Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.3351 | 0.598 | 0.4919 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3351 | 0.598 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3351 | 0.598 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.4716 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3351 | 0.598 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3351 | 0.598 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.3351 | 0.598 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.2686 | 0.402 | 0.402 |
Trypanosoma brucei | AMP deaminase, putative | 0.3351 | 0.598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2686 | 0.402 | 0.402 |
Trypanosoma brucei | AMP deaminase, putative | 0.3351 | 0.598 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.4716 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.4716 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.3351 | 0.598 | 0.4919 |
Plasmodium vivax | adenosine deaminase, putative | 0.4716 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.3351 | 0.598 | 0.4919 |
Leishmania major | adenine aminohydrolase | 0.4716 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4716 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.3351 | 0.598 | 0.598 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3351 | 0.598 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4716 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3351 | 0.598 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4716 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.3351 | 0.598 | 0.4919 |
Treponema pallidum | adenosine deaminase | 0.4716 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.4716 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.4716 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3351 | 0.598 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3351 | 0.598 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.4716 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4716 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4716 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.4716 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4716 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2686 | 0.402 | 0.402 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4716 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.4716 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3351 | 0.598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2686 | 0.402 | 0.402 |
Loa Loa (eye worm) | hypothetical protein | 0.203 | 0.2087 | 0.2087 |
Echinococcus granulosus | adenosine deaminase | 0.4716 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.