Detailed information for compound 82339

Basic information

Technical information
  • TDR Targets ID: 82339
  • Name: N-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4 -(1,2,4-triazol-1-yl)butan-2-yl]-4,7-dimethyl pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide
  • MW: 442.422 | Formula: C20H20F2N8O2
  • H donors: 2 H acceptors: 7 LogP: 0.74 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)[C@]([C@H](NC(=O)c1nnc2n(c1C)nc(c2)C)C)(Cn1cncn1)O
  • InChi: 1S/C20H20F2N8O2/c1-11-6-17-26-27-18(12(2)30(17)28-11)19(31)25-13(3)20(32,8-29-10-23-9-24-29)15-5-4-14(21)7-16(15)22/h4-7,9-10,13,32H,8H2,1-3H3,(H,25,31)/t13-,20-/m1/s1
  • InChiKey: CUZPJHYJBVWOAD-ZUOKHONESA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]-4,7-dimethyl-pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide
  • N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]-4,7-dimethyl-3-pyrazolo[5,1-c][1,2,4]triazinecarboxamide
  • N-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-4,7-dimethyl-pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.027 0.1402 0.1301
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0919 0.6795 0.6757
Schistosoma mansoni hypothetical protein 0.0146 0.037 0.0369
Leishmania major phosphatidylinositol kinase, putative 0.0146 0.037 0.0257
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0146 0.037 0.0369
Toxoplasma gondii target of rapamycin (TOR), putative 0.0146 0.037 0.037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0146 0.037 0.0369
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0146 0.037 0.0257
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0146 0.037 0.0257
Schistosoma mansoni fkbp-rapamycin associated protein 0.0146 0.037 0.0369
Leishmania major S-adenosylhomocysteine hydrolase 0.1305 1 1
Loa Loa (eye worm) hypothetical protein 0.027 0.1402 0.1401
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0919 0.6795 0.6757
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0247 0.1212 0.1211
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0146 0.037 0.0369
Brugia malayi Adenosine/AMP deaminase family protein 0.0172 0.0586 0.0585
Schistosoma mansoni adenosylhomocysteinase 0.0808 0.5867 0.5867
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0146 0.037 0.0257
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0375 0.2271 0.227
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Loa Loa (eye worm) adenosylhomocysteinase 0.1305 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0247 0.1212 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.037 0.0369
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0118 0.0142 0.0141
Entamoeba histolytica adenosine deaminase, putative 0.0172 0.0586 0.0476
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.027 0.1402 0.1401
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0372 0.2245 0.2244
Leishmania major phosphatidylinositol 3-kinase, putative 0.0146 0.037 0.0257
Plasmodium falciparum adenosylhomocysteinase 0.1305 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.027 0.1402 0.1301
Plasmodium vivax adenosine deaminase, putative 0.0172 0.0586 0.0225
Onchocerca volvulus Adenosine deaminase homolog 0.0172 0.0586 0.0668
Loa Loa (eye worm) hypothetical protein 0.0116 0.0121 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0172 0.0586 0.0476
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0118 0.0142 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.0375 0.2271 0.227
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.0146 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.0146 0.037 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.037 0.0369
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0116 0.0115
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.027 0.1402 0.1401
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0372 0.2244 0.2244
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.027 0.1402 0.1401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Echinococcus multilocularis 0.0247 0.1212 0.1109
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.017 0.057 0.0459
Loa Loa (eye worm) hypothetical protein 0.0919 0.6795 0.6795
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0167 0.0543 0.0432
Schistosoma mansoni adenosylhomocysteinase 0.0808 0.5867 0.5867
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0372 0.2245 0.2154
Echinococcus granulosus serine protein kinase ATM 0.0146 0.037 0.0257
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0247 0.1212 0.1109
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0372 0.2245 0.2154
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0146 0.037 0.0257
Brugia malayi phosphofructokinase 0.0115 0.0116 0.0115
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0146 0.037 0.0257
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.037 0.0369
Mycobacterium leprae conserved hypothetical protein 0.0146 0.037 0.0257
Onchocerca volvulus 0.0919 0.6795 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.027 0.1402 0.1301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0247 0.1212 0.0874
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.027 0.1402 0.1301
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.027 0.1402 0.1301
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0146 0.037 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Entamoeba histolytica hypothetical protein 0.027 0.1402 0.1301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.017 0.057 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0118 0.0142 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0124 0.0189 0.0188
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0343 0.2004 0.1911
Leishmania major phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0146 0.037 0.0369
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1305 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.027 0.1402 0.1301
