Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0662 | 0.0662 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0134 | 0.0134 |
Leishmania major | DNA polymerase eta, putative | 0.0042 | 0.1334 | 0.4431 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0096 | 0.0096 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.008 | 0.2746 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.4234 | 0.4234 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0186 | 0.0186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.2774 | 0.2774 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0096 | 0.0235 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.138 | 0.4544 |
Brugia malayi | Flap endonuclease-1 | 0.0026 | 0.0738 | 0.0738 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.6523 | 0.6523 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0016 | 0.038 | 0.1382 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.0061 | 0.2057 | 0.2057 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.006 | 0.1997 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0067 | 0.0067 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0016 | 0.038 | 0.0245 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.4069 | 1 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0096 | 0.0096 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0134 | 0.0329 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0707 | 0.9482 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0473 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0707 | 0.0707 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0134 | 0.0329 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0363 | 0.2164 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0096 | 0.0096 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0096 | 0.0235 |
Plasmodium falciparum | flap endonuclease 1 | 0.0026 | 0.0738 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0067 | 0.0067 |
Echinococcus multilocularis | dna polymerase kappa | 0.008 | 0.2746 | 0.6748 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0274 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.4234 | 0.4234 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2704 | 0.2704 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0483 | 0.0483 |
Echinococcus granulosus | dna polymerase kappa | 0.008 | 0.2746 | 0.6748 |
Schistosoma mansoni | smad | 0.0008 | 0.0067 | 0.0067 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0023 | 0.0627 | 0.429 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0067 | 0.0166 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0483 | 0.0483 |
Onchocerca volvulus | 0.0019 | 0.0483 | 0.074 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0016 | 0.038 | 0.1382 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0483 | 0.0483 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.0483 | 0.5775 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0053 | 0.175 | 0.175 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0053 | 0.175 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0026 | 0.0738 | 0.0738 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0738 | 0.1977 |
Onchocerca volvulus | 0.0009 | 0.0096 | 0.0146 | |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0096 | 0.0096 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0134 | 0.0134 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0096 | 0.0235 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0079 | 0.2704 | 0.9833 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0186 | 0.0457 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0096 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.138 | 0.4544 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0134 | 0.0134 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.138 | 0.4544 |
Schistosoma mansoni | glutaminase | 0.0274 | 1 | 1 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0483 | 0.0483 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0662 | 0.1626 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0707 | 0.0707 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.006 | 0.1997 | 0.7128 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0707 | 0.9148 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0096 | 0.0235 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0096 | 0.0096 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.008 | 0.2746 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.1375 | 0.4524 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0026 | 0.0738 | 0.0738 |
Mycobacterium ulcerans | DNA polymerase IV | 0.008 | 0.2746 | 0.246 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0096 | 0.0096 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.0483 | 0.3051 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0096 | 0.0235 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0483 | 0.1186 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0134 | 0.0329 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0372 | 0.0372 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0553 | 0.6931 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0067 | 0.0166 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0053 | 0.175 | 0.4301 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0053 | 0.175 | 0.8757 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.1375 | 0.4524 |
Leishmania major | DNA damage repair protein, putative | 0.0016 | 0.038 | 0.0555 |
Echinococcus granulosus | RUN | 0.0019 | 0.0483 | 0.1186 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0483 | 0.0483 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0096 | 0.0235 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0483 | 0.1186 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0662 | 0.1626 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0483 | 0.1186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0186 | 0.0457 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0096 | 0.0235 |
Schistosoma mansoni | DNA polymerase eta | 0.0079 | 0.2704 | 0.2704 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0067 | 0.0067 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0016 | 0.038 | 0.0546 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0483 | 0.0483 |
Trichomonas vaginalis | protein kinase inhibitor, putative | 0.0061 | 0.2057 | 0.2057 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0096 | 0.0096 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0483 | 0.0483 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0483 | 0.1186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0483 | 0.0483 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | glutaminase | 0.0274 | 1 | 1 |
