Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Toxoplasma gondii | PAN domain-containing protein | 0.0437 | 0.2034 | 0.2201 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0594 | 0.3752 | 0.6839 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.106 | 0.8843 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | enteropeptidase | 0.0646 | 0.4316 | 0.7867 |
Loa Loa (eye worm) | notch protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1166 | 1 | 1 |
Onchocerca volvulus | 0.0914 | 0.7252 | 0.7252 | |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | neural cadherin | 0.0262 | 0.0112 | 0.0205 |
Brugia malayi | thymidylate synthase | 0.0753 | 0.5486 | 0.5486 |
Giardia lamblia | High cysteine protein | 0.0262 | 0.0112 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0307 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | Notch2 | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | thymidylate synthase | 0.0753 | 0.5486 | 0.5486 |
Schistosoma mansoni | notch | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.3233 | 0.3233 |
Brugia malayi | Kringle domain containing protein | 0.0594 | 0.3752 | 0.3752 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.3233 | 0.3233 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0547 | 0.3233 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0547 | 0.3233 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0547 | 0.3233 | 0.5893 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | thymidylate synthase | 0.0753 | 0.5486 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | protein jagged 1 | 0.0262 | 0.0112 | 0.0205 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | cell polarity protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | Tolloid protein 1 | 0.0547 | 0.3233 | 0.5893 |
Echinococcus granulosus | laminin | 0.0547 | 0.3233 | 0.5893 |
Echinococcus granulosus | enteropeptidase | 0.0646 | 0.4316 | 0.7867 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0358 | 0.1169 | 0.1148 |
Brugia malayi | Fibulin-1 precursor | 0.0547 | 0.3233 | 0.3233 |
Brugia malayi | Dihydrofolate reductase | 0.0307 | 0.0609 | 0.0609 |
Brugia malayi | dihydrofolate reductase family protein | 0.0307 | 0.0609 | 0.0609 |
Echinococcus multilocularis | protein jagged 1 | 0.0262 | 0.0112 | 0.0205 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0594 | 0.3752 | 0.3752 |
Echinococcus multilocularis | fibropellin Ia | 0.0262 | 0.0112 | 0.0205 |
Onchocerca volvulus | 0.0753 | 0.5486 | 0.5486 | |
Brugia malayi | notch-like transmembrane receptor | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.3233 | 0.3233 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.106 | 0.8843 | 1 |
Schistosoma mansoni | notch | 0.0262 | 0.0112 | 0.0112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0358 | 0.1169 | 0.5 |
Onchocerca volvulus | 0.0262 | 0.0112 | 0.0112 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0307 | 0.0609 | 0.0609 |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0262 | 0.0112 | 0.0205 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0262 | 0.0112 | 0.0112 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.106 | 0.8843 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.106 | 0.8843 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1166 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.106 | 0.8843 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0262 | 0.0112 | 0.0205 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0753 | 0.5486 | 0.5486 |
Echinococcus granulosus | slit 2 protein | 0.0262 | 0.0112 | 0.0205 |
Schistosoma mansoni | notch | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0262 | 0.0112 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0262 | 0.0112 | 0.0205 |
Brugia malayi | Delta serrate ligand family protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | notch | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Cadherin domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.3752 | 0.3752 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0646 | 0.4316 | 0.7867 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | notch | 0.0262 | 0.0112 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0307 | 0.0609 | 0.1111 |
Echinococcus granulosus | protein jagged 2 | 0.0262 | 0.0112 | 0.0205 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0547 | 0.3233 | 0.3233 |
Echinococcus multilocularis | thymidylate synthase | 0.0753 | 0.5486 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | protein jagged 1 | 0.0262 | 0.0112 | 0.0205 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0262 | 0.0112 | 0.0205 |
Brugia malayi | hypothetical protein | 0.0358 | 0.1169 | 0.1169 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0646 | 0.4316 | 0.4316 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.3233 | 0.3233 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0547 | 0.3233 | 0.3233 |
Onchocerca volvulus | Slit protein homolog | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | neural cadherin | 0.0262 | 0.0112 | 0.0205 |
Echinococcus granulosus | protein jagged 2 | 0.0262 | 0.0112 | 0.0205 |
Echinococcus granulosus | Mastin | 0.0646 | 0.4316 | 0.7867 |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Onchocerca volvulus | 0.0262 | 0.0112 | 0.0112 | |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0547 | 0.3233 | 0.3233 |
Toxoplasma gondii | PAN domain-containing protein | 0.0437 | 0.2034 | 0.2201 |
Onchocerca volvulus | 0.0262 | 0.0112 | 0.0112 | |
Echinococcus multilocularis | protein jagged 2 | 0.0262 | 0.0112 | 0.0205 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0307 | 0.0609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | Mastin | 0.0646 | 0.4316 | 0.7867 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | notch | 0.0262 | 0.0112 | 0.0112 |
Toxoplasma gondii | kringle domain-containing protein | 0.0594 | 0.3752 | 0.4169 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | notch | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0594 | 0.3752 | 0.3752 |
Onchocerca volvulus | Arrow homolog | 0.0547 | 0.3233 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | fibropellin Ia | 0.0262 | 0.0112 | 0.0205 |
Schistosoma mansoni | septate junction protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0262 | 0.0112 | 0.0205 |
Onchocerca volvulus | Putative cubilin | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0547 | 0.3233 | 0.3233 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0262 | 0.0112 | 0.0205 |
Mycobacterium ulcerans | thymidylate synthase | 0.0753 | 0.5486 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0646 | 0.4316 | 0.7867 |
Echinococcus granulosus | protein jagged 1 | 0.0262 | 0.0112 | 0.0205 |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0547 | 0.3233 | 0.3574 |
Echinococcus multilocularis | fibrillin 1 | 0.0547 | 0.3233 | 0.5893 |
Onchocerca volvulus | 0.0594 | 0.3752 | 0.3752 | |
Echinococcus multilocularis | laminin | 0.0547 | 0.3233 | 0.5893 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0547 | 0.3233 | 0.3574 |
Onchocerca volvulus | 0.0262 | 0.0112 | 0.0112 | |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | delta-like protein 1 | 0.0262 | 0.0112 | 0.0205 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0262 | 0.0112 | 0.0205 |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0594 | 0.3752 | 0.3366 |
Schistosoma mansoni | egf-like domain protein | 0.0547 | 0.3233 | 0.3233 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0262 | 0.0112 | 0.0112 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.106 | 0.8843 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0594 | 0.3752 | 0.6839 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Cadherin domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | slit 2 protein | 0.0262 | 0.0112 | 0.0205 |
Brugia malayi | EGF-like domain containing protein | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Muscle positioning protein 4 | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Onchocerca volvulus | 0.0262 | 0.0112 | 0.0112 | |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.3233 | 0.3233 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0262 | 0.0112 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Brugia malayi | Protein kinase domain containing protein | 0.0594 | 0.3752 | 0.3752 |
Schistosoma mansoni | slit | 0.0262 | 0.0112 | 0.0112 |
Echinococcus multilocularis | notch | 0.0262 | 0.0112 | 0.0205 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0262 | 0.0112 | 0.0205 |
Onchocerca volvulus | 0.1166 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0112 | 0.0112 |
Echinococcus granulosus | dihydrofolate reductase | 0.0307 | 0.0609 | 0.1111 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0753 | 0.5486 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0307 | 0.0609 | 0.1111 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0753 | 0.5486 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.