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0919 0.6795 0.6757
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0146 0.037 0.0257
Mycobacterium tuberculosis Conserved hypothetical protein 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0146 0.037 0.0369
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0375 0.2271 0.227
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.027 0.1402 1
Brugia malayi 6-phosphofructokinase 0.0115 0.0116 0.0115
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0124 0.0189 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0167 0.0543 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0146 0.037 0.0257
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Entamoeba histolytica hypothetical protein 0.0146 0.037 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.037 0.0257
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.027 0.1402 0.1301
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0372 0.2245 0.2154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Leishmania major hypothetical protein, unknown function 0.0146 0.037 0.0257
Leishmania major hypothetical protein, conserved 0.0146 0.037 0.0257
Echinococcus granulosus adenosylhomocysteinase 0.1305 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0247 0.1212 0.1211
Echinococcus granulosus thymidylate synthase 0.0118 0.0142 0.0026
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0185 0.0691 0.069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.037 0.0369
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0372 0.2245 0.2154
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.1305 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0372 0.2245 0.2154
Schistosoma mansoni peptidylglycine monooxygenase 0.0375 0.2271 0.227
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0372 0.2245 0.2154
Echinococcus granulosus adenosine deaminase 0.0172 0.0586 0.0476
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.027 0.1402 0.1301
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0116 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0919 0.6795 0.6757
Loa Loa (eye worm) phosphatidylinositol 3 0.0919 0.6795 0.6795
Schistosoma mansoni adenosylhomocysteinase 0.1305 1 1
Echinococcus multilocularis adenosylhomocysteinase 0.1305 1 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0116 0.0115
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.027 0.1402 0.1402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.1212 0.1211
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.027 0.1402 0.1401
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0116 0.0115
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0167 0.0543 0.0432
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.027 0.1402 0.1401
Schistosoma mansoni adenosine deaminase 0.0172 0.0586 0.0585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0919 0.6795 0.6795
Brugia malayi 6-phosphofructokinase 0.0115 0.0116 0.0115
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0167 0.0543 0.0542
Entamoeba histolytica adenosine deaminase, putative 0.0172 0.0586 0.0476
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1071
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0167 0.0543 0.018
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0146 0.037 0.0257
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0116 0.0115
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0146 0.037 0.0369
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.027 0.1402 0.1401
Plasmodium falciparum phosphatidylinositol 3-kinase 0.027 0.1402 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.027 0.1402 0.1401
Treponema pallidum adenosine deaminase 0.0172 0.0586 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0247 0.1212 0.8163
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.027 0.1402 0.1301
Entamoeba histolytica hypothetical protein 0.0146 0.037 0.0257
Loa Loa (eye worm) hypothetical protein 0.0116 0.0121 0.012
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0919 0.6795 0.6795
Entamoeba histolytica adenosylhomocysteinase, putative 0.1305 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0247 0.1212 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0146 0.037 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0372 0.2245 0.2244
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0146 0.037 0.0257
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0146 0.037 0.0369
Trypanosoma cruzi target of rapamycin kinase 3 0.0146 0.037 0.0369
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0146 0.037 0.0257
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0247 0.1213 0.1213
Leishmania major phosphatidylinositol 4-kinase, putative 0.0247 0.1212 0.1109
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Entamoeba histolytica hypothetical protein 0.0146 0.037 0.0257
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.027 0.1402 0.1301
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0372 0.2245 0.2244
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.027 0.1402 0.1301
Entamoeba histolytica protein kinase rad3, putative 0.0146 0.037 0.0257
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0343 0.2004 0.1911
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0146 0.037 0.0257
Loa Loa (eye worm) thymidylate synthase 0.0118 0.0142 0.0141
Loa Loa (eye worm) phosphatidylinositol 3 0.0247 0.1212 0.1211
Schistosoma mansoni adenosylhomocysteinase 0.0808 0.5867 0.5867
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0146 0.037 0.0369
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0172 0.0586 0.0586
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.027 0.1402 0.1301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0375 0.2271 0.218
