0.023
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0299	0.0869
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0315	0.219
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0244	0.1429	1
Loa Loa (eye worm)	raf kinase	0.0132	0.0726	0.171
Trypanosoma cruzi	cAMP binding protein, putative	0.0017	0.0011	0.0057
Echinococcus multilocularis	serine threonine protein kinase	0.0395	0.2372	0.2372
Trypanosoma brucei	cAMP binding protein, putative	0.0017	0.0011	0.0057
Brugia malayi	Protein kinase domain containing protein	0.0157	0.0882	0.2566
Echinococcus granulosus	protein kinase c eta type	0.0132	0.0726	0.2112
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0132	0.0726	0.0726
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0063	0.0299	0.2074
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.4157
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.0726	0.2112
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0629
Echinococcus granulosus	unc 13 munc13	0.0144	0.0804	0.2338
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.1345	0.3913
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0114	0.0777
Onchocerca volvulus		0.0241	0.1409	0.4201
Entamoeba histolytica	hypothetical protein	0.0035	0.0123	0.0704
Echinococcus multilocularis	RNA directed DNA polymerase	0.0234	0.1367	0.1367
Entamoeba histolytica	protein kinase, putative	0.0149	0.0832	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1409	0.332
Brugia malayi	Ras association domain family 1 isoform A	0.0132	0.0726	0.2112
Echinococcus granulosus	protein kinase c iota type	0.0444	0.2673	0.7775
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0132	0.0726	0.2112
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0086	0.0086
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0003	0.0007
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0208	0.0604
Brugia malayi	hypothetical protein	0.0035	0.0123	0.0358
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0068	0.0161
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.0882	0.6165
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0244	0.1429	0.1429
Schistosoma mansoni	hypothetical protein	0.0338	0.2014	0.5857
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0244	0.1429	1
Schistosoma mansoni	serine/threonine protein kinase	0.0244	0.1429	0.4157
Echinococcus granulosus	Protein kinase C brain isozyme	0.0527	0.3194	0.9291
Schistosoma mansoni	serine/threonine protein kinase	0.0244	0.1429	0.4157
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0149	0.0832	0.2419
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0315	0.219
Brugia malayi	Protein kinase domain containing protein	0.0149	0.0832	0.2419
Schistosoma mansoni	lamin	0.0026	0.0068	0.0198
Echinococcus granulosus	mitogen activated protein kinase 3	0.0063	0.0299	0.0869
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0198	0.0576
Brugia malayi	MAP kinase sur-1	0.0063	0.0299	0.0869
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0132	0.0726	0.2112
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0068	0.016
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0063	0.0299	0.2074
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0065	0.0154
Schistosoma mansoni	unc-13 (munc13)	0.0144	0.0804	0.2338
Entamoeba histolytica	hypothetical protein	0.0132	0.0726	0.4236
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0237	0.1381	0.4016
Onchocerca volvulus		0.0026	0.0068	0.0125
Echinococcus granulosus	geminin	0.0338	0.2014	0.5857
Leishmania major	protein kinase A catalytic subunit	0.0244	0.1429	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 822755