Detailed information for compound 823719

Basic information

Technical information
  • TDR Targets ID: 823719
  • Name: 2-(8-methyl-4-oxochromeno[3,4-d]pyrazol-1-yl) -N-(3-methylphenyl)-N-propylacetamide
  • MW: 389.447 | Formula: C23H23N3O3
  • H donors: 0 H acceptors: 3 LogP: 4.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)Cn1ncc2c1c1cc(C)ccc1oc2=O)c1cccc(c1)C
  • InChi: 1S/C23H23N3O3/c1-4-10-25(17-7-5-6-15(2)11-17)21(27)14-26-22-18-12-16(3)8-9-20(18)29-23(28)19(22)13-24-26/h5-9,11-13H,4,10,14H2,1-3H3
  • InChiKey: ZIWHYRAXHGVUNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(8-methyl-4-oxo-chromeno[3,4-d]pyrazol-1-yl)-N-(3-methylphenyl)-N-propyl-acetamide
  • 2-(8-methyl-4-oxo-1-chromeno[3,4-d]pyrazolyl)-N-(3-methylphenyl)-N-propylacetamide
  • 2-(4-keto-8-methyl-chromeno[3,4-d]pyrazol-1-yl)-N-(3-methylphenyl)-N-propyl-acetamide
  • 2-(8-methyl-4-oxo-chromeno[3,4-d]pyrazol-1-yl)-N-(3-methylphenyl)-N-propyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Smad1 0.0009 0.0053 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.1302 0.2124
Schistosoma mansoni neuroligin 3 (S09 family) 0.0026 0.0777 0.1267
Trichomonas vaginalis esterase, putative 0.0038 0.1302 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0141 0.023
Echinococcus granulosus acetylcholinesterase 0.0152 0.6131 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0141 0.023
Schistosoma mansoni lamin 0.0029 0.0897 0.1463
Onchocerca volvulus 0.0026 0.0777 0.5965
Schistosoma mansoni smad1 5 8 and 0.0009 0.0053 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.1302 0.2124
Mycobacterium tuberculosis Conserved protein 0.0038 0.1302 0.1302
Echinococcus multilocularis Smad4 0.0009 0.0053 0.0086
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0897 0.1463
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0141 0.023
Echinococcus granulosus smad 0.0009 0.0053 0.0086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0751 0.1225
Echinococcus multilocularis lamin dm0 0.0029 0.0897 0.1463
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0026 0.0777 0.1267
Echinococcus granulosus BC026374 protein S09 family 0.0026 0.0777 0.1267
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.1302 0.2124
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0141 0.023
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0751 0.0751
Mycobacterium leprae conserved hypothetical protein 0.0038 0.1302 1
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0141 0.023
Mycobacterium ulcerans hypothetical protein 0.0038 0.1302 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0336 0.0547
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0482 0.5
Brugia malayi MH2 domain containing protein 0.0009 0.0053 0.0086
Onchocerca volvulus 0.0025 0.0751 0.5766
Echinococcus granulosus lamin dm0 0.0029 0.0897 0.1463
Loa Loa (eye worm) hypothetical protein 0.0013 0.0249 0.0407
Echinococcus multilocularis neuroligin 0.0026 0.0777 0.1267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0439 0.0439
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0141 0.023
Brugia malayi steroid hormone receptor 0.0011 0.0141 0.023
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.504 0.822
Onchocerca volvulus 0.0026 0.0777 0.5965
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0751 0.5766
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0751 0.5766
Brugia malayi nuclear receptor NHR-88 0.0011 0.0141 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.1302 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0751 0.5766
Loa Loa (eye worm) hypothetical protein 0.0019 0.0482 0.0786
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0141 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1739 0.2835
Echinococcus granulosus acetylcholinesterase 0.0152 0.6131 1
Schistosoma mansoni smad 0.0009 0.0053 0.0086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.1302 0.1302
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0141 0.1083
Echinococcus granulosus intermediate filament protein 0.0029 0.0897 0.1463
Echinococcus multilocularis carboxylesterase 5A 0.0152 0.6131 1
Onchocerca volvulus 0.0038 0.1302 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0141 0.023
Mycobacterium ulcerans hypothetical protein 0.0025 0.0751 0.5766
Echinococcus multilocularis musashi 0.0029 0.0897 0.1463
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0141 0.023
Schistosoma mansoni smad1 5 8 and 0.0009 0.0053 0.0086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.1302 1
Brugia malayi Carboxylesterase family protein 0.0026 0.0777 0.1267
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0141 0.023
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.1302 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0141 0.023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.1302 0.2124
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0482 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.1302 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.1302 0.1302
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0751 0.5766
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0336 0.0547
Loa Loa (eye worm) carboxylesterase 0.0026 0.0777 0.1267
Echinococcus granulosus Smad4 0.0009 0.0053 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0038 0.1302 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0271 0.0443
Echinococcus multilocularis BC026374 protein (S09 family) 0.0026 0.0777 0.1267
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0141 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0141 0.1083