Onchocerca volvulus 0.0919 0.6795 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0146 0.037 0.0369
Mycobacterium ulcerans thymidylate synthase 0.0118 0.0142 0.0026
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0172 0.0586 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0146 0.037 0.0369
Entamoeba histolytica hypothetical protein 0.0146 0.037 0.0257
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.1305 1 1
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0172 0.0586 0.0476
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0146 0.037 0.0257
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0375 0.2271 0.227
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0247 0.1212 0.1109
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0167 0.0543 0.018
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0146 0.037 0.0257
Toxoplasma gondii adenosylhomocysteinase, putative 0.1305 1 1
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.1305 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Echinococcus multilocularis adenosine deaminase 0.0172 0.0586 0.0476
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0146 0.037 0.0257
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0146 0.037 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Loa Loa (eye worm) hypothetical protein 0.0116 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0375 0.2271 0.227
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.0116 0.0121 0.012
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0375 0.2271 0.218
Leishmania major adenine aminohydrolase 0.0172 0.0586 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.019 0.0738 0.0737
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1305 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.0343 0.2004 0.1911
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.6306 0.6262
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0146 0.037 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Schistosoma mansoni dopamine-beta-monooxygenase 0.071 0.5052 0.5051
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0372 0.2245 0.2244
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.027 0.1402 0.1301
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.1305 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.027 0.1402 0.1401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0372 0.2245 0.2154
Plasmodium falciparum adenosine deaminase 0.0172 0.0586 0.0225
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0146 0.037 0.0257
Trichomonas vaginalis adenosylhomocysteinase, putative 0.041 0.2561 0.2474
Loa Loa (eye worm) phosphatidylinositol 3 0.0919 0.6795 0.6795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis adenosine deaminase, putative 0.0172 0.0586 0.0476
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0146 0.037 0.0257
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.1305 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.027 0.1402 0.1301
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0372 0.2245 0.2244
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1305 1 1
Schistosoma mansoni adenosylhomocysteinase 0.0808 0.5867 0.5867
Brugia malayi thymidylate synthase 0.0118 0.0142 0.0141
Schistosoma mansoni adenosine deaminase-related 0.0172 0.0586 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0124 0.0189 0.0074
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0116 0.0115
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0146 0.037 0.0369
Echinococcus multilocularis Zinc finger, PHD finger 0.027 0.1402 0.1301
Mycobacterium ulcerans adenosine deaminase 0.0172 0.0586 0.0476
Echinococcus multilocularis thymidylate synthase 0.0118 0.0142 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.027 0.1402 0.1401
Loa Loa (eye worm) hypothetical protein 0.0172 0.0586 0.0585
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0146 0.037 0.0257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0919 0.6795 0.6795
Echinococcus multilocularis serine protein kinase ATM 0.0146 0.037 0.0257
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.1305 1 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1305 1 1
Trichomonas vaginalis adenosine deaminase, putative 0.0172 0.0586 0.0476
Toxoplasma gondii FATC domain-containing protein 0.0146 0.037 0.037
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0146 0.037 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.037 0.0257
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1402 0.1301
Leishmania major phosphatidylinositol kinase related protein, putative 0.0146 0.037 0.0257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.027 0.1402 0.1401
Loa Loa (eye worm) phosphatidylinositol kinase 0.0919 0.6795 0.6795
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.027 0.1402 0.1301

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 10 ug ml-1 The compound was tested in vitro for antifungal activity against 10 yeasts. ChEMBL. 9599236
MIC (functional) > 80 ug ml-1 The compound was tested in vitro for antifungal activity against 6 filamentous fungi. ChEMBL. 9599236
Protection (functional) = 0 % In vivo antifungal activity against murine candidosis model after peroral administration with 2.5 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599236
Protection (functional) = 0 % In vivo antifungal activity against murine candidosis model after peroral administration with 2.5 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599236
Protection (functional) = 0 % In vivo antifungal activity against murine candidosis model after peroral administration with 2.5 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599236
Protection (functional) = 0 % In vivo antifungal activity against murine candidosis model after peroral administration with 2.5 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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