TDR Targets

Basic information

Technical information

TDR Targets ID: 822982
Name: N-[(2-fluorophenyl)methyl]-2-(4-methyl-2-oxop yrimido[1,2-b]indazol-6-yl)propanamide
MW: 378.4 | Formula: C21H19FN4O2
H donors: 1 H acceptors: 2 LogP: 2.92 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(n1c2ccccc2c2n1c(C)cc(=O)n2)C)NCc1ccccc1F
InChi: 1S/C21H19FN4O2/c1-13-11-19(27)24-20-16-8-4-6-10-18(16)26(25(13)20)14(2)21(28)23-12-15-7-3-5-9-17(15)22/h3-11,14H,12H2,1-2H3,(H,23,28)
InChiKey: MYBYJCLOFNXAPT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2-fluorophenyl)methyl]-2-(4-methyl-2-oxo-pyrimido[1,2-b]indazol-6-yl)propanamide
N-[(2-fluorophenyl)methyl]-2-(4-methyl-2-oxo-6-pyrimido[1,2-b]indazolyl)propanamide
N-(2-fluorobenzyl)-2-(2-keto-4-methyl-pyrimido[1,2-b]indazol-6-yl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0088	0.2034	0.8648
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.2034	0.9372
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0695	0.0929
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0047	0.0978	0.4083
Echinococcus multilocularis	dual specificity	0.0088	0.2034	0.2717
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0447	0.1786
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0094	0.2168	0.2896
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0087	0.0248
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Echinococcus granulosus	peregrin	0.0009	0.0035	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0327	0.2035
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0377	0.0292
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0939	0.1255
Echinococcus multilocularis	PWWP domain containing protein 2A	0.0009	0.0035	0.0046
Schistosoma mansoni	hypothetical protein	0.0009	0.0035	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trichomonas vaginalis	ran, putative	0.0021	0.0327	0.0242
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.2779	0.3712
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0517	0.1661
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0094	0.2168	1
Plasmodium vivax	thioredoxin reductase, putative	0.0066	0.1471	1
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0088	0.2034	0.9372
Entamoeba histolytica	hypothetical protein	0.0035	0.0695	0.2859
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0377	0.5
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0101	0.2346	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Schistosoma mansoni	hypothetical protein	0.0009	0.0035	0.0046
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0939	0.1255
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0695	0.0929
Entamoeba histolytica	hypothetical protein	0.0011	0.0087	0.0229
Entamoeba histolytica	hypothetical protein	0.0011	0.0087	0.0229
Echinococcus granulosus	dual specificity	0.0088	0.2034	0.2717
Brugia malayi	RNA, U transporter 1	0.0081	0.1845	0.2512
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0023	0.0377	0.5
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0385	0.0514
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0381	0.1623
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0695	0.0929
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Schistosoma mansoni	hepatoma derived growth factor	0.0009	0.0035	0.0046
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0939	0.1255
Echinococcus granulosus	PWWP domain containing protein 2A	0.0009	0.0035	0.0046
Brugia malayi	Importin beta-1 subunit	0.0028	0.0517	0.0704
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0377	0.1606
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0377	0.1606
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0223	0.0304
Echinococcus multilocularis	PWWP domain containing protein 2A	0.0009	0.0035	0.0046
Treponema pallidum	NADH oxidase	0.0023	0.0377	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0939	0.1255
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0517	0.0691
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0976	0.0897
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0447	0.1935
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0377	0.1606
Toxoplasma gondii	thioredoxin reductase	0.0066	0.1471	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Schistosoma mansoni	tsg101-related	0.0047	0.0978	0.1307
Brugia malayi	hypothetical protein	0.0298	0.7345	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0087	0.0248
Schistosoma mansoni	importin beta-1	0.0028	0.0517	0.0691
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0377	0.0439
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Entamoeba histolytica	hypothetical protein	0.0101	0.2346	1
Loa Loa (eye worm)	glutathione reductase	0.0066	0.1471	0.1966
Brugia malayi	PWWP domain containing protein	0.0009	0.0035	0.0047
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0088	0.2034	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0517	0.0691
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0377	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0101	0.2346	0.2279
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0381	0.0296
Brugia malayi	serine/threonine-protein kinase plk-2	0.0094	0.2168	0.2951
Echinococcus granulosus	PWWP domain containing protein 2A	0.0009	0.0035	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.2168	0.2896