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0053 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.1302 0.2124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Brugia malayi MH2 domain containing protein 0.0009 0.0053 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1739 0.2835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0141 0.023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0777 0.1267
Echinococcus multilocularis smad 0.0009 0.0053 0.0086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.6131 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0141 0.023
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0751 0.1225
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0141 0.023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Onchocerca volvulus 0.0011 0.0141 0.1083
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0751 0.1225
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0141 0.023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0141 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0141 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1739 0.2835
Schistosoma mansoni acetylcholinesterase 0.0026 0.0777 0.1267
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0751 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.1302 0.2124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0482 0.0786
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0751 0.5766
Brugia malayi MH1 domain containing protein 0.0009 0.0053 0.0086
Onchocerca volvulus 0.0026 0.0777 0.5965
Trichomonas vaginalis spcc417.12 protein, putative 0.0026 0.0777 0.5965
Onchocerca volvulus 0.0026 0.0777 0.5965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0141 0.023
Leishmania major hypothetical protein, conserved 0.0038 0.1302 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.6131 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0141 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0751 0.5766
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.1302 0.2124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0141 0.023
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.504 0.822
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0141 0.023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0482 0.0786
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0141 0.023
Schistosoma mansoni lamin 0.0029 0.0897 0.1463
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.1302 1
Brugia malayi Carboxylesterase family protein 0.0152 0.6131 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1739 0.2835
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0482 0.3703
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.1302 0.2124
Loa Loa (eye worm) hypothetical protein 0.0013 0.0249 0.0407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0439 0.0439
Brugia malayi Carboxylesterase family protein 0.0026 0.0777 0.1267
Loa Loa (eye worm) hypothetical protein 0.0152 0.6131 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0271 0.0443
Echinococcus granulosus para nitrobenzyl esterase 0.0026 0.0777 0.1267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0482 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0141 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0141 0.023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0141 0.023
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.1302 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0.0777 0.0777
Schistosoma mansoni BC026374 protein (S09 family) 0.0026 0.0777 0.1267
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0.0777 0.0777
Mycobacterium tuberculosis Conserved protein 0.0038 0.1302 0.1302
Brugia malayi MH1 domain containing protein 0.0009 0.0053 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0897 0.1463
Onchocerca volvulus 0.0029 0.0897 0.6889
Onchocerca volvulus 0.0029 0.0897 0.6889
Loa Loa (eye worm) beta-lactamase 0.0038 0.1302 0.2124
Loa Loa (eye worm) hypothetical protein 0.0038 0.1302 0.2124
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0026 0.0777 0.1267
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0141 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0141 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0751 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0141 0.023
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0141 0.1083
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0141 0.023
Mycobacterium tuberculosis Carboxylesterase LipT 0.0026 0.0777 0.0777
Echinococcus granulosus carboxylesterase 5A 0.0152 0.6131 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0751 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0751 0.1225
Loa Loa (eye worm) acetylcholinesterase 1 0.0152 0.6131 1
Mycobacterium ulcerans lipase LipD 0.0038 0.1302 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0053 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0141 0.023
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0141 0.023
Onchocerca volvulus 0.0026 0.0777 0.5965
Echinococcus granulosus lamin 0.0029 0.0897 0.1463
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.1302 1
Toxoplasma gondii ABC1 family protein 0.0038 0.1302 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.1302 0.1302
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.1302 0.1302
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0271 0.0443
Schistosoma mansoni gliotactin 0.0026 0.0777 0.1267
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0897 0.1463
Schistosoma mansoni intermediate filament proteins 0.0029 0.0897 0.1463
Echinococcus multilocularis para nitrobenzyl esterase 0.0026 0.0777 0.1267