Echinococcus granulosus | smad | 0.0008 | 0.0067 | 0.0166 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.008 | 0.2746 | 0.2746 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.6523 | 0.6523 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.1997 | 0.7009 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0026 | 0.0738 | 1 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.0061 | 0.2057 | 0.5054 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0067 | 0.0067 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0016 | 0.038 | 0.0546 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0134 | 0.0329 |
Trichomonas vaginalis | glutaminase, putative | 0.0274 | 1 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0067 | 0.0166 |
Giardia lamblia | DINP protein human, muc B family | 0.006 | 0.1997 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0067 | 0.0166 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.4069 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0096 | 0.0235 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0707 | 0.2574 |
Leishmania major | DNA polymerase kappa, putative | 0.0016 | 0.038 | 0.0555 |
Trypanosoma brucei | unspecified product | 0.0073 | 0.2499 | 0.9013 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0016 | 0.038 | 0.2295 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0053 | 0.175 | 0.175 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0096 | 0.0096 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0067 | 0.0166 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0016 | 0.038 | 0.0546 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0026 | 0.0738 | 0.519 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0738 | 0.2011 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0067 | 0.0067 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0134 | 0.031 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0134 | 0.031 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0067 | 0.0067 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0073 | 0.2499 | 0.9013 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0483 | 0.1186 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0067 | 0.0067 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0243 | 0.0885 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0067 | 0.0166 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.0061 | 0.2057 | 0.5054 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.4069 | 0.4069 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0096 | 0.0096 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0016 | 0.038 | 0.1382 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0243 | 0.1389 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.008 | 0.2746 | 0.2746 |
Echinococcus granulosus | flap endonuclease 1 | 0.0026 | 0.0738 | 0.1814 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0483 | 0.0483 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0662 | 0.0662 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0096 | 0.0235 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0042 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.4288 | 0.4288 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0079 | 0.2704 | 0.2704 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0053 | 0.175 | 0.175 |
Brugia malayi | polk-prov protein | 0.0043 | 0.1375 | 0.1375 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0067 | 0.0067 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0707 | 0.1852 |
Echinococcus multilocularis | dna polymerase eta | 0.0079 | 0.2704 | 0.6645 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0053 | 0.175 | 0.4301 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0707 | 0.2574 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0026 | 0.0738 | 0.1814 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0042 | 0.1334 | 0.4856 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1375 | 0.1375 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0079 | 0.2704 | 0.9848 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.4234 | 0.4234 |
Mycobacterium ulcerans | glutaminase | 0.0274 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0079 | 0.2704 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0738 | 0.2688 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0067 | 0.0166 |
Brugia malayi | DnaJ domain containing protein | 0.0061 | 0.2057 | 0.2057 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0707 | 0.1884 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.6523 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0483 | 0.1186 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0243 | 0.0243 |
Giardia lamblia | DNA damage repair protein | 0.0016 | 0.038 | 0.1319 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.008 | 0.2746 | 1 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0016 | 0.038 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0096 | 0.0096 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0096 | 0.0235 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0016 | 0.038 | 0.1382 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0016 | 0.038 | 0.4068 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.1133 | 0.3557 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0067 | 0.0067 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0707 | 0.4937 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0096 | 0.0096 |
Onchocerca volvulus | 0.0019 | 0.0483 | 0.074 | |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0067 | 0.0067 |
Schistosoma mansoni | flap endonuclease-1 | 0.0024 | 0.0644 | 0.0644 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0053 | 0.175 | 0.175 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0.0738 | 0.4217 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0096 | 0.0096 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0483 | 0.1186 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0134 | 0.0134 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0707 | 0.9482 |
Mycobacterium ulcerans | DNA polymerase IV | 0.008 | 0.2746 | 0.246 |
Brugia malayi | Smad1 | 0.0008 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0483 | 0.0483 |
Echinococcus granulosus | dna polymerase eta | 0.0079 | 0.2704 | 0.6645 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0016 | 0.038 | 0.0546 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.1133 | 0.3557 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0096 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.2057 | 0.2057 |
Leishmania major | DNA polymerase kappa, putative | 0.006 | 0.1997 | 0.7128 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0096 | 0.0096 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0016 | 0.038 | 0.038 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0662 | 0.0662 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0026 | 0.0738 | 0.3242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.