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Entamoeba histolytica	hypothetical protein	0.0011	0.0087	0.0229
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0377	0.0513
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0517	0.0691
Schistosoma mansoni	SET domain protein	0.0032	0.0615	0.0822
Schistosoma mansoni	tsg101-related	0.0057	0.1243	0.1661
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0939	0.1255
Trypanosoma brucei	trypanothione reductase	0.0066	0.1471	0.6736
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0517	0.2262
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0046
Schistosoma mansoni	phd finger protein	0.0009	0.0035	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Leishmania major	trypanothione reductase	0.0066	0.1471	0.6736
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0381	0.0296
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0377	0.1606
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0377	0.2384
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0447	0.0124
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0447	0.0598
Entamoeba histolytica	hypothetical protein	0.0035	0.0695	0.2859
Echinococcus multilocularis	histone lysine N methyltransferase, H3 lysine 36	0.001	0.0062	0.0083
Echinococcus granulosus	histone lysine N methyltransferase H3 lysine 36	0.001	0.0062	0.0083
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0101	0.2346	0.2279
Brugia malayi	Protein kinase domain containing protein	0.0088	0.2034	0.2769
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0447	0.0598
Brugia malayi	Flap endonuclease-1	0.0026	0.0447	0.0609
Giardia lamblia	NADPH oxidoreductase, putative	0.0403	1	1
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0069	0.1534	0.2049
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Schistosoma mansoni	ran	0.0021	0.0327	0.0437
Schistosoma mansoni	SET domain protein	0.001	0.0062	0.0083
Giardia lamblia	NADPH oxidoreductase, putative	0.0403	1	1
Leishmania major	hypothetical protein, conserved	0.0022	0.0352	0.149
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Brugia malayi	hypothetical protein	0.0035	0.0695	0.0947
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.2034	0.9372
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0032	0.0615	0.0822
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0447	0.0598
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0377	0.1606
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0939	0.1255
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0094	0.2168	0.2896
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0022	0.0352	0.149
Trichomonas vaginalis	conserved hypothetical protein	0.0302	0.7451	0.7428
Giardia lamblia	Kinase, PLK	0.0094	0.2168	0.1903
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.2034	0.2717
Echinococcus granulosus	geminin	0.0167	0.4029	0.5383
Brugia malayi	hypothetical protein	0.0009	0.0035	0.0047
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0377	0.2384
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0377	0.0439
Plasmodium falciparum	thioredoxin reductase	0.0066	0.1471	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Entamoeba histolytica	hypothetical protein	0.0023	0.0381	0.1498
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Schistosoma mansoni	hypothetical protein	0.0303	0.7485	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0939	0.1255
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0223	0.0304
Schistosoma mansoni	hypothetical protein	0.0035	0.0695	0.0929
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0377	0.0439
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0377	0.1606
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0381	0.0296
Entamoeba histolytica	protein kinase, putative	0.0088	0.2034	0.8648
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0377	0.0052
Echinococcus granulosus	thioredoxin glutathione reductase	0.0066	0.1471	0.1966
Entamoeba histolytica	protein kinase domain containing protein	0.0088	0.2034	0.8648
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0066	0.1471	0.1966
Entamoeba histolytica	hypothetical protein	0.0035	0.0695	0.2859
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0066	0.1471	1
Brugia malayi	hypothetical protein	0.0069	0.1534	0.2088
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0377	0.0439
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0377	0.0292
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0447	0.2872
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0377	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0403	1	1
Brugia malayi	Thioredoxin reductase	0.0066	0.1471	0.2003
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0327	0.1371
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0088	0.2034	0.9372
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0939	0.1279
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0101	0.2346	1
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0377	0.0439
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Brugia malayi	hypothetical protein	0.0009	0.0035	0.0047
Schistosoma mansoni	tsg101-related	0.0057	0.1243	0.1661
Trypanosoma cruzi	trypanothione reductase, putative	0.0066	0.1471	0.6736
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Schistosoma mansoni	kinase	0.0048	0.1007	0.1346