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0053 0.0086
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0751 0.5766
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0141 0.023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0777 0.1267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0141 0.023
Loa Loa (eye worm) carboxylesterase 0.0026 0.0777 0.1267
Echinococcus multilocularis lamin 0.0029 0.0897 0.1463
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1739 0.2835
Mycobacterium ulcerans beta-lactamase 0.0038 0.1302 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.1302 1
Brugia malayi ecdysteroid receptor 0.0011 0.0141 0.023
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0751 0.5766
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0141 0.023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0141 0.023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0875 0.1427
Brugia malayi Carboxylesterase family protein 0.0152 0.6131 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0141 0.023
Onchocerca volvulus 0.0038 0.1302 1
Brugia malayi beta-lactamase family protein 0.0038 0.1302 0.2124
Brugia malayi beta-lactamase 0.0038 0.1302 0.2124
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0141 0.023
Loa Loa (eye worm) carboxylesterase 0.0152 0.6131 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0751 0.5766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1739 0.2835
Brugia malayi Carboxylesterase family protein 0.0026 0.0777 0.1267
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0141 0.023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0751 1
Schistosoma mansoni Smad4 0.0009 0.0053 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0141 0.023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0141 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1739 0.2835
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0141 0.023
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.1302 0.1302
Loa Loa (eye worm) hypothetical protein 0.0025 0.0751 0.1225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0141 0.023
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0751 0.5766
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0141 0.023
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0026 0.0777 0.5965
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0751 0.5766
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Echinococcus granulosus neuroligin 0.0026 0.0777 0.1267
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0141 0.023
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.1302 0.1302
Brugia malayi intermediate filament protein 0.0029 0.0897 0.1463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0141 0.023
Loa Loa (eye worm) hypothetical protein 0.0038 0.1302 0.2124
Brugia malayi hypothetical protein 0.0026 0.0777 0.1267
Mycobacterium ulcerans carboxylesterase, LipT 0.0026 0.0777 0.5965
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.1302 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0777 0.1267
Schistosoma mansoni smad1 5 8 and 0.0009 0.0053 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0141 0.023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0482 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0141 0.023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.1302 0.2124
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.1302 1
Brugia malayi nuclear hormone receptor 0.0011 0.0141 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0141 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0439 0.0439
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0053 0.0086
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0053 0.0086
Brugia malayi Smad1 0.0009 0.0053 0.0086
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0053 0.0086
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0897 0.1463
Schistosoma mansoni coup transcription factor 0.0011 0.0141 0.023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.1302 0.1302
Loa Loa (eye worm) hypothetical protein 0.0025 0.0751 0.1225
Loa Loa (eye worm) hypothetical protein 0.0011 0.0141 0.023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0141 0.023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1739 0.2835
Loa Loa (eye worm) hypothetical protein 0.0019 0.0482 0.0786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0141 0.023
Brugia malayi beta-lactamase family protein 0.0038 0.1302 0.2124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0777 0.1267
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.1302 0.1302
Brugia malayi MH2 domain containing protein 0.0126 0.504 0.822
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0038 0.1302 0.2124
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0751 0.5766
Brugia malayi Carboxylesterase family protein 0.0026 0.0777 0.1267
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0053 0.0086
Onchocerca volvulus 0.0038 0.1302 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0141 0.023
Echinococcus multilocularis acetylcholinesterase 0.0152 0.6131 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1739 0.2835
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0141 0.023
Mycobacterium leprae Probable lipase LipE 0.0038 0.1302 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0482 0.3703
Echinococcus multilocularis acetylcholinesterase 0.0152 0.6131 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0141 0.023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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