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Echinococcus granulosus	snurportin 1	0.0303	0.7485	1
Schistosoma mansoni	hypothetical protein	0.0009	0.0035	0.0046
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0298	0.7345	0.9813
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Schistosoma mansoni	ran	0.0021	0.0327	0.0437
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0022	0.0352	0.149
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0327	0.1371
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0327	0.0445
Plasmodium falciparum	importin beta, putative	0.0028	0.0517	0.1661
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0381	0.1623
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0447	0.1052
Entamoeba histolytica	Ran family GTPase	0.0021	0.0327	0.1265
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0377	0.5
Leishmania major	GTP-binding protein, putative	0.0021	0.0327	0.1371
Loa Loa (eye worm)	thioredoxin reductase	0.0066	0.1471	0.1966
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Schistosoma mansoni	hepatoma derived growth factor	0.0009	0.0035	0.0046
Schistosoma mansoni	hypothetical protein	0.0167	0.4029	0.5383
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2168	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Schistosoma mansoni	hypothetical protein	0.0167	0.4029	0.5383
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0377	0.0504
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0377	0.1606
Echinococcus multilocularis	hepatoma derived growth factor protein	0.0009	0.0035	0.0046
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0327	0.0437
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0377	0.1606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0939	0.1255
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0517	0.2262
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0377	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0377	0.1606
Plasmodium vivax	glutathione reductase, putative	0.0066	0.1471	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0101	0.2346	0.2279
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0094	0.2168	0.9228
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1534	0.2049
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0377	0.5
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0447	0.1935
Echinococcus multilocularis	snurportin 1	0.0303	0.7485	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0327	0.0437
Echinococcus multilocularis	geminin	0.0167	0.4029	0.5383
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Onchocerca volvulus		0.0298	0.7345	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2014	0.2691
Loa Loa (eye worm)	PWWP domain-containing protein	0.0009	0.0035	0.0046
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0517	0.3358
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0327	0.0437
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0377	0.1606
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2346	0.2279
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.7485	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0327	0.1371
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.2779	0.3712
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2168	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0447	0.0363
Trypanosoma brucei	polo-like protein kinase	0.0094	0.2168	1
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0032	0.0615	0.0822
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0377	0.0504
Brugia malayi	MH2 domain containing protein	0.0118	0.2779	0.3783
Echinococcus multilocularis	peregrin	0.0009	0.0035	0.0046
Plasmodium falciparum	glutathione reductase	0.0023	0.0377	0.0439
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Entamoeba histolytica	hypothetical protein	0.0011	0.0087	0.0229
Entamoeba histolytica	hypothetical protein	0.0035	0.0695	0.2859
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0403	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Trichomonas vaginalis	modulator of drug activity B, putative	0.0101	0.2346	0.2279
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0447	0.1052
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0069	0.1534	0.2049
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0011	0.0087	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2014	0.2691
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0377	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0403	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0976	0.0897
Plasmodium falciparum	glutathione reductase	0.0066	0.1471	1
Brugia malayi	glutathione reductase	0.0066	0.1471	0.2003
Trichomonas vaginalis	hypothetical protein	0.0033	0.0643	0.056
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0447	0.1935
Echinococcus granulosus	hepatoma derived growth factor protein	0.0009	0.0035	0.0046
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2168	0.2099
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0094	0.2168	0.2896
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0403	1	1
Entamoeba histolytica	hypothetical protein	0.0088	0.2034	0.8648
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0094	0.2168	0.2918

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 822982